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Conserved domains on  [gi|530393964|ref|XP_005270020|]
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WD repeat-containing protein 11 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-561 5.99e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 5.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 228 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 306
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 307 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHnlkslrkKQLATreAMARQTV-- 384
Cdd:COG2319  164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 385 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 458
Cdd:COG2319  231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 459 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 534
Cdd:COG2319  296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373
                        330       340
                 ....*....|....*....|....*...
gi 530393964 535 vtfRILDVDWCTSDKVIL-ASDDGCIRV 561
Cdd:COG2319  374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-561 5.99e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 5.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 228 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 306
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 307 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHnlkslrkKQLATreAMARQTV-- 384
Cdd:COG2319  164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 385 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 458
Cdd:COG2319  231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 459 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 534
Cdd:COG2319  296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373
                        330       340
                 ....*....|....*....|....*...
gi 530393964 535 vtfRILDVDWCTSDKVIL-ASDDGCIRV 561
Cdd:COG2319  374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
226-561 3.77e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 3.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 226 QPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNMglvrneLQLVDLPTGRSIA-FRGe 304
Cdd:cd00200   21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKT------IRLWDLETGECVRtLTG- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 305 rgnDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrkKQLATreamarqTV 384
Cdd:cd00200   92 ---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--------GTFVA-------SS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 385 VSDTELSIVESSVISLLQeaeskselsqnisarehfVFTDIDGQVYHLTVEGNsvkdsarippdgsmgsitciawkGDTL 464
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVA------------------TLTGHTGEVNSVAFSPD-----------------------GEKL 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 465 VLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkgNQKLIAMYN-DGA-EVWDTKEVQMVSSLRSGRNvtfRILD 541
Cdd:cd00200  193 LSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSP---DGYLLASGSeDGTiRVWDLRTGECVQTLSGHTN---SVTS 266
                        330       340
                 ....*....|....*....|.
gi 530393964 542 VDWCTSDKVIL-ASDDGCIRV 561
Cdd:cd00200  267 LAWSPDGKRLAsGSADGTIRI 287
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-561 5.99e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 5.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 228 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 306
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 307 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHnlkslrkKQLATreAMARQTV-- 384
Cdd:COG2319  164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 385 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 458
Cdd:COG2319  231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 459 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 534
Cdd:COG2319  296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373
                        330       340
                 ....*....|....*....|....*...
gi 530393964 535 vtfRILDVDWCTSDKVIL-ASDDGCIRV 561
Cdd:COG2319  374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
226-561 3.77e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 3.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 226 QPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNMglvrneLQLVDLPTGRSIA-FRGe 304
Cdd:cd00200   21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKT------IRLWDLETGECVRtLTG- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 305 rgnDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrkKQLATreamarqTV 384
Cdd:cd00200   92 ---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--------GTFVA-------SS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 385 VSDTELSIVESSVISLLQeaeskselsqnisarehfVFTDIDGQVYHLTVEGNsvkdsarippdgsmgsitciawkGDTL 464
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVA------------------TLTGHTGEVNSVAFSPD-----------------------GEKL 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 465 VLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkgNQKLIAMYN-DGA-EVWDTKEVQMVSSLRSGRNvtfRILD 541
Cdd:cd00200  193 LSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSP---DGYLLASGSeDGTiRVWDLRTGECVQTLSGHTN---SVTS 266
                        330       340
                 ....*....|....*....|.
gi 530393964 542 VDWCTSDKVIL-ASDDGCIRV 561
Cdd:cd00200  267 LAWSPDGKRLAsGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
228-521 5.48e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 5.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 228 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 306
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL--ASGSDDG------TVRLWDLATGKLLRtLTGHTG 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 307 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNL-------KSLRKKQLATREAM 379
Cdd:COG2319  206 ----AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLlasgsadGTVRLWDLATGELL 281
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 380 ARQTVVSDTELSIVessvisllqeaeskselsqnISA-REHFVFTDIDGQVYHLTVEGNSVKDSaripPDGSMGSITCIA 458
Cdd:COG2319  282 RTLTGHSGGVNSVA--------------------FSPdGKLLASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVA 337
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530393964 459 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTK 521
Cdd:COG2319  338 FspDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSP--DGRTLASGSADGtVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
228-565 2.10e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 228 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTpnnmglvrNELQLVDLPTGRSIAFRGERgn 307
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--------GTVRLWDLATGLLLRTLTGH-- 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 308 dESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrKKQLATreamarqtvvsd 387
Cdd:COG2319  120 -TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-------GKLLAS------------ 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 388 telsivessvisllqeaeskselsqnisarehfvfTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIAW--KGDTLV 465
Cdd:COG2319  180 -----------------------------------GSDDGTVRLWDLATGKL----LRTLTGHTGAVRSVAFspDGKLLA 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 466 LGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRNvtfRILDVD 543
Cdd:COG2319  221 SGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSP--DGRLLASGSADGtVRLWDLATGELLRTLTGHSG---GVNSVA 295
                        330       340
                 ....*....|....*....|...
gi 530393964 544 WCTSDKVIL-ASDDGCIRVLEMS 565
Cdd:COG2319  296 FSPDGKLLAsGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
225-519 1.64e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 225 YQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSfaTSTPNNmglvrnELQLVDLPTGRSI-AFRG 303
Cdd:cd00200   62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS--SSSRDK------TIKVWDVETGKCLtTLRG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 304 ERGndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrKKQLAtreamarqT 383
Cdd:cd00200  134 HTD----WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-------GEKLL--------S 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 384 VVSDTELSIVESSVISLLQEAESKSElsqnisarehfvftdidgqvyhltvegnsvkdsarippdgsmgSITCIAW--KG 461
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRGHEN-------------------------------------------GVNSVAFspDG 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 462 DTLVLGDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWD 519
Cdd:cd00200  232 YLLASGSEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSP--DGKRLASGSADGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
271-561 2.56e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 271 LSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKN 350
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 351 FPTITALEWSPSHnlkslrkKQLATreAMARQTVVsdtelsivessvisllqeaeskselsqnisarehfVFTDIDGQVY 430
Cdd:COG2319  120 TGAVRSVAFSPDG-------KTLAS--GSADGTVR-----------------------------------LWDLATGKLL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 431 HlTVEGNSvkdsarippdgsmGSITCIAW--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKL 507
Cdd:COG2319  156 R-TLTGHS-------------GAVTSVAFspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKLL 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530393964 508 IAMYNDG-AEVWDTKEVQMVSSLRSGrnvTFRILDVDWCTSDKVIL-ASDDGCIRV 561
Cdd:COG2319  220 ASGSADGtVRLWDLATGKLLRTLTGH---SGSVRSVAFSPDGRLLAsGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
452-589 2.54e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393964 452 GSITCIAWKGDTLVL--GDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkgNQKLIA--MYNDGAEVWDtkevqmv 526
Cdd:cd00200   94 SYVSSVAFSPDGRILssSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP---DGTFVAssSQDGTIKLWD------- 163
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530393964 527 ssLRSGRNV-TFR-----ILDVDWC-TSDKVILASDDGCIRVLEMSMKS--ACFRMDEQELTEPVWCP--YLLV 589
Cdd:cd00200  164 --LRTGKCVaTLTghtgeVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHENGVNSVAFSPdgYLLA 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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