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Conserved domains on  [gi|564262782|ref|XP_006270265|]
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GPI mannosyltransferase 2 isoform X1 [Alligator mississippiensis]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 12-523 2.58e-111

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam04188:

Pssm-ID: 473917  Cd Length: 439  Bit Score: 337.65  E-value: 2.58e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782   12 REVLRFAVWCRALTLLLQALF-NLLVPDHAADAFSPPRLSEPSVCDWLLEWLLGGLSHWDAEHFLFVAEHGYVYEHNFAF 90
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTpIRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782   91 FPVYPLSIRAVAEVTLWPLQGLLCLRSRLLLSAVLLNALFSVLAAVVLYELGCVVLQCRRTAFLSALLFCLTPANVFMTA 170
Cdd:pfam04188  82 SPLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  171 AYSESMFALLAFSAMWQLEKGRSWTSGLLFSFAAGVRSNGVINAGFLLysqsrrlaFQLQAGAGSVMKQAQVWRQLLGLA 250
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSN--------CVLLGIYFIDLIELTKNRKFVKAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  251 ASVVLTCAGLFLPPALFQFYAYLRFCDPdvsperavpqpllqlavdkgyrlaSMTGVKPAWCSHQVPMIYSYIQDVYWNV 330
Cdd:pfam04188 234 CFPFLSGSLMFLPFLYFQYYLYKTFCPQ------------------------RSAGNEPPWCKSQLPLLYSYIQSHYWGV 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  331 GFLRYFQLKQIPNFLLAAPIMMLSAWAAGIYLTANLQHCLTLGLVRRRNKsgggEGAAKPGVGFCSSGVFVYVVHATALL 410
Cdd:pfam04188 290 GFLKYWTPKQIPNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYN----KKAEKPDLGFLSPQVFVLVVHTRALV 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  411 VFGLLCMHVQVLTRLLgSSSPVLYWFSAHLLQDSDAVLWREgdptqtaaslserpclgsallglfgagVSENPLPPLLLN 490
Cdd:pfam04188 366 VIVCFFMHVQVLTRFL-SFLPLHYWFLADLLVSDKKKMWNP---------------------------LGDDKIVKFYIY 417

                         490       500       510
                  ....*....|....*....|....*....|...
gi 564262782  491 YRrntaltkcvlgYFLSFWLLGLILHCNFLPWT 523
Cdd:pfam04188 418 WL-----------ACSFYILLGTLLFANFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 12-523 2.58e-111

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 337.65  E-value: 2.58e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782   12 REVLRFAVWCRALTLLLQALF-NLLVPDHAADAFSPPRLSEPSVCDWLLEWLLGGLSHWDAEHFLFVAEHGYVYEHNFAF 90
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTpIRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782   91 FPVYPLSIRAVAEVTLWPLQGLLCLRSRLLLSAVLLNALFSVLAAVVLYELGCVVLQCRRTAFLSALLFCLTPANVFMTA 170
Cdd:pfam04188  82 SPLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  171 AYSESMFALLAFSAMWQLEKGRSWTSGLLFSFAAGVRSNGVINAGFLLysqsrrlaFQLQAGAGSVMKQAQVWRQLLGLA 250
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSN--------CVLLGIYFIDLIELTKNRKFVKAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  251 ASVVLTCAGLFLPPALFQFYAYLRFCDPdvsperavpqpllqlavdkgyrlaSMTGVKPAWCSHQVPMIYSYIQDVYWNV 330
Cdd:pfam04188 234 CFPFLSGSLMFLPFLYFQYYLYKTFCPQ------------------------RSAGNEPPWCKSQLPLLYSYIQSHYWGV 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  331 GFLRYFQLKQIPNFLLAAPIMMLSAWAAGIYLTANLQHCLTLGLVRRRNKsgggEGAAKPGVGFCSSGVFVYVVHATALL 410
Cdd:pfam04188 290 GFLKYWTPKQIPNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYN----KKAEKPDLGFLSPQVFVLVVHTRALV 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  411 VFGLLCMHVQVLTRLLgSSSPVLYWFSAHLLQDSDAVLWREgdptqtaaslserpclgsallglfgagVSENPLPPLLLN 490
Cdd:pfam04188 366 VIVCFFMHVQVLTRFL-SFLPLHYWFLADLLVSDKKKMWNP---------------------------LGDDKIVKFYIY 417

                         490       500       510
                  ....*....|....*....|....*....|...
gi 564262782  491 YRrntaltkcvlgYFLSFWLLGLILHCNFLPWT 523
Cdd:pfam04188 418 WL-----------ACSFYILLGTLLFANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
67-219 1.58e-08

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 54.96  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  67 SHWDAEHFLFVAEHGY--VYEHNF-AFFPVYPLSIRAVAEVTLWPLQGllclrsrlllsAVLLNALFSVLAAVVLYELgC 143
Cdd:COG5542    2 TAFLSPWYRAIATSGYfaALGKQFgDYFPLYPYLLRLVMYLGLPFLLA-----------GKLVSILADLVAAYLLYRW-V 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564262782 144 VVLQCRRTAFLSALLFCLTPANVFMTAAY--SESMFALLAFSAMWQLEKGRSWTSGLLFSFAAGVRSNGVINAGFLLY 219
Cdd:COG5542   70 KKYYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLI 147
arnT PRK13279
lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase;
128-217 5.91e-03

lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase;


Pssm-ID: 237330 [Multi-domain]  Cd Length: 552  Bit Score: 39.12  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782 128 ALFSVLAAVVLYELGCVVLQCRRTAFLSALLFcLTPANVFMTAAYS--ESMFAL---LAFSAMWQLEKGRSWTSG----L 198
Cdd:PRK13279  89 VFSTLLSALLVYWLALRLWRDRRTALLAALIY-LSLFLVYGIGTYAvlDPMITLwltAAMCSFWLALQAQTRRGKiggyL 167

                         90
                 ....*....|....*....
gi 564262782 199 LFSFAAGVrsnGVINAGFL 217
Cdd:PRK13279 168 LLGLACGM---GFMTKGFL 183
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 12-523 2.58e-111

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 337.65  E-value: 2.58e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782   12 REVLRFAVWCRALTLLLQALF-NLLVPDHAADAFSPPRLSEPSVCDWLLEWLLGGLSHWDAEHFLFVAEHGYVYEHNFAF 90
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTpIRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782   91 FPVYPLSIRAVAEVTLWPLQGLLCLRSRLLLSAVLLNALFSVLAAVVLYELGCVVLQCRRTAFLSALLFCLTPANVFMTA 170
Cdd:pfam04188  82 SPLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  171 AYSESMFALLAFSAMWQLEKGRSWTSGLLFSFAAGVRSNGVINAGFLLysqsrrlaFQLQAGAGSVMKQAQVWRQLLGLA 250
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSN--------CVLLGIYFIDLIELTKNRKFVKAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  251 ASVVLTCAGLFLPPALFQFYAYLRFCDPdvsperavpqpllqlavdkgyrlaSMTGVKPAWCSHQVPMIYSYIQDVYWNV 330
Cdd:pfam04188 234 CFPFLSGSLMFLPFLYFQYYLYKTFCPQ------------------------RSAGNEPPWCKSQLPLLYSYIQSHYWGV 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  331 GFLRYFQLKQIPNFLLAAPIMMLSAWAAGIYLTANLQHCLTLGLVRRRNKsgggEGAAKPGVGFCSSGVFVYVVHATALL 410
Cdd:pfam04188 290 GFLKYWTPKQIPNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYN----KKAEKPDLGFLSPQVFVLVVHTRALV 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  411 VFGLLCMHVQVLTRLLgSSSPVLYWFSAHLLQDSDAVLWREgdptqtaaslserpclgsallglfgagVSENPLPPLLLN 490
Cdd:pfam04188 366 VIVCFFMHVQVLTRFL-SFLPLHYWFLADLLVSDKKKMWNP---------------------------LGDDKIVKFYIY 417

                         490       500       510
                  ....*....|....*....|....*....|...
gi 564262782  491 YRrntaltkcvlgYFLSFWLLGLILHCNFLPWT 523
Cdd:pfam04188 418 WL-----------ACSFYILLGTLLFANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
67-219 1.58e-08

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 54.96  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782  67 SHWDAEHFLFVAEHGY--VYEHNF-AFFPVYPLSIRAVAEVTLWPLQGllclrsrlllsAVLLNALFSVLAAVVLYELgC 143
Cdd:COG5542    2 TAFLSPWYRAIATSGYfaALGKQFgDYFPLYPYLLRLVMYLGLPFLLA-----------GKLVSILADLVAAYLLYRW-V 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564262782 144 VVLQCRRTAFLSALLFCLTPANVFMTAAY--SESMFALLAFSAMWQLEKGRSWTSGLLFSFAAGVRSNGVINAGFLLY 219
Cdd:COG5542   70 KKYYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLI 147
arnT PRK13279
lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase;
128-217 5.91e-03

lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase;


Pssm-ID: 237330 [Multi-domain]  Cd Length: 552  Bit Score: 39.12  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564262782 128 ALFSVLAAVVLYELGCVVLQCRRTAFLSALLFcLTPANVFMTAAYS--ESMFAL---LAFSAMWQLEKGRSWTSG----L 198
Cdd:PRK13279  89 VFSTLLSALLVYWLALRLWRDRRTALLAALIY-LSLFLVYGIGTYAvlDPMITLwltAAMCSFWLALQAQTRRGKiggyL 167

                         90
                 ....*....|....*....
gi 564262782 199 LFSFAAGVrsnGVINAGFL 217
Cdd:PRK13279 168 LLGLACGM---GFMTKGFL 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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