nidogen-2 isoform X2 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
G2F | smart00682 | G2 nidogen domain and fibulin; |
552-784 | 1.01e-104 | ||||
G2 nidogen domain and fibulin; : Pssm-ID: 214774 Cd Length: 227 Bit Score: 331.33 E-value: 1.01e-104
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NIDO | smart00539 | Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; |
108-273 | 3.34e-51 | ||||
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; : Pssm-ID: 214712 Cd Length: 152 Bit Score: 177.23 E-value: 3.34e-51
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TY | cd00191 | Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
918-984 | 2.45e-26 | ||||
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases : Pssm-ID: 238114 Cd Length: 66 Bit Score: 102.93 E-value: 2.45e-26
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TY | cd00191 | Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
998-1063 | 3.38e-23 | ||||
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases : Pssm-ID: 238114 Cd Length: 66 Bit Score: 94.07 E-value: 3.38e-23
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1200-1244 | 8.55e-13 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. : Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.77 E-value: 8.55e-13
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
875-908 | 2.63e-12 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. : Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 62.23 E-value: 2.63e-12
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1157-1199 | 7.40e-12 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. : Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 61.08 E-value: 7.40e-12
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
828-870 | 3.41e-10 | ||||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 56.10 E-value: 3.41e-10
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1245-1287 | 8.40e-10 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. : Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 55.30 E-value: 8.40e-10
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
790-826 | 5.97e-07 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. : Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 46.82 E-value: 5.97e-07
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
515-550 | 7.88e-06 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. : Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 43.74 E-value: 7.88e-06
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1113-1151 | 2.73e-05 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. : Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.59 E-value: 2.73e-05
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Name | Accession | Description | Interval | E-value | ||||
G2F | smart00682 | G2 nidogen domain and fibulin; |
552-784 | 1.01e-104 | ||||
G2 nidogen domain and fibulin; Pssm-ID: 214774 Cd Length: 227 Bit Score: 331.33 E-value: 1.01e-104
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nidG2 | cd00255 | Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ... |
554-778 | 6.09e-103 | ||||
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria. Pssm-ID: 238158 Cd Length: 224 Bit Score: 326.19 E-value: 6.09e-103
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G2F | pfam07474 | G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ... |
554-740 | 6.63e-75 | ||||
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens. Pssm-ID: 462175 Cd Length: 184 Bit Score: 246.35 E-value: 6.63e-75
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NIDO | smart00539 | Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; |
108-273 | 3.34e-51 | ||||
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; Pssm-ID: 214712 Cd Length: 152 Bit Score: 177.23 E-value: 3.34e-51
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NIDO | pfam06119 | Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ... |
179-272 | 4.65e-33 | ||||
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function. Pssm-ID: 461833 Cd Length: 90 Bit Score: 123.17 E-value: 4.65e-33
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TY | cd00191 | Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
918-984 | 2.45e-26 | ||||
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases Pssm-ID: 238114 Cd Length: 66 Bit Score: 102.93 E-value: 2.45e-26
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Thyroglobulin_1 | pfam00086 | Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ... |
919-984 | 4.33e-26 | ||||
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6. Pssm-ID: 459665 Cd Length: 66 Bit Score: 102.38 E-value: 4.33e-26
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TY | cd00191 | Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
998-1063 | 3.38e-23 | ||||
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases Pssm-ID: 238114 Cd Length: 66 Bit Score: 94.07 E-value: 3.38e-23
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Thyroglobulin_1 | pfam00086 | Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ... |
998-1063 | 6.04e-23 | ||||
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6. Pssm-ID: 459665 Cd Length: 66 Bit Score: 93.52 E-value: 6.04e-23
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TY | smart00211 | Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
939-984 | 4.65e-17 | ||||
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin. Pssm-ID: 214561 Cd Length: 46 Bit Score: 75.88 E-value: 4.65e-17
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TY | smart00211 | Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
1019-1063 | 4.38e-16 | ||||
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin. Pssm-ID: 214561 Cd Length: 46 Bit Score: 73.18 E-value: 4.38e-16
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1200-1244 | 8.55e-13 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.77 E-value: 8.55e-13
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
875-908 | 2.63e-12 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 62.23 E-value: 2.63e-12
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1157-1199 | 7.40e-12 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 61.08 E-value: 7.40e-12
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Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
1177-1217 | 3.03e-10 | ||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 56.40 E-value: 3.03e-10
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
828-870 | 3.41e-10 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 56.10 E-value: 3.41e-10
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1245-1287 | 8.40e-10 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 55.30 E-value: 8.40e-10
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
872-909 | 1.51e-09 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 54.56 E-value: 1.51e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
872-904 | 5.30e-09 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.02 E-value: 5.30e-09
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YncE | COG3391 | DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
1064-1274 | 5.71e-09 | ||||
DNA-binding beta-propeller fold protein YncE [General function prediction only]; Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 5.71e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
828-861 | 5.73e-09 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 52.64 E-value: 5.73e-09
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
828-859 | 1.51e-07 | ||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 48.77 E-value: 1.51e-07
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Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
1220-1262 | 2.12e-07 | ||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 48.31 E-value: 2.12e-07
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
790-826 | 5.97e-07 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 46.82 E-value: 5.97e-07
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
515-550 | 7.88e-06 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 43.74 E-value: 7.88e-06
|
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1113-1151 | 2.73e-05 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.59 E-value: 2.73e-05
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NHL_PKND_like | cd14952 | NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1162-1228 | 1.77e-03 | ||||
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 1.77e-03
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Name | Accession | Description | Interval | E-value | ||||
G2F | smart00682 | G2 nidogen domain and fibulin; |
552-784 | 1.01e-104 | ||||
G2 nidogen domain and fibulin; Pssm-ID: 214774 Cd Length: 227 Bit Score: 331.33 E-value: 1.01e-104
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nidG2 | cd00255 | Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ... |
554-778 | 6.09e-103 | ||||
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria. Pssm-ID: 238158 Cd Length: 224 Bit Score: 326.19 E-value: 6.09e-103
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G2F | pfam07474 | G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ... |
554-740 | 6.63e-75 | ||||
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens. Pssm-ID: 462175 Cd Length: 184 Bit Score: 246.35 E-value: 6.63e-75
|
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NIDO | smart00539 | Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; |
108-273 | 3.34e-51 | ||||
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins; Pssm-ID: 214712 Cd Length: 152 Bit Score: 177.23 E-value: 3.34e-51
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NIDO | pfam06119 | Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ... |
179-272 | 4.65e-33 | ||||
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function. Pssm-ID: 461833 Cd Length: 90 Bit Score: 123.17 E-value: 4.65e-33
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TY | cd00191 | Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
918-984 | 2.45e-26 | ||||
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases Pssm-ID: 238114 Cd Length: 66 Bit Score: 102.93 E-value: 2.45e-26
|
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Thyroglobulin_1 | pfam00086 | Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ... |
919-984 | 4.33e-26 | ||||
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6. Pssm-ID: 459665 Cd Length: 66 Bit Score: 102.38 E-value: 4.33e-26
|
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TY | cd00191 | Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
998-1063 | 3.38e-23 | ||||
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases Pssm-ID: 238114 Cd Length: 66 Bit Score: 94.07 E-value: 3.38e-23
|
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Thyroglobulin_1 | pfam00086 | Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ... |
998-1063 | 6.04e-23 | ||||
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6. Pssm-ID: 459665 Cd Length: 66 Bit Score: 93.52 E-value: 6.04e-23
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TY | smart00211 | Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
939-984 | 4.65e-17 | ||||
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin. Pssm-ID: 214561 Cd Length: 46 Bit Score: 75.88 E-value: 4.65e-17
|
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TY | smart00211 | Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ... |
1019-1063 | 4.38e-16 | ||||
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin. Pssm-ID: 214561 Cd Length: 46 Bit Score: 73.18 E-value: 4.38e-16
|
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1200-1244 | 8.55e-13 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.77 E-value: 8.55e-13
|
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
875-908 | 2.63e-12 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 62.23 E-value: 2.63e-12
|
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1157-1199 | 7.40e-12 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 61.08 E-value: 7.40e-12
|
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Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
1177-1217 | 3.03e-10 | ||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 56.40 E-value: 3.03e-10
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
828-870 | 3.41e-10 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 56.10 E-value: 3.41e-10
|
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1245-1287 | 8.40e-10 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 55.30 E-value: 8.40e-10
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
872-909 | 1.51e-09 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 54.56 E-value: 1.51e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
872-904 | 5.30e-09 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.02 E-value: 5.30e-09
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YncE | COG3391 | DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
1064-1274 | 5.71e-09 | ||||
DNA-binding beta-propeller fold protein YncE [General function prediction only]; Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 5.71e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
828-861 | 5.73e-09 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 52.64 E-value: 5.73e-09
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
828-859 | 1.51e-07 | ||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 48.77 E-value: 1.51e-07
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Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
1220-1262 | 2.12e-07 | ||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 48.31 E-value: 2.12e-07
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
790-826 | 5.97e-07 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 46.82 E-value: 5.97e-07
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EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
874-905 | 6.42e-07 | ||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 47.09 E-value: 6.42e-07
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
832-869 | 1.04e-06 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 46.44 E-value: 1.04e-06
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
515-550 | 7.88e-06 | ||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 43.74 E-value: 7.88e-06
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EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
831-861 | 9.53e-06 | ||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 43.62 E-value: 9.53e-06
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
845-869 | 1.17e-05 | ||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 43.39 E-value: 1.17e-05
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
872-900 | 2.07e-05 | ||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 42.61 E-value: 2.07e-05
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LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
1113-1151 | 2.73e-05 | ||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.59 E-value: 2.73e-05
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
823-865 | 3.05e-05 | ||||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 46.99 E-value: 3.05e-05
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NHL_PKND_like | cd14952 | NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1135-1229 | 4.87e-05 | ||||
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 46.43 E-value: 4.87e-05
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
875-904 | 8.16e-05 | ||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.83 E-value: 8.16e-05
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EGF | smart00181 | Epidermal growth factor-like domain; |
874-904 | 1.57e-04 | ||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 40.19 E-value: 1.57e-04
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EGF | smart00181 | Epidermal growth factor-like domain; |
831-870 | 6.64e-04 | ||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 38.27 E-value: 6.64e-04
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Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
1135-1174 | 8.41e-04 | ||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 38.29 E-value: 8.41e-04
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SGL | pfam08450 | SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ... |
1125-1290 | 8.85e-04 | ||||
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE. Pssm-ID: 462480 [Multi-domain] Cd Length: 246 Bit Score: 42.63 E-value: 8.85e-04
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YvrE | COG3386 | Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1130-1277 | 1.70e-03 | ||||
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.80 E-value: 1.70e-03
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NHL_PKND_like | cd14952 | NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1162-1228 | 1.77e-03 | ||||
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 1.77e-03
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NHL_like_5 | cd14963 | Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1093-1262 | 2.61e-03 | ||||
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 41.12 E-value: 2.61e-03
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Vgb | COG4257 | Streptogramin lyase [Defense mechanisms]; |
1160-1344 | 2.91e-03 | ||||
Streptogramin lyase [Defense mechanisms]; Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 41.16 E-value: 2.91e-03
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
812-831 | 7.45e-03 | ||||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 35.08 E-value: 7.45e-03
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
853-874 | 7.68e-03 | ||||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 35.08 E-value: 7.68e-03
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hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
880-901 | 7.99e-03 | ||||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 35.00 E-value: 7.99e-03
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