CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 558126884   9 DFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
Cdd:cd14362    1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQKES 42

Uncharacterized protein, contains DUF3084 domain [Function unknown];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558126884 539 QKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLE-EMQQLRSCNRQLQIDIDCLTKEIDLFQA 617
Cdd:COG4372   71 ARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQkERQDLEQQRKQLEAQIAELQSEIAEREE 150

                 .
gi 558126884 618 R 618
Cdd:COG4372  151 E 151

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 558126884   9 DFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
Cdd:cd14362    1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQKES 42

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 558126884   11 QVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
Cdd:pfam02845   3 QMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42

Uncharacterized protein, contains DUF3084 domain [Function unknown];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558126884 539 QKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLE-EMQQLRSCNRQLQIDIDCLTKEIDLFQA 617
Cdd:COG4372   71 ARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQkERQDLEQQRKQLEAQIAELQSEIAEREE 150

                 .
gi 558126884 618 R 618
Cdd:COG4372  151 E 151

Zn-finger in Ran binding protein and others;

                          10        20
                  ....*....|....*....|....*
gi 558126884  666 QWNCTACTFLNHPALIRCEQCEMPR 690
Cdd:pfam00641   4 DWDCSKCLVQNFATSTKCVACQAPK 28

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 558126884   9 DFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
Cdd:cd14362    1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQKES 42

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 558126884   11 QVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
Cdd:pfam02845   3 QMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42

Uncharacterized protein, contains DUF3084 domain [Function unknown];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558126884 539 QKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLE-EMQQLRSCNRQLQIDIDCLTKEIDLFQA 617
Cdd:COG4372   71 ARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQkERQDLEQQRKQLEAQIAELQSEIAEREE 150

                 .
gi 558126884 618 R 618
Cdd:COG4372  151 E 151

Phage shock protein A [Transcription, Signal transduction mechanisms];

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558126884 519 ARK-LSMGSDDAAyTQAL--LVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRS 579
Cdd:COG1842   74 ARLaLEKGREDLA-REALerKAELEAQAEALEAQLAQLEEQVEKLKEALRQLESKLEELKAKKD 136

Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2; ROCK2 is a serine/threonine protein kinase and was the first identified target of activated RhoA. It plays a role in stress fiber and focal adhesion formation, and is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK2 contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a Rho-binding HR1 domain and a pleckstrin homology (PH) domain. ROCK2 is auto-inhibited by HR1 and PH domains interacting with the catalytic domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558126884 533 QALLVHQKARMERlQRELEIQKKKLdkLKSEVNEMENNLtrRRLKRSNSISQIpSLEEMQQLRscnRQL 601
Cdd:cd11638    1 KALLQHKNTEYQR-KAEHEADRKRN--LENEVNSLKDQL--EDLKKKNQNSQI-SNEKNIQLQ---RQL 60

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558126884 515 RISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSnsisqipslEEMQQL 594
Cdd:COG4942  148 RREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELA---------AELAEL 218

                         90       100
                 ....*....|....*....|....*.
gi 558126884 595 RSCNRQLQIDIDCLTKEIDLFQARGP 620
Cdd:COG4942  219 QQEAEELEALIARLEAEAAAAAERTP 244