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Conserved domains on  [gi|530366462|ref|XP_005273312|]
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C4b-binding protein beta chain isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 22-133 1.93e-13

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 67.37  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  22 CPELPPVDNSIFVAKE---VEGQILgTYVCIKGYHLVGKKTLFCNASkEWDNTTTeCRLGHCPDPVLVNGEFSSSGPVNV 98
Cdd:PHA02927 148 CQSPPSISNGRHNGYEdfyTDGSVV-TYSCNSGYSLIGNSGVLCSGG-EWSDPPT-CQIVKCPHPTISNGYLSSGFKRSY 224

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530366462  99 S--DKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:PHA02927 225 SynDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 22-133 1.93e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 67.37  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  22 CPELPPVDNSIFVAKE---VEGQILgTYVCIKGYHLVGKKTLFCNASkEWDNTTTeCRLGHCPDPVLVNGEFSSSGPVNV 98
Cdd:PHA02927 148 CQSPPSISNGRHNGYEdfyTDGSVV-TYSCNSGYSLIGNSGVLCSGG-EWSDPPT-CQIVKCPHPTISNGYLSSGFKRSY 224

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530366462  99 S--DKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:PHA02927 225 SynDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 80-134 7.94e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.24  E-value: 7.94e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530366462  80 CPDP-VLVNGEFS-SSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK 134
Cdd:cd00033    1 CPPPpVPENGTVTgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 80-133 7.25e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.60  E-value: 7.25e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366462    80 CPDP-VLVNGEF-SSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:smart00032   1 CPPPpDIENGTVtSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
80-133 3.62e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 3.62e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366462   80 CPDP-VLVNGEFSSS-GPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:pfam00084   1 CPPPpDIPNGKVSATkNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 22-133 1.93e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 67.37  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  22 CPELPPVDNSIFVAKE---VEGQILgTYVCIKGYHLVGKKTLFCNASkEWDNTTTeCRLGHCPDPVLVNGEFSSSGPVNV 98
Cdd:PHA02927 148 CQSPPSISNGRHNGYEdfyTDGSVV-TYSCNSGYSLIGNSGVLCSGG-EWSDPPT-CQIVKCPHPTISNGYLSSGFKRSY 224

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530366462  99 S--DKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:PHA02927 225 SynDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
PHA02639 PHA02639
EEV host range protein; Provisional
 46-136 3.92e-10

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 58.52  E-value: 3.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  46 YVCIKGYHLVGKKTLFCNASKE---WDNTTTECRLGHCPDP-VLVNGE-FSSSGPVNVSDKITFMCNDH----YILKGSN 116
Cdd:PHA02639  48 YTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCMLKECNDPpSIINGKiYNKREMYKVGDEIYYVCNEHkgvqYSLVGNE 127

                         90       100
                 ....*....|....*....|
gi 530366462 117 RSQCLEDHTWAPPFPICKSI 136
Cdd:PHA02639 128 KITCIQDKSWKPDPPICKMI 147
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 80-134 7.94e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.24  E-value: 7.94e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530366462  80 CPDP-VLVNGEFS-SSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK 134
Cdd:cd00033    1 CPPPpVPENGTVTgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 80-133 7.25e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.60  E-value: 7.25e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366462    80 CPDP-VLVNGEF-SSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:smart00032   1 CPPPpDIENGTVtSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 16-133 2.90e-08

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 52.25  E-value: 2.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  16 SASDEHCPELPP--VDNSIFVAKEV--EGQILgTYVCIKG-----YHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLV 86
Cdd:PHA02817  17 SLCDLNKCCYPPsiKNGYIYNKKTEynIGSNV-TFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQ 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530366462  87 NGeFSSSGPVN----VSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:PHA02817  96 NG-FVNGIPDSkkfyYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPIC 145
Sushi pfam00084
Sushi repeat (SCR repeat);
80-133 3.62e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 3.62e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366462   80 CPDP-VLVNGEFSSS-GPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
Cdd:pfam00084   1 CPPPpDIPNGKVSATkNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 45-133 1.01e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 48.06  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  45 TYVC----IKGYHLVGKKTLFCnASKEWDNTTTECRLGHCPDPVLVNGEFSS-SGPVNVSDKITFMCNDHYILKGSNRSQ 119
Cdd:PHA02831 103 TYACkvnkLEKYSIVGNETVKC-INKQWVPKYPVCKLIRCKYPALQNGFLNVfEKKFYYGDIVNFKCKKGFILLGSSVST 181

                         90
                 ....*....|....
gi 530366462 120 CLEDHTWAPPFPIC 133
Cdd:PHA02831 182 CDINSIWYPGIPKC 195
PHA02639 PHA02639
EEV host range protein; Provisional
 46-133 6.53e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 45.81  E-value: 6.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  46 YVCI--KG--YHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFS---SSGPVNVSDKITFMCNDHYILKGSNRS 118
Cdd:PHA02639 111 YVCNehKGvqYSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNGYINgipSNKKFYYKTRVGFSCKSGFDLVGEKYS 190

                         90
                 ....*....|....*
gi 530366462 119 QCLEDHTWAPPFPIC 133
Cdd:PHA02639 191 TCNINATWFPSIPTC 205
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 22-76 1.18e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 1.18e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530366462  22 CPELPPVDNSIFV---AKEVEGQILgTYVCIKGYHLVGKKTLFCNASKEWDNTTTECR 76
Cdd:cd00033    1 CPPPPVPENGTVTgskGSYSYGSTV-TYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 46-141 1.40e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 45.03  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  46 YVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHT 125
Cdd:PHA02927  52 YLCLPGYRKQKMGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGST 131

                         90       100
                 ....*....|....*....|
gi 530366462 126 ----WAPPFPICKSIPQTRP 141
Cdd:PHA02927 132 gsmvWNPEAPICESVKCQSP 151
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 22-75 4.78e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.82  E-value: 4.78e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 530366462    22 CPELPPVDNSIFVAKE---VEGQILgTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC 75
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtySYGDTV-TYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 45-133 4.62e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 40.45  E-value: 4.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366462  45 TYVCIKGYHLVGKKTLFCNASkEWdNTTTECRlGHCPDPVLVNGEFSSSgPVNVSDKITFMCNDHYILKGSNRSQCLeDH 124
Cdd:PHA02954 154 TINCDVGYEVIGASYISCTAN-SW-NVIPSCQ-QKCDIPSLSNGLISGS-TFSIGGVIHLSCKSGFTLTGSPSSTCI-DG 228


                 ....*....
gi 530366462 125 TWAPPFPIC 133
Cdd:PHA02954 229 KWNPVLPIC 237
PHA02817 PHA02817
EEV Host range protein; Provisional
 80-136 2.37e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 38.00  E-value: 2.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530366462  80 CPDPVLVNGEFSSSGPV-NVSDKITFMCNDH-----YILKGSNRSQCLEDHTWAPPFPICKSI 136
Cdd:PHA02817  25 CYPPSIKNGYIYNKKTEyNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCKII 87
PHA02831 PHA02831
EEV host range protein; Provisional
 79-136 7.93e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 36.51  E-value: 7.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530366462  79 HCPDPVLV-NGEFSS-SGPVNVSDKITFMCN----DHYILKGSNRSQCLeDHTWAPPFPICKSI 136
Cdd:PHA02831  77 NCKDPVTIlNGYIKNkKDQYSFGDSVTYACKvnklEKYSIVGNETVKCI-NKQWVPKYPVCKLI 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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