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Conserved domains on  [gi|1810995093|ref|XP_006188065|]
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SLIT and NTRK-like protein 6 [Camelus ferus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
368-520 3.04e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 368 RKLILAGNIIHTLmKSDLVEYFTLEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSgGMFLGLHSLEYLYLEYN 447
Cdd:COG4886   139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1810995093 448 GVKEiLPGTFNPMPKLKVLYLNNNLLQVLPphIFSGVP-LTRINLKTNQFTHLPVsniLDDLDLLTQIDLEDNP 520
Cdd:COG4886   216 QLTD-LPEPLANLTNLETLDLSNNQLTDLP--ELGNLTnLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-215 3.94e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  71 LSLLNNGLTVLhTNDFSGFTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEDtFHGLENLEFLQADNNFI 150
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1810995093 151 TVIePSAFSKLHRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 215
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRRCT smart00082
Leucine rich repeat C-terminal domain;
519-569 1.73e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.73e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1810995093  519 NPWDCSCDLVGLQQWIQKLSRNTVTDEILCTSPEHLDRKELKALNSELLCP 569
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
220-270 1.00e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 1.00e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1810995093  220 NKWACNCDLLQLKLWLEN--MPPQSVigDIVCNSPPFFKGSILSRLKKESICP 270
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDPV--DLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
368-520 3.04e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 368 RKLILAGNIIHTLmKSDLVEYFTLEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSgGMFLGLHSLEYLYLEYN 447
Cdd:COG4886   139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1810995093 448 GVKEiLPGTFNPMPKLKVLYLNNNLLQVLPphIFSGVP-LTRINLKTNQFTHLPVsniLDDLDLLTQIDLEDNP 520
Cdd:COG4886   216 QLTD-LPEPLANLTNLETLDLSNNQLTDLP--ELGNLTnLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-215 3.94e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  71 LSLLNNGLTVLhTNDFSGFTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEDtFHGLENLEFLQADNNFI 150
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1810995093 151 TVIePSAFSKLHRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 215
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR_8 pfam13855
Leucine rich repeat;
390-447 5.12e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 5.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1810995093 390 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSGGMFLGLHSLEYLYLEYN 447
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 347-520 1.30e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 347 IHCQERNIESLSDLKPPPqNPRKLILAGNIIHTLmkSDLVEYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 426
Cdd:cd21340     7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 427 KLSGgmFLGLHSLEYLYLEYNGVKEILPGTFNPM------PKLKVLYLNNNLLQVLPPhIFSGVPLTRINLKTNQFTHL- 499
Cdd:cd21340    82 VVEG--LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLe 158

                         170       180
                  ....*....|....*....|.
gi 1810995093 500 PVSNILDDLDLLTQIDLEDNP 520
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
94-148 3.13e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1810995093  94 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 148
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRRCT smart00082
Leucine rich repeat C-terminal domain;
519-569 1.73e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.73e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1810995093  519 NPWDCSCDLVGLQQWIQKLSRNTVTDEILCTSPEHLDRKELKALNSELLCP 569
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-221 5.89e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 5.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  70 HLSLLNNGLTVLhtNDFSGFTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNF 149
Cdd:cd21340     6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 150 ITVIEpsAFSKLHRLKVLILNDNAIEslPPNIFRFVP---------LTHLDLRGNQLQTLPYVGFLEHIgRILDlqLEDN 220
Cdd:cd21340    80 ISVVE--GLENLTNLEELHIENQRLP--PGEKLTFDPrslaalsnsLRVLNISGNNIDSLEPLAPLRNL-EQLD--ASNN 152


                  .
gi 1810995093 221 K 221
Cdd:cd21340   153 Q 153
LRRCT smart00082
Leucine rich repeat C-terminal domain;
220-270 1.00e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 1.00e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1810995093  220 NKWACNCDLLQLKLWLEN--MPPQSVigDIVCNSPPFFKGSILSRLKKESICP 270
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDPV--DLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-563 4.15e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 390 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNhltKLSGGM--FLGLH-SLEYLYLEYNGVKEILPGTFNPMPKL-KV 465
Cdd:PLN00113  309 NLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN---KFSGEIpkNLGKHnNLTVLDLSTNNLTGEIPEGLCSSGNLfKL 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 466 LYLNNNLLQVLPPHIFSGVPLTRINLKTN--------QFTHLPVSNILDDLDLLTQIDLEDNPWdcscDLVGLQqwIQKL 537
Cdd:PLN00113  386 ILFSNSLEGEIPKSLGACRSLRRVRLQDNsfsgelpsEFTKLPLVYFLDISNNNLQGRINSRKW----DMPSLQ--MLSL 459

                         170       180
                  ....*....|....*....|....*.
gi 1810995093 538 SRNTVTDEIlctsPEHLDRKELKALN 563
Cdd:PLN00113  460 ARNKFFGGL----PDSFGSKRLENLD 481
LRR smart00370
Leucine-rich repeats, outliers;
460-483 9.37e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.37e-03
                           10        20
                   ....*....|....*....|....
gi 1810995093  460 MPKLKVLYLNNNLLQVLPPHIFSG 483
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
368-520 3.04e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 368 RKLILAGNIIHTLmKSDLVEYFTLEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSgGMFLGLHSLEYLYLEYN 447
Cdd:COG4886   139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1810995093 448 GVKEiLPGTFNPMPKLKVLYLNNNLLQVLPphIFSGVP-LTRINLKTNQFTHLPVsniLDDLDLLTQIDLEDNP 520
Cdd:COG4886   216 QLTD-LPEPLANLTNLETLDLSNNQLTDLP--ELGNLTnLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-215 3.94e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  71 LSLLNNGLTVLhTNDFSGFTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEDtFHGLENLEFLQADNNFI 150
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1810995093 151 TVIePSAFSKLHRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 215
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-221 6.33e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 6.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  70 HLSLLNNGLTVLHTnDFSGFTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 149
Cdd:COG4886   140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1810995093 150 ITVIePSAFSKLHRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 221
Cdd:COG4886   217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
390-447 5.12e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 5.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1810995093 390 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSGGMFLGLHSLEYLYLEYN 447
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 347-520 1.30e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 347 IHCQERNIESLSDLKPPPqNPRKLILAGNIIHTLmkSDLVEYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 426
Cdd:cd21340     7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 427 KLSGgmFLGLHSLEYLYLEYNGVKEILPGTFNPM------PKLKVLYLNNNLLQVLPPhIFSGVPLTRINLKTNQFTHL- 499
Cdd:cd21340    82 VVEG--LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLe 158

                         170       180
                  ....*....|....*....|.
gi 1810995093 500 PVSNILDDLDLLTQIDLEDNP 520
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
413-473 1.26e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.26e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1810995093 413 TRLQKLYLNGNHLTKLSGGMFLGLHSLEYLYLEYNGVKEILPGTFNPMPKLKVLYLNNNLL 473
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-201 2.47e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  46 MLINCEEKGIKKLSQISVPPSRPFHLSLLNNGLTVLHTNDFSGFTNALSIHLGFNNIADIETGAFNGLGLLKQLHinhnS 125
Cdd:COG4886    25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----E 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1810995093 126 LEILKEDTFHGLENLEFLQADNNFITVIePSAFSKLHRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLP 201
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175
LRR_8 pfam13855
Leucine rich repeat;
94-148 3.13e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1810995093  94 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 148
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
139-197 3.96e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 3.96e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 139 NLEFLQADNNFITVIEPSAFSKLHRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQL 197
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
116-174 3.28e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.28e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1810995093 116 LKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLHRLKVLILNDNAI 174
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
396-520 5.80e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 5.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 396 LGNNRIEVLEEGSFMNLTRLQKLYLNGNhltklsgGMFLGLHSLEYLYLEYNGVKEiLPGTFNPMPKLKVLYLNNNLLQV 475
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTD 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1810995093 476 LPPHIFSGVPLTRINLKTNQFTHLPVSniLDDLDLLTQIDLEDNP 520
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQ 193
LRRCT smart00082
Leucine rich repeat C-terminal domain;
519-569 1.73e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.73e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1810995093  519 NPWDCSCDLVGLQQWIQKLSRNTVTDEILCTSPEHLDRKELKALNSELLCP 569
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
438-496 2.33e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.33e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 438 SLEYLYLEYNGVKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVP-LTRINLKTNQF 496
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-221 5.89e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 5.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  70 HLSLLNNGLTVLhtNDFSGFTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNF 149
Cdd:cd21340     6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 150 ITVIEpsAFSKLHRLKVLILNDNAIEslPPNIFRFVP---------LTHLDLRGNQLQTLPYVGFLEHIgRILDlqLEDN 220
Cdd:cd21340    80 ISVVE--GLENLTNLEELHIENQRLP--PGEKLTFDPrslaalsnsLRVLNISGNNIDSLEPLAPLRNL-EQLD--ASNN 152


                  .
gi 1810995093 221 K 221
Cdd:cd21340   153 Q 153
LRR_8 pfam13855
Leucine rich repeat;
368-425 1.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1810995093 368 RKLILAGNIIHTLMKsdlvEYFT----LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 425
Cdd:pfam13855   4 RSLDLSNNRLTSLDD----GAFKglsnLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-221 1.68e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  70 HLSLLNNGLTVLHtNDFSGFTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEdtFHGLENLEFLQADNNF 149
Cdd:COG4886   186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQ 261

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1810995093 150 ITVIEPSAfsKLHRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNK 221
Cdd:COG4886   262 LTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
461-520 1.72e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.72e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1810995093 461 PKLKVLYLNNNLLQVLPPHIFSGVP-LTRINLKTNQFTHLPvSNILDDLDLLTQIDLEDNP 520
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-201 3.21e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093  70 HLSLLNNGLTVLhtNDFSGFTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 143
Cdd:cd21340    50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1810995093 144 QADNNFITVIEPsaFSKLHRLKVLILNDNAIESLP---PNIFRFVPLTHLDLRGNQLQTLP 201
Cdd:cd21340   126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 100-195 4.72e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 43.69  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 100 NNIADIETGAFNGLGLLKQLHINhNSLEILKEDTFHG--LENLEFlqadNNFITVIEPSAFSKLHRLKVLILNDNaIESL 177
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 1810995093 178 PPNIFRFVPLTHLDLRGN 195
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
LRR_8 pfam13855
Leucine rich repeat;
71-126 8.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 8.07e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1810995093  71 LSLLNNGLTVLHTNDFSGFTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSL 126
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
220-270 1.00e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 1.00e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1810995093  220 NKWACNCDLLQLKLWLEN--MPPQSVigDIVCNSPPFFKGSILSRLKKESICP 270
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDPV--DLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
163-221 1.06e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 163 RLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTLPYVGFlEHIGRILDLQLEDNK 221
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-563 4.15e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 390 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNhltKLSGGM--FLGLH-SLEYLYLEYNGVKEILPGTFNPMPKL-KV 465
Cdd:PLN00113  309 NLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN---KFSGEIpkNLGKHnNLTVLDLSTNNLTGEIPEGLCSSGNLfKL 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995093 466 LYLNNNLLQVLPPHIFSGVPLTRINLKTN--------QFTHLPVSNILDDLDLLTQIDLEDNPWdcscDLVGLQqwIQKL 537
Cdd:PLN00113  386 ILFSNSLEGEIPKSLGACRSLRRVRLQDNsfsgelpsEFTKLPLVYFLDISNNNLQGRINSRKW----DMPSLQ--MLSL 459

                         170       180
                  ....*....|....*....|....*.
gi 1810995093 538 SRNTVTDEIlctsPEHLDRKELKALN 563
Cdd:PLN00113  460 ARNKFFGGL----PDSFGSKRLENLD 481
LRR smart00370
Leucine-rich repeats, outliers;
460-483 9.37e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.37e-03
                           10        20
                   ....*....|....*....|....
gi 1810995093  460 MPKLKVLYLNNNLLQVLPPHIFSG 483
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
460-483 9.37e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.37e-03
                           10        20
                   ....*....|....*....|....
gi 1810995093  460 MPKLKVLYLNNNLLQVLPPHIFSG 483
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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