TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1191855641  927 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 969
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191855641   356 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 391
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191855641  1080 DVDECQDPTACRHG-RCVNLPGSYRCECRPPWVPGPS 1115
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 1191855641   864 DIDECSqDPGLCLPHGACENLQGSYVCICDEGFT 897
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191855641   824 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 863
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|
gi 1191855641  1034 DVDECLDESNCRNG-VCENTRGGYRCACTP 1062
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  292 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 322
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1191855641  927 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 969
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191855641   356 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 391
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191855641  1080 DVDECQDPTACRHG-RCVNLPGSYRCECRPPWVPGPS 1115
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1191855641   658 DLNECSKPHLCGDGGFCINFPGHYKCNCYPGYR 690
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191855641 1080 DVDECQDPTACR-HGRCVNLPGSYRCECRppwvPGPSGRDCQ 1120
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCP----PGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191855641  783 DVDECEAGDVCDN-GICNNTPGSFQCQCLSGYHLSR 817
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191855641 1144 GMCAVPVSGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1191855641  864 DIDECSQdPGLCLPHGACENLQGSYVCICDEGFT 897
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191855641  488 PPKPQQLPESPSRAPPPEDTEEERGVSTDSPVVEEHSAQQShPTVTTSPARPYPELISRPSPPR-----FLPDLPPSRSA 562
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRstesfALPPDQPERPP 2909

                           90
                   ....*....|...
gi 1191855641  563 VEIAPTQVTETDE 575
Cdd:PHA03247  2910 QPQAPPPPQPQPQ 2922

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  783 DVDEC-EAGDVCD-NGICNNTPGSFQCQCLSG 812
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  356 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 385
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1191855641 1034 DVDECLDESNCRN-GVCENTRGGYRCACTP 1062
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 1191855641  765 RCTCAQGYAPSPDGRSCLDVDE 786
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  292 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 322
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191855641  701 DIDECRDPS-SCPDS-KCENKPGSFKCIaCPPG 731
Cdd:pfam07645    1 DVDECATGThNCPANtVCVNTIGSFECR-CPDG 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1191855641  927 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 969
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191855641   356 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 391
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191855641  1080 DVDECQDPTACRHG-RCVNLPGSYRCECRPPWVPGPS 1115
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1191855641   658 DLNECSKPHLCGDGGFCINFPGHYKCNCYPGYR 690
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191855641 1080 DVDECQDPTACR-HGRCVNLPGSYRCECRppwvPGPSGRDCQ 1120
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCP----PGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191855641  783 DVDECEAGDVCDN-GICNNTPGSFQCQCLSGYHLSR 817
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191855641 1144 GMCAVPVSGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1191855641  864 DIDECSQdPGLCLPHGACENLQGSYVCICDEGFT 897
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191855641  488 PPKPQQLPESPSRAPPPEDTEEERGVSTDSPVVEEHSAQQShPTVTTSPARPYPELISRPSPPR-----FLPDLPPSRSA 562
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRstesfALPPDQPERPP 2909

                           90
                   ....*....|...
gi 1191855641  563 VEIAPTQVTETDE 575
Cdd:PHA03247  2910 QPQAPPPPQPQPQ 2922

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  783 DVDEC-EAGDVCD-NGICNNTPGSFQCQCLSG 812
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  356 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 385
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1191855641 1034 DVDECLDESNCRN-GVCENTRGGYRCACTP 1062
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191855641  485 PDGPPKPQQLPESPSRAPPPEDTEEErgvSTDSPVVEEHSAQQSHPTVTTSPARPYPELISRPSPPRfLPDLPPSRSAVE 564
Cdd:NF041121    29 PTAASQPATPPPPAAPPSPPGDPPEP---PAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVR-VPAPPALPNPLE 104

                   ..
gi 1191855641  565 IA 566
Cdd:NF041121   105 LA 106

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 1191855641  765 RCTCAQGYAPSPDGRSCLDVDE 786
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191855641  292 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 322
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1191855641  661 ECSKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 694
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191855641  614 DVNECE-AEPCGAGrGICMNTGGSYNCHCNRGYRLH 648
Cdd:cd00054      1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35