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Conserved domains on  [gi|530397963|ref|XP_005271547|]
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tripartite motif-containing protein 29 isoform X4 [Homo sapiens]

Protein Classification

OmpH family outer membrane protein( domain architecture ID 12048616)

OmpH family outer membrane protein may play an active role either as folding catalysts or as chaperones in extracytoplasmic compartments; similar to Flavobacterium psychrophilum outer membrane protein P18

Gene Ontology:  GO:0051082|GO:0016020
PubMed:  2318304

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1-88 9.80e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


:

Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.79  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963    1 MTELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 79
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQPIqDKI 100


                  ....*....
gi 530397963   80 MDALDERAK 88
Cdd:pfam03938 101 NKAIKEVAK 109
 
Name Accession Description Interval E-value
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1-88 9.80e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.79  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963    1 MTELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 79
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQPIqDKI 100


                  ....*....
gi 530397963   80 MDALDERAK 88
Cdd:pfam03938 101 NKAIKEVAK 109
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 9-102 5.95e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.61  E-value: 5.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963   9 EQLQLKIIEIEDEAEKWQKEKDrIKSFttnEKAileQNFRDLVRDLEKQKEEVRAALEQrEQDAVDQVKVIMDALDERAK 88
Cdd:COG0542  414 DELERRLEQLEIEKEALKKEQD-EASF---ERL---AELRDELAELEEELEALKARWEA-EKELIEEIQELKEELEQRYG 485

                         90
                 ....*....|....
gi 530397963  89 VLHEDKQTREQLHS 102
Cdd:COG0542  486 KIPELEKELAELEE 499
PRK12704 PRK12704
phosphodiesterase; Provisional
 8-104 3.28e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 38.99  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963   8 KEQLQLKIIEIEDEAEKWQKE-----KDRIKSFTTNEKAIL--EQNFRDLVRDLEKQKEEV---RAALEQREQDavdqvk 77
Cdd:PRK12704  52 EAIKKEALLEAKEEIHKLRNEfekelRERRNELQKLEKRLLqkEENLDRKLELLEKREEELekkEKELEQKQQE------ 125

                         90       100
                 ....*....|....*....|....*...
gi 530397963  78 vimdaLDERAKVLHE-DKQTREQLHSIS 104
Cdd:PRK12704 126 -----LEKKEEELEElIEEQLQELERIS 148
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-88 3.62e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 37.18  E-value: 3.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963     7 QKEQLQLKIIEIEDEAEKWQKEKDrikSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVIMDALDE 85
Cdd:smart00935  30 RQAELEKLEKELQKLKEKLQKDAA---TLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQKIlDKINKAIKE 106


                   ...
gi 530397963    86 RAK 88
Cdd:smart00935 107 VAK 109
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-100 6.13e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963     3 ELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVR---DLEKQKEEVRAALEQREQ------DAV 73
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAlrkDLARLEAEVEQLEERIAQlskeltELE 760

                           90       100
                   ....*....|....*....|....*..
gi 530397963    74 DQVKVIMDALDERAKVLHEDKQTREQL 100
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEEL 787
 
Name Accession Description Interval E-value
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1-88 9.80e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.79  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963    1 MTELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 79
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQPIqDKI 100


                  ....*....
gi 530397963   80 MDALDERAK 88
Cdd:pfam03938 101 NKAIKEVAK 109
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 9-102 5.95e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.61  E-value: 5.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963   9 EQLQLKIIEIEDEAEKWQKEKDrIKSFttnEKAileQNFRDLVRDLEKQKEEVRAALEQrEQDAVDQVKVIMDALDERAK 88
Cdd:COG0542  414 DELERRLEQLEIEKEALKKEQD-EASF---ERL---AELRDELAELEEELEALKARWEA-EKELIEEIQELKEELEQRYG 485

                         90
                 ....*....|....
gi 530397963  89 VLHEDKQTREQLHS 102
Cdd:COG0542  486 KIPELEKELAELEE 499
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 17-88 7.08e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 39.82  E-value: 7.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963  17 EIEDEAEKWQKEKDRI---------------KSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVIM 80
Cdd:COG2825   47 KLEKEFKKRQAELQKLekelqalqeklqkeaATLSEEERQKKERELQKKQQELQRKQQEAQQDLQKRQQELLQPIlEKIQ 126


                 ....*...
gi 530397963  81 DALDERAK 88
Cdd:COG2825  127 KAIKEVAK 134
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
9-100 8.08e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 8.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963   9 EQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKailEQNFRDLVRDLEKQKEEVRAALEQRE--QDAVDQVKVIMDALDER 86
Cdd:COG4717  159 RELEEELEELEAELAELQEELEELLEQLSLAT---EEELQDLAEELEELQQRLAELEEELEeaQEELEELEEELEQLENE 235

                         90
                 ....*....|....
gi 530397963  87 AKVLHEDKQTREQL 100
Cdd:COG4717  236 LEAAALEERLKEAR 249
PRK12704 PRK12704
phosphodiesterase; Provisional
 8-104 3.28e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 38.99  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963   8 KEQLQLKIIEIEDEAEKWQKE-----KDRIKSFTTNEKAIL--EQNFRDLVRDLEKQKEEV---RAALEQREQDavdqvk 77
Cdd:PRK12704  52 EAIKKEALLEAKEEIHKLRNEfekelRERRNELQKLEKRLLqkEENLDRKLELLEKREEELekkEKELEQKQQE------ 125

                         90       100
                 ....*....|....*....|....*...
gi 530397963  78 vimdaLDERAKVLHE-DKQTREQLHSIS 104
Cdd:PRK12704 126 -----LEKKEEELEElIEEQLQELERIS 148
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-88 3.62e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 37.18  E-value: 3.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963     7 QKEQLQLKIIEIEDEAEKWQKEKDrikSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVIMDALDE 85
Cdd:smart00935  30 RQAELEKLEKELQKLKEKLQKDAA---TLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQKIlDKINKAIKE 106


                   ...
gi 530397963    86 RAK 88
Cdd:smart00935 107 VAK 109
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3-113 5.98e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963   3 ELSLQKEQLQlkiIEIEDEAEKWQKEKDRIKSFTTNEKAI--LEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVI- 79
Cdd:COG4717  129 PLYQELEALE---AELAELPERLEELEERLEELRELEEELeeLEAELAELQEELEELLEQLSLATEEELQDLAEELEELq 205

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530397963  80 --MDALDERAKVLHEDKQT-REQLHSISDSVLFLQEF 113
Cdd:COG4717  206 qrLAELEEELEEAQEELEElEEELEQLENELEAAALE 242
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-100 6.13e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397963     3 ELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVR---DLEKQKEEVRAALEQREQ------DAV 73
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAlrkDLARLEAEVEQLEERIAQlskeltELE 760

                           90       100
                   ....*....|....*....|....*..
gi 530397963    74 DQVKVIMDALDERAKVLHEDKQTREQL 100
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEEL 787
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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