sideroflexin-4 isoform X3 [Homo sapiens]
Protein Classification
sideroflexin family transporter( domain architecture ID 2167)
sideroflexin family transporter is a mitochondrial membrane protein implicated in one-carbon metabolism; similar to sideroflexin-1, which acts as a mitochondrial serine transporter
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| SFXNs super family | cl04275 | Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ... |
3-220 | 3.78e-48 | ||||
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3. The actual alignment was detected with superfamily member pfam03820: Pssm-ID: 470990 Cd Length: 319 Bit Score: 160.36 E-value: 3.78e-48
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| Name | Accession | Description | Interval | E-value | ||||
| SFXNs | pfam03820 | Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ... |
3-220 | 3.78e-48 | ||||
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3. Pssm-ID: 461063 Cd Length: 319 Bit Score: 160.36 E-value: 3.78e-48
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| mtc | TIGR00798 | tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ... |
1-220 | 3.36e-21 | ||||
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 129880 Cd Length: 318 Bit Score: 89.35 E-value: 3.36e-21
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| Name | Accession | Description | Interval | E-value | ||||
| SFXNs | pfam03820 | Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ... |
3-220 | 3.78e-48 | ||||
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3. Pssm-ID: 461063 Cd Length: 319 Bit Score: 160.36 E-value: 3.78e-48
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| mtc | TIGR00798 | tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ... |
1-220 | 3.36e-21 | ||||
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 129880 Cd Length: 318 Bit Score: 89.35 E-value: 3.36e-21
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| Blast search parameters | ||||
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