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Conserved domains on  [gi|568921773|ref|XP_006501053|]
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pro-epidermal growth factor isoform X3 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 13891139)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
596-639 7.16e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 7.16e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
639-682 5.81e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 5.81e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    639 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 682
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
553-595 1.00e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.00e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
366-401 1.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 1.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
445-482 5.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 5.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568921773   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
510-552 1.03e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 1.03e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    510 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA pfam07645
Calcium-binding EGF domain;
877-909 2.36e-07

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.00  E-value: 2.36e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568921773   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
751-786 2.54e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 2.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   751 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 786
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
158-199 1.13e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 1.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
PHA02887 super family cl31518
EGF-like protein; Provisional
941-978 5.56e-05

EGF-like protein; Provisional


The actual alignment was detected with superfamily member PHA02887:

Pssm-ID: 165214  Cd Length: 126  Bit Score: 44.15  E-value: 5.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568921773  941 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 978
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
125-156 1.06e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.06e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568921773    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
414-442 1.93e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 568921773   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
683-724 3.44e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 3.44e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
86-114 6.22e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.22e-03
                            10        20
                    ....*....|....*....|....*....
gi 568921773     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
596-639 7.16e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 7.16e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
639-682 5.81e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 5.81e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    639 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 682
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
616-657 8.48e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.16  E-value: 8.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   616 RRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDY 657
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
553-595 1.00e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.00e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
366-401 1.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 1.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
445-482 5.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 5.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568921773   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
358-399 8.71e-08

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 54.31  E-value: 8.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568921773  358 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGK 399
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
510-552 1.03e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 1.03e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    510 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA pfam07645
Calcium-binding EGF domain;
877-909 2.36e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.00  E-value: 2.36e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568921773   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
751-786 2.54e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 2.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   751 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 786
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 2.83e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 2.83e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpDGKQC 401
Cdd:smart00179    1 DIDECAS-GNPCQNGgtCVNTVGSYRCECPPGYT---DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
573-613 3.09e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 3.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   573 RRIYWTDSG-KSVVGGSDLSGKHHRIIIQERISRPRGIAVHP 613
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
660-700 3.80e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 3.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   660 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVFE 700
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
877-917 3.16e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.16e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568921773    877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEgDGISC 917
Cdd:smart00179    1 DIDECAS-GNPCQN-GGTCVNTVGSYRCECPPGYT-DGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
158-199 1.13e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 1.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
877-913 1.48e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568921773  877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 913
Cdd:cd00054     1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35
PHA02887 PHA02887
EGF-like protein; Provisional
941-978 5.56e-05

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 44.15  E-value: 5.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568921773  941 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 978
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
125-156 1.06e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.06e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568921773    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
414-442 1.93e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 568921773   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
94-174 7.80e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 7.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921773   94 RLYWVDVERQVLLRVFLNGTGLEKVCNVERKVSGLAIDwiDDEVLWVDQQNGVITVTDMTGKNSRVLLSSLKHPSN---- 169
Cdd:COG3386    20 RLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFD--PDGRLLVADHGRGLVRFDPADGEVTVLADEYGKPLNrpnd 97

                  ....*
gi 568921773  170 IAVDP 174
Cdd:COG3386    98 GVVDP 102
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
949-978 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.66e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568921773  949 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 978
Cdd:cd00054    11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
683-724 3.44e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 3.44e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
86-114 6.22e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.22e-03
                            10        20
                    ....*....|....*....|....*....
gi 568921773     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
596-639 7.16e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 7.16e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
639-682 5.81e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 5.81e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    639 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 682
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
616-657 8.48e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.16  E-value: 8.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   616 RRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDY 657
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
553-595 1.00e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.00e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
366-401 1.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 1.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
445-482 5.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 5.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568921773   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
358-399 8.71e-08

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 54.31  E-value: 8.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568921773  358 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGK 399
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
510-552 1.03e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 1.03e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    510 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA pfam07645
Calcium-binding EGF domain;
877-909 2.36e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.00  E-value: 2.36e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568921773   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
751-786 2.54e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 2.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   751 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 786
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 2.83e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 2.83e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpDGKQC 401
Cdd:smart00179    1 DIDECAS-GNPCQNGgtCVNTVGSYRCECPPGYT---DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
573-613 3.09e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 3.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   573 RRIYWTDSG-KSVVGGSDLSGKHHRIIIQERISRPRGIAVHP 613
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
660-700 3.80e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 3.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   660 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVFE 700
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
895-917 1.63e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.67  E-value: 1.63e-06
                           10        20
                   ....*....|....*....|...
gi 568921773   895 CINTEGGYVCRCSEGYEGDGISC 917
Cdd:pfam12947   14 CTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
362-401 2.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568921773  362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpdGKQC 401
Cdd:cd00054     1 DIDECAS-GNPCQNGgtCVNTVGSYRCSCPPGYT----GRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
877-917 3.16e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.16e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568921773    877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEgDGISC 917
Cdd:smart00179    1 DIDECAS-GNPCQN-GGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
366-401 5.00e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 5.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568921773   366 CATQNHGCTLG--CENTPGSYHCTCPTGFVLlpDGKQC 401
Cdd:pfam12947    1 CSDNNGGCHPNatCTNTGGSFTCTCNDGYTG--DGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
158-199 1.13e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 1.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
877-913 1.48e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568921773  877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 913
Cdd:cd00054     1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35
PHA02887 PHA02887
EGF-like protein; Provisional
941-978 5.56e-05

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 44.15  E-value: 5.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568921773  941 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 978
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
125-156 1.06e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.06e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568921773    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA pfam07645
Calcium-binding EGF domain;
362-391 1.86e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 1.86e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568921773   362 DVNECATQNHGCTLG--CENTPGSYHCTCPTG 391
Cdd:pfam07645    1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
414-442 1.93e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 568921773   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
941-978 7.49e-04

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.16  E-value: 7.49e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568921773  941 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 978
Cdd:PHA03099   45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQ 81
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
94-174 7.80e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 7.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921773   94 RLYWVDVERQVLLRVFLNGTGLEKVCNVERKVSGLAIDwiDDEVLWVDQQNGVITVTDMTGKNSRVLLSSLKHPSN---- 169
Cdd:COG3386    20 RLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFD--PDGRLLVADHGRGLVRFDPADGEVTVLADEYGKPLNrpnd 97

                  ....*
gi 568921773  170 IAVDP 174
Cdd:COG3386    98 GVVDP 102
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
572-707 1.45e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921773  572 GRRIYWTDSGKSVVGGSDL-SGKHHRIIIQerISRPRGIAVHPRARRLFWTDvgmspriesaslQGSDRVLI---ASSNL 647
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLaTGKVVATIPV--GGGPRGLAVDPDGGRLYVAD------------SGNGRVSVidtATGKV 144
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568921773  648 L-------EPSGITIDYLTDTLYWCDTKR-------SVIEMAnlDGSKRRRLiqnDVG-HPFSLAVFED--HLWVSD 707
Cdd:COG3391   145 VatipvgaGPHGIAVDPDGKRLYVANSGSntvsvivSVIDTA--TGKVVATI---PVGgGPVGVAVSPDgrRLYVAN 216
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
949-978 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.66e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568921773  949 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 978
Cdd:cd00054    11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
683-724 3.44e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.43  E-value: 3.44e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
365-394 3.97e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.97e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568921773  365 ECATqNHGCTLG--CENTPGSYHCTCPTGFVL 394
Cdd:cd00053     1 ECAA-SNPCSNGgtCVNTPGSYRCVCPPGYTG 31
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
86-114 6.22e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.22e-03
                            10        20
                    ....*....|....*....|....*....
gi 568921773     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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