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Conserved domains on  [gi|565364364|ref|XP_006348895|]
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PREDICTED: probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 7 [Solanum tuberosum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02205 super family cl31841
alpha,alpha-trehalose-phosphate synthase [UDP-forming]
 1-848 0e+00

alpha,alpha-trehalose-phosphate synthase [UDP-forming]


The actual alignment was detected with superfamily member PLN02205:

Pssm-ID: 177855 [Multi-domain]  Cd Length: 854  Bit Score: 1310.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   1 MMSRSYTNLLDLASGNFPVMGRERDRRRMsrVMTVPGSICELDDDQAVSVSSDNQSSLAG-DRMIVVANQLPLKAKRRPD 79
Cdd:PLN02205   1 MVSRSYSNLLELASGESPSFGRMNRRIPR--IMTVAGIMSDIDDDPSESVCSDPSSSSVPkDRIIIVANQLPIRAQRKSD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  80 -NKGWSFSWNEDSLLLRLKDGLPED-MEVLFVGSLSVDVDPIEQDDVSSYLLDKFRCVPTFLPPNIVEKYYEGFCKRHLW 157
Cdd:PLN02205  79 gSKGWIFSWDENSLLLQLKDGLGDDeIEVIYVGCLKEEIHLNEQEEVSQILLETFKCVPTFLPPDLFTRYYHGFCKQQLW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 158 PLFHYMLPFSPDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPEDDFVWIHDYHLMVLPTFLRRRFNRLRIGFFLHSPFPS 237
Cdd:PLN02205 159 PLFHYMLPLSPDLGGRFNRSLWQAYVSVNKIFADRIMEVINPEDDFVWIHDYHLMVLPTFLRKRFNRVKLGFFLHSPFPS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 238 SEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRGYIGLEYYGRTVGIKIMPVGIHMGHIESMK 317
Cdd:PLN02205 239 SEIYKTLPIREELLRALLNSDLIGFHTFDYARHFLSCCSRMLGLSYESKRGYIGLEYYGRTVSIKILPVGIHMGQLQSVL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 318 KISDKELKFKELKQQF--EGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIANPMRGKGIDLEEIQAEI 395
Cdd:PLN02205 319 SLPETEAKVKELIKQFcdQDRIMLLGVDDMDIFKGISLKLLAMEQLLMQHPEWQGKVVLVQIANPARGKGKDVKEVQAET 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 396 QESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQG------VSGAETDSgvg 469
Cdd:PLN02205 399 HSTVKRINETFGKPGYDPIVLIDAPLKFYERVAYYVVAECCLVTAVRDGMNLIPYEYIISRQGnekldkLLGLEPST--- 475

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 470 gPDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRSFLQDMERTCA 549
Cdd:PLN02205 476 -PKKSMLVVSEFIGCSPSLSGAIRVNPWNIDAVADAMDSALEMAEPEKQLRHEKHYRYVSTHDVGYWARSFLQDLERTCR 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 550 DHFRKRCYGIGLGFGFRVVSLDPNFRKLSIDDIVNAYIKSKSRAIFLDYDGTVMPQNSIIKSPSANVISILNKLSGDPNN 629
Cdd:PLN02205 555 DHSRRRCWGIGFGLSFRVVALDPNFRKLSMEHIVSAYKRTTTRAILLDYDGTLMPQASIDKSPSSKSIDILNTLCRDKNN 634

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 630 TVFIVSGRGRESLTKWFSPCRKLGLAAEHGYFLRWEREQKWEVCSQTSDFGWMQLAEPVMQSYTDATDGSCIERKESAIV 709
Cdd:PLN02205 635 MVFIVSARSRKTLADWFSPCEKLGIAAEHGYFLRLKRDVEWETCVPVADCSWKQIAEPVMQLYTETTDGSTIEDKETALV 714

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 710 WQYSDADSGFGFSQAKEMLDHLESVLANEPVAVKSGQHIVEVKPQGVTKGLVAEKVFTSLAVKGKLADFVLCIGDDRSDE 789
Cdd:PLN02205 715 WCYEDADPDFGSCQAKELLDHLESVLANEPVTVKSGQNIVEVKPQGVSKGLVAKRLLSIMQERGMLPDFVLCIGDDRSDE 794

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 565364364 790 DMFEIIGDALSRNIISYDAKVFACTVGQKPSKAKYYLDDTSEVVLMLDSLADATDTPVT 848
Cdd:PLN02205 795 DMFEVITSSMAGPSIAPRAEVFACTVGQKPSKAKYYLDDTAEIVRLMQGLASVSEQILP 853
 
Name Accession Description Interval E-value
PLN02205 PLN02205
alpha,alpha-trehalose-phosphate synthase [UDP-forming]
 1-848 0e+00

alpha,alpha-trehalose-phosphate synthase [UDP-forming]


Pssm-ID: 177855 [Multi-domain]  Cd Length: 854  Bit Score: 1310.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   1 MMSRSYTNLLDLASGNFPVMGRERDRRRMsrVMTVPGSICELDDDQAVSVSSDNQSSLAG-DRMIVVANQLPLKAKRRPD 79
Cdd:PLN02205   1 MVSRSYSNLLELASGESPSFGRMNRRIPR--IMTVAGIMSDIDDDPSESVCSDPSSSSVPkDRIIIVANQLPIRAQRKSD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  80 -NKGWSFSWNEDSLLLRLKDGLPED-MEVLFVGSLSVDVDPIEQDDVSSYLLDKFRCVPTFLPPNIVEKYYEGFCKRHLW 157
Cdd:PLN02205  79 gSKGWIFSWDENSLLLQLKDGLGDDeIEVIYVGCLKEEIHLNEQEEVSQILLETFKCVPTFLPPDLFTRYYHGFCKQQLW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 158 PLFHYMLPFSPDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPEDDFVWIHDYHLMVLPTFLRRRFNRLRIGFFLHSPFPS 237
Cdd:PLN02205 159 PLFHYMLPLSPDLGGRFNRSLWQAYVSVNKIFADRIMEVINPEDDFVWIHDYHLMVLPTFLRKRFNRVKLGFFLHSPFPS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 238 SEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRGYIGLEYYGRTVGIKIMPVGIHMGHIESMK 317
Cdd:PLN02205 239 SEIYKTLPIREELLRALLNSDLIGFHTFDYARHFLSCCSRMLGLSYESKRGYIGLEYYGRTVSIKILPVGIHMGQLQSVL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 318 KISDKELKFKELKQQF--EGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIANPMRGKGIDLEEIQAEI 395
Cdd:PLN02205 319 SLPETEAKVKELIKQFcdQDRIMLLGVDDMDIFKGISLKLLAMEQLLMQHPEWQGKVVLVQIANPARGKGKDVKEVQAET 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 396 QESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQG------VSGAETDSgvg 469
Cdd:PLN02205 399 HSTVKRINETFGKPGYDPIVLIDAPLKFYERVAYYVVAECCLVTAVRDGMNLIPYEYIISRQGnekldkLLGLEPST--- 475

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 470 gPDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRSFLQDMERTCA 549
Cdd:PLN02205 476 -PKKSMLVVSEFIGCSPSLSGAIRVNPWNIDAVADAMDSALEMAEPEKQLRHEKHYRYVSTHDVGYWARSFLQDLERTCR 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 550 DHFRKRCYGIGLGFGFRVVSLDPNFRKLSIDDIVNAYIKSKSRAIFLDYDGTVMPQNSIIKSPSANVISILNKLSGDPNN 629
Cdd:PLN02205 555 DHSRRRCWGIGFGLSFRVVALDPNFRKLSMEHIVSAYKRTTTRAILLDYDGTLMPQASIDKSPSSKSIDILNTLCRDKNN 634

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 630 TVFIVSGRGRESLTKWFSPCRKLGLAAEHGYFLRWEREQKWEVCSQTSDFGWMQLAEPVMQSYTDATDGSCIERKESAIV 709
Cdd:PLN02205 635 MVFIVSARSRKTLADWFSPCEKLGIAAEHGYFLRLKRDVEWETCVPVADCSWKQIAEPVMQLYTETTDGSTIEDKETALV 714

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 710 WQYSDADSGFGFSQAKEMLDHLESVLANEPVAVKSGQHIVEVKPQGVTKGLVAEKVFTSLAVKGKLADFVLCIGDDRSDE 789
Cdd:PLN02205 715 WCYEDADPDFGSCQAKELLDHLESVLANEPVTVKSGQNIVEVKPQGVSKGLVAKRLLSIMQERGMLPDFVLCIGDDRSDE 794

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 565364364 790 DMFEIIGDALSRNIISYDAKVFACTVGQKPSKAKYYLDDTSEVVLMLDSLADATDTPVT 848
Cdd:PLN02205 795 DMFEVITSSMAGPSIAPRAEVFACTVGQKPSKAKYYLDDTAEIVRLMQGLASVSEQILP 853
Glyco_transf_20 pfam00982
Glycosyltransferase family 20; Members of this family belong to glycosyl transferase family 20. ...
 62-546 0e+00

Glycosyltransferase family 20; Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,.


Pssm-ID: 425972 [Multi-domain]  Cd Length: 471  Bit Score: 631.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   62 RMIVVANQLPLKAKRRPDNKGWSFSWNEDSL-LLRLKDGLPEDMEVLFVGSLSVDVDPIE-QDDVSSYLLDKFRCVPTFL 139
Cdd:pfam00982   2 RLVVVSNRLPVTAVRDEEDGKWEFSIKMSSGgLVSALNGLSAATEGVWVGWPGVPVDESEpKDKVSQSLKEKFNCVPVFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  140 PPNIVEKYYEGFCKRHLWPLFHYMLPfsPDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLR 219
Cdd:pfam00982  82 SDELFDSYYNGFSNSILWPLFHYMIP--PNNEDAFDRSWWDAYVKVNKLFADKIVEVYKD-GDLIWIHDYHLMLLPQMLR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  220 RRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRgyiGLEYYGRTV 299
Cdd:pfam00982 159 KRLPDAKIGFFLHTPFPSSEIFRCLPVREEILEGLLGADLIGFHTYDYARHFLSCCSRLLGLETRSDG---GVEYGGRTV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  300 GIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKT-VLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIA 378
Cdd:pfam00982 236 SVKAFPIGIDPGRIESGLASPSVQEKIKELKERFGNKKkLIVGVDRLDYIKGIPQKLLAFERFLEEYPEWRGKVVLVQIA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  379 NPMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQG 458
Cdd:pfam00982 316 VPSRGDVEEYQNLRSQIEELVGRINGEFGTLDYTPVHFLHRPLDFDELIALYAVADVCLVTSLRDGMNLVAYEYVACQQG 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  459 vsgaetdsgvggpDKSMLVVSEFIGCSPSL-SGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWS 537
Cdd:pfam00982 396 -------------RKGVLILSEFAGAAQSLnDGAILVNPWDIDEVAEAINEALTMSEEERKKRHKKLYKYISKHDSQHWA 462


                  ....*....
gi 565364364  538 RSFLQDMER 546
Cdd:pfam00982 463 ESFLSDLKR 471
GT20_TPS cd03788
trehalose-6-phosphate synthase; Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a ...
 62-545 0e+00

trehalose-6-phosphate synthase; Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.


Pssm-ID: 340820 [Multi-domain]  Cd Length: 463  Bit Score: 599.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  62 RMIVVANQLPLKAKRRPDnkGWSFSWNEDSLLLRLKDGLPEDMEVLFVGSLSVDVDPIEQD-DVSSYLLDKFRCVPTFLP 140
Cdd:cd03788    1 RLIVVSNRLPVTLERDDD--GEVEFRRSAGGLVTALKGLLKSTGGLWVGWPGIEADEEESDqVVSPELLEEYNVVPVFLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 141 PNIVEKYYEGFCKRHLWPLFHYMLPfspDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLRR 220
Cdd:cd03788   79 DEDFEGYYNGFSNSVLWPLFHYLLP---LPDGRFEREWWEAYVRVNQAFADAVVEVYRP-GDLIWVHDYHLLLLPQMLRE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 221 RFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSkrgYIGLEYYGRTVG 300
Cdd:cd03788  155 RLPDARIGFFLHIPFPSSEIFRCLPWREEILRGLLGADLIGFQTFEYARHFLSCCSRLLGLETTS---AGGVEYGGRRVR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 301 IKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIANP 380
Cdd:cd03788  232 VGAFPIGIDPDRFRRLAASPEVQERARELRERYKGKKLIVGVDRLDYTKGIPEKLLAFERFLERYPEWRGKVVLVQVAVP 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 381 MRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQGvs 460
Cdd:cd03788  312 SRTDVEEYQELRREVEELVGRINGRFGTLDWTPVVYLHQSLDREELLALYRAADVALVTSLRDGMNLVAKEYVACQRD-- 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 461 gaetdsgvggpDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRSF 540
Cdd:cd03788  390 -----------NPGVLILSEFAGAASELDGAILVNPWDIEEVAEAINRALTMSPEERKERHQKLRKYVETHDVQAWANSF 458


                 ....*
gi 565364364 541 LQDME 545
Cdd:cd03788  459 LDDLA 463
trehalose_OtsA TIGR02400
alpha,alpha-trehalose-phosphate synthase [UDP-forming]; This enzyme catalyzes the key, ...
 62-546 2.27e-150

alpha,alpha-trehalose-phosphate synthase [UDP-forming]; This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 274112  Cd Length: 456  Bit Score: 449.80  E-value: 2.27e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   62 RMIVVANQLPLKAKRrpdnKGWSFSwnEDSLLLRLKDGLpEDMEVLFVGSLSVDV-DPIEQDDVSSYLLDKFRCVPTFLP 140
Cdd:TIGR02400   1 RLIVVSNRLPVPITR----GGLEPS--AGGLAVALLGAL-KATGGVWFGWSGKTVeEDEGEPFLRTELEGKITLAPVFLS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  141 PNIVEKYYEGFCKRHLWPLFHYMLPFSpdhggRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLRR 220
Cdd:TIGR02400  74 EEDVDGYYNGFSNSTLWPLFHYRPDLI-----RYDRKAWEAYRRVNRLFAEALAPLLQP-GDIVWVHDYHLMLLPAMLRE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  221 RFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKrgyiGLEYYGRTVG 300
Cdd:TIGR02400 148 LGVQNKIGFFLHIPFPSSEIYRTLPWRRELLEGLLAYDLVGFQTYDDARNFLSAVSRELGLETLPN----GVESGGRTVR 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  301 IKIMPVGIHMGHI-ESMKKISDKELkFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIAN 379
Cdd:TIGR02400 224 VGAFPIGIDVDRFaEQAKKPSVQKR-IAELRESLKGRKLIIGVDRLDYSKGLPERLLAFERFLEEHPEWRGKVVLVQIAV 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  380 PMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQgv 459
Cdd:TIGR02400 303 PSRGDVPEYQQLRRQVEELVGRINGRFGTLDWTPIRYLNRSYDREELMALYRAADVGLVTPLRDGMNLVAKEYVAAQD-- 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  460 sgaetdsgvggPDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRS 539
Cdd:TIGR02400 381 -----------PKDGVLILSEFAGAAQELNGALLVNPYDIDGMADAIARALTMPLEEREERHRAMMDKLRKNDVQRWRED 449


                  ....*..
gi 565364364  540 FLQDMER 546
Cdd:TIGR02400 450 FLSDLNS 456
OtsA COG0380
Trehalose-6-phosphate synthase, GT20 family [Carbohydrate transport and metabolism];
60-547 7.99e-140

Trehalose-6-phosphate synthase, GT20 family [Carbohydrate transport and metabolism];


Pssm-ID: 440149  Cd Length: 474  Bit Score: 422.99  E-value: 7.99e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  60 GDRMIVVANQLPLKAKRRPDNKGWS---------------------FSWNedslllrlkdGLPEDMEVLFVGSLSVDVDp 118
Cdd:COG0380    1 GSRLVVVSNRLPVPHVREDGSIRVKrsagglvtalepvlrrrgglwVGWS----------GGDADREAVEEPRGPVPPD- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 119 ieqddvssylLDKFRCVPTFLPPNIVEKYYEGFCKRHLWPLFHYMlpfsPDHGgRFDRSMWEAYVSANKMFSQKVVEVLN 198
Cdd:COG0380   70 ----------LGGYTLAPVDLSAEEVDGYYEGFSNETLWPLFHYR----LDLP-EFDREDWEAYRRVNRRFAEALAEEAE 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 199 PeDDFVWIHDYHLMVLPTFLRRRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRM 278
Cdd:COG0380  135 P-DDVVWVHDYHLLLVPAMLRELGPDARIGFFLHIPFPPPEIFRILPWREEILEGLLGADLIGFQTPRDARNFLDCVRRL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 279 LGLEyQSKRGYIglEYYGRTVGIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAM 358
Cdd:COG0380  214 LGAE-VDEGGTV--RYGGRTVRVGAFPIGIDVEEFAELARSPEVRARAERLREELGGRKLILGVDRLDYTKGIPERLRAF 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 359 EHMLKQHPSWQGQAVLVQIANPMRGkgiDLEE---IQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAEC 435
Cdd:COG0380  291 ERLLERHPELRGKVTLLQIAVPSRE---DVPAyreLRREIEELVGRINGRFGTLDWTPIRYLNRSLPREELAALYRAADV 367

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 436 VVVTAVRDGMNLTPYEYIVCRQGvsgaetDSGVggpdksmLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQ 515
Cdd:COG0380  368 ALVTPLRDGMNLVAKEYVAAQPD------DPGV-------LVLSEFAGAAEELTEALLVNPYDIDGMAEAIHRALTMPLE 434

                        490       500       510
                 ....*....|....*....|....*....|..
gi 565364364 516 EKQLRHEKHYRYVSTHDVAYWSRSFLQDMERT 547
Cdd:COG0380  435 ERRRRMRALRERVRRYDVHRWADDFLDALAAV 466
 
Name Accession Description Interval E-value
PLN02205 PLN02205
alpha,alpha-trehalose-phosphate synthase [UDP-forming]
 1-848 0e+00

alpha,alpha-trehalose-phosphate synthase [UDP-forming]


Pssm-ID: 177855 [Multi-domain]  Cd Length: 854  Bit Score: 1310.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   1 MMSRSYTNLLDLASGNFPVMGRERDRRRMsrVMTVPGSICELDDDQAVSVSSDNQSSLAG-DRMIVVANQLPLKAKRRPD 79
Cdd:PLN02205   1 MVSRSYSNLLELASGESPSFGRMNRRIPR--IMTVAGIMSDIDDDPSESVCSDPSSSSVPkDRIIIVANQLPIRAQRKSD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  80 -NKGWSFSWNEDSLLLRLKDGLPED-MEVLFVGSLSVDVDPIEQDDVSSYLLDKFRCVPTFLPPNIVEKYYEGFCKRHLW 157
Cdd:PLN02205  79 gSKGWIFSWDENSLLLQLKDGLGDDeIEVIYVGCLKEEIHLNEQEEVSQILLETFKCVPTFLPPDLFTRYYHGFCKQQLW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 158 PLFHYMLPFSPDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPEDDFVWIHDYHLMVLPTFLRRRFNRLRIGFFLHSPFPS 237
Cdd:PLN02205 159 PLFHYMLPLSPDLGGRFNRSLWQAYVSVNKIFADRIMEVINPEDDFVWIHDYHLMVLPTFLRKRFNRVKLGFFLHSPFPS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 238 SEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRGYIGLEYYGRTVGIKIMPVGIHMGHIESMK 317
Cdd:PLN02205 239 SEIYKTLPIREELLRALLNSDLIGFHTFDYARHFLSCCSRMLGLSYESKRGYIGLEYYGRTVSIKILPVGIHMGQLQSVL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 318 KISDKELKFKELKQQF--EGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIANPMRGKGIDLEEIQAEI 395
Cdd:PLN02205 319 SLPETEAKVKELIKQFcdQDRIMLLGVDDMDIFKGISLKLLAMEQLLMQHPEWQGKVVLVQIANPARGKGKDVKEVQAET 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 396 QESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQG------VSGAETDSgvg 469
Cdd:PLN02205 399 HSTVKRINETFGKPGYDPIVLIDAPLKFYERVAYYVVAECCLVTAVRDGMNLIPYEYIISRQGnekldkLLGLEPST--- 475

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 470 gPDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRSFLQDMERTCA 549
Cdd:PLN02205 476 -PKKSMLVVSEFIGCSPSLSGAIRVNPWNIDAVADAMDSALEMAEPEKQLRHEKHYRYVSTHDVGYWARSFLQDLERTCR 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 550 DHFRKRCYGIGLGFGFRVVSLDPNFRKLSIDDIVNAYIKSKSRAIFLDYDGTVMPQNSIIKSPSANVISILNKLSGDPNN 629
Cdd:PLN02205 555 DHSRRRCWGIGFGLSFRVVALDPNFRKLSMEHIVSAYKRTTTRAILLDYDGTLMPQASIDKSPSSKSIDILNTLCRDKNN 634

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 630 TVFIVSGRGRESLTKWFSPCRKLGLAAEHGYFLRWEREQKWEVCSQTSDFGWMQLAEPVMQSYTDATDGSCIERKESAIV 709
Cdd:PLN02205 635 MVFIVSARSRKTLADWFSPCEKLGIAAEHGYFLRLKRDVEWETCVPVADCSWKQIAEPVMQLYTETTDGSTIEDKETALV 714

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 710 WQYSDADSGFGFSQAKEMLDHLESVLANEPVAVKSGQHIVEVKPQGVTKGLVAEKVFTSLAVKGKLADFVLCIGDDRSDE 789
Cdd:PLN02205 715 WCYEDADPDFGSCQAKELLDHLESVLANEPVTVKSGQNIVEVKPQGVSKGLVAKRLLSIMQERGMLPDFVLCIGDDRSDE 794

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 565364364 790 DMFEIIGDALSRNIISYDAKVFACTVGQKPSKAKYYLDDTSEVVLMLDSLADATDTPVT 848
Cdd:PLN02205 795 DMFEVITSSMAGPSIAPRAEVFACTVGQKPSKAKYYLDDTAEIVRLMQGLASVSEQILP 853
Glyco_transf_20 pfam00982
Glycosyltransferase family 20; Members of this family belong to glycosyl transferase family 20. ...
 62-546 0e+00

Glycosyltransferase family 20; Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,.


Pssm-ID: 425972 [Multi-domain]  Cd Length: 471  Bit Score: 631.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   62 RMIVVANQLPLKAKRRPDNKGWSFSWNEDSL-LLRLKDGLPEDMEVLFVGSLSVDVDPIE-QDDVSSYLLDKFRCVPTFL 139
Cdd:pfam00982   2 RLVVVSNRLPVTAVRDEEDGKWEFSIKMSSGgLVSALNGLSAATEGVWVGWPGVPVDESEpKDKVSQSLKEKFNCVPVFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  140 PPNIVEKYYEGFCKRHLWPLFHYMLPfsPDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLR 219
Cdd:pfam00982  82 SDELFDSYYNGFSNSILWPLFHYMIP--PNNEDAFDRSWWDAYVKVNKLFADKIVEVYKD-GDLIWIHDYHLMLLPQMLR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  220 RRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRgyiGLEYYGRTV 299
Cdd:pfam00982 159 KRLPDAKIGFFLHTPFPSSEIFRCLPVREEILEGLLGADLIGFHTYDYARHFLSCCSRLLGLETRSDG---GVEYGGRTV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  300 GIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKT-VLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIA 378
Cdd:pfam00982 236 SVKAFPIGIDPGRIESGLASPSVQEKIKELKERFGNKKkLIVGVDRLDYIKGIPQKLLAFERFLEEYPEWRGKVVLVQIA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  379 NPMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQG 458
Cdd:pfam00982 316 VPSRGDVEEYQNLRSQIEELVGRINGEFGTLDYTPVHFLHRPLDFDELIALYAVADVCLVTSLRDGMNLVAYEYVACQQG 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  459 vsgaetdsgvggpDKSMLVVSEFIGCSPSL-SGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWS 537
Cdd:pfam00982 396 -------------RKGVLILSEFAGAAQSLnDGAILVNPWDIDEVAEAINEALTMSEEERKKRHKKLYKYISKHDSQHWA 462


                  ....*....
gi 565364364  538 RSFLQDMER 546
Cdd:pfam00982 463 ESFLSDLKR 471
PRK14501 PRK14501
putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional
 62-842 0e+00

putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional


Pssm-ID: 184712 [Multi-domain]  Cd Length: 726  Bit Score: 620.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  62 RMIVVANQLPLKAKRRPDnkGWSFSWNEDSLLLRLKdGLPEDMEVLFVG--SLSVDVDPIEQDDVSSYLLDKFRCVPTFL 139
Cdd:PRK14501   2 RLIIVSNRLPVTVVREDG--GVELTPSVGGLATGLR-SFHERGGGLWVGwpGLDLEEESEEQRARIEPRLEELGLVPVFL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 140 PPNIVEKYYEGFCKRHLWPLFHYMLPFSPdhggrFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLR 219
Cdd:PRK14501  79 SAEEVDRYYEGFCNSTLWPLFHYFPEYTE-----FEDRFWESYERVNQRFAEAIAAIARP-GDVVWVHDYQLMLLPAMLR 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 220 RRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRGYIGleyyGRTV 299
Cdd:PRK14501 153 ERLPDARIGFFLHIPFPSFEVFRLLPWREEILEGLLGADLIGFHTYDYVRHFLSSVLRVLGYETELGEIRLG----GRIV 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 300 GIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIAN 379
Cdd:PRK14501 229 RVDAFPMGIDYDKFHNSAQDPEVQEEIRRLRQDLRGRKIILSIDRLDYTKGIPRRLLAFERFLEKNPEWRGKVRLVQVAV 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 380 PMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRqgv 459
Cdd:PRK14501 309 PSRTGVPQYQEMKREIDELVGRINGEFGTVDWTPIHYFYRSLPFEELVALYRAADVALVTPLRDGMNLVAKEYVASR--- 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 460 sgaeTDsgvggpDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRS 539
Cdd:PRK14501 386 ----TD------GDGVLILSEMAGAAAELAEALLVNPNDIEGIAAAIKRALEMPEEEQRERMQAMQERLRRYDVHKWASD 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 540 FLQDMERTCADHFRkrcygiglgfgFRVVSLDPNfrklSIDDIVNAYIKSKSRAIFLDYDGTV-----MPQNSIiksPSA 614
Cdd:PRK14501 456 FLDELREAAEKNKA-----------FASKPITPA----AAEEIIARYRAASRRLLLLDYDGTLvpfapDPELAV---PDK 517

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 615 NVISILNKLSGDPNNTVFIVSGRGRESLTKWFSPcRKLGLAAEHGYFLRwEREQKWEVcSQTSDFGWMQLAEPVMQSYTD 694
Cdd:PRK14501 518 ELRDLLRRLAADPNTDVAIISGRDRDTLERWFGD-LPIHLVAEHGAWSR-APGGEWQL-LEPVATEWKDAVRPILEEFVD 594

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 695 ATDGSCIERKESAIVWQYSDADSGFGFSQAKEMLDHLESVLANEPVAVKSGQHIVEVKPQGVTKGLVAEKVFTSLAvkgk 774
Cdd:PRK14501 595 RTPGSFIEEKEASLAWHYRNADPELGEARANELILALSSLLSNAPLEVLRGNKVVEVRPAGVNKGRAVRRLLEAGP---- 670

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 775 lADFVLCIGDDRSDEDMFEiigdALSRNiisydakvfACT--VGQKPSKAKYYLDDTSEVVLMLDSLADA 842
Cdd:PRK14501 671 -YDFVLAIGDDTTDEDMFR----ALPET---------AITvkVGPGESRARYRLPSQREVRELLRRLLDI 726
GT20_TPS cd03788
trehalose-6-phosphate synthase; Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a ...
 62-545 0e+00

trehalose-6-phosphate synthase; Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.


Pssm-ID: 340820 [Multi-domain]  Cd Length: 463  Bit Score: 599.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  62 RMIVVANQLPLKAKRRPDnkGWSFSWNEDSLLLRLKDGLPEDMEVLFVGSLSVDVDPIEQD-DVSSYLLDKFRCVPTFLP 140
Cdd:cd03788    1 RLIVVSNRLPVTLERDDD--GEVEFRRSAGGLVTALKGLLKSTGGLWVGWPGIEADEEESDqVVSPELLEEYNVVPVFLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 141 PNIVEKYYEGFCKRHLWPLFHYMLPfspDHGGRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLRR 220
Cdd:cd03788   79 DEDFEGYYNGFSNSVLWPLFHYLLP---LPDGRFEREWWEAYVRVNQAFADAVVEVYRP-GDLIWVHDYHLLLLPQMLRE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 221 RFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSkrgYIGLEYYGRTVG 300
Cdd:cd03788  155 RLPDARIGFFLHIPFPSSEIFRCLPWREEILRGLLGADLIGFQTFEYARHFLSCCSRLLGLETTS---AGGVEYGGRRVR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 301 IKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIANP 380
Cdd:cd03788  232 VGAFPIGIDPDRFRRLAASPEVQERARELRERYKGKKLIVGVDRLDYTKGIPEKLLAFERFLERYPEWRGKVVLVQVAVP 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 381 MRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQGvs 460
Cdd:cd03788  312 SRTDVEEYQELRREVEELVGRINGRFGTLDWTPVVYLHQSLDREELLALYRAADVALVTSLRDGMNLVAKEYVACQRD-- 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 461 gaetdsgvggpDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRSF 540
Cdd:cd03788  390 -----------NPGVLILSEFAGAASELDGAILVNPWDIEEVAEAINRALTMSPEERKERHQKLRKYVETHDVQAWANSF 458


                 ....*
gi 565364364 541 LQDME 545
Cdd:cd03788  459 LDDLA 463
PLN03063 PLN03063
alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional
 62-853 6.55e-177

alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional


Pssm-ID: 215555 [Multi-domain]  Cd Length: 797  Bit Score: 530.21  E-value: 6.55e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  62 RMIVVANQLPLKAKRRPDNKgWSFSWNED---SLLLRLKDglpedMEVLFVGSLSVDV-DPIEQDDVSSYLLDKfRCVPT 137
Cdd:PLN03063  12 RLLVVANRLPVSAKRTGEDS-WSLEMSPGglvSALLGVKE-----FETKWIGWPGVDVhDEIGKAALTESLAEK-GCIPV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 138 FLPpNIVEKYYEGFCKRHLWPLFHYM-LPFSPDHGG-RFDRSMWEAYVSANKMFSQKVVEVLNpEDDFVWIHDYHLMVLP 215
Cdd:PLN03063  85 FLN-EVFDQYYNGYCNNILWPIFHYMgLPQEDRHDAtRTFESQYDAYKKANRMFLDVVKENYE-EGDVVWCHDYHLMFLP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 216 TFLRRRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKrgyiGLEYY 295
Cdd:PLN03063 163 QYLKEYNNKMKVGWFLHTPFPSSEIYKTLPSRSELLRAVLTADLIGFHTYDFARHFLSACTRILGVEGTHE----GVVDQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 296 GRTVGIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLV 375
Cdd:PLN03063 239 GKVTRVAVFPIGIDPERFINTCELPEVKQHMKELKRFFAGRKVILGVDRLDMIKGIPQKYLAFEKFLEENPEWRDKVMLV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 376 QIANPMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVC 455
Cdd:PLN03063 319 QIAVPTRNDVPEYQKLKSQVHELVGRINGRFGSVSSVPIHHLDCSVDFNYLCALYAITDVMLVTSLRDGMNLVSYEFVAC 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 456 RQGVSGaetdsgvggpdksMLVVSEFIGCSPSL-SGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVA 534
Cdd:PLN03063 399 QKAKKG-------------VLVLSEFAGAGQSLgAGALLVNPWNITEVSSAIKEALNMSDEERETRHRHNFQYVKTHSAQ 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 535 YWSRSFLQDMertcadhfrkrcYGIGLGFGFRVVSLDPNfrkLSIDDIVNAYIKSKSRAIFLDYDGTVM-PQNSIIKSPS 613
Cdd:PLN03063 466 KWADDFMSEL------------NDIIVEAELRTRNIPLE---LPEQDVIQQYSKSNNRLLILGFYGTLTePRNSQIKEMD 530

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 614 ----ANVISILNKLSGDPNNTVFIVSGRGRESLTKWFSPcRKLGLAAEHGYFLRWEREQKWEVCSQTSDFGWMQLAEPVM 689
Cdd:PLN03063 531 lglhPELKETLKALCSDPKTTVVVLSRSGKDILDKNFGE-YNIWLAAENGMFLRHTSGEWVTTMPEHMNLDWVDGVKNVF 609

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 690 QSYTDATDGSCIERKESAIVWQYSDADSGFGFSQAKEMLDHL-ESVLANEPVAVKSGQHIVEVKPQGVTKGLVAEKVFTS 768
Cdd:PLN03063 610 KYFTDRTPRSYVEKSETSLVWNYEYADVEFGRAQARDMLQHLwAGPISNASVDVVRGQKSVEVHAIGVTKGAAIGRILGE 689

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 769 LAVKGKLA---DFVLCIGDDRS-DEDMF-----EIIGDALSRNIISYDAK--------------VFACTVGQKPSKAKYY 825
Cdd:PLN03063 690 IVHNKSMTtpiDFVFCSGYFLEkDEDVYtffepEILSKKKSSSSNYSDSDkkvssnlvdlkgenYFSCAIGQARTKARYV 769

                        810       820
                 ....*....|....*....|....*...
gi 565364364 826 LDDTSEVVLMLDSLADATDTpvTSDDEP 853
Cdd:PLN03063 770 LDSSNDVVSLLHKLAVANTT--MTDSFS 795
PLN03064 PLN03064
alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional
 62-845 1.20e-172

alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional


Pssm-ID: 215556 [Multi-domain]  Cd Length: 934  Bit Score: 523.98  E-value: 1.20e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  62 RMIVVANQLPLKAKRRPDNKgWSFSWNEDSL---LLRLKDglpedMEVLFVGSLSVDV-DPIEQDDVSSYLLDKfRCVPT 137
Cdd:PLN03064  95 RLLVVANRLPVSAVRRGEDS-WSLEISAGGLvsaLLGVKE-----FEARWIGWAGVNVpDEVGQKALTKALAEK-RCIPV 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 138 FLPPNIVEKYYEGFCKRHLWPLFHYM-LPFSpdhggrfDR--------SMWEAYVSANKMFSQKVVEVLNpEDDFVWIHD 208
Cdd:PLN03064 168 FLDEEIVHQYYNGYCNNILWPLFHYLgLPQE-------DRlattrsfqSQFAAYKKANQMFADVVNEHYE-EGDVVWCHD 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 209 YHLMVLPTFLRRRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKrg 288
Cdd:PLN03064 240 YHLMFLPKCLKEYNSNMKVGWFLHTPFPSSEIHRTLPSRSELLRSVLAADLVGFHTYDYARHFVSACTRILGLEGTPE-- 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 289 yiGLEYYGRTVGIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSW 368
Cdd:PLN03064 318 --GVEDQGRLTRVAAFPIGIDSDRFIRALETPQVQQHIKELKERFAGRKVMLGVDRLDMIKGIPQKILAFEKFLEENPEW 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 369 QGQAVLVQIANPMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLT 448
Cdd:PLN03064 396 RDKVVLLQIAVPTRTDVPEYQKLTSQVHEIVGRINGRFGTLTAVPIHHLDRSLDFHALCALYAVTDVALVTSLRDGMNLV 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 449 PYEYIVCRqgvsgaetdsgvgGPDKSMLVVSEFIGCSPSL-SGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRY 527
Cdd:PLN03064 476 SYEFVACQ-------------DSKKGVLILSEFAGAAQSLgAGAILVNPWNITEVAASIAQALNMPEEEREKRHRHNFMH 542

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 528 VSTHDVAYWSRSFLQDMERTCAD-HFRKRcygiglgfgfRVVSLdpnfrkLSIDDIVNAYIKSKSRAIFLDYDGTVMPQN 606
Cdd:PLN03064 543 VTTHTAQEWAETFVSELNDTVVEaQLRTR----------QVPPQ------LPPEDAIQRYLQSNNRLLILGFNATLTEPV 606

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 607 SIIKSPSANVISI-----------LNKLSGDPNNTVFIVSGRGRESLTKWFSPCrKLGLAAEHGYFLRWEREQKWEVCSQ 675
Cdd:PLN03064 607 DTPGRRGDQIKEMelrlhpelkepLRALCSDPKTTIVVLSGSDRSVLDENFGEF-DMWLAAENGMFLRHTKGEWMTTMPE 685

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 676 TSDFGWMQLAEPVMQSYTDATDGSCIERKESAIVWQYSDADSGFGFSQAKEMLDHL-ESVLANEPVAVKSGQHIVEVKPQ 754
Cdd:PLN03064 686 HLNMDWVDSVKHVFEYFTERTPRSHFETRETSLVWNYKYADVEFGRLQARDMLQHLwTGPISNAAVDVVQGSRSVEVRPV 765

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 755 GVTKGLVAEKVFTSLaVKGKLA----DFVLCIGDDRS-DEDMFEIIGDALSRNIISY----------------------- 806
Cdd:PLN03064 766 GVTKGAAIDRILGEI-VHSKSMttpiDYVLCIGHFLGkDEDIYTFFEPELPSDSPAIarsrspdglkssgdrrpsgklps 844

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 807 ----------------------------------------------DAK---VFACTVGQKPSKAKYYLDDTSEVVLMLD 837
Cdd:PLN03064 845 srsnsknsqgkkqrsllssaksgvnhaashgsdrrpspekigwsvlDLKgenYFSCAVGRKRSNARYLLGSSDDVVSFLK 924


                 ....*...
gi 565364364 838 SLADATDT 845
Cdd:PLN03064 925 ELANASSS 932
trehalose_OtsA TIGR02400
alpha,alpha-trehalose-phosphate synthase [UDP-forming]; This enzyme catalyzes the key, ...
 62-546 2.27e-150

alpha,alpha-trehalose-phosphate synthase [UDP-forming]; This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 274112  Cd Length: 456  Bit Score: 449.80  E-value: 2.27e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364   62 RMIVVANQLPLKAKRrpdnKGWSFSwnEDSLLLRLKDGLpEDMEVLFVGSLSVDV-DPIEQDDVSSYLLDKFRCVPTFLP 140
Cdd:TIGR02400   1 RLIVVSNRLPVPITR----GGLEPS--AGGLAVALLGAL-KATGGVWFGWSGKTVeEDEGEPFLRTELEGKITLAPVFLS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  141 PNIVEKYYEGFCKRHLWPLFHYMLPFSpdhggRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLRR 220
Cdd:TIGR02400  74 EEDVDGYYNGFSNSTLWPLFHYRPDLI-----RYDRKAWEAYRRVNRLFAEALAPLLQP-GDIVWVHDYHLMLLPAMLRE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  221 RFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKrgyiGLEYYGRTVG 300
Cdd:TIGR02400 148 LGVQNKIGFFLHIPFPSSEIYRTLPWRRELLEGLLAYDLVGFQTYDDARNFLSAVSRELGLETLPN----GVESGGRTVR 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  301 IKIMPVGIHMGHI-ESMKKISDKELkFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIAN 379
Cdd:TIGR02400 224 VGAFPIGIDVDRFaEQAKKPSVQKR-IAELRESLKGRKLIIGVDRLDYSKGLPERLLAFERFLEEHPEWRGKVVLVQIAV 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  380 PMRGKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQgv 459
Cdd:TIGR02400 303 PSRGDVPEYQQLRRQVEELVGRINGRFGTLDWTPIRYLNRSYDREELMALYRAADVGLVTPLRDGMNLVAKEYVAAQD-- 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  460 sgaetdsgvggPDKSMLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRS 539
Cdd:TIGR02400 381 -----------PKDGVLILSEFAGAAQELNGALLVNPYDIDGMADAIARALTMPLEEREERHRAMMDKLRKNDVQRWRED 449


                  ....*..
gi 565364364  540 FLQDMER 546
Cdd:TIGR02400 450 FLSDLNS 456
OtsA COG0380
Trehalose-6-phosphate synthase, GT20 family [Carbohydrate transport and metabolism];
60-547 7.99e-140

Trehalose-6-phosphate synthase, GT20 family [Carbohydrate transport and metabolism];


Pssm-ID: 440149  Cd Length: 474  Bit Score: 422.99  E-value: 7.99e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  60 GDRMIVVANQLPLKAKRRPDNKGWS---------------------FSWNedslllrlkdGLPEDMEVLFVGSLSVDVDp 118
Cdd:COG0380    1 GSRLVVVSNRLPVPHVREDGSIRVKrsagglvtalepvlrrrgglwVGWS----------GGDADREAVEEPRGPVPPD- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 119 ieqddvssylLDKFRCVPTFLPPNIVEKYYEGFCKRHLWPLFHYMlpfsPDHGgRFDRSMWEAYVSANKMFSQKVVEVLN 198
Cdd:COG0380   70 ----------LGGYTLAPVDLSAEEVDGYYEGFSNETLWPLFHYR----LDLP-EFDREDWEAYRRVNRRFAEALAEEAE 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 199 PeDDFVWIHDYHLMVLPTFLRRRFNRLRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRM 278
Cdd:COG0380  135 P-DDVVWVHDYHLLLVPAMLRELGPDARIGFFLHIPFPPPEIFRILPWREEILEGLLGADLIGFQTPRDARNFLDCVRRL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 279 LGLEyQSKRGYIglEYYGRTVGIKIMPVGIHMGHIESMKKISDKELKFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAM 358
Cdd:COG0380  214 LGAE-VDEGGTV--RYGGRTVRVGAFPIGIDVEEFAELARSPEVRARAERLREELGGRKLILGVDRLDYTKGIPERLRAF 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 359 EHMLKQHPSWQGQAVLVQIANPMRGkgiDLEE---IQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAEC 435
Cdd:COG0380  291 ERLLERHPELRGKVTLLQIAVPSRE---DVPAyreLRREIEELVGRINGRFGTLDWTPIRYLNRSLPREELAALYRAADV 367

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 436 VVVTAVRDGMNLTPYEYIVCRQGvsgaetDSGVggpdksmLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQ 515
Cdd:COG0380  368 ALVTPLRDGMNLVAKEYVAAQPD------DPGV-------LVLSEFAGAAEELTEALLVNPYDIDGMAEAIHRALTMPLE 434

                        490       500       510
                 ....*....|....*....|....*....|..
gi 565364364 516 EKQLRHEKHYRYVSTHDVAYWSRSFLQDMERT 547
Cdd:COG0380  435 ERRRRMRALRERVRRYDVHRWADDFLDALAAV 466
Trehalose_PPase pfam02358
Trehalose-phosphatase; This family consist of trehalose-phosphatases EC:3.1.3.12 these enzyme ...
 595-829 4.12e-81

Trehalose-phosphatase; This family consist of trehalose-phosphatases EC:3.1.3.12 these enzyme catalyze the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate. The aligned region is present in trehalose-phosphatases and comprises the entire length of the protein it is also found in the C-terminus of trehalose-6-phosphate synthase EC:2.4.1.15 adjacent to the trehalose-6-phosphate synthase domain - pfam00982. It would appear that the two equivalent genes in the E. coli otsBA operon otsA the trehalose-6-phosphate synthase and otsB trehalose-phosphatase (this family) have undergone gene fusion in most eukaryotes and Swiss:P93653. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance.


Pssm-ID: 426737 [Multi-domain]  Cd Length: 234  Bit Score: 260.73  E-value: 4.12e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  595 FLDYDGTVMPQ--NSIIKSPSANVISILNKLSGDPNNTVFIVSGRGRESLtKWFSPCRKLGLAAEHGYFLRWEREQKWEV 672
Cdd:pfam02358   1 FLDYDGTLSPIvsDPIAAVPSDRMLSALQDLASDPPNTVAIISGRSRQEE-DLFVGVPNLGLAAEHGAFVRLPGGGDWYN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  673 CSQTSDFGWMQLAEPVMQSYTDATDGSCIERKESAIVWQYSDADSGFGFSQAKEMLDHLESVLANE-PVAVKSGQHIVEV 751
Cdd:pfam02358  80 QAEVEDLPWKKEVAPILEYYTERTPGSYVENKKSALSWHYRNADDDFGSFQAKELAEHLESVLQDNpPLRVTQGKKVVEV 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 565364364  752 KPQGVTKGLVAEKVFTSLAVKGKLADFVLCIGDDRSDEDMFEIIGDALSRNIIsydAKVFACTVGQKPSKAKYYLDDT 829
Cdd:pfam02358 160 RPVGVSKGKAVEFILEELGSAGSLPDFPLCIGDDRTDEDMFSVLRPTKPSGVG---IEVFAVSVGSKPSSASYFLDDP 234
HAD_TPP cd01627
trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase ...
 593-834 1.39e-65

trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2; Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319767 [Multi-domain]  Cd Length: 228  Bit Score: 218.70  E-value: 1.39e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 593 AIFLDYDGTVMPqnsIIKSP-----SANVISILNKLSGDPNNTVFIVSGRGRESLTKWFSPCRkLGLAAEHGYFLRWERE 667
Cdd:cd01627    1 LLFLDYDGTLAP---IVPDPdaavpSPELLEALKKLAADPKNAVAIVSGRDLDDLDKWLGLPG-IGLAGEHGAEIRLPGG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 668 QKWEVCSQTSDFGWMQLAEPVMQSYTDATDGSCIERKESAIVWQYSDADSgFGFSQAKEMLDHLESVLANEPVaVKSGQH 747
Cdd:cd01627   77 GEWVTLAPKADLEWKEEVEAIFKYFTERTPGSLVEDKGASLAWHYRNADP-EGARAALELALHLASDLLKALE-VVPGKK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 748 IVEVKPQGVTKGLVAEKVFTSLavkGKLADFVLCIGDDRSDEDMFEIIgdalsrniisYDAKVFACTVGQKPSKAKYYLD 827
Cdd:cd01627  155 VVEVRPVGVNKGEAVERILGEL---PFAGDFVLCAGDDVTDEDAFRAL----------NGEGGFSVKVGEGPTAAKFRLD 221


                 ....*..
gi 565364364 828 DTSEVVL 834
Cdd:cd01627  222 DPPDVVA 228
PRK10117 PRK10117
trehalose-6-phosphate synthase; Provisional
 145-547 8.51e-63

trehalose-6-phosphate synthase; Provisional


Pssm-ID: 182249  Cd Length: 474  Bit Score: 219.24  E-value: 8.51e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 145 EKYYEGFCKRHLWPLFHYMLPFSpdhggRFDRSMWEAYVSANKMFSQKVVEVLNPeDDFVWIHDYHLMVLPTFLRRRFNR 224
Cdd:PRK10117  74 DEYYNQFSNAVLWPAFHYRLDLV-----QFQRPAWEGYLRVNALLADKLLPLLKD-DDIIWIHDYHLLPFASELRKRGVN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 225 LRIGFFLHSPFPSSEIYRTLPVREEILKALLCSDLVGFHTFDYARHFLSCCSRMLGLEYQSKRGYIGleyYGRTVGIKIM 304
Cdd:PRK10117 148 NRIGFFLHIPFPTPEIFNALPPHDELLEQLCDYDLLGFQTENDRLAFLDCLSNLTRVTTRSGKSHTA---WGKAFRTEVY 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 305 PVGIHMghiESMKKISDKEL--KFKELKQQFEGKTVLLGVDDLDIFKGINLKLLAMEHMLKQHPSWQGQAVLVQIANPMR 382
Cdd:PRK10117 225 PIGIEP---DEIAKQAAGPLppKLAQLKAELKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSR 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 383 GKGIDLEEIQAEIQESCKRINKQFGKPGYEPIVYIDRSVSSSERMAYYSVAECVVVTAVRDGMNLTPYEYIVCRQgvsga 462
Cdd:PRK10117 302 GDVQAYQDIRHQLETEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEYVAAQD----- 376

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 463 ETDSGVggpdksmLVVSEFIGCSPSLSGAIRINPWNVEATAEAMNEAVSMAEQEKQLRHEKHYRYVSTHDVAYWSRSFLQ 542
Cdd:PRK10117 377 PANPGV-------LVLSQFAGAANELTSALIVNPYDRDEVAAALDRALTMPLAERISRHAEMLDVIVKNDINHWQECFIS 449


                 ....*
gi 565364364 543 DMERT 547
Cdd:PRK10117 450 DLKQI 454
OtsB COG1877
Trehalose-6-phosphate phosphatase [Carbohydrate transport and metabolism];
589-842 2.58e-46

Trehalose-6-phosphate phosphatase [Carbohydrate transport and metabolism];


Pssm-ID: 441481 [Multi-domain]  Cd Length: 242  Bit Score: 165.75  E-value: 2.58e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 589 SKSRAIFLDYDGTVMPqnsiIKS------PSANVISILNKLSGDPNNTVFIVSGRGRESLTKWFSPCRkLGLAAEHGYFl 662
Cdd:COG1877    1 APRLLLFLDFDGTLAP----IVPdpdaarPPPELRELLRRLAARPGGAVAIVSGRDLADLDRLLGPLG-LPLAGSHGAE- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 663 RWEREQKWEVCSQTSDF-GWMQLAEPVMQSYTDATDGSCIERKESAIVWQYSDADSGfgfsQAKEMLDHLESVLA--NEP 739
Cdd:COG1877   75 RRLPGGEWEVLPLAAEApEWLDALRAALEALAARTPGVLVEDKGASLALHYRQAPPE----EAEELRAALRELAArlGPG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 740 VAVKSGQHIVEVKPQGVTKGLVAEKVFTSLAVkgklADFVLCIGDDRSDEDMFEiigdALSRNIISydakvfaCTVGQKP 819
Cdd:COG1877  151 LEVLPGKKVVELRPAGVDKGRAVRALLAELPF----GRAPVFIGDDVTDEDAFA----ALPAGGLG-------IKVGSGP 215

                        250       260
                 ....*....|....*....|...
gi 565364364 820 SKAKYYLDDTSEVVLMLDSLADA 842
Cdd:COG1877  216 TAARYRLADPAEVRALLARLAEA 238
T6PP TIGR00685
trehalose-phosphatase; Trehalose, a neutral disaccharide of two glucose residues, is an ...
 589-840 1.10e-26

trehalose-phosphatase; Trehalose, a neutral disaccharide of two glucose residues, is an important osmolyte for dessication and/or salt tolerance in a number of prokaryotic and eukaryotic species, including E. coli, Saccharomyces cerevisiae, and Arabidopsis thaliana. Many bacteria also utilize trehalose in the synthesis of trehalolipids, specialized cell wall constituents believed to be involved in the uptake of hydrophobic substances. Trehalose dimycolate (TDM, cord factor) and related substances are important constituents of the mycobacterial waxy coat and responsible for various clinically important immunological interactions with host organism. This enzyme, trehalose-phosphatase, removes a phosphate group in the final step of trehalose biosynthesis. The trehalose-phosphatase from Saccharomyces cerevisiae is fused to the synthase. At least 18 distinct sequences from Arabidopsis have been identified, roughly half of these are of the fungal type, with a fused synthase and half are like the bacterial members having only the phosphatase domain. It has been suggested that trehalose is being used in Arabidopsis as a regulatory molecule in development and possibly other processes. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273219 [Multi-domain]  Cd Length: 244  Bit Score: 109.54  E-value: 1.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  589 SKSRAIFLDYDGTVMPqnsIIKSPSANVIS-----ILNKLSGDPNNTVFIVSGRGRESLTKWFSPCRkLGLAAEHGYFLR 663
Cdd:TIGR00685   1 ARKRAFFFDYDGTLSE---IVPDPDAAVVSdrlltILQKLAARPHNAIWIISGRKFLEKWLGVKLPG-LGLAGEHGCEMK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  664 WE-REQKWeVCSQTSDFGWMQLAEPVMQSYTDaTDGSCIERKESAIVWQYSDA-DSGFGFSQAKEMLdhlESVLANEPVA 741
Cdd:TIGR00685  77 DNgSCQDW-VNLTEKIPSWKVRANELREEITT-RPGVFIERKGVALAWHYRQApVPELARFRAKELK---EKILSFTDLE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  742 VKSGQHIVEVKPQGVTKGLVAEKVFTSLAVKGKLAdfvLCIGDDRSDEDMFEIIGDALSRniisYDAKVFACTVGQKPSK 821
Cdd:TIGR00685 152 VMDGKAVVELKPRFVNKGEIVKRLLWHQPGSGISP---VYLGDDITDEDAFRVVNNQWGN----YGFYPVPIGSGSKKTV 224

                         250
                  ....*....|....*....
gi 565364364  822 AKYYLDDTSEVVLMLDSLA 840
Cdd:TIGR00685 225 AKFHLTGPQQVLEFLGLLV 243
HAD-SF-IIB TIGR01484
HAD-superfamily hydrolase, subfamily IIB; This subfamily falls within the Haloacid ...
 593-800 1.11e-17

HAD-superfamily hydrolase, subfamily IIB; This subfamily falls within the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class II subfamilies are characterized by a domain that is located between the second and third conserved catalytic motifs of the superfamily domain. The IIB subfamily is distinguished from the IIA subfamily (TIGR01460) by homology and the predicted secondary structure of this domain by PSI-PRED. The IIB subfamily's Class II domain has the following predicted structure: Helix-Sheet-Sheet-(Helix or Sheet)-Helix-Sheet-(variable)-Helix-Sheet-Sheet. The IIB subfamily consists of Trehalose-6-phosphatase (TIGR00685), plant and cyanobacterial Sucrose-phosphatase and a closely related group of bacterial and archaeal sequences, eukaryotic phosphomannomutase (pfam03332), a large subfamily ("Cof-like hydrolases", TIGR00099) containing many closely related bacterial sequences, a hypothetical equivalog containing the E. coli YedP protein, as well as two small clusters containing OMNI|TC0379 and OMNI|SA2196 whose relationship to the other groups is unclear. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273651 [Multi-domain]  Cd Length: 207  Bit Score: 82.43  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  593 AIFLDYDGTVMPQNSIIKSPSanVISILNKLSGDpNNTVFIVSGRGRESLTKWFSPCR-KLGLAAEHGYFLRWEREQKWE 671
Cdd:TIGR01484   1 LLFFDLDGTLLDPNAHELSPE--TIEALERLREA-GVKVVIVTGRSLAEIKELLKQLNlPLPLIAENGALIFYPGEILYI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364  672 VCSQTSDF--GWMQ-LAEPVMQSYTDATDGSCIERKESAIVWQYSDADSGFGFsqAKEMLDHLESVLANEPV--AVKSGQ 746
Cdd:TIGR01484  78 EPSDVFEEilGIKFeEIGAELKSLSEHYVGTFIEDKAIAVAIHYVGAELGQEL--DSKMRERLEKIGRNDLEleAIYSGK 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 565364364  747 HIVEVKPQGVTKGLVAEKVFTSLAVKgklADFVLCIGDDRSDEDMFEIIGDALS 800
Cdd:TIGR01484 156 TDLEVLPAGVNKGSALQALLQELNGK---KDEILAFGDSGNDEEMFEVAGLAVA 206
PLN02151 PLN02151
trehalose-phosphatase
 588-841 2.27e-12

trehalose-phosphatase


Pssm-ID: 177812  Cd Length: 354  Bit Score: 69.32  E-value: 2.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 588 KSKSRAIFLDYDGTVMPqnsIIKSPSANVISilNKLsgdpNNTV---------FIVSGRGRESLTKwFSPCRKLGLAAEH 658
Cdd:PLN02151  95 EGKQIVMFLDYDGTLSP---IVDDPDRAFMS--KKM----RNTVrklakcfptAIVSGRCREKVSS-FVKLTELYYAGSH 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 659 GYFLR-------WEREQKWEVCSQTSDFgwMQLAEPVMQSY---TDATDGSCIERKESAIVWQYSDADSgfgfSQAKEML 728
Cdd:PLN02151 165 GMDIKgpeqgskYKKENQSLLCQPATEF--LPVINEVYKKLvekTKSIPGAKVENNKFCASVHFRCVEE----NKWSDLA 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 729 DHLESVLANEP-VAVKSGQHIVEVKPQ-GVTKGLVAEKVFTSLAVKGKLADFVLCIGDDRSDEDMFEIIGDalSRNIISY 806
Cdd:PLN02151 239 NQVRSVLKNYPkLMLTQGRKVLEIRPIiKWDKGKALEFLLESLGYANCTDVFPIYIGDDRTDEDAFKILRD--KKQGLGI 316

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 565364364 807 DAKVFActvgqKPSKAKYYLDDTSEVVLMLDSLAD 841
Cdd:PLN02151 317 LVSKYA-----KETNASYSLQEPDEVMEFLERLVE 346
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
 592-793 1.05e-09

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 58.61  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 592 RAIFLDYDGTVMPQNSIIkspSANVISILNKLSgDPNNTVFIVSGRGRESLTKWFspcRKLGLaaeHGYFlrwereqkwe 671
Cdd:COG0561    3 KLIALDLDGTLLNDDGEI---SPRTKEALRRLR-EKGIKVVIATGRPLRSALPLL---EELGL---DDPL---------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 672 VCSqtsdfgwmqlaepvmqsytdatDGSCIERKESAIVWqysdaDSGFGFSQAKEMLDHLESVLANEPVAVKSGQHIVEV 751
Cdd:COG0561   63 ITS----------------------NGALIYDPDGEVLY-----ERPLDPEDVREILELLREHGLHLQVVVRSGPGFLEI 115

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 565364364 752 KPQGVTKGLVAEKVFTSLAVKgklADFVLCIGDDRSDEDMFE 793
Cdd:COG0561  116 LPKGVSKGSALKKLAERLGIP---PEEVIAFGDSGNDLEMLE 154
PLN03017 PLN03017
trehalose-phosphatase
 588-841 1.77e-08

trehalose-phosphatase


Pssm-ID: 178591 [Multi-domain]  Cd Length: 366  Bit Score: 57.34  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 588 KSKSRAIFLDYDGTVMPqnsIIKSPSANVISILNKLSGDPNNTVF---IVSGRGRESLTKwFSPCRKLGLAAEHGY---- 660
Cdd:PLN03017 108 RGKQIVMFLDYDGTLSP---IVDDPDKAFMSSKMRRTVKKLAKCFptaIVTGRCIDKVYN-FVKLAELYYAGSHGMdikg 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 661 ----FLRWEREQKWEVCSQTSDFGWM------QLAEPvmqsyTDATDGSCIERKESAIVWQYSDADSgfgfSQAKEMLDH 730
Cdd:PLN03017 184 pakgFSRHKRVKQSLLYQPANDYLPMidevyrQLLEK-----TKSTPGAKVENHKFCASVHFRCVDE----KKWSELVLQ 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 731 LESVLANEP-VAVKSGQHIVEVKPQ-GVTKGLVAEKVFTSLAVKGKLADFVLCIGDDRSDEDMFEIIGDAlsrniisydA 808
Cdd:PLN03017 255 VRSVLKNFPtLKLTQGRKVFEIRPMiEWDKGKALEFLLESLGFGNTNNVFPVYIGDDRTDEDAFKMLRDR---------G 325

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 565364364 809 KVFACTVGQKP--SKAKYYLDDTSEVVLMLDSLAD 841
Cdd:PLN03017 326 EGFGILVSKFPkdTDASYSLQDPSEVMDFLARLVE 360
PRK10187 PRK10187
trehalose-6-phosphate phosphatase; Provisional
 593-840 1.00e-07

trehalose-6-phosphate phosphatase; Provisional


Pssm-ID: 182291 [Multi-domain]  Cd Length: 266  Bit Score: 54.36  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 593 AIFLDYDGT---VMPQNSIIKSPsANVISILNKLSGDPNNTVFIVSGRGRESLTKWFSPCRkLGLAAEHGYFLRWEREQK 669
Cdd:PRK10187  16 AWFFDLDGTlaeIKPHPDQVVVP-DNILQGLQLLATANDGALALISGRSMVELDALAKPYR-FPLAGVHGAERRDINGKT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 670 WEVCSQTSdfgwmqLAEPVMQSYTDAT---DGSCIERKESAIVWQYSdadsgfgfsQAKEmldHLESVLA--------NE 738
Cdd:PRK10187  94 HIVHLPDA------IARDISVQLHTALaqlPGAELEAKGMAFALHYR---------QAPQ---HEDALLAlaqritqiWP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 739 PVAVKSGQHIVEVKPQGVTKGLVAEKVFTSLAVKGKLADFVlciGDDRSDEDMFEIIGDAlsrNIISydakvfaCTVGQK 818
Cdd:PRK10187 156 QLALQPGKCVVEIKPRGTNKGEAIAAFMQEAPFAGRTPVFV---GDDLTDEAGFAVVNRL---GGIS-------VKVGTG 222

                        250       260
                 ....*....|....*....|..
gi 565364364 819 PSKAKYYLDDTSEVVLMLDSLA 840
Cdd:PRK10187 223 ATQASWRLAGVPDVWSWLEMIT 244
PLN02580 PLN02580
trehalose-phosphatase
 578-839 2.09e-06

trehalose-phosphatase


Pssm-ID: 215317 [Multi-domain]  Cd Length: 384  Bit Score: 50.96  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 578 SIDDIVNaYIKSKSRAIFLDYDGTVMPqnsIIKSP-----SANVISILNKLSgdpnnTVF---IVSGRGRE------SLT 643
Cdd:PLN02580 107 SFEQIAN-FAKGKKIALFLDYDGTLSP---IVDDPdralmSDAMRSAVKNVA-----KYFptaIISGRSRDkvyelvGLT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 644 KWF----------SPCRKlGLAAEHGYFLRWEREQKWEV--CSQTSDFgwMQLAEPVMQSYTDATD---GSCIERKESAI 708
Cdd:PLN02580 178 ELYyagshgmdimGPVRE-SVSNDHPNCIKSTDQQGKEVnlFQPASEF--LPMIDEVFRSLVESTKdikGAKVENHKFCV 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565364364 709 VWQYSDADSGFGFSQAKEMLDHLEsvlaNEP-VAVKSGQHIVEVKPQ-GVTKGLVAEKVFTSLAVKGKlaDFVLCI--GD 784
Cdd:PLN02580 255 SVHYRNVDEKNWPLVAQCVHDVLK----KYPrLRLTHGRKVLEVRPViDWNKGKAVEFLLESLGLSNC--DDVLPIyiGD 328

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 565364364 785 DRSDEDMFEIIGDalsRNiisydaKVFACTVGQKP--SKAKYYLDDTSEVVLMLDSL 839
Cdd:PLN02580 329 DRTDEDAFKVLRE---GN------RGYGILVSSVPkeSNAFYSLRDPSEVMEFLKSL 376
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
 723-796 2.74e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 40.30  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 565364364  723 QAKEMLDHLESVLANEPVAVKSGQHIVEVKPQGVTKGLVAEKVFTSLavKGKLADfVLCIGDDRSDEDMFEIIG 796
Cdd:pfam08282 153 DLDELEKELKELFGSLITITSSGPGYLEIMPKGVSKGTALKALAKHL--NISLEE-VIAFGDGENDIEMLEAAG 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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