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Conserved domains on  [gi|568922405|ref|XP_006501358|]
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thrombospondin-3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 536-733 1.19e-121

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 362.34  E-value: 1.19e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405  536 QIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 615
Cdd:pfam05735   1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405  616 PFRAVAQPGLQLKAVTSISGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWRLLHRPQVGYIRVKLYEGPQL 695
Cdd:pfam05735  81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568922405  696 VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCND 733
Cdd:pfam05735 161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 346-381 1.25e-10

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 56.60  E-value: 1.25e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568922405  346 KDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQ 381
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 483-517 5.67e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 5.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568922405  483 KDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVT 517
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANID 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 111-147 7.92e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 7.92e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568922405 111 DINECAHADPCFPGSSCINTMPGFHCEaCPPGYKGTR 147
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCS-CPPGYTGRN 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 405-442 6.76e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 46.20  E-value: 6.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568922405  405 TDADSDLVGDVCDtnEDSDGDGHQDTKDNCPQLPNSSQ 442
Cdd:pfam02412   1 TDSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-506 1.42e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQAlpcMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 633 DSDSASDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDAcDNDVDGDGipnglDNCPKVPNPLQTDRDEDGVGDAcDSCPEMSNPTQTDADSDLV 412
Cdd:NF033609 710 S-DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 781

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 413 GDvCDTNEDSDGDGHQDT-KDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPNPNQKDSDGNGVG 491
Cdd:NF033609 782 SD-SDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDS 860

                        250
                 ....*....|....*
gi 568922405 492 DVCEDDFDNDAVVDP 506
Cdd:NF033609 861 NSDSESGSNNNVVPP 875
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 173-202 2.21e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 568922405  173 NNGGCDPNSICTNTVGSFKCgPCRLGFLGN 202
Cdd:pfam12947   4 NNGGCHPNATCTNTGGSFTC-TCNDGYTGD 32
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 536-733 1.19e-121

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 362.34  E-value: 1.19e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405  536 QIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 615
Cdd:pfam05735   1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405  616 PFRAVAQPGLQLKAVTSISGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWRLLHRPQVGYIRVKLYEGPQL 695
Cdd:pfam05735  81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568922405  696 VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCND 733
Cdd:pfam05735 161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 346-381 1.25e-10

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 56.60  E-value: 1.25e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568922405  346 KDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQ 381
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 483-517 5.67e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 5.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568922405  483 KDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVT 517
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANID 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 111-147 7.92e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 7.92e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568922405 111 DINECAHADPCFPGSSCINTMPGFHCEaCPPGYKGTR 147
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
111-143 1.61e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568922405   111 DINECAHADPCFPGSSCINTMPGFHCEaCPPGY 143
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE-CPPGY 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 405-442 6.76e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 46.20  E-value: 6.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568922405  405 TDADSDLVGDVCDtnEDSDGDGHQDTKDNCPQLPNSSQ 442
Cdd:pfam02412   1 TDSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-506 1.42e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQAlpcMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 633 DSDSASDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDAcDNDVDGDGipnglDNCPKVPNPLQTDRDEDGVGDAcDSCPEMSNPTQTDADSDLV 412
Cdd:NF033609 710 S-DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 781

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 413 GDvCDTNEDSDGDGHQDT-KDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPNPNQKDSDGNGVG 491
Cdd:NF033609 782 SD-SDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDS 860

                        250
                 ....*....|....*
gi 568922405 492 DVCEDDFDNDAVVDP 506
Cdd:NF033609 861 NSDSESGSNNNVVPP 875
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 173-202 2.21e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 568922405  173 NNGGCDPNSICTNTVGSFKCgPCRLGFLGN 202
Cdd:pfam12947   4 NNGGCHPNATCTNTGGSFTC-TCNDGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
165-199 1.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568922405   165 DIDECNDGNNggCDPNSICTNTVGSFKCGpCRLGF 199
Cdd:smart00179   1 DIDECASGNP--CQNGGTCVNTVGSYRCE-CPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 165-201 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568922405 165 DIDECNDGNNggCDPNSICTNTVGSFKCGpCRLGFLG 201
Cdd:cd00054    1 DIDECASGNP--CQNGGTCVNTVGSYRCS-CPPGYTG 34
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-505 2.06e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.90  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQAlpcMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 603 DSDSASDSDSA---SDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 679

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDA-CDNDVDGDGIPNGlDNCPKVPNPLQTDRDEDGVGDA-CDSCPEMSNPTQTDADSD 410
Cdd:NF033609 680 S-DSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSD 757

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 411 LVGDvCDTNEDSDGDGHQDTkDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPNPNQKDSDGNGV 490
Cdd:NF033609 758 SDSD-SDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 835

                        250
                 ....*....|....*
gi 568922405 491 GDvCEDDFDNDAVVD 505
Cdd:NF033609 836 SD-SDSDSDSDSDSD 849
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-479 3.92e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.66  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQalpcmDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 663 DSDSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 737

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDAcDNDVDGDGipnglDNCPKVPNPLQTDRDEDGVGDAcDSCPEMSNPTQTDADSDLV 412
Cdd:NF033609 738 S-DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 809

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568922405 413 GDvCDTNEDSDGDGHQDT-KDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPN 479
Cdd:NF033609 810 SD-SDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPN 876
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 321-447 8.65e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.51  E-value: 8.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 321 DQQNSDTDSFGDAcDNCPNVPNNDQKDTDGNGEGD-ACDNDVDGDGiPNGLDNCPKVPNPLQTDRDEDGVGD-ACDSCPE 398
Cdd:NF033609 572 DSSNSDSGSDSGS-DSTSDSGSDSASDSDSASDSDsASDSDSASDS-DSASDSDSASDSDSASDSDSASDSDsDSDSDSD 649

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568922405 399 MSNPTQTDADSDLVGDvCDTNEDSDGDGHQDTkDNCPQLPNSSQLDSDN 447
Cdd:NF033609 650 SDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDS 696
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 536-733 1.19e-121

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 362.34  E-value: 1.19e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405  536 QIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 615
Cdd:pfam05735   1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405  616 PFRAVAQPGLQLKAVTSISGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWRLLHRPQVGYIRVKLYEGPQL 695
Cdd:pfam05735  81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568922405  696 VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCND 733
Cdd:pfam05735 161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 346-381 1.25e-10

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 56.60  E-value: 1.25e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568922405  346 KDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQ 381
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 483-517 5.67e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 5.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568922405  483 KDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVT 517
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANID 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 111-147 7.92e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 7.92e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568922405 111 DINECAHADPCFPGSSCINTMPGFHCEaCPPGYKGTR 147
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
111-143 1.61e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568922405   111 DINECAHADPCFPGSSCINTMPGFHCEaCPPGY 143
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE-CPPGY 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 405-442 6.76e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 46.20  E-value: 6.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568922405  405 TDADSDLVGDVCDtnEDSDGDGHQDTKDNCPQLPNSSQ 442
Cdd:pfam02412   1 TDSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-506 1.42e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQAlpcMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 633 DSDSASDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDAcDNDVDGDGipnglDNCPKVPNPLQTDRDEDGVGDAcDSCPEMSNPTQTDADSDLV 412
Cdd:NF033609 710 S-DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 781

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 413 GDvCDTNEDSDGDGHQDT-KDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPNPNQKDSDGNGVG 491
Cdd:NF033609 782 SD-SDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDS 860

                        250
                 ....*....|....*
gi 568922405 492 DVCEDDFDNDAVVDP 506
Cdd:NF033609 861 NSDSESGSNNNVVPP 875
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 173-202 2.21e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 568922405  173 NNGGCDPNSICTNTVGSFKCgPCRLGFLGN 202
Cdd:pfam12947   4 NNGGCHPNATCTNTGGSFTC-TCNDGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
165-199 1.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568922405   165 DIDECNDGNNggCDPNSICTNTVGSFKCGpCRLGF 199
Cdd:smart00179   1 DIDECASGNP--CQNGGTCVNTVGSYRCE-CPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 165-201 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568922405 165 DIDECNDGNNggCDPNSICTNTVGSFKCGpCRLGFLG 201
Cdd:cd00054    1 DIDECASGNP--CQNGGTCVNTVGSYRCS-CPPGYTG 34
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-505 2.06e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.90  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQAlpcMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 603 DSDSASDSDSA---SDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 679

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDA-CDNDVDGDGIPNGlDNCPKVPNPLQTDRDEDGVGDA-CDSCPEMSNPTQTDADSD 410
Cdd:NF033609 680 S-DSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSD 757

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 411 LVGDvCDTNEDSDGDGHQDTkDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPNPNQKDSDGNGV 490
Cdd:NF033609 758 SDSD-SDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 835

                        250
                 ....*....|....*
gi 568922405 491 GDvCEDDFDNDAVVD 505
Cdd:NF033609 836 SD-SDSDSDSDSDSD 849
EGF_CA pfam07645
Calcium-binding EGF domain;
165-192 2.35e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*...
gi 568922405  165 DIDECNDGNNGgCDPNSICTNTVGSFKC 192
Cdd:pfam07645   1 DVDECATGTHN-CPANTVCVNTIGSFEC 27
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 114-147 4.86e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 4.86e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 568922405 114 ECAHADPCFPGSSCINTMPGFHCEaCPPGYKGTR 147
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCV-CPPGYTGDR 33
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 253-479 3.92e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.66  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 253 DTDIDGYPDQalpcmDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGD 332
Cdd:NF033609 663 DSDSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 737

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 333 AcDNCPNVPNNDQKDTDGNGEGDAcDNDVDGDGipnglDNCPKVPNPLQTDRDEDGVGDAcDSCPEMSNPTQTDADSDLV 412
Cdd:NF033609 738 S-DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 809

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568922405 413 GDvCDTNEDSDGDGHQDT-KDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLVPN 479
Cdd:NF033609 810 SD-SDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPN 876
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 321-447 8.65e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.51  E-value: 8.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922405 321 DQQNSDTDSFGDAcDNCPNVPNNDQKDTDGNGEGD-ACDNDVDGDGiPNGLDNCPKVPNPLQTDRDEDGVGD-ACDSCPE 398
Cdd:NF033609 572 DSSNSDSGSDSGS-DSTSDSGSDSASDSDSASDSDsASDSDSASDS-DSASDSDSASDSDSASDSDSASDSDsDSDSDSD 649

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568922405 399 MSNPTQTDADSDLVGDvCDTNEDSDGDGHQDTkDNCPQLPNSSQLDSDN 447
Cdd:NF033609 650 SDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDS 696
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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