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isocitrate dehydrogenase [NADP] cytoplasmic isoform X2 [Sus scrofa]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10015366 )
NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 846.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 1 MSQ KI Q - GGS VVE MQ GDEMTRIIW EL IKEKLI F PY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKK YN VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLI L PY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKK HK VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV S GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ISY TP R 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 160 DGS PKMTYM V H DF TD c GGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK SQ F 239
Cdd:PTZ00435 162 DGS EPQRVD V F DF KG - GGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVL I CPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVL V CPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 320 QKG Q ETSTN P IASIFAWTRGLAHRAKLD S N K EL SI F AN ALE EV CIETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAWTRGLAHRAKLD N N Q EL VK F CQ ALE RS CIETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 545875430 400 K LG E N LK I KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 846.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 1 MSQ KI Q - GGS VVE MQ GDEMTRIIW EL IKEKLI F PY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKK YN VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLI L PY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKK HK VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV S GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ISY TP R 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 160 DGS PKMTYM V H DF TD c GGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK SQ F 239
Cdd:PTZ00435 162 DGS EPQRVD V F DF KG - GGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVL I CPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVL V CPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 320 QKG Q ETSTN P IASIFAWTRGLAHRAKLD S N K EL SI F AN ALE EV CIETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAWTRGLAHRAKLD N N Q EL VK F CQ ALE RS CIETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 545875430 400 K LG E N LK I KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-411
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 784.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 3 Q KI QGGS - VVEM Q GDEMTRIIWELIK E KLI F PYVELDL HS YDLG I E N RDATNDQVT K DAAEAIKKYNVGVKCATITPDE K 81
Cdd:TIGR00127 1 S KI KVAN p VVEM D GDEMTRIIWELIK D KLI L PYVELDL KY YDLG V E Y RDATNDQVT V DAAEAIKKYNVGVKCATITPDE A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 82 RVEEFKLK Q MWKSPNGTIRNILGGTVFRE A IICKNIPRLV S GW V KPIIIGRHA Y GDQYRATDFVVPGPGK V E IS Y T P R DG 161
Cdd:TIGR00127 81 RVEEFKLK K MWKSPNGTIRNILGGTVFRE P IICKNIPRLV P GW E KPIIIGRHA F GDQYRATDFVVPGPGK L E LV Y K P K DG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 162 SP K M T YM V H DF TDC GGVAM G MYN Q D K SIE D FAHSSFQ M AL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK QYKS Q FEA 241
Cdd:TIGR00127 161 TQ K V T LK V Y DF EEG GGVAM A MYN T D E SIE G FAHSSFQ L AL E K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA QYKS K FEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 242 QK IWYEHRLIDDMVAQA M KSEGGFIWACKNYDGDVQSD S VAQG Y GSLG M MTSVLICPDGKT V EAEAAHGTVTRHYRMYQK 321
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQA L KSEGGFIWACKNYDGDVQSD I VAQG F GSLG L MTSVLICPDGKT F EAEAAHGTVTRHYRMYQK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 322 GQETSTN P IASIFAW T RGLAHRAKLD S N K ELS I FAN A LE EV CI E T I EAG F MTKDLA ACIK G L P n V Q RS D YLNT F EF M D KL 401
Cdd:TIGR00127 321 GQETSTN S IASIFAW S RGLAHRAKLD N N P ELS K FAN I LE SA CI N T V EAG I MTKDLA LILG G S P - V E RS A YLNT E EF I D AV 399
410
....*....|
gi 545875430 402 G E N LK I K L A Q 411
Cdd:TIGR00127 400 E E R LK K K I A A 409
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
10-406
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 515.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 10 VVEMQ GD ---- E M TR I IW EL I KEKLIFP Y --- VELDLHSY D L G IEN RD A T N D QVTKDA AEAIK K Y N VG V K CATI TP DE kr 82
Cdd:COG0538 21 IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk RDIEWKEV D A G EKA RD E T G D WLPDET AEAIK E Y G VG I K GPLT TP VG -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 83 veefklk QM W K S P N G TIR N IL GGT V F R EAI - IC K NI P RL V SGWV K - P I I I G R HAYG D Q Y RATDFVVPG P GKVEISYTPR D 160
Cdd:COG0538 99 ------- GG W R S L N V TIR Q IL DLY V C R RPV r YF K GV P SP V KHPE K v D I V I F R ENTE D I Y AGIEWKAGS P EALKLIFFLE D 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 161 G spk M TYM V HD F TDCG G VAMGMYN q D KSI E DFAHSSF Q M AL SKG - WPLY L ST K NT I L K KYD G R FKD IFQ E IYDKQYKSQ F 239
Cdd:COG0538 172 E --- M GVT V IR F PEDS G IGIKPVS - D EGT E RLVRAAI Q Y AL DNK r KSVT L VH K GN I M K FTE G A FKD WGY E VAEEEFGDK F 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 240 ------------- E A Q KI W Y EH R LI DDM VA Q AMKSE G G - FIW A C KN YD GD VQ SD SV A QGY G S LG MMTSVL I CP DG K t V E A 305
Cdd:COG0538 248 itegpwekykgpk P A G KI V Y KD R IA DDM LQ Q ILLRP G E y DVI A T KN LN GD YI SD AL A AQV G G LG IAPGAN I GD DG G - A E F 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 306 EA A HGT VTRH yrmyqk GQET STNP IAS I FAW T RG L A HR AK L DS nkelsif A NAL E EVCIE TIE A G FM T K DLA ACIK G LP n 385
Cdd:COG0538 327 EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HR GW L EA ------- A DLI E KAVEK TIE S G KV T Y DLA RLME G AT - 392
410 420
....*....|....*....|.
gi 545875430 386 vqrsd Y L N T F EF M D KLG ENL K 406
Cdd:COG0538 393 ----- E L S T S EF G D AII ENL D 408
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
11-401
4.53e-89
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 273.40
E-value: 4.53e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 11 VEMQ G D E MTRIIWELI K EK L IFPYV E LDLHSY D L G IENR D A T NDQVTKDAA EA I KK YNVGVKC A TIT P D ---- EK R V E EF 86
Cdd:pfam00180 7 GDGI G P E VMAAALKVL K AA L EKAPL E FEFEER D V G GAAI D E T GEPLPDETL EA C KK ADAVLLG A VGG P K wdpa GV R P E NG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 87 k L KQMW K SP n G TIR N ILGGT VF R e AIICKNIPRLVSGW V K p I I I G R HAY G DQ Y RATDFVVP G P G KV eisytprdgspkmt 166
Cdd:pfam00180 87 - L LALR K EL - G LFA N LRPAK VF P - PLGDASPLKNEVEG V D - I V I V R ELT G GI Y FGIEKGIK G S G NE -------------- 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 167 ymvhdftdc GG V AMGM Y NQ D K s IE DF A HSS F QM A LSK G - WPLYLST K NTI LK KY D g RFKD I FQ E IYDKQ Y K sqfeaq KIW 245
Cdd:pfam00180 149 --------- VA V DTKL Y SR D E - IE RI A RVA F EL A RKR G r KKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVE 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 246 Y EH R L I D DMVA Q AM K SEGG F - IWACK N YD GD VQ SD SVAQGY GSLG MMT S VLICPD G k TVEA E AA HG TVTRHYR myq KG Q e 324
Cdd:pfam00180 212 L EH Q L V D NAAM Q LV K NPSQ F d VIVTP N LF GD IL SD EASMLT GSLG LLP S ASLGAN G - FGIF E PV HG SAPDIAG --- KG I - 286
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 545875430 325 ts T NPIA S I FAWTRG L AHRAK L DSN kelsif A NAL E EVCIETI E A G FM T K DLA A cikglpnvq RSD Y LN T F EF MDKL 401
Cdd:pfam00180 287 -- A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL E S G IR T G DLA G --------- SAT Y VS T S EF GEAV 346
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 846.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 1 MSQ KI Q - GGS VVE MQ GDEMTRIIW EL IKEKLI F PY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKK YN VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLI L PY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKK HK VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV S GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ISY TP R 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 160 DGS PKMTYM V H DF TD c GGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK SQ F 239
Cdd:PTZ00435 162 DGS EPQRVD V F DF KG - GGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVL I CPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVL V CPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 320 QKG Q ETSTN P IASIFAWTRGLAHRAKLD S N K EL SI F AN ALE EV CIETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAWTRGLAHRAKLD N N Q EL VK F CQ ALE RS CIETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 545875430 400 K LG E N LK I KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
4-409
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 815.25
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 4 KI Q - GGS VVE MQ GDEMTRIIW EL IK E KLI F PY VEL DL HS YDLGIENRDAT N DQVT K DAA E AIKKY N VGVKCATITPDE K R 82
Cdd:PRK08299 3 KI K v KNP VVE LD GDEMTRIIW KF IK D KLI L PY LDI DL EY YDLGIENRDAT D DQVT I DAA N AIKKY G VGVKCATITPDE A R 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 83 V E EF K LK Q MWKSPNGTIRNILGGTVFRE A IICKN I PRLV S GW V KPI I IGRHAYGDQYRATDF V VPG P GK VEISY T PR DG S 162
Cdd:PRK08299 83 V K EF N LK K MWKSPNGTIRNILGGTVFRE P IICKN V PRLV P GW T KPI V IGRHAYGDQYRATDF K VPG K GK LTLVF T GE DG E 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 163 P k MTYM VHDF TD c G GVAMGMYN Q D K SI E DFA HS SF QMA L SKGW P L YLSTKNTILK K YDGRFKDIFQE I Y DKQY K SQ FEA Q 242
Cdd:PRK08299 163 P - IEHE VHDF PG - A GVAMGMYN L D E SI R DFA RA SF NYG L DRKY P V YLSTKNTILK A YDGRFKDIFQE V Y EAEF K EK FEA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 243 K I W YEHRLIDDMVA Q A M K S EGG FI WACKNYDGDVQSD S VAQG Y GSLG M MTSVL IC PDGKTVEAEAAHGTVTRHYR MY QKG 322
Cdd:PRK08299 241 G I T YEHRLIDDMVA S A L K W EGG YV WACKNYDGDVQSD T VAQG F GSLG L MTSVL MT PDGKTVEAEAAHGTVTRHYR QH QKG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 323 Q ETSTNPIASIFAWTRGLAHR A KLD S N K EL SI FA NA LE E VCIET I E A GFMTKDLA ACIK gl P NVQ rsd Y L N T F EF M D KLG 402
Cdd:PRK08299 321 E ETSTNPIASIFAWTRGLAHR G KLD G N P EL VK FA DT LE K VCIET V E S GFMTKDLA LLVG -- P DQK --- W L T T E EF L D AID 395
....*..
gi 545875430 403 ENL KIK L 409
Cdd:PRK08299 396 ENL EKA L 402
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-411
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 784.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 3 Q KI QGGS - VVEM Q GDEMTRIIWELIK E KLI F PYVELDL HS YDLG I E N RDATNDQVT K DAAEAIKKYNVGVKCATITPDE K 81
Cdd:TIGR00127 1 S KI KVAN p VVEM D GDEMTRIIWELIK D KLI L PYVELDL KY YDLG V E Y RDATNDQVT V DAAEAIKKYNVGVKCATITPDE A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 82 RVEEFKLK Q MWKSPNGTIRNILGGTVFRE A IICKNIPRLV S GW V KPIIIGRHA Y GDQYRATDFVVPGPGK V E IS Y T P R DG 161
Cdd:TIGR00127 81 RVEEFKLK K MWKSPNGTIRNILGGTVFRE P IICKNIPRLV P GW E KPIIIGRHA F GDQYRATDFVVPGPGK L E LV Y K P K DG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 162 SP K M T YM V H DF TDC GGVAM G MYN Q D K SIE D FAHSSFQ M AL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK QYKS Q FEA 241
Cdd:TIGR00127 161 TQ K V T LK V Y DF EEG GGVAM A MYN T D E SIE G FAHSSFQ L AL E K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA QYKS K FEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 242 QK IWYEHRLIDDMVAQA M KSEGGFIWACKNYDGDVQSD S VAQG Y GSLG M MTSVLICPDGKT V EAEAAHGTVTRHYRMYQK 321
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQA L KSEGGFIWACKNYDGDVQSD I VAQG F GSLG L MTSVLICPDGKT F EAEAAHGTVTRHYRMYQK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 322 GQETSTN P IASIFAW T RGLAHRAKLD S N K ELS I FAN A LE EV CI E T I EAG F MTKDLA ACIK G L P n V Q RS D YLNT F EF M D KL 401
Cdd:TIGR00127 321 GQETSTN S IASIFAW S RGLAHRAKLD N N P ELS K FAN I LE SA CI N T V EAG I MTKDLA LILG G S P - V E RS A YLNT E EF I D AV 399
410
....*....|
gi 545875430 402 G E N LK I K L A Q 411
Cdd:TIGR00127 400 E E R LK K K I A A 409
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
10-414
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 727.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 10 V VEM Q GDEMTR I IW EL IK E KLIFPY VE LD LHSY DLGI E NRDAT N D Q VT KDA AEA IK KYNV GV KCATITPDE K RV E EF K LK 89
Cdd:PLN03065 80 I VEM D GDEMTR V IW QM IK D KLIFPY LD LD IKYF DLGI L NRDAT D D K VT VES AEA TL KYNV AI KCATITPDE A RV K EF G LK 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 90 Q MW K SPNGTIRNIL G GTVFRE A I I CKNIPRLV S GW V KPI I IGRHA Y GDQYRATD F V VP GPGK VEISYT P R DG SPKMTYM V 169
Cdd:PLN03065 160 S MW R SPNGTIRNIL N GTVFRE P I L CKNIPRLV P GW K KPI C IGRHA F GDQYRATD T V IK GPGK LKMVFV P E DG NAPVELD V 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 170 H DF TD c G GVA MG MYN Q D K SI ED FA H SS FQ MAL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK Q Y K SQ FE AQK IWYEHR 249
Cdd:PLN03065 240 Y DF KG - P GVA LA MYN V D E SI RA FA E SS MA MAL Q K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EE Q W K QK FE EHS IWYEHR 318
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 250 LIDDMVA Q A M KSEGG FI WACKNYDGDVQSD SV AQG Y GSLG M MTSVL ICP DGKT V EAEAAHGTVTRH Y R MY QKGQETSTN P 329
Cdd:PLN03065 319 LIDDMVA Y A V KSEGG YV WACKNYDGDVQSD LL AQG F GSLG L MTSVL LSS DGKT L EAEAAHGTVTRH F R LH QKGQETSTN S 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 330 IASIFAWTRGL A HRAKLD S N K EL SI F ANA LE EV CIET I E A G F MTKDLA AC I K G l P N V Q R SD YLNT F EF M D KLGEN L KI K L 409
Cdd:PLN03065 399 IASIFAWTRGL E HRAKLD K N E EL LD F VHK LE SA CIET V E S G K MTKDLA IL I H G - P K V S R EF YLNT E EF I D AVAQT L AT K R 477
....*
gi 545875430 410 AQAKL 414
Cdd:PLN03065 478 GEPAV 482
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
10-409
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 700.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 10 V VEM Q GDEMTR I IW EL IK E KLIFP YVE LD LHSY DLG IE NRDAT N D Q VT KDA AEA IK KYNV GV KCATITPDE K RV E EF K LK 89
Cdd:PLN00103 12 I VEM D GDEMTR V IW KS IK D KLIFP FLD LD IKYF DLG LP NRDAT D D K VT VES AEA TL KYNV AI KCATITPDE A RV K EF G LK 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 90 QMWKSPNGTIRNIL G GTVFRE A IICKNIPRLV S GW V KPI I IGRHA Y GDQYRATD F V VP GPGK VEISYT P RDGSP K MTYM V 169
Cdd:PLN00103 92 QMWKSPNGTIRNIL N GTVFRE P IICKNIPRLV P GW T KPI C IGRHA F GDQYRATD A V IK GPGK LKLVFV P EGKDE K TELE V 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 170 HD FT DC GGVA MG MYN Q D K SI ED FA HS S FQM A LS K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK Q Y KS Q FEA QK IWYEHR 249
Cdd:PLN00103 172 YN FT GA GGVA LS MYN T D E SI RA FA EA S MNT A YQ K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA Q W KS K FEA AG IWYEHR 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 250 LIDDMVA Q A M KSEGG FI WACKNYDGDVQSD SV AQG Y GSLG M MTSVL I CPDGKT V EAEAAHGTVTRHYR MY QKG Q ETSTN P 329
Cdd:PLN00103 252 LIDDMVA Y A L KSEGG YV WACKNYDGDVQSD FL AQG F GSLG L MTSVL V CPDGKT I EAEAAHGTVTRHYR VH QKG G ETSTN S 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 330 IASIFAW T RGLAHRAKLD S N KE L SI F ANA LE EV C IE T I E A G F MTKDLA AC I K G l P N V Q R SD YLNT F EF M D KLG E N LK IK L 409
Cdd:PLN00103 332 IASIFAW S RGLAHRAKLD G N AR L LD F TEK LE AA C VG T V E S G K MTKDLA LL I H G - P K V S R DQ YLNT E EF I D AVA E E LK AR L 410
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
10-406
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 515.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 10 VVEMQ GD ---- E M TR I IW EL I KEKLIFP Y --- VELDLHSY D L G IEN RD A T N D QVTKDA AEAIK K Y N VG V K CATI TP DE kr 82
Cdd:COG0538 21 IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk RDIEWKEV D A G EKA RD E T G D WLPDET AEAIK E Y G VG I K GPLT TP VG -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 83 veefklk QM W K S P N G TIR N IL GGT V F R EAI - IC K NI P RL V SGWV K - P I I I G R HAYG D Q Y RATDFVVPG P GKVEISYTPR D 160
Cdd:COG0538 99 ------- GG W R S L N V TIR Q IL DLY V C R RPV r YF K GV P SP V KHPE K v D I V I F R ENTE D I Y AGIEWKAGS P EALKLIFFLE D 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 161 G spk M TYM V HD F TDCG G VAMGMYN q D KSI E DFAHSSF Q M AL SKG - WPLY L ST K NT I L K KYD G R FKD IFQ E IYDKQYKSQ F 239
Cdd:COG0538 172 E --- M GVT V IR F PEDS G IGIKPVS - D EGT E RLVRAAI Q Y AL DNK r KSVT L VH K GN I M K FTE G A FKD WGY E VAEEEFGDK F 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 240 ------------- E A Q KI W Y EH R LI DDM VA Q AMKSE G G - FIW A C KN YD GD VQ SD SV A QGY G S LG MMTSVL I CP DG K t V E A 305
Cdd:COG0538 248 itegpwekykgpk P A G KI V Y KD R IA DDM LQ Q ILLRP G E y DVI A T KN LN GD YI SD AL A AQV G G LG IAPGAN I GD DG G - A E F 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 306 EA A HGT VTRH yrmyqk GQET STNP IAS I FAW T RG L A HR AK L DS nkelsif A NAL E EVCIE TIE A G FM T K DLA ACIK G LP n 385
Cdd:COG0538 327 EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HR GW L EA ------- A DLI E KAVEK TIE S G KV T Y DLA RLME G AT - 392
410 420
....*....|....*....|.
gi 545875430 386 vqrsd Y L N T F EF M D KLG ENL K 406
Cdd:COG0538 393 ----- E L S T S EF G D AII ENL D 408
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
11-401
4.53e-89
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 273.40
E-value: 4.53e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 11 VEMQ G D E MTRIIWELI K EK L IFPYV E LDLHSY D L G IENR D A T NDQVTKDAA EA I KK YNVGVKC A TIT P D ---- EK R V E EF 86
Cdd:pfam00180 7 GDGI G P E VMAAALKVL K AA L EKAPL E FEFEER D V G GAAI D E T GEPLPDETL EA C KK ADAVLLG A VGG P K wdpa GV R P E NG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 87 k L KQMW K SP n G TIR N ILGGT VF R e AIICKNIPRLVSGW V K p I I I G R HAY G DQ Y RATDFVVP G P G KV eisytprdgspkmt 166
Cdd:pfam00180 87 - L LALR K EL - G LFA N LRPAK VF P - PLGDASPLKNEVEG V D - I V I V R ELT G GI Y FGIEKGIK G S G NE -------------- 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 167 ymvhdftdc GG V AMGM Y NQ D K s IE DF A HSS F QM A LSK G - WPLYLST K NTI LK KY D g RFKD I FQ E IYDKQ Y K sqfeaq KIW 245
Cdd:pfam00180 149 --------- VA V DTKL Y SR D E - IE RI A RVA F EL A RKR G r KKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVE 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 246 Y EH R L I D DMVA Q AM K SEGG F - IWACK N YD GD VQ SD SVAQGY GSLG MMT S VLICPD G k TVEA E AA HG TVTRHYR myq KG Q e 324
Cdd:pfam00180 212 L EH Q L V D NAAM Q LV K NPSQ F d VIVTP N LF GD IL SD EASMLT GSLG LLP S ASLGAN G - FGIF E PV HG SAPDIAG --- KG I - 286
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 545875430 325 ts T NPIA S I FAWTRG L AHRAK L DSN kelsif A NAL E EVCIETI E A G FM T K DLA A cikglpnvq RSD Y LN T F EF MDKL 401
Cdd:pfam00180 287 -- A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL E S G IR T G DLA G --------- SAT Y VS T S EF GEAV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
10-405
1.44e-52
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 180.61
E-value: 1.44e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 10 V V EMQ G D EMTR IIWE LI KE K L I F P Y V ELD - LHSY DL GIE NRD A T N DQV TK D AA EA IKKYNVGV K CA TITP DEKR V EEFK L 88
Cdd:PLN00096 1 M V YVA G E EMTR YTMD LI LA K W I E P H V DTS a WEFF DL RAK NRD D T E DQV LR D VI EA GARLKAIF K EP TITP TADQ V KRLG L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 89 K QM W K SPNG TI R NILG G - T VF R EA I ick N I PRLVS G WV KP IIIG RHA Y G DQ Y R A t DFVVP G P G KVEISYT P RD G SPKMTY 167
Cdd:PLN00096 81 K KA W G SPNG AM R RGWN G i T IS R DT I --- H I DGVEL G YK KP VFFE RHA V G GE Y S A - GYKIV G K G TLVTTFV P EE G GKPIVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 168 MVHDF TD CGGVAMGMY N QDKSIEDF A HSS F QMA L SK G WPL Y LS TK N T IL k K YDGR F KD I FQEIY D KQY KS Q F EAQKIWYE 247
Cdd:PLN00096 157 DDRTI TD DLNAVVTYH N PLDNVHHL A RIF F GRC L DA G IVP Y VV TK K T VF - K WQEP F WE I MKKVF D EEF KS K F VDKGVMKS 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 248 ----- H R L I D dmv A QA MK ---- SE GGF IW A CK NYDGDV QS D SV AQ GYG S L G MM TS V L ICP D GKTV --- E A EA A HGTVT RH 315
Cdd:PLN00096 236 gdelv H L L S D --- A AT MK lvvw TD GGF GM A AH NYDGDV LT D EL AQ VHK S P G FI TS N L VGV D ENGT lik E F EA S HGTVT DM 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545875430 316 YRMYQK G Q ETS T NP IASIFAWTRGLA H R A KLDSN KE LSI - F ANA L EE V CIETIEA G FM T K DL AA cikglpnvqr SDY L N T 394
Cdd:PLN00096 313 DEARLR G E ETS L NP LGMVEGLIGAMN H A A DVHGG KE RVH p F TAK L RA V IHKLFRE G RG T R DL CG ---------- AGG L T T 382
410
....*....|.
gi 545875430 395 FE F M D KLG E N L 405
Cdd:PLN00096 383 EQ F I D AVA E E L 393
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
