|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
56-300 |
2.31e-148 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 421.38 E-value: 2.31e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:COG0626 146 LVFLETPSNPTLEVVDIAAIAAIAHAAG-ALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEEL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:COG0626 225 AERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGG 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDR 295
Cdd:COG0626 305 MLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQ 384
|
....*
gi 568921412 296 ALKAA 300
Cdd:COG0626 385 ALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
18-298 |
8.56e-144 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 409.32 E-value: 8.56e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 18 ATQAIHVGQEPEQwNSRAVVLPISLATTFKQDFPGQSS------------------------------------------ 55
Cdd:pfam01053 1 DTLAVHAGQRPDP-QTGAVSVPIYLTSTYVFDFAGEEGgydysrsgnptrdvleeriaaleggaaalafssgmaaitaai 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 -------------------------------------------------------LVWIETPTNPTLKLADIGACAQIVH 80
Cdd:pfam01053 80 lallkagdhivatddlyggtyrlfnkvlprfgievtfvdtsdpedleaaikpntkAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 81 KRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCR 160
Cdd:pfam01053 160 KHG-ILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 161 GLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTL 240
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 568921412 241 AESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 298
Cdd:pfam01053 319 AVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
56-298 |
3.48e-142 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 405.05 E-value: 3.48e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:cd00614 128 LVYVESPTNPTLKVVDIEAIAELAHEHG-ALLVVDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEAL 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:cd00614 207 IQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGG 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDR 295
Cdd:cd00614 287 VFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQ 366
|
...
gi 568921412 296 ALK 298
Cdd:cd00614 367 ALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
12-299 |
7.90e-118 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 343.94 E-value: 7.90e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 12 PSFQHFATQAIHVGQEPEQWNSrAVVLPISLATTFKQDFPGQ----------------------------------SS-- 55
Cdd:PRK07811 8 HANQGFATRAIHAGYEPDPATG-AVNPPIYASSTFAQDGVGGlrggyeyartgnptrtaleeqlaaleggaygrafSSgm 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 --------------------------------------------------------------LVWIETPTNPTLKLADIG 73
Cdd:PRK07811 87 aatdcllravlrpgdhivipndayggtfrlidkvftrwgveytpvdlsdldavraaitprtkLIWVETPTNPLLSITDIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 74 ACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPF 153
Cdd:PRK07811 167 ALAELAHDAG-AKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 154 DCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLK 233
Cdd:PRK07811 246 DAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568921412 234 NLKLFTLAESLGGYESLAELPAIMTHASVPEkdrATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 299
Cdd:PRK07811 326 RTKVFTLAESLGGVESLIEHPSAMTHASTAG---SQLEVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
57-298 |
8.99e-111 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 325.52 E-value: 8.99e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 57 VWIETPTNPTLKLADIGACAQIVhKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLN 136
Cdd:PRK07671 138 IYVETPTNPLLKITDIKKISTIA-KEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELA 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 137 SRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGM 216
Cdd:PRK07671 217 EDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGM 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 217 VSFYIkGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRA 296
Cdd:PRK07671 297 ISFDV-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQA 375
|
..
gi 568921412 297 LK 298
Cdd:PRK07671 376 LA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
44-299 |
5.24e-103 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 306.05 E-value: 5.24e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 44 TTFKQDFPGQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDV 123
Cdd:PRK06176 125 SQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHG-LLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 124 VMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQH 203
Cdd:PRK06176 204 VAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNH 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 204 ELAKRQCSGCPGMVSFYIKGALQhAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGL 283
Cdd:PRK06176 284 ELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGI 362
|
250
....*....|....*.
gi 568921412 284 EDEQDLLEDLDRALKA 299
Cdd:PRK06176 363 EHEQDLLEDLEQAFAK 378
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
53-300 |
9.12e-98 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 292.86 E-value: 9.12e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 53 QSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNS 132
Cdd:TIGR02080 136 KPKLVLIETPSNPLLRVVDIAKICHLAKAVG-AVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKD 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 133 DDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSG 212
Cdd:TIGR02080 215 PQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKG 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 213 CPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLED 292
Cdd:TIGR02080 295 FGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIAD 374
|
....*...
gi 568921412 293 LDRALKAA 300
Cdd:TIGR02080 375 LEQGLRAA 382
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
56-297 |
2.20e-95 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 287.11 E-value: 2.20e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRG-DIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDD 134
Cdd:PRK06234 152 VVYLETPANPTLKVTDIKAISNIAHENNkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEF 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 135 LNS-RLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGC 213
Cdd:PRK06234 232 INQvKLFGIKDMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLP 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 214 PGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDL 293
Cdd:PRK06234 312 GAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADL 391
|
....
gi 568921412 294 DRAL 297
Cdd:PRK06234 392 KQAL 395
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
32-300 |
1.20e-90 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 274.40 E-value: 1.20e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 32 NSRAVVLPISLATT--FKQDFPGQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADIC 109
Cdd:TIGR01329 108 RSGVVVVHVDTTDLdkVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQN-ALVVVDNTMMSPLLCNPLELGADIV 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 110 MCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRV 189
Cdd:TIGR01329 187 YHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 190 EKVVYPGLPSHPQHELAKRQCSGcPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRAT 269
Cdd:TIGR01329 267 KKVRYAGLPSHPGFHLHFSQAKG-AGSVLSFETGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREE 345
|
250 260 270
....*....|....*....|....*....|.
gi 568921412 270 LGINDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:TIGR01329 346 RGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
29-299 |
4.34e-90 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 273.30 E-value: 4.34e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 29 EQWNSRAVVLPISLATTFKQDFPGQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADI 108
Cdd:TIGR01328 120 TKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQG-VKVIVDNTFATPMLTNPVALGVDV 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 109 CMCSATKYMNGHSDVVMGLVSVNSDDLNS-RLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNP 187
Cdd:TIGR01328 199 VVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 188 RVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDR 267
Cdd:TIGR01328 279 AVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEER 358
|
250 260 270
....*....|....*....|....*....|..
gi 568921412 268 ATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 299
Cdd:TIGR01328 359 EAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
53-301 |
6.19e-87 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 265.90 E-value: 6.19e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 53 QSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNS 132
Cdd:PRK07503 150 KTRMVYFETPANPNMRLVDIAAVAEIAHGAG-AKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLV-VGG 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 133 DDLNSRLRF--LQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQC 210
Cdd:PRK07503 228 KALADRIRLegLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQM 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 211 SGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLL 290
Cdd:PRK07503 308 ALPGGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADIL 387
|
250
....*....|.
gi 568921412 291 EDLDRALKAAH 301
Cdd:PRK07503 388 ADLAQALDACA 398
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
52-299 |
5.62e-86 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 262.69 E-value: 5.62e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 52 GQSSLVWIETPTNPTLKLADIGACAQiVHKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVN 131
Cdd:PRK08574 136 GRTKLVFIETMTNPTLKVIDVPEVAK-AAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAW 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 132 SDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRqCS 211
Cdd:PRK08574 215 SGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKR-LF 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 212 GCP---GMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQD 288
Cdd:PRK08574 294 GKDlygGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVED 373
|
250
....*....|.
gi 568921412 289 LLEDLDRALKA 299
Cdd:PRK08574 374 LIEDLDQALGS 384
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
39-300 |
4.57e-85 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 261.08 E-value: 4.57e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 39 PISLATTFKQdfpgQSSLVWIETPTNPTLKLADIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMN 118
Cdd:PRK08776 135 PRSLADALAQ----SPKLVLIETPSNPLLRITDLRFVIEAAHKVGALT-VVDNTFLSPALQKPLEFGADLVLHSTTKYIN 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 119 GHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLP 198
Cdd:PRK08776 210 GHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLA 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 199 SHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIR 278
Cdd:PRK08776 290 SHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLR 369
|
250 260
....*....|....*....|..
gi 568921412 279 LSVGLEDEQDLLEDLDRALKAA 300
Cdd:PRK08776 370 LSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
46-300 |
1.95e-83 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 256.36 E-value: 1.95e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 46 FKQDFPGQSSLVWIETPTNPTLKLADIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVM 125
Cdd:PRK08045 130 LRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVS-VVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVA 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 126 GLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHEL 205
Cdd:PRK08045 209 GVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEI 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 206 AKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLED 285
Cdd:PRK08045 289 AARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIED 368
|
250
....*....|....*
gi 568921412 286 EQDLLEDLDRALKAA 300
Cdd:PRK08045 369 GEDLIADLENGFRAA 383
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
47-302 |
1.60e-82 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 253.93 E-value: 1.60e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 47 KQDFPGQSSLVWIETPTNPTLKLADIGACAQIVhKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMG 126
Cdd:PRK08064 132 AQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLA-KAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAG 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 127 LVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELA 206
Cdd:PRK08064 211 LAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQ 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 207 KRQCSGCPGMVSFYIKGAlQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDE 286
Cdd:PRK08064 291 QSQATSAGAVLSFTLQSE-EAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENV 369
|
250
....*....|....*.
gi 568921412 287 QDLLEDLDRALKAAHP 302
Cdd:PRK08064 370 DDLIADFEQALSYVEE 385
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
53-302 |
2.41e-82 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 256.11 E-value: 2.41e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 53 QSSLVWIETPTNPTLKLADIGACAQIVHKRGDIILVvDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNS 132
Cdd:PLN02509 217 QTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLV-DNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 133 DDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSG 212
Cdd:PLN02509 296 EKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKG 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 213 CPGMVSFyIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLED 292
Cdd:PLN02509 376 AGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISD 454
|
250
....*....|
gi 568921412 293 LDRALKAAHP 302
Cdd:PLN02509 455 LDIAFRTGPL 464
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
56-300 |
2.34e-80 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 248.27 E-value: 2.34e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:PRK08861 141 LILLETPSNPLVRVVDIAELCQKAKAVGALV-AVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEH 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK08861 220 AEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGS 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDR 295
Cdd:PRK08861 300 MLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQ 379
|
....*
gi 568921412 296 ALKAA 300
Cdd:PRK08861 380 AFAKA 384
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
56-300 |
3.08e-80 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 248.50 E-value: 3.08e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVvMGLVSVNSDDL 135
Cdd:PRK08249 152 LLYLETPTNPTLKIVDIERLAAAAKKVGALV-VVDNTFATPINQNPLALGADLVIHSATKFLSGHADA-LGGVVCGSKEL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK08249 230 MEQVYHYREINGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGG 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDR 295
Cdd:PRK08249 310 ILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQ 389
|
....*
gi 568921412 296 ALKAA 300
Cdd:PRK08249 390 AFAHL 394
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
57-300 |
6.81e-80 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 246.54 E-value: 6.81e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 57 VWIETPTNPTLKLADIGACAQIVhKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLN 136
Cdd:PRK08247 140 IFIETPTNPLMQETDIAAIAKIA-KKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELC 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 137 SRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGlpshpqhelakrqcSGcpGM 216
Cdd:PRK08247 219 ERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPG--------------RG--GM 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 217 VSFYIKGAlQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRA 296
Cdd:PRK08247 283 LSFRLQDE-EWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQA 361
|
....
gi 568921412 297 LKAA 300
Cdd:PRK08247 362 FKQV 365
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
56-300 |
8.14e-80 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 248.02 E-value: 8.14e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV--SVNSD 133
Cdd:COG2873 151 AIFGETIGNPALDVLDIEAIAEIAHEHG-VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdGGNFD 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 134 -DLNSR-------------LRF----------------LQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFL 183
Cdd:COG2873 230 wAANGKfpeltepdpsyhgLVYteafgnaafitkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 184 ETNPRVEKVVYPGLPSHPQHELAKRQCS-GCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASV 262
Cdd:COG2873 310 EAHPKVAWVNYPGLPSHPYHELAQKYLPkGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQL 389
|
250 260 270
....*....|....*....|....*....|....*...
gi 568921412 263 PEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:COG2873 390 SEEEQAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
54-298 |
3.13e-79 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 245.52 E-value: 3.13e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 54 SSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSD 133
Cdd:PRK06767 147 TKLIFVETPINPTMKLIDLKQVIRVAKRNG-LLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 134 DLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYpglpshPQHELAKRQCSGC 213
Cdd:PRK06767 226 ALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRG 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 214 PGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDL 293
Cdd:PRK06767 300 GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDL 379
|
....*
gi 568921412 294 DRALK 298
Cdd:PRK06767 380 EQALK 384
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
56-299 |
2.49e-78 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 243.37 E-value: 2.49e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:PRK08133 149 LFFLETPSNPLTELADIAALAEIAHAAG-ALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELM 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQnSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK08133 228 EEVFGFLR-TAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDR 295
Cdd:PRK08133 307 IVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLAR 386
|
....
gi 568921412 296 ALKA 299
Cdd:PRK08133 387 GLAA 390
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
49-299 |
1.87e-77 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 240.96 E-value: 1.87e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 49 DF-PGQSSLVWIETPTNPTLKLADIGACAQIVHKRgdiILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGL 127
Cdd:PRK06434 143 DFdPSNYDLIYAESITNPTLKVPDIKNVSSFCHEN---DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGV 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 128 VSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLpshpqhELAK 207
Cdd:PRK06434 220 AGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGK 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 208 RQCSGCPGMVSFYIKgALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQ 287
Cdd:PRK06434 294 KVLRGFGGMLSFELR-SMEDVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDID 372
|
250
....*....|..
gi 568921412 288 DLLEDLDRALKA 299
Cdd:PRK06434 373 DLIKDIENALSK 384
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
52-300 |
2.26e-77 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 241.88 E-value: 2.26e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 52 GQSSLVWIETPTNPTLKLADIGA----CAQIVHKRGDI-ILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMG 126
Cdd:PRK07049 173 GRVSLILIETPANPTNSLVDVAAvrrvADAIEARQGHRpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 127 LVsVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGL--PSHPQHE 204
Cdd:PRK07049 253 AV-LGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGA 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 205 LAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLE 284
Cdd:PRK07049 332 VYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIE 411
|
250
....*....|....*.
gi 568921412 285 DEQDLLEDLDRALKAA 300
Cdd:PRK07049 412 HPDDLIADLAQALDAA 427
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
56-299 |
1.44e-74 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 232.79 E-value: 1.44e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:PRK07269 139 IVYIETPTNPLMVEFDIEKVAKLAHAKG-AKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLEL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLpshpqhelakrqcsgcPG 215
Cdd:PRK07269 218 YEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GG 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYI--KGALQHakaFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDL 293
Cdd:PRK07269 282 MISFKVadETRIPH---ILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADL 358
|
....*.
gi 568921412 294 DRALKA 299
Cdd:PRK07269 359 KQALEG 364
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
14-297 |
3.15e-74 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 232.43 E-value: 3.15e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 14 FQHFATQAIHV-GQEPEQWnSRAVVLPislattfkqdfpgqSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNT 92
Cdd:TIGR01325 114 LPRFGVQTVFVdGTDLSAW-EAALKPN--------------TKAVFVETPSNPLQELVDIAAVAELAHAAG-AKVVVDNV 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 93 FMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKH 172
Cdd:TIGR01325 178 FATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQ 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 173 FKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGAlQHAKAFLKNLKLFTLAESLGGYESLAE 252
Cdd:TIGR01325 258 NASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDAMRLVDISNNLGDAKSTIT 336
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 568921412 253 LPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 297
Cdd:TIGR01325 337 HPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
56-297 |
1.42e-73 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 230.49 E-value: 1.42e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:PRK06460 133 VVFVENITNPLLRVVDITELSKVCKENG-SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NsRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK06460 212 N-VIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGG 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDR 295
Cdd:PRK06460 291 VLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDR 370
|
..
gi 568921412 296 AL 297
Cdd:PRK06460 371 AL 372
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
49-300 |
1.12e-70 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 222.95 E-value: 1.12e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 49 DFPGqSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV 128
Cdd:PRK07582 129 ALAG-ADLVLAETPSNPGLDVCDLAALAAAAHAAG-ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 129 SVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKR 208
Cdd:PRK07582 207 AGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAAR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 209 QCSGCPGMVSFYIKGAlQHAKAFLKNLKLFTLAESLGGYESLAElpaimthasvpekDRATLG--INDTLIRLSVGLEDE 286
Cdd:PRK07582 287 QMRRFGGLVSFELADA-AAAERFVAASRLVVAATSFGGVHTSAD-------------RRARWGdaVPEGFVRLSCGIEDT 352
|
250
....*....|....
gi 568921412 287 QDLLEDLDRALKAA 300
Cdd:PRK07582 353 DDLVADLERALDAL 366
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
58-300 |
2.05e-65 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 210.38 E-value: 2.05e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 58 WIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNS 137
Cdd:PRK07504 155 FLESPTNPTLEVIDIAAVAKIANQAG-AKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEE 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 138 RLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMV 217
Cdd:PRK07504 234 HLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLV 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 218 SFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 297
Cdd:PRK07504 314 AFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAAL 393
|
...
gi 568921412 298 KAA 300
Cdd:PRK07504 394 KKV 396
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
25-298 |
4.88e-63 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 204.20 E-value: 4.88e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 25 GQEPEQWNSravvlpiSLATtfkqdfPGQSslVWIETPTNPTLKLADIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLAL 104
Cdd:PRK07810 142 GEDLSQWEE-------ALSV------PTQA--VFFETPSNPMQSLVDIAAVSELAHAAGAKV-VLDNVFATPLLQRGLPL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 105 GADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLE 184
Cdd:PRK07810 206 GADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLE 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 185 TNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKG----ALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHA 260
Cdd:PRK07810 286 GHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDApedaAKKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHR 365
|
250 260 270
....*....|....*....|....*....|....*...
gi 568921412 261 SVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 298
Cdd:PRK07810 366 AMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
56-300 |
6.36e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 196.18 E-value: 6.36e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGDIILVvDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:PRK05967 152 VVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMM-DNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCW 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 nSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK05967 231 -PQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASG 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKGAL----QHAKAFLKNLKLFTLAESLGGYESLAelpaimTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLE 291
Cdd:PRK05967 310 IFSFVLAAGPekgkAKAHAFLDALEIFGLGYSWGGYESLA------LHVKLGDRTVAKAPYAGPVIRLQIGLEDVPDLKA 383
|
....*....
gi 568921412 292 DLDRALKAA 300
Cdd:PRK05967 384 DLERGFAAA 392
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
56-300 |
1.02e-59 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 196.50 E-value: 1.02e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV------- 128
Cdd:PRK08134 152 LLFGETLGNPGLEVLDIPTVAAIAHEAG-VPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfd 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 129 --------------------------SVNSDDLNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARF 182
Cdd:PRK08134 231 weasgkfpeltepyagfhgmvfaeesTVAAFLLRARREGLRD-FGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAF 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 183 LETNPRVEKVVYPGLPSHPQHELAKRQC-SGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHAS 261
Cdd:PRK08134 310 LASHPAVARVAHPELESHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFR 389
|
250 260 270
....*....|....*....|....*....|....*....
gi 568921412 262 VPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:PRK08134 390 MDAAALAAAGIGEGTIRLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
46-300 |
1.41e-58 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 193.52 E-value: 1.41e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 46 FKQDFPGQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVM 125
Cdd:PRK08248 142 FEAAITDKTKALFAETIGNPKGDVLDIEAVAAIAHEHG-IPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIG 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 126 GLVsVNSDD----------------------------------LNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEK 171
Cdd:PRK08248 221 GVI-VDSGKfdwkgsgkfpgltepdpsyhglvytdavgeaayiTKARVQLLRD-LGAALSPFNSFLLLQGLETLHLRMER 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 172 HFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQC-SGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESL 250
Cdd:PRK08248 299 HSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSL 378
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568921412 251 AELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:PRK08248 379 IIHPASTTHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQAIRQS 428
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
56-300 |
1.45e-57 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 189.94 E-value: 1.45e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDL 135
Cdd:PRK07050 153 LIWLEAPGSVTMEVPDVPAITAAARARG-VVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAEL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK07050 232 HAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGG 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIKG--ALQHAKAFLKNLKLFTLAESLGGYESLAeLPaimthASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDL 293
Cdd:PRK07050 312 LFSVVFDErySPAQVDAFVEALELFAIGWSWGGACSLA-MP-----YDVASMRTAKWPHRGTLVRLYIGLEDEADLIADL 385
|
....*..
gi 568921412 294 DRALKAA 300
Cdd:PRK07050 386 EQALEAA 392
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
51-300 |
1.04e-55 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 184.90 E-value: 1.04e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 51 PGqSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsV 130
Cdd:PRK05968 146 PG-AKLLYLESPTSWVFELQDVAALAALAKRHG-VVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVV-A 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 131 NSDDLNSRLRFLQNS-LGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELakrq 209
Cdd:PRK05968 223 GSKEHIARINAEAYPyLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL---- 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 210 cSGCPGMVSFYIKGALqHAKAFLKNLKLFTLAESLGGYESLAeLPAIMTHASVPEKDR-ATLGINDTLIRLSVGLEDEQD 288
Cdd:PRK05968 299 -SGTSGLFSFIFREGI-DVRAFADALKLFRLGVSWGGHESLV-VPAEVVLQQKAQPNSaARFGVSPRSVRLHVGLEGTEA 375
|
250
....*....|..
gi 568921412 289 LLEDLDRALKAA 300
Cdd:PRK05968 376 LWADLEQALAAA 387
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
27-302 |
2.89e-54 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 182.26 E-value: 2.89e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 27 EPEQWnsRAVVLPislattfkqdfpgQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGA 106
Cdd:PRK07812 144 DLDAW--RAAVRP-------------NTKAFFAETISNPQIDVLDIPGVAEVAHEAG-VPLIVDNTIATPYLIRPLEHGA 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 107 DICMCSATKYMNGHSDVVMGLV--------------SVNSDD-----------------LNSRLRFLQNsLGAVPSPFDC 155
Cdd:PRK07812 208 DIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpGFTTPDpsyhgvvfaelgppayaLKARVQLLRD-LGSAISPFNA 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 156 YLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQC-SGCPGMVSFYIKGALQHAKAFLKN 234
Cdd:PRK07812 287 FLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLApKGTGAVLSFELAGGVEAGKAFVNA 366
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568921412 235 LKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAHP 302
Cdd:PRK07812 367 LTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADLEAGFAAAKA 434
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
56-300 |
3.26e-54 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 181.04 E-value: 3.26e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVS------ 129
Cdd:PRK05939 134 MVFVETIANPGTQVADLAGIGALCRERG-LLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfd 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 130 ----VNSDD------------LNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVV 193
Cdd:PRK05939 213 wsayPNIFPayrkgdpqqwglTQIRKKGLRD-MGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVY 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 194 YPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQhAKAFLKNLKLFTLAESLGGYESLAeLPAIMT--HASVPEKdRATLG 271
Cdd:PRK05939 292 YPGLASHPQHARATELFRHYGGLLSFELADGID-CFDFLNRLKLVIKATHLGDTRTLV-IPVAPTiyYEMGAER-RASMG 368
|
250 260
....*....|....*....|....*....
gi 568921412 272 INDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:PRK05939 369 IADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
57-300 |
4.66e-54 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 181.64 E-value: 4.66e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 57 VWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNSDDL- 135
Cdd:PRK06084 147 VFCESIGNPAGNIIDIQALADAAHRHG-VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIV-VDSGKFp 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 ----NSRLRFLQN-----------------------------SLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARF 182
Cdd:PRK06084 225 waehKERFALLNTpdpsyhgvtyteafgpaafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARY 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 183 LETNPRVEKVVYPGLPSHPQHELAKRQCSGCP-GMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHAS 261
Cdd:PRK06084 305 LQQHPQVAWVKYAGLPDHPEHELARRYMGGKPaSILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQ 384
|
250 260 270
....*....|....*....|....*....|....*....
gi 568921412 262 VPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:PRK06084 385 LNDEELEKAGVSRDMVRLSIGIEHIDDIIADLAQALDAS 423
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
54-300 |
1.73e-53 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 178.92 E-value: 1.73e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 54 SSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNsD 133
Cdd:TIGR01324 136 TKVLFLEAPSSITFEIQDIPAIAKAARNPG-IVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVAN-A 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 134 DLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGC 213
Cdd:TIGR01324 214 RTWDQLREHSYLMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGS 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 214 PGMVSFYIKGALQHA-KAFLKNLKLFTLAESLGGYESLAeLPAIMTHASVPEKDRATLGindTLIRLSVGLEDEQDLLED 292
Cdd:TIGR01324 294 SGLFSFVLQRLTQKQvHAFLDHLQLFGLGYSWGGYESLA-LCNQPELGHRPNIKRNLEG---PLIRVHIGLENVDDLKAD 369
|
....*...
gi 568921412 293 LDRALKAA 300
Cdd:TIGR01324 370 LKAGFEAI 377
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
56-297 |
3.06e-52 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 176.08 E-value: 3.06e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 56 LVWIETPTNPTLKLADIGACAQIVHKrGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGlVSVNSDDL 135
Cdd:PRK09028 149 VLFLESPGSITMEVQDVPTLSRIAHE-HDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLG-TATANEKH 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 136 NSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPG 215
Cdd:PRK09028 227 WDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNG 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 216 MVSFYIK-GALQHAKAFLKNLKLFTLAESLGGYESLaelpaIMTHASVPEKDRAT-LGINDTLIRLSVGLEDEQDLLEDL 293
Cdd:PRK09028 307 LFSFVLKqGDPKAVTALVEGMQHFKMGFSWGGFESL-----ILGVFGINKLRTATnWDFSKPLIRLHIGLEDVDDLIADL 381
|
....
gi 568921412 294 DRAL 297
Cdd:PRK09028 382 EAGF 385
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
45-300 |
1.76e-51 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 174.90 E-value: 1.76e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 45 TFKQDFPGQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVV 124
Cdd:PRK05994 140 SFERAITPRTKAIFIESIANPGGTVTDIAAIAEVAHRAG-LPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSM 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 125 MGL-VSVNSDDLNSRLRF--------------LQNS-----------------LGAVPSPFDCYLCCRGLKTLQVRMEKH 172
Cdd:PRK05994 219 GGIiVDGGTFDWSKSGKYpmlseprpeyhglvLHETfgnfafaiaarvlglrdLGPAISPFNAFLILTGIETLPLRMQRH 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 173 FKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMV-SFYIKGALQHAKAFLKNLKLFTLAESLGGYESLA 251
Cdd:PRK05994 299 SDNALAVAEWLKGHPKVSWVNYAGLPDDPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLV 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568921412 252 ELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 300
Cdd:PRK05994 379 IHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
57-294 |
5.91e-47 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 162.18 E-value: 5.91e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 57 VWIETPTNPTLKLADIGACAQIVHKRG-DIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNS--- 132
Cdd:PRK08114 151 VFLESPGSITMEVHDVPAIVAAVRSVNpDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANArcw 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 133 DDL--NSRLrflqnsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQC 210
Cdd:PRK08114 231 EQLreNSYL------MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDF 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 211 SGCPGMVSFYIKGALQHAK--AFLKNLKLFTLAESLGGYESLaelpaIMthASVPEKDRA-----TLGINDTLIRLSVGL 283
Cdd:PRK08114 305 TGSSGLFSFVLKKKLTDEQlaNYLDNFSLFSMAYSWGGFESL-----IL--ANQPEEIAAirpagEVDFTGTLIRLHIGL 377
|
250
....*....|.
gi 568921412 284 EDEQDLLEDLD 294
Cdd:PRK08114 378 EDVDDLIADLA 388
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
60-299 |
2.39e-44 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 156.19 E-value: 2.39e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 60 ETPTNPTLKLADIGACAQIVHKRgDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV--------SVN 131
Cdd:PRK05613 162 ETFANPQADVLDIPAVAEVAHRN-QVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwTVE 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 132 SDD----------------------------LNSRLRFLQNSlGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFL 183
Cdd:PRK05613 241 RDGkpvfpyfvtpdpayhglkyadlgapafgLKARAGLLRDT-GATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFL 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 184 ETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMV-SFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASV 262
Cdd:PRK05613 320 NNHEKVAKVNFAGLKDSPWYATKEKLGLKYTGSVlSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQS 399
|
250 260 270
....*....|....*....|....*....|....*..
gi 568921412 263 PEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 299
Cdd:PRK05613 400 DEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
53-297 |
2.45e-38 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 140.19 E-value: 2.45e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 53 QSSLVWIETPTNPTLKLADIGACAQIVhKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVS--- 129
Cdd:PRK06702 147 KTKLVYAESLGNPAMNVLNFKEFSDAA-KELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdgg 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 130 ------------VNSDDLNSRLRFLQN----------------SLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVAR 181
Cdd:PRK06702 226 nfdwtngkypelVEPDPSYHGVSYVQNfgaaayivkarvqllrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAK 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 182 FLETNPRVEKVVYPGLPSHPQHELAKRQCS-GCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHA 260
Cdd:PRK06702 306 WLADHERIEWVNYPGLDSNENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHR 385
|
250 260 270
....*....|....*....|....*....|....*..
gi 568921412 261 SVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 297
Cdd:PRK06702 386 QLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
51-298 |
3.08e-37 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 136.82 E-value: 3.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 51 PGQSSLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFmSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSV 130
Cdd:PLN02242 161 PGKTKVLYFESISNPTLTVADIPELARIAHEKG-VTVVVDNTF-APMVLSPARLGADVVVHSISKFISGGADIIAGAVCG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 131 NSDDLNSRLRFLQNS---LGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARfletnpRVE----KVVYPGLPSHPQH 203
Cdd:PLN02242 239 PAELVNSMMDLHHGAlmlLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAK------RMKelglKVIYPGLEDHPQH 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921412 204 ELAKRQ---CSGCPGMVSFYIkGALQHAKAFLKNLKLFT----LAESLGGYESLAELPAIMTHASVPEKDRATLGINDTL 276
Cdd:PLN02242 313 ALLKSMankGYGFGGLLCLDM-DTEERANRLMRYLQNSTqfgfMAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGL 391
|
250 260
....*....|....*....|....*.
gi 568921412 277 IRLSVG----LEDEQDLLEDLDRALK 298
Cdd:PLN02242 392 VRMSVGytgtLEQRWSQFEKALSAMK 417
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
55-119 |
5.34e-05 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 42.75 E-value: 5.34e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568921412 55 SLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTF----MSAYFQRPLALGADICMCSATKYMNG 119
Cdd:cd01494 94 ALIVITPNTTSGGVLVPLKEIRKIAKEYG-ILLLVDAASaggaSPAPGVLIPEGGADVVTFSLHKNLGG 161
|
|
| |
