|
Name |
Accession |
Description |
Interval |
E-value |
| mam_aldehyde_ox |
TIGR02969 |
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ... |
6-1338 |
0e+00 |
|
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.
Pssm-ID: 132014 [Multi-domain] Cd Length: 1330 Bit Score: 2765.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 6 ELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPVTKRIRHYPANACLMPICSVYGAA 85
Cdd:TIGR02969 2 ELLFYVNGRKVVEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 86 VTTVEGIGSTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYRPIIDACKTFC 165
Cdd:TIGR02969 82 VTTVEGIGSTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 166 NTSGCCQSKENGVCCLNQGINGFPELEEGNKTSSKLFSEEEFLPLDPTQELIFPPELMIMAEKQPPRTRVFAGERMTWIS 245
Cdd:TIGR02969 162 KTSGCCQSKENGVCCLDQGINGLPEFEEGDETSPELFSEEEFLPLDPTQELIFPPELMRMAEKQPQRTRVFYSERMMWIS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 246 PVTLKELLEAKAKYPQAPVIMGNTSTGPEVKFKGVFHPVIISPDRIEELNVVNSANNGLTLGAGLSLAQVKDTLAAVVLK 325
Cdd:TIGR02969 242 PVTLKELLEAKFKYPQAPVVMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHTGDGLTLGAGLSLAQVKDILADVVQK 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 326 LPEERTQTYRALLKQLGTLAGAQIRNMASLGGHIVSRHVDSDLNPLLAVGGCTLNLLSKEGARQIPVNEQFLRKCPSADL 405
Cdd:TIGR02969 322 LPEETTQTYRALLKHLGTLAGSQIRNMASLGGHIISRHLDSDLNPLLAVGNCTLNLLSKEGKRQIPLSEQFLSKCPDADL 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 406 KPEEILISVNIPYSRKWEFVSAFRQAQRPQNALAIVNSGMRVFFGEGDGIIREFSISYGGVGPTTICAQNSCQKLIGRPW 485
Cdd:TIGR02969 402 KPQEILVSVNIPYSRKWEFVSAFRQAQRQQNALAIVNSGMRVFFGEGDGIIRELSISYGGVGPTTICAKNSCQKLIGRPW 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 486 NEEMLDAACRLVLDEVSLPGSAPGGKVEFKRTLIISFLFKFYLEVSQLLRRMDPVHYPSLADKHESALEDFHPRHRQSAL 565
Cdd:TIGR02969 482 NEEMLDTACRLILDEVSLAGSAPGGKVEFKRTLIISFLFKFYLEVSQILKRMDPGHYPSLADKYESALEDLHSKHHWSTL 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 566 KYQKVDPKQPPQDPVGHPIMHLSGIKHATGEAIYCDDMPAMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEE 645
Cdd:TIGR02969 562 KHQNVDSMQLPQDPIGHPIMHLSGVKHATGEAIYCDDMPAVDQELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITAE 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 646 HLQGVNSFcflgQPEKLLESEMVFCVGQLVCAVIADSEIQARRAAKRVKIVYQDLEPVILTIEEAIQHKSFFEPERKLEY 725
Cdd:TIGR02969 642 HLQDANTF----GTEKLLATDKVHCVGQLVCAVIADSEVQAKQAAKHVKIVYRDLEPLILTIEEAIQHKSFFEPERKLEY 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 726 GNVDEAFKVVDHIVEGEIHLGGQEHFYMETQSMLAVPKGEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGG 805
Cdd:TIGR02969 718 GNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVAATLKLPVNKVMCHVRRVGG 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 806 AFGGKAFKTGVMAAITAFAANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLL 885
Cdd:TIGR02969 798 AFGGKVGKTSIMAAITAFAANKHGRAVRCTLERGEDMLITGGRHPYLGKYKAGFMNDGRIVALDVEHYSNGGSSLDESLW 877
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 886 VLEIGLLKLDNAYKFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMYKEIDQTHYK 965
Cdd:TIGR02969 878 VIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAGLITEACITEVAAKCGLSPEKVRTINMYKEIDQTPYK 957
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 966 QEINAKNLIQCWRECMAMSSYSLRKAAVEKFNSENSWKKKGLAMVPVKFPIGLGSRAAGQAAALVHIYLDGSVLVTHGGI 1045
Cdd:TIGR02969 958 QEINAKNLFQCWRECMAKSSYSERKVAVEKFNAENYWKKRGLAVIPLKFPVGLGSVAMGQAAALVHIYLDGSVLVTHGGI 1037
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1046 EMGQGVHTKMIQVASRELRMPLSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPIISKNPRGTWKDW 1125
Cdd:TIGR02969 1038 EMGQGVHTKMIQVVSRELKMPMSNVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDW 1117
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1126 AQAAFDESISLSATGYFRGYESNMNWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGCSINPALDIGQIE 1205
Cdd:TIGR02969 1118 AQTAFDQSISLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVE 1197
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1206 GAFIQGMGLYTIEELNYSPQGVLYTRGPDQYKIPTICDIPTEFHVSFLPPSQDSNTLYSSKGLGESGVFLGCSVFFAIHD 1285
Cdd:TIGR02969 1198 GAFIQGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTELHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHD 1277
|
1290 1300 1310 1320 1330
....*....|....*....|....*....|....*....|....*....|...
gi 554558462 1286 AVSAARQERGLRGPLKLNSPLTPEKIRMACEDKFTKMIPRDKPGSYVPWNIPI 1338
Cdd:TIGR02969 1278 AVRAARQERGLSGPWKLTSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWNVPV 1330
|
|
| PLN02906 |
PLN02906 |
xanthine dehydrogenase |
54-1321 |
0e+00 |
|
xanthine dehydrogenase
Pssm-ID: 215491 [Multi-domain] Cd Length: 1319 Bit Score: 1372.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 54 VMISRYNPVTKRIRHYPANACLMPICSVYGAAVTTVEGIGSTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHP 133
Cdd:PLN02906 30 VMVSHYDRKTGKCVHYAVNACLAPLYSVEGMHVITVEGIGNRRDGLHPVQEALASMHGSQCGFCTPGFIMSMYALLRSSK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 134 D-PTLDQLTDALGGNLCRCTGYRPIIDACKTFC--------NTSGCCQSKENGVC------CLNQGINGFPELEEGNKTS 198
Cdd:PLN02906 110 TpPTEEQIEECLAGNLCRCTGYRPILDAFRVFAktddalytGVSSLSLQDGEPICpstgkpCSCGSKTTSAAGTCKSDRF 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 199 SKLFSEEEFLPLDPTQELIFPPELMiMAEKQPPRTRVFAGerMTWISPVTLKELLEAKAKYPQAPVIMGNTSTGPEVKFK 278
Cdd:PLN02906 190 QPISYSEIDGSWYTEKELIFPPELL-LRKLTPLKLLGNGG--LTWYRPTSLQHLLELKAEYPDAKLVVGNTEVGIEMRFK 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 279 GVFHPVIISPDRIEELNVVNSANNGLTLGAGLSLAQVKDTLAAVVLKLPEERTQTYRALLKQLGTLAGAQIRNMASLGGH 358
Cdd:PLN02906 267 NAQYPVLISPTHVPELNAIKVKDDGLEIGAAVRLSELQNLFRKVVKERPAHETSACKAFIEQLKWFAGTQIRNVASIGGN 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 359 IVSRHVDSDLNPLLAVGGCTLNLLSKEG-ARQIPVNEQFL--RKcpsADLKPEEILISVNIPYSRKWEFVSAFRQAQRPQ 435
Cdd:PLN02906 347 ICTASPISDLNPLWMAAGATFVIISCDGdIRSVPASDFFLgyRK---VDLKPDEILLSVFLPWTRPFEYVKEFKQAHRRD 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 436 NALAIVNSGMRVFFGEGDG--IIREFSISYGGVGPTTICAQNSCQKLIGRPWNEEMLDAACRLVLDEVSLPGSAPGGKVE 513
Cdd:PLN02906 424 DDIAIVNAGMRVKLEEKDGewIVSDASIAYGGVAPLSVSARKTEEFLIGKPWNKETLQDALKVLQKDILIKEDAPGGMVE 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 514 FKRTLIISFLFKFYLEVSQLLrrmdpvhypslaDKHESALEDFHPRHRQSALKYQ------KVDPKQPPQ-DPVGHPIMH 586
Cdd:PLN02906 504 FRKSLALSFFFKFFLWVSHQL------------EADGSTIETFPESHLSAAQPFPrpssvgMQDYETVKQgTAVGQPEVH 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 587 LSGIKHATGEAIYCDDMPAMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGVNSFCFLGQPEKLLESE 666
Cdd:PLN02906 572 LSAELQVTGEAEYADDIPMPPNTLHAALVLSTKPHARILSIDDSEAKSSPGFAGIFLAKDVPGDNMIGPVVHDEELFATD 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 667 MVFCVGQLVCAVIADSEIQARRAAKRVKIVYQDLePVILTIEEAIQHKSFFE-PERKLEYGNVDEAFKV--VDHIVEGEI 743
Cdd:PLN02906 652 VVTCVGQVIGVVVADTQENAKAAARKVKVEYEEL-PAILSIEEAIEAGSFHPnTERRLEKGDVELCFASgqCDRIIEGEV 730
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 744 HLGGQEHFYMETQSMLAVPKGEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGGAFGGKAFKTGVMAAITAF 823
Cdd:PLN02906 731 QMGGQEHFYLEPNSSLVWTSDSGNEVHMISSTQAPQKHQKYVAHVLGLPMSKVVCKTKRIGGGFGGKETRSAFIAAAAAV 810
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 824 AANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLLVLEIGLLKLDNAYKFPNL 903
Cdd:PLN02906 811 PAYLLNRPVKLTLDRDVDMMITGQRHAFLGKYKVGFTNEGKILALDLEIYNNGGNSLDLSGAVLERAMFHSDNVYEIPNV 890
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 904 RCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMYKEIDQTHYKQEINAKNLIQCWRECMAM 983
Cdd:PLN02906 891 RIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAVELNKSPEEIREMNFQGEGSVTHYGQVLQHCTLPQLWDELKVS 970
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 984 SSYSLRKAAVEKFNSENSWKKKGLAMVPVKFPIGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVASREL 1063
Cdd:PLN02906 971 CDFLKRREEVDEFNAKNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTHGGVEMGQGLHTKVAQVAASAF 1050
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1064 RMPLSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPIISKNPRGTWKDWAQAAFDESISLSATGYFR 1143
Cdd:PLN02906 1051 NIPLSSVFISETSTDKVPNASPTAASASSDMYGAAVLDACEQIKARMEPVASKLNFSSFAELVTACYFQRIDLSAHGFYI 1130
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1144 GYESNMNWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGCSINPALDIGQIEGAFIQGMGLYTIEELNYS 1223
Cdd:PLN02906 1131 TPDIGFDWKTGKGNPFNYFTYGAAFAEVEIDTLTGDFHTRRVDIVMDLGYSINPAIDIGQIEGAFVQGLGWVALEELKWG 1210
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1224 -------PQGVLYTRGPDQYKIPTICDIPTEFHVSFLPPSQDSNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGL 1296
Cdd:PLN02906 1211 daahkwiRPGSLFTCGPGTYKIPSVNDIPFKFNVSLLKGAPNPKAIHSSKAVGEPPFFLAASVFFAIKDAIKAARAEVGL 1290
|
1290 1300
....*....|....*....|....*
gi 554558462 1297 RGPLKLNSPLTPEKIRMACEDKFTK 1321
Cdd:PLN02906 1291 HGWFPLDTPATPERIRMACGDEITA 1315
|
|
| XdhB |
COG4631 |
Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and ... |
569-1316 |
0e+00 |
|
Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and metabolism];
Pssm-ID: 443669 [Multi-domain] Cd Length: 769 Bit Score: 874.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 569 KVDPKQPPQDPVGHPIMHLSGIKHATGEAIYCDDMPAMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQ 648
Cdd:COG4631 3 KALSPPPAAGAVGKSLPHESARLHVTGEARYIDDLPEPAGTLHAAPGLSPVAHARILSIDLSAVRAAPGVVAVLTAADIP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 649 GVNSFCFLGQPEKLLESEMVFCVGQLVCAVIADSEIQARRAAKRVKIVYQDLEPvILTIEEAIQHKSFFEPERKLEYGNV 728
Cdd:COG4631 83 GENDIGPIIHDEPLLADGEVEYVGQPVFAVVAESREAARRAARLAKIEYEELPA-ILTIEEALAAGSFVLPPHTLRRGDA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 729 DEAFKVVDHIVEGEIHLGGQEHFYMETQSMLAVPkGEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGGAFG 808
Cdd:COG4631 162 DAALAAAPHRLEGEFEIGGQEHFYLEGQIALAIP-GEDGGMLVHSSTQHPSEVQHLVAHVLGVPMHAVTVEVRRMGGGFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 809 GKAFKTGVMAAITAFAANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLLVLE 888
Cdd:COG4631 241 GKESQAALFAALAALAARKTGRPVKLRLDRDDDMVMTGKRHPFRIDYEVGFDDDGRILGLDITLAARCGWSADLSGPVAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 889 IGLLKLDNAYKFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMYKEI--DQTHYKQ 966
Cdd:COG4631 321 RAMFHADNAYYLPAVRITGHRCKTNTQSNTAFRGFGGPQGMLAIERVIDDIARALGLDPLDVRRRNFYGPAerNTTPYGQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 967 EInAKNLIQ-CWRECMAMSSYSLRKAAVEKFNSENSWKKKGLAMVPVKFPIGLGSRAAGQAAALVHIYLDGSVLVTHGGI 1045
Cdd:COG4631 401 PV-EDNILHeLVDELEESSDYAARRAAIAAFNAASPVLKRGLALTPVKFGISFTATHLNQAGALVHVYTDGSVQLNHGGT 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1046 EMGQGVHTKMIQVASRELRMPLSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEP------------- 1112
Cdd:COG4631 480 EMGQGLHTKVAQVVADELGVPLERVRITATDTDKVPNTSATAASSGSDLNGMAAQDACRQIRERLAAfaaellgvepedv 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1113 ------IISKNPRGTWKDWAQAAFDESISLSATGYFRGYESNMNWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTD 1186
Cdd:COG4631 560 rfadgrVRVGGQSLSFAELVKAAYLARVSLSATGFYKTPKIHWDRATGQGRPFYYFAYGAAVSEVEIDTLTGEYRVLRVD 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1187 IVMDVGCSINPALDIGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPDQYKIPTICDIPTEFHVSFLPPSQDSNTLYSSK 1266
Cdd:COG4631 640 ILHDVGRSLNPAIDIGQIEGGFVQGMGWLTTEELVWDDKGRLLTHAPSTYKIPAASDRPEDFNVALLERPNREDTIYRSK 719
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 554558462 1267 GLGESGVFLGCSVFFAIHDAVSAARQErglRGPLKLNSPLTPEKIRMACE 1316
Cdd:COG4631 720 AVGEPPLMLGISVFEALRDAVAAVGDY---RVSPPLDAPATPERVLMAVE 766
|
|
| xanthine_xdhB |
TIGR02965 |
xanthine dehydrogenase, molybdopterin binding subunit; Members of the protein family are the ... |
580-1317 |
0e+00 |
|
xanthine dehydrogenase, molybdopterin binding subunit; Members of the protein family are the molybdopterin-containing large subunit (or, in, eukaryotes, the molybdopterin-binding domain) of xanthine dehydrogenase, and enzyme that reduces the purine pool by catabolizing xanthine to urate. This model is based primarily on bacterial sequences; it does not manage to include all eukaryotic xanthine dehydrogenases and thereby discriminate them from the closely related enzyme aldehyde dehydrogenase. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274367 [Multi-domain] Cd Length: 758 Bit Score: 708.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 580 VGHPIMHLSGIKHATGEAIYCDDMPAMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGVNSFCFLGQP 659
Cdd:TIGR02965 1 VGTSLKHESAHKHVAGTAVYIDDIPEPAGTLHAALGLSTRAHARITSMDLSAVRAAPGVVDVLTAADIPGENDISPIIHD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 660 EKLLESEMVFCVGQLVCAVIADSEIQARRAAKRVKIVYQDLEPvILTIEEAIQHKSFFE-PERKLEYGNVDEAFKVVDHI 738
Cdd:TIGR02965 81 DPLLADGKVEFVGQPIFAVVATSRDAARRAARLAKIEYEELPA-VLDIEEALAAGSRLVtPPLTLERGDAAAALAAAPHR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 739 VEGEIHLGGQEHFYMETQSMLAVPkGEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGGAFGGKAFKTGVMA 818
Cdd:TIGR02965 160 LSGTMRIGGQEHFYLEGQIALAVP-GEDGGMHVWSSTQHPSEVQHLVAHVLGVPSHAVTVEVRRMGGGFGGKETQANLFA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 819 AITAFAANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLLVLEIGLLKLDNAY 898
Cdd:TIGR02965 239 CLAAVAARKTGRPVKLRPDRDDDMMITGKRHDFRVDYDVGFDDEGRILGVDIDMAARCGFSADLSGPVTDRALFHADNAY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 899 KFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMY--KEIDQTHYKQEINAKNLIQC 976
Cdd:TIGR02965 319 FLPDVTITSHPLKTNTQSNTAFRGFGGPQGMVAIERIMDEVARALGKDPLEVRKRNFYgkDERNVTPYHQTVEDNIIHEI 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 977 WRECMAMSSYSLRKAAVEKFNSENSWKKKGLAMVPVKFPIGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMI 1056
Cdd:TIGR02965 399 IEELEASSDYAARRAAIRAFNATSPVLKKGIALTPVKFGISFTVTHLNQAGALVHVYTDGSIHLNHGGTEMGQGLNTKVA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1057 QVASRELRMPLSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRL-----------------EP--IISKN 1117
Cdd:TIGR02965 479 QVVAEEFQVDIDRVKITATDTGKVPNTSATAASSGSDLNGMAAQDAARQIKERLvefaaekwqvpeedvrfAPnhVRVGE 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1118 PRGTWKDWAQAAFDESISLSATGYFRGYESNMNWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGCSINP 1197
Cdd:TIGR02965 559 QRVPFAELVQQAYFARVQLSSTGFYKTPKIHWDRAKGRGRPFYYFAYGAACSEVSVDTLTGEYKVLRADILHDVGRSLNP 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1198 ALDIGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPDQYKIPTICDIPTEFHVSFLPPSQD-SNTLYSSKGLGESGVFLG 1276
Cdd:TIGR02965 639 AIDIGQIEGGFVQGMGWLTTEELVWDEKGRLRTHAPSTYKIPAASDRPKDFNVRLFEWGENrEDTIHRSKAVGEPPLMLG 718
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 554558462 1277 CSVFFAIHDAVSAArqeRGLRGPLKLNSPLTPEKIRMACED 1317
Cdd:TIGR02965 719 ISVLFAISDAVASV---ADYRVCPRLDAPATPERVLMAVEA 756
|
|
| PLN00192 |
PLN00192 |
aldehyde oxidase |
4-1293 |
0e+00 |
|
aldehyde oxidase
Pssm-ID: 215096 [Multi-domain] Cd Length: 1344 Bit Score: 702.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 4 TAELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPVTKRIRHYPANACLMPICSVYG 83
Cdd:PLN00192 3 NMSLVFAVNGERFELSSVDPSTTLLEFLRTQTPFKSVKLGCGEGGCGACVVLLSKYDPVLDQVEDFTVSSCLTLLCSVNG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 84 AAVTTVEGIGSTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLL-------RNHPDPTLDQLT-----DALGGNLCRC 151
Cdd:PLN00192 83 CSITTSEGLGNSKDGFHPIHKRFAGFHASQCGFCTPGMCISLFSALvnadktdRPEPPSGFSKLTvveaeKAVSGNLCRC 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 152 TGYRPIIDACKTFCNTsgccqskengVCCLNQGINGFPELEEGN-KTSSKLfseeefLPLDPTQELIFPPELMimaEKQP 230
Cdd:PLN00192 163 TGYRPIVDACKSFAAD----------VDIEDLGLNSFWKKGESEeAKLSKL------PPYNHSDHICTFPEFL---KKEI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 231 PRTRVFAGERMTWISPVTLKE---LLEA-KAKYPQAPVIMGNTSTGpevKFKGV-FHPVIISPDRIEELNVVNSANNGLT 305
Cdd:PLN00192 224 KSSLLLDSSRYRWYTPVSVEElqsLLESnNFDGVSVKLVVGNTGTG---YYKDEeLYDKYIDIRHIPELSMIRRDEKGIE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 306 LGAGLSLAQVKDTLAavvlklpEERTQTY--RALLKQLGTLAGAQIRNMASLGGHIV---SRHVDSDLNPLLAVGGCTLN 380
Cdd:PLN00192 301 IGAVVTISKAIEALR-------EESKSEYvfKKIADHMEKIASRFVRNTGSIGGNLVmaqRKQFPSDIATILLAAGSTVN 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 381 LLSKEGARQIPVnEQFLRKCPsadLKPEEILISVNIPysrKWEFVSA---------FRQAQRPQ-NALAIVNSGM--RVF 448
Cdd:PLN00192 374 IQNASKREKLTL-EEFLERPP---LDSKSLLLSVEIP---SWTSSSGsdtkllfetYRAAPRPLgNALPYLNAAFlaEVS 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 449 FGE--GDGIIREFSISYGGVGPT-TICAQNSCQKLIGRPWNEEMLDAACRLVLDEVSlPG---SAPggkvEFKRTLIISF 522
Cdd:PLN00192 447 QDAssGGIVVNDCRLAFGAYGTKhAIRARKVEEFLTGKVLSDSVLYEAVRLLKGIVV-PEdgtSHP----EYRSSLAVGF 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 523 LFKFYLEVSQLLrrmdpvhypslaDKHESALEDFHPRHRQSALKYQKVDPKQPPQ------------DPVGHPIMHLSGI 590
Cdd:PLN00192 522 LFDFLSPLIESN------------AKSSNGWLDGGSNTKQNPDQHDDVKKPTLLLsskqqveenneyHPVGEPIKKVGAA 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 591 KHATGEAIYCDDMPAMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHL----QGVNSFCFLGqPEKLLESE 666
Cdd:PLN00192 590 LQASGEAVYVDDIPSPKNCLYGAFIYSTKPLARVKGIKFKSNLVPQGVLAVITFKDIpkggQNIGSKTIFG-PEPLFADE 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 667 MVFCVGQLVCAVIADSEIQARRAAKRVKIVY--QDLEPVILTIEEAIQHKSFFE------PErklEYGNVDEAFKVVDH- 737
Cdd:PLN00192 669 VTRCAGQRIALVVADTQKHADMAANLAVVEYdtENLEPPILTVEDAVKRSSLFEvppflyPK---PVGDISKGMAEADHk 745
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 738 IVEGEIHLGGQEHFYMETQSMLAVPKgEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGGAFGGKAFKTGVM 817
Cdd:PLN00192 746 ILSAEIKLGSQYYFYMETQTALALPD-EDNCIVVYSSTQCPEYVHSVIARCLGIPEHNVRVITRRVGGGFGGKAVKSMPV 824
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 818 AAITAFAANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLLVLE--IGLLKld 895
Cdd:PLN00192 825 ATACALAAFKLQRPVRMYLNRKTDMIMAGGRHPMKITYSVGFKSDGKITALHLDILINAGISPDISPIMPRniIGALK-- 902
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 896 nAYKFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMYK-EIDQTHYKQ---EINAK 971
Cdd:PLN00192 903 -KYDWGALSFDIKVCKTNLSSRSAMRAPGEVQGSYIAEAIIEHVASTLSMDVDSVRKINLHTyESLKLFYGDsagEPSEY 981
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 972 NLIQCWRECMAMSSYSLRKAAVEKFNSENSWKKKGLAMVPVKFPIGLGSraagqAAALVHIYLDGSVLVTHGGIEMGQGV 1051
Cdd:PLN00192 982 TLPSIWDKLASSSEFKQRTEMVKEFNRSNKWKKRGISRVPIVHEVMLRP-----TPGKVSILSDGSIAVEVGGIEIGQGL 1056
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1052 HTKMIQVASRELRMP--------LSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPI----ISKNPR 1119
Cdd:PLN00192 1057 WTKVKQMAAFGLGMIkcdggedlLDKIRVIQSDTLSMIQGGFTAGSTTSESSCEAVRLCCVILVERLKPIkerlQEQMGS 1136
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1120 GTWKDWAQAAFDESISLSATGYFrgyesnmnweTGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGCSINPAL 1199
Cdd:PLN00192 1137 VTWDMLISQAYMQSVNLSASSYY----------TPDPSSMEYLNYGAAVSEVEVDLLTGETTILRSDIIYDCGQSLNPAV 1206
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1200 DIGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPDQYKIPTICDIPTEFHVSFLPPSQDSNTLYSSKGLGESGVFLGCSV 1279
Cdd:PLN00192 1207 DLGQIEGAFVQGIGFFMLEEYTTNSDGLVVTDGTWTYKIPTVDTIPKQFNVEILNSGHHKKRVLSSKASGEPPLLLAASV 1286
|
1370
....*....|....
gi 554558462 1280 FFAIHDAVSAARQE 1293
Cdd:PLN00192 1287 HCATRAAIREARKQ 1300
|
|
| CoxL |
COG1529 |
Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]; ... |
580-1314 |
2.24e-162 |
|
Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]; Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 441138 [Multi-domain] Cd Length: 741 Bit Score: 504.38 E-value: 2.24e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 580 VGHPIMHLSGIKHATGEAIYCDDMPaMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGVN-SFCFLGQ 658
Cdd:COG1529 10 IGKPVPRVDGPAKVTGRARYTDDIR-LPGMLYAAVVRSPHAHARIKSIDTSAALALPGVVAVLTGEDLPGLKfGLPGPDP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 659 PEKLLESEMVFCVGQLVCAVIADSEIQARRAAKRVKIVYQDLEPViLTIEEAI---------QHKSFFEPERKLEYGNVD 729
Cdd:COG1529 89 DQPPLADDKVRYVGEPVAAVVAETREAARDAAELIKVEYEPLPAV-VDPEAALapgaplvheELPGNVAAEWRGERGDVD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 730 EAFKVVDHIVEGEIHLGGQEHFYMETQSMLAVPKGEDqEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGGAFGG 809
Cdd:COG1529 168 AAFAEADVVVEATYTTPRLAHAPMEPRAAVAEWDGDG-RLTVWASTQGPHLVRRALARALGLPPEKVRVIAPDVGGGFGG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 810 KAFkTGVMAAITAFAANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLLVLEI 889
Cdd:COG1529 247 KLD-VYPEEVLAALAARKLGRPVKLVLTREEDFLADTHRHATVQRVRLGADKDGKITALRHDVVADTGAYASFGEAVLPL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 890 GLLKLDNAYKFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMYKEIDQTHYKQEIN 969
Cdd:COG1529 326 GATMATGPYAIPNVRVEARAVYTNTPPTGAYRGPGRPQAAFALESAMDELAEELGMDPVELRLRNLIRPGDFPPTGQPYD 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 970 AKNLIQCWRECMAMSSYSLRKAAVEKfnSENSWKK-KGLAMvpVKFPIGLGSraaGQAAALVHIYLDGSVLVTHGGIEMG 1048
Cdd:COG1529 406 SGRLAECLEKAAEAFGWGERRARPAE--ARAGKLRgIGVAA--YIEGSGGGG---DPESARVRLNPDGSVTVYTGATDIG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1049 QGVHTKMIQVASRELRMPLSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPI--------------- 1113
Cdd:COG1529 479 QGHETVLAQIAAEELGVPPEDVRVVLGDTDLTPYGGGTGGSRSTAVGGSAVRKAAEKLREKLLELaahllgadpedlefe 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1114 ----ISKNPRGTWKDWAQAAFDEsiSLSATGYFRGYESNMnwetgeghpfeyFVYGAACSEVEIDCLTGAHKNIRTDIVM 1189
Cdd:COG1529 559 dgrvRVPGRSVSLAELAAAAYYG--GLEATGTYDPPTYPT------------YSFGAHVAEVEVDPETGEVRVLRVVAVH 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1190 DVGCSINPALDIGQIEGAFIQGMG--LYtiEELNYSPQGVLYTRGPDQYKIPTICDIPtEFHVSFLpPSQDSNTLYSSKG 1267
Cdd:COG1529 625 DCGRVINPLLVEGQVEGGVVQGIGqaLY--EELVYDEDGQLLNANFADYLVPRAADVP-EIEVIFV-ETPDPTNPLGAKG 700
|
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 554558462 1268 LGESGVflgCSVFFAIHDAVSAArqeRGLRgPLKLnsPLTPEKIRMA 1314
Cdd:COG1529 701 VGEPGT---IGVAPAIANAVYDA---TGVR-IRDL--PITPEKVLAA 738
|
|
| xanthine_xdhA |
TIGR02963 |
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ... |
9-530 |
1.93e-118 |
|
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274365 [Multi-domain] Cd Length: 467 Bit Score: 377.77 E-value: 1.93e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 9 FYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPVTKrIRHYPANACLMPICSVYGAAVTT 88
Cdd:TIGR02963 3 FFLNGETVTLSDVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVGELVDGGK-LRYRSVNACIQFLPSLDGKAVVT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 89 VEGIGSTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYRPIIDACKTFCNtS 168
Cdd:TIGR02963 82 VEDLRQPDGRLHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYRPILDAAEAAFD-Y 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 169 GCCQskengvcclnqgingfpeleegnktssklfseeeflPLDPTQELIFpPELMIMAEKQPPRTrVFAGERMtwISPVT 248
Cdd:TIGR02963 161 PCSD------------------------------------PLDADRAPII-ERLRALRAGETVEL-NFGGERF--IAPTT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 249 LKELLEAKAKYPQAPVIMGNTSTGPEVKFKGVFHPVIISPDRIEELNVVNSANNGLTLGAGLSLAQVKDTLAAVVLKLPE 328
Cdd:TIGR02963 201 LDDLAALKAAHPDARIVAGSTDVGLWVTKQMRDLPDVIYVGQVAELKRIEETDDGIEIGAAVTLTDAYAALAKRYPELGE 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 329 ertqtyrallkQLGTLAGAQIRNMASLGGHIVSRHVDSDLNPLLAVGGCTLNLLSKEGARQIPVNEQFL--RKcpsADLK 406
Cdd:TIGR02963 281 -----------LLRRFASLQIRNAGTLGGNIANGSPIGDSPPALIALGARLTLRKGEGRRTLPLEDFFIdyGK---TDRQ 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 407 PEEILISVNIPYSRKWEFVSAFRQAQRPQNALAIVNSGMRVFFgeGDGIIREFSISYGGVGPTTICAQNSCQKLIGRPWN 486
Cdd:TIGR02963 347 PGEFVEALHVPRPTPGERFRAYKISKRFDDDISAVCAAFNLEL--DGGVVAEIRIAFGGMAATPKRAAATEAALLGKPWN 424
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 554558462 487 EEMLDAACRLVLDEVS-LPGSAPGGkvEFKRTLIISFLFKFYLEV 530
Cdd:TIGR02963 425 EATVEAAMAALAGDFTpLSDMRASA--EYRLLTAKNLLRRFFLET 467
|
|
| MoCoBD_2 |
pfam20256 |
Molybdopterin cofactor-binding domain; |
979-1245 |
1.13e-113 |
|
Molybdopterin cofactor-binding domain;
Pssm-ID: 466407 [Multi-domain] Cd Length: 282 Bit Score: 357.62 E-value: 1.13e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 979 ECMAMSSYSLRKAAVEKFNSENswKKKGLAMVPVKFPIGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQV 1058
Cdd:pfam20256 1 KALELSDYDERRAEQAEFNRGN--RKRGIGIAPYVEGSGLGPGALNQAGALVRLNPDGSVTVYTGGTEMGQGLETKLAQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1059 ASRELRMPLSNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPIISK--------------------NP 1118
Cdd:pfam20256 79 AAEALGIPPEDVRVVEGDTDTVPNGGGTGASRSTDVGGNAVLLAAEKLRERLLKIAAHlleaspedlefedgkvyvkgDP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1119 RG-TWKDWAQAAFDESISLSATGYFRGYesnmNWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGCSINP 1197
Cdd:pfam20256 159 RSvTFAELAAAAYGEGVGLSATGFYTPP----DDETGQGPPFAYYPYGAHAAEVEVDPETGEVRVLRYVAVHDCGRVINP 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 554558462 1198 ALDIGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPDQYKIPTICDIP 1245
Cdd:pfam20256 235 AIVEGQIEGGFVQGIGLALMEELVYDEDGQLLTASLMDYKIPTAADIP 282
|
|
| MoCoBD_1 |
pfam02738 |
Molybdopterin cofactor-binding domain; |
724-955 |
3.86e-109 |
|
Molybdopterin cofactor-binding domain;
Pssm-ID: 460671 [Multi-domain] Cd Length: 244 Bit Score: 343.67 E-value: 3.86e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 724 EYGNVDEAFKVVDHIVEGEIHLGGQEHFYMETQSMLAVPKGEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRV 803
Cdd:pfam02738 14 EKGDVEAAFAEADHVVEGEYRTGRQEHFYMETRAALAVPDDEDGRLTVYSSTQGPHLVRRLVARVLGIPENKVRVIVPRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 804 GGAFGGKAFkTGVMAAITAFAANKHGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDES 883
Cdd:pfam02738 94 GGGFGGKTQ-SYPEEALAALAARKTGRPVKWVLDREEDMLATGHRHPFLIKYKVGADKDGKILALDVDLYADGGAYADLS 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 554558462 884 LLVLEIGLLKLDNAYKFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINM 955
Cdd:pfam02738 173 PAVPERALSHLDGPYKIPNVRVDGRAVYTNTPPNGAFRGFGRPQGMFALERLMDELAEELGMDPLELRRRNL 244
|
|
| XdhA |
COG4630 |
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and ... |
9-529 |
5.77e-82 |
|
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and metabolism];
Pssm-ID: 443668 [Multi-domain] Cd Length: 476 Bit Score: 277.40 E-value: 5.77e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 9 FYVNGRKVIEKNVDPETMLLPYLRKKLRLtgtkygcggggcgactVMISRynPVTKRIRHYPANACLMPICSVYGAAVTT 88
Cdd:COG4630 3 FLLNGELVELSDVPPTTTLLDWLREDRGLtgtkegcaegdcgactVVVGE--LDDGGLRYRAVNACILFLPQLDGKALVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 89 VEGIGSTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYRPIIDACKtfcnts 168
Cdd:COG4630 81 VEGLAGPDGALHPVQQAMVDHHGSQCGFCTPGFVMSLFALYERGPAPDRADIEDALSGNLCRCTGYRPIIDAAR------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 169 gccqskengvcclnqgingfpeleegnktssKLFSEEEFLPLDPTQELIFPPelmiMAEKQPPRTRVFAGERMTWISPVT 248
Cdd:COG4630 155 -------------------------------AMAEAPAPDPFAADRAAVAAA----LRALADGETVELGAGGSRFLAPAT 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 249 LKELLEAKAKYPQAPVIMGNTSTGPEVKFKGVFHPVIISPDRIEELNVVNSANNGLTLGAGLSLAQVKDTLAAVvlkLPE 328
Cdd:COG4630 200 LDELAALLAAHPDARLVAGATDVGLWVTKQLRDLPPVIFLGRVAELRRIEETDDGLEIGAAVTLSDAEAALAAH---FPE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 329 ertqtYRALLKQlgtLAGAQIRNMASLGGHIVSrhvDS---DLNPLLAVGGCTLNLLSKEGARQIPVNEQFL--RKcpsA 403
Cdd:COG4630 277 -----LAELLRR---FASRQIRNAGTLGGNIAN---GSpigDSPPALIALGAELVLRSGDGRRTLPLEDFFLgyRK---T 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 404 DLKPEEILISVNIPYSRKWEFVSAFRQAQRPQNALAIVNSGMRVFFgeGDGIIREFSISYGGVGPTTICAQNSCQKLIGR 483
Cdd:COG4630 343 DLQPGEFVEAIRIPLPAAGQRLRAYKVSKRFDDDISAVCAAFALTL--DDGTVTEARIAFGGMAATPKRARAAEAALLGQ 420
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 554558462 484 PWNEEMLDAACRLVLDEVSlP-----GSApggkvEFKRTLIISFLFKFYLE 529
Cdd:COG4630 421 PWTEATVAAAAAALAQDFT-PlsdmrASA-----EYRLAVAANLLRRFFLE 465
|
|
| PRK09970 |
PRK09970 |
xanthine dehydrogenase subunit XdhA; Provisional |
580-1290 |
2.52e-79 |
|
xanthine dehydrogenase subunit XdhA; Provisional
Pssm-ID: 236637 [Multi-domain] Cd Length: 759 Bit Score: 278.50 E-value: 2.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 580 VGHPIMHLSGIKHATGEAIYCDDMPaMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGvNSFCFLGQP 659
Cdd:PRK09970 3 IGKSIMRVDAIAKVTGRAKYTDDYV-MAGMLYAKYVRSPIAHGKVKSIDTEEARSLPGVEAVFTWEDVPD-IPFPTAGHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 660 -----------EKLLESEMVFCVGQLVCAVIADSEIQARRAAKRVKIVYQDLePVILTIEEAIQH-KSFFEPER------ 721
Cdd:PRK09970 81 wsldpnhrdiaDRALLTRHVRHHGDAVAAVVARDELTAEKALKLIKVEYEEL-PVITDPEAALAEgAPPIHNGRgnllkq 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 722 -KLEYGNVDEAFKVVDHIVEGEIHLGGQEHFYMETQSMLAVpKGEDQEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHV 800
Cdd:PRK09970 160 sTMSTGNVQQTIKAADYQVQGHYETPIVQHCHMENVTSYAY-MEDDGRITIVSSTQIPHIVRRVVGQALGIPWGKVRVIK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 801 KRVGGAFGGKafKTGVMAAITAFAANK-HGRAVRCILERGEDMLITAGRHPYLGKYKAGFMKDGRILALDMEHYGNGGAF 879
Cdd:PRK09970 239 PYVGGGFGNK--QDVLEEPLAAFLTSKvGGRPVKVSLSREECFLATRTRHAFTIDIKMGVNRDGTLKGYSLDVLSNTGAY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 880 PDESLLVLEIGLLKLDNAYKFPNLRCRGWACRTNLPPNTAFRGFGFPQAGLITEACITDVAAKCGLSPEKVRMINMYKEI 959
Cdd:PRK09970 317 ASHGHSIASAGGNKVAYLYPRCAYKYSSKTVYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEFRLRNAAREG 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 960 DQTHY-KQEINAKNLIQCWRECMAMSSYSLRKAaveKFNSENSWKKKGLAMVPVK-----FPIGLGSraagqAAALVHIY 1033
Cdd:PRK09970 397 DANPLsGKRIYSAGLPECLEKGRKIFEWDKRRA---ECKNQQGNLRRGVGVACFSytsgtWPVGLEI-----AGARLLMN 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1034 LDGSVLVTHGGIEMGQGVHTKMIQVASRELRMPLSNVHLRGTSTETV----PNANVSGGSVVAdlnGLAVKDACQTL--- 1106
Cdd:PRK09970 469 QDGTVQVQSGATEIGQGSDTVFSQMVAETVGIPVSDVRVISTQDTDVtpfdPGAYASRQSYVA---GPAIRKAALELkek 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1107 -------LKRLEP---------IISKNPRG---TWKDWA-QAAFDESISLSATGyfrgyESNMNWETGEghpfeyFVYGA 1166
Cdd:PRK09970 546 ilahaavMLHQSAmnldiidghIVVKRPGEplmSLEELAmDAYYHPERGGQITA-----ESSIKTTTNP------PAFGC 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1167 ACSEVEIDCLTGAHKNIRTDIVMDVGCSINPALDIGQIEGAFIQGMGLYTIEELNYSPQ-GVlyTRGPD--QYKIPTICD 1243
Cdd:PRK09970 615 TFVDVEVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDEKtGV--VRNPNllDYKLPTMMD 692
|
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 554558462 1244 IPtEFHVSFLPPSqDSNTLYSSKGLGESGVflgCSVFFAIHDAVSAA 1290
Cdd:PRK09970 693 LP-QLESAFVEIY-EPQSAYGHKSLGEPPI---ISPAPAIRNAVLMA 734
|
|
| PRK09800 |
PRK09800 |
putative hypoxanthine oxidase; Provisional |
578-1311 |
1.04e-56 |
|
putative hypoxanthine oxidase; Provisional
Pssm-ID: 182084 [Multi-domain] Cd Length: 956 Bit Score: 214.31 E-value: 1.04e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 578 DPVGHPIMHLSGIKHATGEAIYCDDMPAMDGeLFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGVnSFCFLG 657
Cdd:PRK09800 170 EVIGKHYPKTDAAKMVQAKPCYVEDRVTADA-CVIKMLRSPHAHALITHLDVSKAEALPGVVHVITHLNCPDI-YYTPGG 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 658 Q--PEKLLESEMVFC-----VGQLVCAVIADSEIQARRAAKRVKIVYQDLEPViLTIEEAI------------------- 711
Cdd:PRK09800 248 QsaPEPSPLDRRMFGkkmrhVGDRVAAVVAESEEIALEALKLIDVEYEVLKPV-MSIDEAMaedapvvhdepvvyvagap 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 712 -----QHKSFFEPERKLEY--------------------GNVDEAFKVVDHIVEGEIHLGGQEHFYMETQSMLAVPKGEd 766
Cdd:PRK09800 327 dtledDNSHAAQRGEHMIInfpigsrprkniaasihghiGDMDKGFADADVIIERTYNSTQAQQCPTETHICFTRMDGD- 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 767 qEMDVYVSTQYPKGIQDIVASVLKLPANKVMCHVKRVGGAFGGKafKTGVMAAITAFAANKHGRAVRCILERGEDMLITA 846
Cdd:PRK09800 406 -RLVIHASTQVPWHLRRQVARLVGMKQHKVHVIKERVGGGFGSK--QDILLEEVCAWATCVTGRPVLFRYTREEEFIANT 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 847 GRHPYLGKYKAGFMKDGRILALDMEHYGNGGAFPDESLLVLEIGLLKLDNAYKFPNLRCRGWACRTNLPPNTAFRGFGFP 926
Cdd:PRK09800 483 SRHVAKVTVKLGAKKDGRLTAVKMDFRANTGPYGNHSLTVPCNGPALSLPLYPCDNVDFQVTTYYSNICPNGAYQGYGAP 562
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 927 QAGLITEACITDVAAKCGLspEKVRMInmykEIDQTHYKQEINAKNLIQCWRecMAMSSYSLRKAAVEKFNSEN----SW 1002
Cdd:PRK09800 563 KGNFAITMALAELAEQLQI--DQLEII----ERNRVHEGQELKILGAIGEGK--APTSVPSAASCALEEILRQGremiQW 634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1003 KK-----------KGLAMVPVKFpiglGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVASRELRMPLSNVH 1071
Cdd:PRK09800 635 SSpkpqngdwhigRGVAIIMQKS----GIPDIDQANCMIKLESDGTFIVHSGGADIGTGLDTVVTKLAAEVLHCPPQDVH 710
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1072 LRGTSTETVP---NANVSGGSVvadLNGLAVKDACQTLLKRL---------EPIisknprgtwkdwaqaafdESISLSAT 1139
Cdd:PRK09800 711 VISGDTDHALfdkGAYASSGTC---FSGNAARLAAENLREKIlfhgaqmlgEPV------------------ADVQLATP 769
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1140 GYFRGYESNMNW-------ETGEGH-----------PFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGCSINPALDI 1201
Cdd:PRK09800 770 GVVRGKKGEVSFgdiahkgETGTGFgslvgtgsyitPDFAFPYGANFAEVAVNTRTGEIRLDKFYALLDCGTPVNPELAL 849
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 1202 GQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPDQYKIPTICDIPTEFHvSFLPPSQDSNTLYSSKGLGESGVFlGCS--V 1279
Cdd:PRK09800 850 GQIYGATLRAIGHSMSEEIIYDAEGHPLTRDLRSYGAPKIGDIPRDFR-AVLVPSDDKVGPFGAKSISEIGVN-GAApaI 927
|
810 820 830
....*....|....*....|....*....|..
gi 554558462 1280 FFAIHDAVSAARQERglrgplklnsPLTPEKI 1311
Cdd:PRK09800 928 ATAIHDACGIWLREW----------HFTPEKI 949
|
|
| FAD_binding_5 |
pfam00941 |
FAD binding domain in molybdopterin dehydrogenase; |
240-419 |
3.30e-52 |
|
FAD binding domain in molybdopterin dehydrogenase;
Pssm-ID: 460007 [Multi-domain] Cd Length: 170 Bit Score: 180.82 E-value: 3.30e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 240 RMTWISPVTLKELLEAKAKYPQAPVIMGNTSTGPEVKFKGVFHPVIISPDRIEELNVVNSANNGLTLGAGLSLAQVKDTL 319
Cdd:pfam00941 2 KFGYYRPASLAEALELLAAGPDAKLVAGGTSLGPLMKLRLARPDHLIDINGIPELRGIEETDGGLEIGAAVTLSEIAEPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 320 AAvvlklpeertQTYRALLKQLGTLAGAQIRNMASLGGHIVSRHVDSDLNPLLAVGGCTLNLLSKEGARQIPVnEQFLRK 399
Cdd:pfam00941 82 LR----------EAYPALSEALRKIASPQIRNVGTIGGNIANASPISDLPPALLALDAKVELRSGEGERTVPL-EDFFLG 150
|
170 180
....*....|....*....|
gi 554558462 400 CPSADLKPEEILISVNIPYS 419
Cdd:pfam00941 151 YGKTALEPGELITAVIIPLP 170
|
|
| CutS |
COG2080 |
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ... |
9-160 |
1.05e-39 |
|
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 441683 [Multi-domain] Cd Length: 155 Bit Score: 144.46 E-value: 1.05e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 9 FYVNGRKViEKNVDPETMLLPYLRKKLRLTGtkygcggggcgactvmisrynpvTKR-------------IRHYPANACL 75
Cdd:COG2080 6 LTVNGKPV-EVDVDPDTPLLDVLRDDLGLTG-----------------------TKFgcghgqcgactvlVDGKAVRSCL 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 76 MPICSVYGAAVTTVEGIGsTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYR 155
Cdd:COG2080 62 TLAVQADGKEITTIEGLA-EDGELHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYV 140
|
....*
gi 554558462 156 PIIDA 160
Cdd:COG2080 141 RIVRA 145
|
|
| Ald_Xan_dh_C |
smart01008 |
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses ... |
594-701 |
5.77e-39 |
|
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase catalyses the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups.
Pssm-ID: 214971 [Multi-domain] Cd Length: 107 Bit Score: 140.35 E-value: 5.77e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 594 TGEAIYCDDMPaMDGELFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGVNSFCFLGQPEKLLESEMVFCVGQ 673
Cdd:smart01008 1 TGEARYGDDIR-LPGMLHAAVVRSPVAHARIKSIDTSAARAMPGVVAVLTAKDVPGLNDFGPLGPDEPVLADDKVRYVGQ 79
|
90 100
....*....|....*....|....*...
gi 554558462 674 LVCAVIADSEIQARRAAKRVKIVYQDLE 701
Cdd:smart01008 80 PVAAVVAETEEAARDAAEAVKVEYEELP 107
|
|
| CO_deh_flav_C |
pfam03450 |
CO dehydrogenase flavoprotein C-terminal domain; |
426-530 |
3.99e-36 |
|
CO dehydrogenase flavoprotein C-terminal domain;
Pssm-ID: 460921 [Multi-domain] Cd Length: 102 Bit Score: 132.30 E-value: 3.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 426 SAFRQAQRPQNALAIVNSGMRVFFGegDGIIREFSISYGGVGPTTICAQNSCQKLIGRPWNEEMLDAACRLVLDEVSlPG 505
Cdd:pfam03450 1 AAYKQAKRRDDDIAIVNAAFRVRLD--GGTVEDARIAFGGVAPTPIRATEAEAALIGKPWDEETLEAAAALLLEDLS-PL 77
|
90 100
....*....|....*....|....*
gi 554558462 506 SAPGGKVEFKRTLIISFLFKFYLEV 530
Cdd:pfam03450 78 SDPRGSAEYRRHLARSLLFRFLLEA 102
|
|
| Ald_Xan_dh_C |
pfam01315 |
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; |
594-701 |
9.75e-36 |
|
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain;
Pssm-ID: 426197 [Multi-domain] Cd Length: 107 Bit Score: 131.20 E-value: 9.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 594 TGEAIYCDDMPAMDGElFLAFVTSSRAHAKIVSIDVSEALSLPGVVDVLAEEHLQGVNSFCFLGQPEKLLESEMVFCVGQ 673
Cdd:pfam01315 1 TGEAVYVDDIPAPGNL-YGAFVRSTIAHAKIVSIDTSAALALPGVVAVITAKDLPGGNYNIGPIPLDPLFATDKVRHVGQ 79
|
90 100
....*....|....*....|....*...
gi 554558462 674 LVCAVIADSEIQARRAAKRVKIVYQDLE 701
Cdd:pfam01315 80 PIAAVVADDEETARRAAKLVKVEYEELP 107
|
|
| CutB |
COG1319 |
Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit [Energy production and conversion] ... |
240-519 |
1.98e-35 |
|
Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 440930 [Multi-domain] Cd Length: 285 Bit Score: 136.79 E-value: 1.98e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 240 RMTWISPVTLKELLEAKAKY-PQAPVIMGNTSTGPEVKFkGVFHP-VIISPDRIEELNVVNSANNGLTLGAGLSLAQVkd 317
Cdd:COG1319 3 PFEYHRPTSLEEALALLAEHgPDARVLAGGTDLLPLMKL-RLARPeHLVDINRIPELRGIEEEGGGLRIGALVTHAEL-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 318 tLAAVVLKlpeertQTYRALLKQLGTLAGAQIRNMASLGGHIVsrHVD--SDLNPLLAVGGCTLNLLSKEGARQIPVNEq 395
Cdd:COG1319 80 -AASPLVR------ERYPLLAEAARAIASPQIRNRGTIGGNLA--NADpaADLPPALLALDATVELAGPDGERTIPAAD- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 396 FLRKCPSADLKPEEILISVNIPYSRKWEfVSAFRQ-AQRPQNALAIVNSGMRVFFGegDGIIREFSISYGGVGPTTICAQ 474
Cdd:COG1319 150 FFLGPGETALEPGELITAVRLPAPPAGA-GSAYLKvGRRASDAIALVSVAVALRLD--GGTIRDARIALGGVAPTPWRAR 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 554558462 475 NSCQKLIGRPWNEEMLDAACRLVLDEVSlPGSAPGGKVEFKRTLI 519
Cdd:COG1319 227 EAEAALAGKPLSEEAIEAAAEAAAAAAD-PIDDVRASAEYRRHLA 270
|
|
| Fer2_2 |
pfam01799 |
[2Fe-2S] binding domain; |
88-161 |
5.40e-34 |
|
[2Fe-2S] binding domain;
Pssm-ID: 460336 [Multi-domain] Cd Length: 73 Bit Score: 125.24 E-value: 5.40e-34
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 554558462 88 TVEGIGSTRTriHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLD-QLTDALGGNLCRCTGYRPIIDAC 161
Cdd:pfam01799 1 TIEGLAESGG--EPVQQAFAEAGAVQCGYCTPGMIMSAYALLERNPPPPTEaEIREALSGNLCRCTGYRRIVDAV 73
|
|
| CO_deh_flav_C |
smart01092 |
CO dehydrogenase flavoprotein C-terminal domain; |
427-530 |
1.37e-27 |
|
CO dehydrogenase flavoprotein C-terminal domain;
Pssm-ID: 215021 [Multi-domain] Cd Length: 102 Bit Score: 107.70 E-value: 1.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 427 AFRQAQRPQNALAIVNSGMRVFFGegDGIIREFSISYGGVGPTTICAQNSCQKLIGRPWNEEMLDAACRLVLDEVSLPGS 506
Cdd:smart01092 1 AYKKSRRRDGDIALVSAAVALTLD--GGRVTEARIALGGVAPTPKRAAEAEAALVGKPLTDEALARAAAAALAQDFTPLS 78
|
90 100
....*....|....*....|....
gi 554558462 507 APGGKVEFKRTLIISFLFKFYLEV 530
Cdd:smart01092 79 DMRASAEYRRQLAANLLRRALLEA 102
|
|
| glyceraldDH_gamma |
NF041020 |
glyceraldehyde dehydrogenase subunit gamma; |
11-162 |
1.24e-26 |
|
glyceraldehyde dehydrogenase subunit gamma;
Pssm-ID: 468949 [Multi-domain] Cd Length: 162 Bit Score: 107.57 E-value: 1.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 11 VNGrKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISrynpvTKRIRhypanACLMPICSVYGAAVTTVE 90
Cdd:NF041020 15 VNG-VWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMN-----GKSVK-----SCTVLAVQADGAEITTIE 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 554558462 91 GIGSTrTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYRPIIDACK 162
Cdd:NF041020 84 GLSKD-GKLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVK 154
|
|
| 4hydroxCoAred |
TIGR03193 |
4-hydroxybenzoyl-CoA reductase, gamma subunit; 4-hydroxybenzoyl-CoA reductase converts ... |
70-163 |
1.19e-22 |
|
4-hydroxybenzoyl-CoA reductase, gamma subunit; 4-hydroxybenzoyl-CoA reductase converts 4-hydroxybenzoyl-CoA to benzoyl-CoA, a common intermediate in the degradation of aromatic compounds. This protein family represents the gamma chain of this three-subunit enzyme.
Pssm-ID: 132237 [Multi-domain] Cd Length: 148 Bit Score: 95.33 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 70 PANACLMPICSVYGAAVTTVEGIgSTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLC 149
Cdd:TIGR03193 54 PRLACSTLAHRVAGRKVETVEGL-ATNGRLSRLQQAFHERLGTQCGFCTPGMIMAAEALLRRNPSPSRDEIRAALAGNLC 132
|
90
....*....|....
gi 554558462 150 RCTGYRPIIDACKT 163
Cdd:TIGR03193 133 RCTGYVKIIESVEA 146
|
|
| pucE |
TIGR03198 |
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ... |
5-165 |
2.16e-21 |
|
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.
Pssm-ID: 132242 [Multi-domain] Cd Length: 151 Bit Score: 91.84 E-value: 2.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 5 AELLFYVNGRKViEKNVDPETMLLPYLRKKLRLTGTKYGCGgggcgactvmISRYNPVTKRIRHYPANACLMPICSVYGA 84
Cdd:TIGR03198 2 EQFRFTVNGQAW-EVAAVPTTRLSDLLRKELQLTGTKVSCG----------IGRCGACSVLIDGKLANACLTMAYQADGH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 85 AVTTVEGIgsTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYRPIIDACKTF 164
Cdd:TIGR03198 71 EITTIEGI--AENELDPCQTAFLEEGGFQCGYCTPGMVVALKALFRETPQPSDEDMEEGLSGNLCRCTGYGGIIRSACRI 148
|
.
gi 554558462 165 C 165
Cdd:TIGR03198 149 R 149
|
|
| PRK09971 |
PRK09971 |
xanthine dehydrogenase subunit XdhB; Provisional |
246-519 |
2.33e-21 |
|
xanthine dehydrogenase subunit XdhB; Provisional
Pssm-ID: 182175 [Multi-domain] Cd Length: 291 Bit Score: 95.88 E-value: 2.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 246 PVTLKELLEAKAKYPQAPVIMGNTSTGPEVKFKGVFHPVIISPDRIEELNVVNSANNG-LTLGAGLSLAQVKDtlaavvl 324
Cdd:PRK09971 10 AATLEEAIELLADNPQAKLIAGGTDVLIQLHHHNDRYRHLVSIHNIAELRGITLAEDGsIRIGAATTFTQIIE------- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 325 klpEERTQTY-RALLKQLGTLAGAQIRNMASLGGHIVSRHVDSDLNPLLAVGGCTLNLLSKEGARQIPVNEqFLRKCPSA 403
Cdd:PRK09971 83 ---DPIIQKHlPALAEAAVSIGGPQIRNVATIGGNICNGATSADSAPPLFALDAKLEIHSPNGVRFVPING-FYTGPGKV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 404 DLKPEEILISVNIPYSRKWEFVSA-FRQAQRpqNALAIVNSGMRVFFGEGDGIIREFSISYGGVGPTTICAQNSCQKLIG 482
Cdd:PRK09971 159 SLEHDEILVAFIIPPEPYEHAGGAyIKYAMR--DAMDIATIGCAVLCRLDNGNFEDLRLAFGVAAPTPIRCQHAEQTAKG 236
|
250 260 270
....*....|....*....|....*....|....*..
gi 554558462 483 RPWNEEMLDAACRLVLDEVSLPGSAPGGKvEFKRTLI 519
Cdd:PRK09971 237 APLNLETLEAIGELVLQDVAPRSSWRASK-EFRLHLI 272
|
|
| Se_dep_XDH |
TIGR03311 |
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional ... |
9-166 |
3.01e-19 |
|
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 132354 [Multi-domain] Cd Length: 848 Bit Score: 94.14 E-value: 3.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 9 FYVNGRKViekNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISrynpvTKRIRhypanACLMPICSVYGAAVTT 88
Cdd:TIGR03311 3 FIVNGREV---DVNEEKKLLEFLREDLRLTGVKNGCGEGACGACTVIVN-----GKAVR-----ACRFTTAKLAGKEITT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 89 VEGIGSTRTRIHPVQerIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLCRCTGYRPIID----ACKTF 164
Cdd:TIGR03311 70 VEGLTEREKDVYAWA--FAKAGAVQCGFCIPGMVISAKALLDKNPNPTEAEIKKALKGNICRCTGYVKIIKavrlAAKAF 147
|
..
gi 554558462 165 CN 166
Cdd:TIGR03311 148 RE 149
|
|
| PRK11433 |
PRK11433 |
aldehyde oxidoreductase 2Fe-2S subunit; Provisional |
4-160 |
1.10e-14 |
|
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
Pssm-ID: 236910 [Multi-domain] Cd Length: 217 Bit Score: 74.81 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 4 TAELLFYVNGrKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISrynpvTKRIrhypaNACLMPICSVYG 83
Cdd:PRK11433 49 ISPVTLKVNG-KTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVN-----GRRL-----NACLTLAVMHQG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 84 AAVTTVEGIGsTRTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLR-------NH--------PDPTLDQLTDALGGNL 148
Cdd:PRK11433 118 AEITTIEGLG-SPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKeikdgipSHvtvdltaaPELTADEIRERMSGNI 196
|
170
....*....|..
gi 554558462 149 CRCTGYRPIIDA 160
Cdd:PRK11433 197 CRCGAYSNILEA 208
|
|
| PRK09908 |
PRK09908 |
xanthine dehydrogenase iron sulfur-binding subunit XdhC; |
72-167 |
1.87e-14 |
|
xanthine dehydrogenase iron sulfur-binding subunit XdhC;
Pssm-ID: 182139 [Multi-domain] Cd Length: 159 Bit Score: 72.26 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 72 NACLMPICSVYGAAVTTVEGIGSTrTRIHPVQERIARCHGTQCGFCTPGMVMSIYTLL---RNHPdPTLDQLTDALGGNL 148
Cdd:PRK09908 62 DSCLYLAAWAEGKEIRTLEGEAKG-GKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLakpREKP-LTITEIRRGLAGNL 139
|
90
....*....|....*....
gi 554558462 149 CRCTGYRPIIDACKTFCNT 167
Cdd:PRK09908 140 CRCTGYQMIVNTVLDCEKT 158
|
|
| PRK09800 |
PRK09800 |
putative hypoxanthine oxidase; Provisional |
70-155 |
1.24e-06 |
|
putative hypoxanthine oxidase; Provisional
Pssm-ID: 182084 [Multi-domain] Cd Length: 956 Bit Score: 53.30 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554558462 70 PANACLMPICSVYGAAVTTVEGIGSTRtRIHPVQERIARCHGTQCGFCTPGMVMSIYTLLRNHPDPTLDQLTDALGGNLC 149
Cdd:PRK09800 55 IVNASLLIAAQLEKADIRTAESLGKWN-ELSLVQQAMVDVGVVQSGYNDPAAALIITDLLDRIAAPTREEIDDALSGLFS 133
|
....*.
gi 554558462 150 RCTGYR 155
Cdd:PRK09800 134 RDAGWQ 139
|
|
| |
