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Conserved domains on  [gi|530383347|ref|XP_005266870|]
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kelch-like protein 32 isoform X1 [Homo sapiens]

Protein Classification

kelch-like protein 32( domain architecture ID 20003498)

kelch-like protein 32 (KLHL32) may be ssociated with Tourette syndrome and obsessive-compulsive disorder in humans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 70-167 6.25e-65

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


:

Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 206.29  E-value: 6.25e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*...
gi 530383347 150 CHYQYMDELLQYIRFGLM 167
Cdd:cd18471   81 CRYQYMDELLQYVRFGLM 98
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1-77 1.95e-50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18261:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 133  Bit Score: 169.76  E-value: 1.95e-50
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLD 77
Cdd:cd18261   57 MFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
255-526 2.22e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 2.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 255 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 333
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 334 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 410
Cdd:COG3055   76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 411 MLQRRVYHSMAAV-QRKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGYSIW 489
Cdd:COG3055  155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 530383347 490 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 526
Cdd:COG3055  219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
Kelch smart00612
Kelch domain;
222-277 1.10e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   222 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 277
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 70-167 6.25e-65

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 206.29  E-value: 6.25e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*...
gi 530383347 150 CHYQYMDELLQYIRFGLM 167
Cdd:cd18471   81 CRYQYMDELLQYVRFGLM 98
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-77 1.95e-50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 169.76  E-value: 1.95e-50
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLD 77
Cdd:cd18261   57 MFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
255-526 2.22e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 2.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 255 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 333
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 334 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 410
Cdd:COG3055   76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 411 MLQRRVYHSMAAV-QRKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGYSIW 489
Cdd:COG3055  155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 530383347 490 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 526
Cdd:COG3055  219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 24-521 2.68e-32

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 130.27  E-value: 2.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  24 LKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLS 103
Cdd:PHA03098  59 FNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIE 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 104 ELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPL 181
Cdd:PHA03098 139 LIYND--PDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSkkNNKYKDICLILKVLRITFLSEEGIKKLKRWKLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 182 VQASetaTALVNEALE---YHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENAliaaianws 258
Cdd:PHA03098 217 IKKK---KIVFNKRCIkiiYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--------- 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 259 elapmpvgRSHHCVAVMGDFLFVAGGEVEhasgRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRn 338
Cdd:PHA03098 285 --------VYCFGSVVLNNVIYFIGGMNK----NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI- 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 339 ELRQVLPTVERYCPKKNKWTFVQS--FDRSLSCHAGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRV 416
Cdd:PHA03098 352 YNSISLNTVESWKPGESKWREEPPliFPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHY 429

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 417 YHSMAAVQRKLYVLGGndLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEpl 494
Cdd:PHA03098 430 GGCAIYHDGKIYVIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE-- 504

                        490       500
                 ....*....|....*....|....*..
gi 530383347 495 acIQVLDVsrEGKEEVFYGPTLPFASN 521
Cdd:PHA03098 505 --IEVYDD--KTNTWTLFCKFPKVIGS 527
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 75-175 9.38e-25

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 98.57  E-value: 9.38e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347    75 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HY 152
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSS--EEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPekRR 78

                           90       100
                   ....*....|....*....|...
gi 530383347   153 QYMDELLQYIRFGLMDVDTLHTV 175
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 76-175 2.67e-19

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 82.98  E-value: 2.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   76 LDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQ 153
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKS--EEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDveRRKK 79

                          90       100
                  ....*....|....*....|..
gi 530383347  154 YMDELLQYIRFGLMDVDTLHTV 175
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNL 101
Kelch_6 pfam13964
Kelch motif;
267-319 7.27e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.17  E-value: 7.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530383347  267 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 319
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
222-277 1.10e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   222 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 277
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
426-478 1.38e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 1.38e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530383347   426 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNG 478
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 1-68 3.48e-04

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 40.32  E-value: 3.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347    1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQIlLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQ 68
Cdd:pfam00651  39 LFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIK 105
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 1-70 5.15e-04

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 39.60  E-value: 5.15e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347     1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 70
Cdd:smart00225  28 LFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
 
Name Accession Description Interval E-value
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 70-167 6.25e-65

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 206.29  E-value: 6.25e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*...
gi 530383347 150 CHYQYMDELLQYIRFGLM 167
Cdd:cd18471   81 CRYQYMDELLQYVRFGLM 98
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-77 1.95e-50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 169.76  E-value: 1.95e-50
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLD 77
Cdd:cd18261   57 MFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
255-526 2.22e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 2.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 255 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 333
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 334 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 410
Cdd:COG3055   76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 411 MLQRRVYHSMAAV-QRKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGYSIW 489
Cdd:COG3055  155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 530383347 490 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 526
Cdd:COG3055  219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 24-521 2.68e-32

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 130.27  E-value: 2.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  24 LKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLS 103
Cdd:PHA03098  59 FNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIE 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 104 ELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPL 181
Cdd:PHA03098 139 LIYND--PDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSkkNNKYKDICLILKVLRITFLSEEGIKKLKRWKLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 182 VQASetaTALVNEALE---YHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENAliaaianws 258
Cdd:PHA03098 217 IKKK---KIVFNKRCIkiiYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--------- 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 259 elapmpvgRSHHCVAVMGDFLFVAGGEVEhasgRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRn 338
Cdd:PHA03098 285 --------VYCFGSVVLNNVIYFIGGMNK----NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI- 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 339 ELRQVLPTVERYCPKKNKWTFVQS--FDRSLSCHAGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRV 416
Cdd:PHA03098 352 YNSISLNTVESWKPGESKWREEPPliFPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHY 429

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 417 YHSMAAVQRKLYVLGGndLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEpl 494
Cdd:PHA03098 430 GGCAIYHDGKIYVIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE-- 504

                        490       500
                 ....*....|....*....|....*..
gi 530383347 495 acIQVLDVsrEGKEEVFYGPTLPFASN 521
Cdd:PHA03098 505 --IEVYDD--KTNTWTLFCKFPKVIGS 527
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
220-432 1.93e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.70  E-value: 1.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 220 DTLYIIGGkkrevckvkeLRYFNPVDQENALIAAIANWSELAPMP-VGRSHHCVAVMGDFLFVAGGEVEHASGRTcAVRT 298
Cdd:COG3055   23 GKVYVAGG----------LSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSST-PLND 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 299 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVlPTVERYCPKKNKWTFVQSFDRSLSCHAGYVA-DG 377
Cdd:COG3055   92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 378 LLWISGGVTNTAQYQ---------------------NRLMV-------------YEPNQNKWISRSPMLQRRVYHSMAAV 423
Cdd:COG3055  171 KILVIGGRNGSGFSNtwttlaplptaraghaaavlgGKILVfggesgfsdeveaYDPATNTWTALGELPTPRHGHAAVLT 250


                 ....*....
gi 530383347 424 QRKLYVLGG 432
Cdd:COG3055  251 DGKVYVIGG 259
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 75-175 9.38e-25

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 98.57  E-value: 9.38e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347    75 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HY 152
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSS--EEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPekRR 78

                           90       100
                   ....*....|....*....|...
gi 530383347   153 QYMDELLQYIRFGLMDVDTLHTV 175
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 76-175 2.67e-19

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 82.98  E-value: 2.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   76 LDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQ 153
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKS--EEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDveRRKK 79

                          90       100
                  ....*....|....*....|..
gi 530383347  154 YMDELLQYIRFGLMDVDTLHTV 175
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNL 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
218-399 1.29e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.20  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 218 QSDTLYIIGGKKREVCKVKELR---YFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHAsgrtc 294
Cdd:COG3055   69 QDGKLYVFGGFTGANPSSTPLNdvyVYDPATNT---------WTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG----- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 295 AVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEE-YLYAVGGRNE---------------------------------- 339
Cdd:COG3055  135 NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfgg 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 340 LRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYE 399
Cdd:COG3055  215 ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-71 1.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 67.42  E-value: 1.33e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 71
Cdd:cd18255   47 MFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMS 117
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 70-149 9.06e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 60.80  E-value: 9.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQS--QEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHD 78
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 70-199 3.02e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 61.26  E-value: 3.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQH--EEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530383347 150 CH--YQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYH 199
Cdd:cd18452   79 KEerEDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH 130
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 70-199 3.10e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 60.85  E-value: 3.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLG--EEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530383347 150 --CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYH 199
Cdd:cd18513   79 keARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 74-164 2.75e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 57.05  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH-NCHY 152
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLST--GDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHeDDRM 82

                         90
                 ....*....|..
gi 530383347 153 QYMDELLQYIRF 164
Cdd:cd18449   83 QFAAKLMENIRF 94
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 81-172 1.15e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 55.90  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  81 LADLFNLTLLEKAVIDFLVKHLSELLKSR--PEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-CHYQYMDE 157
Cdd:cd18473   12 IAARFGLPDALKAAEKYIISNLWRLLASDadDAGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQDeSRLAYANA 91

                         90
                 ....*....|....*
gi 530383347 158 LLQYIRFGLMDVDTL 172
Cdd:cd18473   92 LLSRIRYGLVPVEEL 106
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 74-167 1.26e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 55.70  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CH 151
Cdd:cd18445    5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKG--EEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDpeNR 82

                         90
                 ....*....|....*.
gi 530383347 152 YQYMDELLQYIRFGLM 167
Cdd:cd18445   83 KEHLAELLEHVRLPLL 98
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 70-199 3.64e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 55.04  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLS--EEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530383347 150 --CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYH 199
Cdd:cd18512   79 keVRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-52 5.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 52.94  E-value: 5.70e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSH 52
Cdd:cd18186   30 MFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-70 7.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 54.04  E-value: 7.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 70
Cdd:cd18239   54 MFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGV 123
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 69-166 9.74e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 52.75  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  69 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 148
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKT--DEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKY 78

                         90       100
                 ....*....|....*....|
gi 530383347 149 NC--HYQYMDELLQYIRFGL 166
Cdd:cd18447   79 DEpnRQPYMVDILAKVRFPL 98
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 70-167 1.56e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 52.70  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKS--EEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYD 78

                         90       100
                 ....*....|....*....|
gi 530383347 150 C--HYQYMDELLQYIRFGLM 167
Cdd:cd18457   79 RenREEYLPELLSKVRLPLL 98
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 70-168 2.22e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 52.09  E-value: 2.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH- 148
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNH--EEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYk 78

                         90       100
                 ....*....|....*....|.
gi 530383347 149 -NCHYQYMDELLQYIRFGLMD 168
Cdd:cd18446   79 eSERLPLLPRVLENVRLPLLD 99
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 74-127 2.46e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 50.35  E-value: 2.46e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKS 127
Cdd:cd14733    4 NCLGILELADLYNLEELKEKALKFILENFEEVSKS--EEFLELSVELLLELLSS 55
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 74-168 1.41e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 49.76  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVrwlehncHYQ 153
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTF--SRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGAL-------LYH 75

                         90       100
                 ....*....|....*....|....*....
gi 530383347 154 YMDE--------------LLQYIRFGLMD 168
Cdd:cd18461   76 YTPEqvekdqvslqeppkLLEAVRFPLME 104
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 74-149 2.79e-07

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 48.17  E-value: 2.79e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18508    4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQG--EEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 76-167 3.00e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 48.75  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  76 LDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-CHYQY 154
Cdd:cd18465    7 LNIGQMATTFSLASLKESVDAFTFRHFLQI--AEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDpSRRAS 84

                         90
                 ....*....|...
gi 530383347 155 MDELLQYIRFGLM 167
Cdd:cd18465   85 ASHVLCHIRFPLM 97
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-76 3.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 49.41  E-value: 3.48e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYL 76
Cdd:cd18237   50 MFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 70-146 3.57e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 47.77  E-value: 3.57e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWL 146
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEV--AASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-82 4.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 49.12  E-value: 4.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYR 80
Cdd:cd18266   54 MFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQE 133


                 ..
gi 530383347  81 LA 82
Cdd:cd18266  134 LA 135
PLN02193 PLN02193
nitrile-specifier protein
 379-487 5.60e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.27  E-value: 5.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 379 LWISGGVTNTAQYqNRLMVYEPNQNKWISRSPMLQ---RRVYHSMAAVQRKLYVLGGndldyNNDRILVRHIDSYNIDTD 455
Cdd:PLN02193 231 LYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGG-----VSATARLKTLDSYNIVDK 304

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530383347 456 QWTRCN--FNLLTGQNESGVAVHNGRIYLVGGYS 487
Cdd:PLN02193 305 KWFHCStpGDSFSIRGGAGLEVVQGKVWVVYGFN 338
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-68 6.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 48.05  E-value: 6.36e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQ 68
Cdd:cd18247   48 MFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
Kelch_6 pfam13964
Kelch motif;
267-319 7.27e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.17  E-value: 7.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530383347  267 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 319
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 74-163 1.13e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 47.10  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRW----LEHN 149
Cdd:cd18460    5 NCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKG--EQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWvkadPKHR 82

                         90
                 ....*....|....
gi 530383347 150 CHyqYMDELLQYIR 163
Cdd:cd18460   83 QH--FWPELLQHVR 94
PLN02153 PLN02153
epithiospecifier protein
 264-487 1.15e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 50.76  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 264 PVGRSHHCVAVMGDFLFVAGGEV---EHASgrtcavRTACRYDPRSNSWAEIAPMKNCREHFVLG----AMEEYLYAVGG 336
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGELkpnEHID------KDLYVFDFNTHTWSIAPANGDVPRISCLGvrmvAVGTKLYIFGG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 337 RNELRQvLPTVERYCPKKNKWTFVQSFDrslschagyvadgllwISGGvtntaqyqnrlmvyePnqnkwisrspmlQRRV 416
Cdd:PLN02153  94 RDEKRE-FSDFYSYDTVKNEWTFLTKLD----------------EEGG---------------P------------EART 129

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530383347 417 YHSMAAVQRKLYVLGG---NDLDYNNDRIlvRHIDSYNIDTDQWTRC-----NFNLLTGqneSGVAVHNGRIYLVGGYS 487
Cdd:PLN02153 130 FHSMASDENHVYVFGGvskGGLMKTPERF--RTIEAYNIADGKWVQLpdpgeNFEKRGG---AGFAVVQGKIWVVYGFA 203
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 69-167 1.38e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 46.98  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  69 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLksRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 148
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI--RNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRH 78

                         90       100
                 ....*....|....*....|.
gi 530383347 149 NCHYQYMD--ELLQYIRFGLM 167
Cdd:cd18511   79 DVEQRRKDlsKLLAYIRLPLL 99
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-70 2.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 47.10  E-value: 2.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 70
Cdd:cd18264   57 LFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNL 126
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 414-460 3.85e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 3.85e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530383347  414 RRVYHSMAAVQRKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRC 460
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKL 42
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 70-149 5.68e-06

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 44.26  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDV--SGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 70-163 7.06e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 44.66  E-value: 7.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLeKAVIDFLVKHLSELLkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18479    1 INAENCVRLLSFADLFSCEEL-KQSAKRMVEHKFTAV-YHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYN 78

                         90
                 ....*....|....*.
gi 530383347 150 C--HYQYMDELLQYIR 163
Cdd:cd18479   79 TesRSQYLSSVLSQIR 94
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 90-159 7.43e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 44.59  E-value: 7.43e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530383347  90 LEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HYQYMDELL 159
Cdd:cd18458   22 LHKKAREYIYMHFSEVSQS--EEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEenRRQYLEALL 91
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-77 1.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 44.80  E-value: 1.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347  12 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLD 77
Cdd:cd18260   55 QRVELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
Kelch smart00612
Kelch domain;
222-277 1.10e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   222 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 277
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 319-362 1.66e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530383347  319 REHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 362
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPS 44
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 70-149 2.58e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 42.60  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKsRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAK-DSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-74 2.99e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 43.58  E-value: 2.99e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 74
Cdd:cd18242   50 MFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 82-149 3.14e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 42.69  E-value: 3.14e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347  82 ADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18455   12 AERFSCPHVHYVATEYLETHFRDV--SSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHD 77
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 267-316 3.31e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 3.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530383347  267 RSHHCVAVMGDFLFVAGGevehaSGRTCAVRTACRYDPRSNSWAEIAPMK 316
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG-----FDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 70-172 3.39e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 42.99  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSlSEEQIWQLAVRWLEHN 149
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSS--EGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEHN 77

                         90       100
                 ....*....|....*....|....
gi 530383347 150 C-HYQYMDELLQYIRFGLMDVDTL 172
Cdd:cd14822   78 PdSKEDAKEILEAVRLPLMSLTEL 101
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 69-167 4.25e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 42.60  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  69 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 148
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKN--QEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRH 78

                         90       100
                 ....*....|....*....|.
gi 530383347 149 N--CHYQYMDELLQYIRFGLM 167
Cdd:cd18510   79 DlqNRQKDLGMLLSYIRLPLL 99
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 74-164 5.68e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 42.29  E-value: 5.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--H 151
Cdd:cd18448    6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVEC--EEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPqhR 83

                         90
                 ....*....|...
gi 530383347 152 YQYMDELLQYIRF 164
Cdd:cd18448   84 KRHLDDLLSQVRL 96
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-76 6.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 41.97  E-value: 6.78e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYL 76
Cdd:cd18234   30 MFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-76 7.47e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 42.72  E-value: 7.47e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYL 76
Cdd:cd18336   48 MFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCL 123
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 111-167 9.09e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 41.65  E-value: 9.09e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530383347 111 EEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HYQYMDELLQYIRFGLM 167
Cdd:cd18459   41 EEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIqeRRPHLPQVLQHVRLPLL 99
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 70-163 9.96e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 41.65  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYclLQEVLKSDRLTSlSEEQIWQLAVRWLEHN 149
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASE--LLDYLGDDELCG-EEEQVFETLMVWIRHD 77

                         90
                 ....*....|....*.
gi 530383347 150 CHYQ--YMDELLQYIR 163
Cdd:cd18476   78 PKARkgYIHDLFKKVR 93
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-71 1.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 42.32  E-value: 1.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 71
Cdd:cd18246   68 MFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 138
PHA02713 PHA02713
hypothetical protein; Provisional
 311-454 1.17e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.00  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 311 EIAPMKNCREHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 390
Cdd:PHA02713 334 ELPPMIKNRCRFSLAVIDDTIYAIGGQNG-TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHID 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347 391 Y-----------------QNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLggndLDYNNDRILVRHIDSYNID 453
Cdd:PHA02713 413 YtsvhhmnsidmeedthsSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV----CDIKDEKNVKTCIFRYNTN 488


                 .
gi 530383347 454 T 454
Cdd:PHA02713 489 T 489
Kelch smart00612
Kelch domain;
426-478 1.38e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 1.38e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530383347   426 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNG 478
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-80 1.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 42.12  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYR 80
Cdd:cd18273   63 MFTGGLYESKQETVTIHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 74-167 1.46e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 41.42  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTL--LEKAVIDFLVKHLSELLkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-C 150
Cdd:cd18454    5 NCAEIMRLLDDFSVNIegVREKLDSFLLENFVPLM-SRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDrR 83

                         90
                 ....*....|....*..
gi 530383347 151 HYQYMDELLQYIRFGLM 167
Cdd:cd18454   84 RWRHTDTIIQNIRFCLM 100
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 70-170 1.52e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 41.14  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKT--EEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHD 78

                         90       100
                 ....*....|....*....|...
gi 530383347 150 C--HYQYMDELLQYIRFGLMDVD 170
Cdd:cd18456   79 VdgRRQHVPRLMKCVRLPLLSRD 101
PRK14131 PRK14131
N-acetylneuraminate epimerase;
420-487 1.65e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530383347 420 MAAVQRKLYVLGGNDlDYNNDR--ILVRHIDSYNIDTDQWTRCNFNL---LTGQneSGVAVHNGRIYLVGGYS 487
Cdd:PRK14131  80 AAFIDGKLYVFGGIG-KTNSEGspQVFDDVYKYDPKTNSWQKLDTRSpvgLAGH--VAVSLHNGKAYITGGVN 149
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-74 1.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 41.29  E-value: 1.94e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 74
Cdd:cd18250   50 MFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSN 123
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 74-164 1.99e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 40.86  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CH 151
Cdd:cd18468    4 NCLGIWALAEALQCTELHNMAKAYALQNFPDV--ARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDpkNR 81

                         90
                 ....*....|...
gi 530383347 152 YQYMDELLQYIRF 164
Cdd:cd18468   82 KQHIAELLAVVRL 94
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-74 2.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 41.24  E-value: 2.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 74
Cdd:cd18256   49 LFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSN 122
Kelch smart00612
Kelch domain;
331-362 2.13e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.13e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530383347   331 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 362
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 76-164 3.24e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 40.18  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  76 LDLY------RLADLFNLTLLEKAVIDFLVKHLSELLKsRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18482    1 LDLSncagilKFADAFDNRELKSKALAFIARNFQQLLA-KEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEAN 79

                         90
                 ....*....|....*..
gi 530383347 150 CHYQYMD--ELLQYIRF 164
Cdd:cd18482   80 LKERAASaaEVLKCVRW 96
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 74-148 3.39e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 39.41  E-value: 3.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 148
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQA--ARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDA 77
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-74 3.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 40.74  E-value: 3.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 74
Cdd:cd18274   52 MFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQN 125
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 1-68 3.48e-04

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 40.32  E-value: 3.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347    1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQIlLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQ 68
Cdd:pfam00651  39 LFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIK 105
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 70-108 3.69e-04

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 39.07  E-value: 3.69e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKS 108
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDD 39
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 70-167 3.84e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 40.00  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLksRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVI--RNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYD 79

                         90       100
                 ....*....|....*....|
gi 530383347 150 CHYQ--YMDELLQYIRFGLM 167
Cdd:cd18509   80 MQRRcsDLSMLLAYIRLPLL 99
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 81-165 4.52e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 39.47  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  81 LADLFNLTLLEKAVIDFLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC-HYQYMDELL 159
Cdd:cd18470   12 IAETYGLKNTKEAAQKFIRDNFIEF--SETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQkRVKYAADLL 89


                 ....*.
gi 530383347 160 QYIRFG 165
Cdd:cd18470   90 SNIRFG 95
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 70-149 4.60e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 39.17  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQD--EEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRN 78
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 1-70 5.15e-04

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 39.60  E-value: 5.15e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347     1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 70
Cdd:smart00225  28 LFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-51 5.68e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 39.97  E-value: 5.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS 51
Cdd:cd18238   44 MFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAAS 94
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 108-167 5.94e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 39.19  E-value: 5.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530383347 108 SRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLM 167
Cdd:cd18515   36 CKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYdlKKRHCYLSELLQTVRLALL 97
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-78 9.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 39.38  E-value: 9.52e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDL 78
Cdd:cd18268   52 MFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
Kelch smart00612
Kelch domain;
378-424 9.59e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 9.59e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 530383347   378 LLWISGGvTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQ 424
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-70 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 39.55  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 70
Cdd:cd18244   59 MFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKI 128
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-66 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 38.86  E-value: 1.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530383347  14 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYL 66
Cdd:cd18245   58 IELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-76 1.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 39.04  E-value: 1.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYL 76
Cdd:cd18259   61 MFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 79-146 1.52e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 37.56  E-value: 1.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347  79 YRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWL 146
Cdd:cd18493    9 LQYAKMCGHKELAEACLEFIAWNFEKVLKS--PDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-78 1.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 38.87  E-value: 1.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDL 78
Cdd:cd18335   48 MFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 97-169 1.97e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 37.78  E-value: 1.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530383347  97 FLVKHLSELlkSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQYMDELLQYIRFGLMDV 169
Cdd:cd18485   28 YLYQHFTEV--CLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNrkSRVQHLVELLKQVRLELVSP 100
Kelch smart00612
Kelch domain;
279-322 2.57e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 2.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 530383347   279 LFVAGGeveHASGRTCavRTACRYDPRSNSWAEIAPMKNCREHF 322
Cdd:smart00612   2 IYVVGG---FDGGQRL--KSVEVYDPETNKWTPLPSMPTPRSGH 40
Kelch_3 pfam13415
Galactose oxidase, central domain;
376-423 3.80e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 3.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530383347  376 DGLLWISGG-VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 423
Cdd:pfam13415   1 GDKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 74-167 4.86e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 36.93  E-value: 4.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--H 151
Cdd:cd18444    6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQN--QEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLpeR 83

                         90
                 ....*....|....*.
gi 530383347 152 YQYMDELLQYIRFGLM 167
Cdd:cd18444   84 KKHLAKLLALIRLPLL 99
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1-70 5.03e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 36.83  E-value: 5.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQI-LLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 70
Cdd:cd18300   38 MFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApILEDGDCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-51 5.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 36.39  E-value: 5.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQI----------LLEPGVIQDVLAAGS 51
Cdd:cd18319   30 LYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVhesqgdstdtLEENELLEDLVEAAS 90
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 74-167 5.10e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 36.66  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSelLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQ 153
Cdd:cd18516    5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQ--LIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEER 82

                         90
                 ....*....|....*.
gi 530383347 154 YMD--ELLQYIRFGLM 167
Cdd:cd18516   83 TKAlpVLLESIRFRLM 98
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-71 5.77e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 37.13  E-value: 5.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 71
Cdd:cd18257   47 MFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-66 6.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 37.15  E-value: 6.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530383347  14 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYL 66
Cdd:cd18228   68 LDLHHVTVTGFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
Kelch_4 pfam13418
Galactose oxidase, central domain;
414-459 6.19e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 6.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530383347  414 RRVYHSMAAVQR-KLYVLGGndldYNNDRILVRHIDSYNIDTDQWTR 459
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGG----EGEDGTLLSDLWVFDLSTNEWTR 43
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 70-161 6.33e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 36.44  E-value: 6.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPyCLLQEVLKSDR--LTSLSEEQIWQLAVRWL- 146
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAES--KEFLKLP-RLQIEVILESNqeLESINERKLCQLVLEWVq 77

                         90
                 ....*....|....*....
gi 530383347 147 ----EHNCHyqyMDELLQY 161
Cdd:cd18502   78 rsieEGGLD---LDDLTEK 93
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-51 6.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 36.82  E-value: 6.79e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 530383347  13 EVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS 51
Cdd:cd18231   56 ELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAA 94
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 74-126 6.86e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 36.29  E-value: 6.86e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKsRPeEVLTLPYCLLQEVLK 126
Cdd:cd18478    5 NCLELYRLAQVYGLRDLAEACLKFMATHYHPMLR-RP-EFRPLPSSLKQQLRE 55
Kelch_6 pfam13964
Kelch motif;
415-460 7.02e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 7.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530383347  415 RVYHSMAAVQRKLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRC 460
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEEL 43
Kelch_6 pfam13964
Kelch motif;
374-415 7.67e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 7.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530383347  374 VADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRR 415
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1-51 7.97e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 35.72  E-value: 7.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530383347   1 MFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS 51
Cdd:cd01165   27 LFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAAN 77
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 70-167 8.09e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 36.08  E-value: 8.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  70 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 149
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQT--EEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYD 78

                         90       100
                 ....*....|....*....|
gi 530383347 150 CH--YQYMDELLQYIRFGLM 167
Cdd:cd18467   79 VQerQKYLAQLLHCVRLPLL 98
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 74-167 8.30e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 35.97  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530383347  74 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSElLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH----- 148
Cdd:cd18475    5 NYLYLQELASIYSLERLDSFIDSFILQNFGT-LSFTPDFLQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQspere 83

                         90
                 ....*....|....*....
gi 530383347 149 NCHYQymdeLLQYIRFGLM 167
Cdd:cd18475   84 NEAYQ----VLSNIHFPLI 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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