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Conserved domains on  [gi|568934534|ref|XP_006504168|]
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putative methyltransferase NSUN7 isoform X5 [Mus musculus]

Protein Classification

RsmB/NOP family class I SAM-dependent RNA methyltransferase( domain architecture ID 1000767)

RsmB/NOP family class I SAM-dependent RNA methyltransferase similar to Homo sapiens mitochondrial tRNA (cytosine(34)-C(5))-methyltransferase, which mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met), and to 5-methylcytosine rRNA methyltransferase NSUN4 involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RsmB super family cl33775
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
35-195 3.26e-09

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


The actual alignment was detected with superfamily member COG0144:

Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 58.48  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534  35 DFNARKL------FTRMGCQNIEILHetfLSIESKDHRLQNV--KVILLLPrCSSLGVsnpvefiLNEHEDKSLLQDlsq 106
Cdd:COG0144  281 DISEHRLkrlrenLARLGLSNVEVVV---ADARELLEWLPGKfdRVLLDAP-CSGTGT-------LRRHPDIKWRRT--- 346
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534 107 gglPKDkLETLVQQQFEQLTHAMKFTKVQ-AIVYCTCSVSKEENEDVVEKALEyQSSGVKMQPYRLSPPVLPLCTLKEIE 185
Cdd:COG0144  347 ---PED-IAELAALQRELLDAAARLLKPGgRLVYSTCSLLPEENEEVVEAFLA-RHPDFELVPLAELLPGLALTDGGYLR 421
                        170
                 ....*....|....*..
gi 568934534 186 L-----SMDRFF--RLE 195
Cdd:COG0144  422 LlphrhGTDGFFiaRLR 438
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
35-195 3.26e-09

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 58.48  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534  35 DFNARKL------FTRMGCQNIEILHetfLSIESKDHRLQNV--KVILLLPrCSSLGVsnpvefiLNEHEDKSLLQDlsq 106
Cdd:COG0144  281 DISEHRLkrlrenLARLGLSNVEVVV---ADARELLEWLPGKfdRVLLDAP-CSGTGT-------LRRHPDIKWRRT--- 346
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534 107 gglPKDkLETLVQQQFEQLTHAMKFTKVQ-AIVYCTCSVSKEENEDVVEKALEyQSSGVKMQPYRLSPPVLPLCTLKEIE 185
Cdd:COG0144  347 ---PED-IAELAALQRELLDAAARLLKPGgRLVYSTCSLLPEENEEVVEAFLA-RHPDFELVPLAELLPGLALTDGGYLR 421
                        170
                 ....*....|....*..
gi 568934534 186 L-----SMDRFF--RLE 195
Cdd:COG0144  422 LlphrhGTDGFFiaRLR 438
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
43-157 2.90e-07

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 50.50  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534   43 TRMGCQNIEILHETfLSIESKDHRLQNVKVILLLPRCSSLGVsnpvefiLNEHEDKSLLQDlsqgglPKDkLETLVQQQF 122
Cdd:pfam01189  54 HRLGVTNTIILNGD-GRQPDQWLGGVLFDRILLDAPCSGTGV-------IRRHPDVKWLRQ------EAD-IAQLAQLQK 118
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568934534  123 EQLTHAMKFTKVQA-IVYCTCSVSKEENEDVVEKAL 157
Cdd:pfam01189 119 ELLSAAIDLLKPGGvLVYSTCSVLPEENEAVIEYFL 154
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
44-177 3.57e-06

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 48.77  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534  44 RMGCQNIEIL--HETFLSIESKDHRLQNVKVILLLPrCSSLGvsnpvefILNEHEDKSLLQDlsqgglpKDKLETLVQQQ 121
Cdd:PRK14901 299 RLGLKSIKILaaDSRNLLELKPQWRGYFDRILLDAP-CSGLG-------TLHRHPDARWRQT-------PEKIQELAPLQ 363
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568934534 122 FEQLTHAMKFTKVQA-IVYCTCSVSKEENEDVVEKALEyQSSGVKMQPyrLSPPVLP 177
Cdd:PRK14901 364 AELLESLAPLLKPGGtLVYATCTLHPAENEAQIEQFLA-RHPDWKLEP--PKQKIWP 417
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
44-158 2.48e-03

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 39.37  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534   44 RMGCQNIEILHetFLSIESKDHRLQNVKVILLLPrCSSLGVSnpvefilneHEDKSLLQDLSqgglPKDKLEtLVQQQFE 123
Cdd:TIGR00446 118 RMGVLNTIVIN--ADGRKFGAYLLKFDAILLDAP-CSGEGVI---------RKDPSRKRNWS----EEDIKY-CSLLQKE 180
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568934534  124 QLTHAMKFTKVQA-IVYCTCSVSKEENEDVVEKALE 158
Cdd:TIGR00446 181 LIDAAIDALKPGGvLVYSTCSLEVEENEEVIDYILR 216
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
35-195 3.26e-09

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 58.48  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534  35 DFNARKL------FTRMGCQNIEILHetfLSIESKDHRLQNV--KVILLLPrCSSLGVsnpvefiLNEHEDKSLLQDlsq 106
Cdd:COG0144  281 DISEHRLkrlrenLARLGLSNVEVVV---ADARELLEWLPGKfdRVLLDAP-CSGTGT-------LRRHPDIKWRRT--- 346
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534 107 gglPKDkLETLVQQQFEQLTHAMKFTKVQ-AIVYCTCSVSKEENEDVVEKALEyQSSGVKMQPYRLSPPVLPLCTLKEIE 185
Cdd:COG0144  347 ---PED-IAELAALQRELLDAAARLLKPGgRLVYSTCSLLPEENEEVVEAFLA-RHPDFELVPLAELLPGLALTDGGYLR 421
                        170
                 ....*....|....*..
gi 568934534 186 L-----SMDRFF--RLE 195
Cdd:COG0144  422 LlphrhGTDGFFiaRLR 438
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
43-157 2.90e-07

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 50.50  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534   43 TRMGCQNIEILHETfLSIESKDHRLQNVKVILLLPRCSSLGVsnpvefiLNEHEDKSLLQDlsqgglPKDkLETLVQQQF 122
Cdd:pfam01189  54 HRLGVTNTIILNGD-GRQPDQWLGGVLFDRILLDAPCSGTGV-------IRRHPDVKWLRQ------EAD-IAQLAQLQK 118
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568934534  123 EQLTHAMKFTKVQA-IVYCTCSVSKEENEDVVEKAL 157
Cdd:pfam01189 119 ELLSAAIDLLKPGGvLVYSTCSVLPEENEAVIEYFL 154
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
44-177 3.57e-06

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 48.77  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534  44 RMGCQNIEIL--HETFLSIESKDHRLQNVKVILLLPrCSSLGvsnpvefILNEHEDKSLLQDlsqgglpKDKLETLVQQQ 121
Cdd:PRK14901 299 RLGLKSIKILaaDSRNLLELKPQWRGYFDRILLDAP-CSGLG-------TLHRHPDARWRQT-------PEKIQELAPLQ 363
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568934534 122 FEQLTHAMKFTKVQA-IVYCTCSVSKEENEDVVEKALEyQSSGVKMQPyrLSPPVLP 177
Cdd:PRK14901 364 AELLESLAPLLKPGGtLVYATCTLHPAENEAQIEQFLA-RHPDWKLEP--PKQKIWP 417
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
37-158 5.64e-05

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 45.17  E-value: 5.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534  37 NARklftRMGCQNIEI-------LHETFlsIESKDhrlqnvKVILLLPrCSSLGVsnpvefILNEHE---DKSllqdlsq 106
Cdd:PRK14902 294 NAK----RLGLTNIETkaldarkVHEKF--AEKFD------KILVDAP-CSGLGV------IRRKPDikyNKT------- 347
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568934534 107 gglPKDkLETLVQQQFEQLTHAMKFTKVQAI-VYCTCSVSKEENEDVVEKALE 158
Cdd:PRK14902 348 ---KED-IESLQEIQLEILESVAQYLKKGGIlVYSTCTIEKEENEEVIEAFLE 396
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
113-158 3.71e-04

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 42.74  E-value: 3.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568934534 113 KLETLVQQQFEQLTHAMKFTKVQAI-VYCTCSVSKEENEDVVEKALE 158
Cdd:PRK14904 348 KLAELVGLQAELLDHAASLLKPGGVlVYATCSIEPEENELQIEAFLQ 394
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
44-158 2.48e-03

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 39.37  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934534   44 RMGCQNIEILHetFLSIESKDHRLQNVKVILLLPrCSSLGVSnpvefilneHEDKSLLQDLSqgglPKDKLEtLVQQQFE 123
Cdd:TIGR00446 118 RMGVLNTIVIN--ADGRKFGAYLLKFDAILLDAP-CSGEGVI---------RKDPSRKRNWS----EEDIKY-CSLLQKE 180
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568934534  124 QLTHAMKFTKVQA-IVYCTCSVSKEENEDVVEKALE 158
Cdd:TIGR00446 181 LIDAAIDALKPGGvLVYSTCSLEVEENEEVIDYILR 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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