NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

321-567

5.65e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 187.29 E-value: 5.65e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 321 WERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSSvcFSAmgTVVLDGQIYVCGG 400
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRH--HAA--AVAQDGKLYVFGG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 401 YDGN----SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNK 476
Cdd:COG3055   79 FTGAnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 477 RCRHGAASLGS-KMFVCGGYDGSGFlsiaemyssvADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNlsSVEMYD 555
Cdd:COG3055  159 RDHLAAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYD 226

                        250
                 ....*....|..
gi 767922822 556 PETDCWTFMAPM 567
Cdd:COG3055  227 PATNTWTALGEL 238

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

140-242

1.33e-45

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 156.17 E-value: 1.33e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  140 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPY 219
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 767922822  220 LPELLSNIRLPLCRPQFLSDRVQ 242
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

140-240

2.86e-39

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 139.01 E-value: 2.86e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   140 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPY 219
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 767922822   220 LPELLSNIRLPLCRPQFLSDR 240
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

28-135

5.63e-35

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 127.37 E-value: 5.63e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLaIDQQN 107
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 767922822  108 VQSLLMGASFLQLQSIKDACCTFLRERL 135
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

39-135

1.72e-29

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 111.63 E-value: 1.72e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822    39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFL 118
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 767922822   119 QLQSIKDACCTFLRERL 135
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Kelch

Kelch domain;

394-440

2.00e-16

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 72.98 E-value: 2.00e-16

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767922822   394 QIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEG 440
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

330-375

1.65e-15

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 70.33 E-value: 1.65e-15

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767922822  330 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMN 375
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Name

Accession

Description

Interval

E-value

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-134

7.69e-78

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 241.42 E-value: 7.69e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  19 ELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYN 98
Cdd:cd18247    1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822  99 GNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18247   81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

135-241

6.12e-74

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 231.04 E-value: 6.12e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSDRV 241
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107

PHA03098

kelch-like protein; Provisional

34-562

1.36e-63

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 218.10 E-value: 1.36e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKI--GDHKFSAHRIVLAASIPYFHAMFTNDMMEckqDEIVMQGmDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:PHA03098   6 LQKFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 112 LMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRD 191
Cdd:PHA03098  82 LSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 192 ELNVKSEEQVFEAALAWVRYDREQRGPYLPELLsnirlPLCRPQFLSdrvqqddlVRCCHKCRDLVDEAKDYHLMPERRP 271
Cdd:PHA03098 162 KLNVSSEDVVLEIIIKWLTSKKNNKYKDICLIL-----KVLRITFLS--------EEGIKKLKRWKLRIKKKKIVFNKRC 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 272 hLPAFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPiancWERCRPMTTARSR--VGVAVVNGLLYAIGGY 349
Cdd:PHA03098 229 -IKIIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNYSP----LSEINTIIDIHYVycFGSVVLNNVIYFIGGM 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 350 DGQ-LRLSTVEAYNPETDTWTRVGSMNSKRSSVcfsamGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSS 428
Cdd:PHA03098 304 NKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNP-----GVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIF 378

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 429 NRSAAGVTVFEGRIYVSGG-HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY---DGSGFLSIA 504
Cdd:PHA03098 379 PRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIV 458

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767922822 505 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWT 562
Cdd:PHA03098 459 ESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

135-270

6.31e-57

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 187.61 E-value: 6.31e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERR 270
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

321-567

5.65e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 187.29 E-value: 5.65e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 321 WERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSSvcFSAmgTVVLDGQIYVCGG 400
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRH--HAA--AVAQDGKLYVFGG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 401 YDGN----SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNK 476
Cdd:COG3055   79 FTGAnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 477 RCRHGAASLGS-KMFVCGGYDGSGFlsiaemyssvADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNlsSVEMYD 555
Cdd:COG3055  159 RDHLAAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYD 226

                        250
                 ....*....|..
gi 767922822 556 PETDCWTFMAPM 567
Cdd:COG3055  227 PATNTWTALGEL 238

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

282-555

5.50e-53

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 182.28 E-value: 5.50e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 282 CCTSIAGLIYAVGGLNsaanfyAGDSLNVVEVFDPIANCWERCRPM-TTARSRVGVAVVNGLLYAIGGYDGQLR----LS 356
Cdd:COG3055   17 AAALLDGKVYVAGGLS------GGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstpLN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 357 TVEAYNPETDTWTRVGSMNSKRSSVcfsamGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNR-SAAGV 435
Cdd:COG3055   91 DVYVYDPATNTWTKLAPMPTPRGGA-----TALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 436 TVFEGRIYVSGGHDGlqifssvehyNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYdgSGFLSIAEMYSSVADQWC 515
Cdd:COG3055  166 VLPDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWT 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767922822 516 LIVPMHTRRSRVSLVASCGRLYAVGGYDGQ----SNLSSVEMYD 555
Cdd:COG3055  234 ALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

135-248

5.27e-47

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 160.48 E-value: 5.27e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVR 248
Cdd:cd18445   81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

140-242

1.33e-45

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 156.17 E-value: 1.33e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  140 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPY 219
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 767922822  220 LPELLSNIRLPLCRPQFLSDRVQ 242
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-142

1.94e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 156.30 E-value: 1.94e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA 102
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767922822 103 IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18238   81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

273-499

3.66e-43

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 155.70 E-value: 3.66e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 273 LPAFRTRPR---CCTSIAGLIYAVGGLNSAANfyAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 349
Cdd:COG3055   53 LAPLPGPPRhhaAAVAQDGKLYVFGGFTGANP--SSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGW 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 350 DGQLRLSTVEAYNPETDTWTRVGSMNSKRssvcFSAMGTVVLDGQIYVCGGYDGNSSlssvetyspeTDKWTVVTSMSSN 429
Cdd:COG3055  131 DDGGNVAWVEVYDPATGTWTQLAPLPTPR----DHLAAAVLPDGKILVIGGRNGSGF----------SNTWTTLAPLPTA 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 430 RSAAGVTVFEGRIYVSGGHDGlqIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSG 499
Cdd:COG3055  197 RAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPG 264

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

134-239

9.40e-43

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 148.63 E-value: 9.40e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 213
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....*.
gi 767922822 214 EQRGPYLPELLSNIRLPLCRPQFLSD 239
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFLAD 106

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

18-142

9.97e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 149.18 E-value: 9.97e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  18 SELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAY 97
Cdd:cd18237    2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767922822  98 NGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18237   82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

135-264

4.90e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 144.82 E-value: 4.90e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYH 264
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-141

1.21e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 142.89 E-value: 1.21e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGAS 116
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                         90       100
                 ....*....|....*....|....*
gi 767922822 117 FLQLQSIKDACCTFLRERLHPKNCL 141
Cdd:cd18234   81 LLQLSEVVEACCGFLMKQLHPSNCL 105

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-144

1.36e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 143.65 E-value: 1.36e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18336   10 MENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDT 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVR 144
Cdd:cd18336   90 IESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-137

3.28e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 142.18 E-value: 3.28e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  22 SRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNL 101
Cdd:cd18235    6 QKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEI 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 102 AIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18235   86 QVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

135-264

4.45e-40

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 142.48 E-value: 4.45e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYH 264
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

140-240

2.86e-39

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 139.01 E-value: 2.86e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   140 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPY 219
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 767922822   220 LPELLSNIRLPLCRPQFLSDR 240
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-142

1.57e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 135.22 E-value: 1.57e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18256   11 LNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSN 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18256   91 VQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-137

2.42e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 134.20 E-value: 2.42e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18257    9 LNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQAT 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18257   89 VESLLPAANLLQIKLVLKECCDFLESQLDP 118

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-140

2.70e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 134.49 E-value: 2.70e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18242   12 MNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVEN 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18242   92 VQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-142

5.67e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 133.73 E-value: 5.67e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18249   13 AINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEG 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18249   93 NVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

28-135

5.63e-35

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 127.37 E-value: 5.63e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLaIDQQN 107
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 767922822  108 VQSLLMGASFLQLQSIKDACCTFLRERL 135
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-144

1.00e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 124.77 E-value: 1.00e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18335   10 MESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDT 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVR 144
Cdd:cd18335   90 IENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-144

2.10e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 124.02 E-value: 2.10e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18337   14 MENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDN 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVR 144
Cdd:cd18337   94 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

135-239

3.63e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 122.44 E-value: 3.63e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|....*
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSD 239
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLLAD 106

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-135

3.78e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 122.87 E-value: 3.78e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  17 VSELPSRGYGVMEEIRRQGKLCDVTLKIG----DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEAL 92
Cdd:cd18248    1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767922822  93 INFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERL 135
Cdd:cd18248   81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-137

3.83e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 122.87 E-value: 3.83e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA 102
Cdd:cd18338    7 KAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQ 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 103 IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18338   87 VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

134-239

5.25e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 122.10 E-value: 5.25e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 213
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....*.
gi 767922822 214 EQRGPYLPELLSNIRLPLCRPQFLSD 239
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

4-137

7.16e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 120.14 E-value: 7.16e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   4 DGAEELEDLVHFSVSELPSRGYG----VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEI 79
Cdd:cd18246    2 EGGVQLLNRDGHSISHNSKRHYHdafvSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767922822  80 VMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18246   82 TLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

134-232

7.54e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 118.69 E-value: 7.54e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 213
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*....
gi 767922822 214 EQRGPYLPELLSNIRLPLC 232
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLL 99

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-137

4.94e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 117.13 E-value: 4.94e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA 102
Cdd:cd18339    7 KAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIE 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 103 IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18339   87 VTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-143

5.94e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 116.98 E-value: 5.94e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18306    9 LNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADL 88

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18306   89 VKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-118

8.14e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 114.96 E-value: 8.14e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGAS 116
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 767922822 117 FL 118
Cdd:cd18186   81 KL 82

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-140

8.61e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 116.27 E-value: 8.61e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18240    7 VFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAE 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18240   87 NVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

135-224

3.71e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 113.54 E-value: 3.71e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81

                         90
                 ....*....|
gi 767922822 215 QRGPYLPELL 224
Cdd:cd18458   82 NRRQYLEALL 91

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

134-239

7.30e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 113.09 E-value: 7.30e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 213
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....*.
gi 767922822 214 EQRGPYLPELLSNIRLPLCRPQFLSD 239
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLLAD 106

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-140

1.23e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 113.26 E-value: 1.23e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQS 110
Cdd:cd18255   12 LRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQD 91

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 111 LLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18255   92 VLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

39-135

1.72e-29

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 111.63 E-value: 1.72e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822    39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFL 118
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 767922822   119 QLQSIKDACCTFLRERL 135
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-142

2.37e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 112.41 E-value: 2.37e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ-GMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18254   13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDFAYSSRIIINEE 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18254   93 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

134-230

4.62e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 110.47 E-value: 4.62e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 213
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 767922822 214 EQRGPYLPELLSNIRLP 230
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

135-236

4.70e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 110.86 E-value: 4.70e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|..
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQF 236
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLLSRDF 102

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

20-142

8.32e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 111.46 E-value: 8.32e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  20 LPSRGYGVME---EIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFA 96
Cdd:cd18259   12 LPSHPQSILDglqTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFA 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767922822  97 YNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18259   92 YTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

137-228

1.10e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 109.71 E-value: 1.10e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 137 PKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQR 216
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|..
gi 767922822 217 GPYLPELLSNIR 228
Cdd:cd18455   82 KVHLKDLMSSCW 93

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

7-143

1.11e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 111.07 E-value: 1.11e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   7 EELEDLVHFSV--SELPSrgygvmeeIRRQGKLCDVTLKI--------GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQ 76
Cdd:cd18273    2 EELEDAAHARAllAQLKS--------FYDARLLTDVTIEVngpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQ 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767922822  77 DEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18273   74 ETVTIHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-142

1.16e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 110.71 E-value: 1.16e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18236   15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQN 94

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18236   95 VQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-140

1.56e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 110.24 E-value: 1.56e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18250   12 LSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDN 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18250   92 VEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

136-237

2.54e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 108.65 E-value: 2.54e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 136 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQ 215
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 767922822 216 RGPYLPELLSNIRLPLCRPQFL 237
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

135-231

1.41e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 106.57 E-value: 1.41e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*..
gi 767922822 215 QRGPYLPELLSNIRLPL 231
Cdd:cd18467   81 ERQKYLAQLLHCVRLPL 97

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-143

2.40e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 107.11 E-value: 2.40e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18269   18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQN 97

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18269   98 VQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-143

1.26e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 105.30 E-value: 1.26e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  35 GKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMG 114
Cdd:cd18340   25 NKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAA 104

                         90       100
                 ....*....|....*....|....*....
gi 767922822 115 ASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18340  105 ANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-143

1.53e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 104.87 E-value: 1.53e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18268   14 LNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDN 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18268   94 VLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

135-242

2.44e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 103.32 E-value: 2.44e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*...
gi 767922822 215 QRGPYLPELLSNIRLPLCRPQFLSDRVQ 242
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

2.77e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 104.69 E-value: 2.77e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ-GMDPSALEALINFAYNGNLAIDQQNVQ 109
Cdd:cd18267   34 LRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHdSIHPEVLELLLDYAYSSRVIINEENAE 113

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 110 SLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18267  114 SLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-143

4.30e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 103.53 E-value: 4.30e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKIgDH--KFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:cd18274   19 EGQLTDIVVEV-DHgkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQAL 97

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767922822 112 LMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18274   98 FTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

139-231

1.40e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 100.90 E-value: 1.40e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 218
Cdd:cd18447    6 NCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQP 85

                         90
                 ....*....|...
gi 767922822 219 YLPELLSNIRLPL 231
Cdd:cd18447   86 YMVDILAKVRFPL 98

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-140

2.22e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 101.07 E-value: 2.22e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18253    8 VFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18253   88 NVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-142

2.47e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 101.39 E-value: 2.47e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:cd18265   18 RRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESV 97

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767922822 112 LMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18265   98 LEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

3.69e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 97.95 E-value: 3.69e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQS 110
Cdd:cd18276   15 MKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQG 94

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767922822 111 LLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18276   95 VATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

139-212

3.78e-24

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 95.94 E-value: 3.78e-24

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 212
Cdd:cd18508    4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

135-212

8.64e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 94.99 E-value: 8.64e-24

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSM-SEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 212
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-143

1.01e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 96.84 E-value: 1.01e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18341   18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGN 97

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18341   98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-142

1.05e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 96.43 E-value: 1.05e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  35 GKLCDVTLKIGDHK-FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLM 113
Cdd:cd18252   19 GLFTDITLQCASGQiFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLE 98

                         90       100
                 ....*....|....*....|....*....
gi 767922822 114 GASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18252   99 AADLLQFISVKKACEQFLVRHLDIDNCLG 127

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

137-237

3.37e-23

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 94.47 E-value: 3.37e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 137 PKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQR 216
Cdd:cd18466    3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                         90       100
                 ....*....|....*....|.
gi 767922822 217 GPYLPELLSNIRLPLCRPQFL 237
Cdd:cd18466   83 KKHVVEVLEPVRFPLLPPQRL 103

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

135-231

3.37e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 94.14 E-value: 3.37e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*..
gi 767922822 215 QRGPYLPELLSNIRLPL 231
Cdd:cd18514   81 KRKDYLPELLRNVRLAL 97

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

135-233

7.37e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 93.32 E-value: 7.37e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*....
gi 767922822 215 QRGPYLPELLSNIRLPLCR 233
Cdd:cd18460   81 HRQHFWPELLQHVRLPFVR 99

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

134-211

3.59e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 90.53 E-value: 3.59e-22

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767922822 134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRY 211
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

135-234

9.41e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 90.17 E-value: 9.41e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90       100
                 ....*....|....*....|
gi 767922822 215 QRGPYLPELLSNIRLPLCRP 234
Cdd:cd18485   81 SRVQHLVELLKQVRLELVSP 100

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-147

1.10e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 91.11 E-value: 1.10e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18266   16 LNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGN 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Cdd:cd18266   96 IDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-130

1.33e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 89.48 E-value: 1.33e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  38 CDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMeCKQDE----IVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLM 113
Cdd:cd18307    2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDM-KATDElsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                         90
                 ....*....|....*..
gi 767922822 114 GASFLQLQSIKDACCTF 130
Cdd:cd18307   81 GAKYFNIPRLKDHCVDF 97

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-131

1.51e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 89.71 E-value: 1.51e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD--EIVMQGMDPSALEALINFAYNGNLAID 104
Cdd:cd18245    4 ALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLS 83

                         90       100
                 ....*....|....*....|....*..
gi 767922822 105 QQNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18245   84 EDNIQDIVQAADLLLMTDLKDLCCEFL 110

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-140

2.47e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 90.02 E-value: 2.47e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  22 SRGYGVMEEirrQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNL 101
Cdd:cd18244   18 SAGFRALYE---EGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTI 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767922822 102 AIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18244   95 ELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

136-231

2.77e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 88.71 E-value: 2.77e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 136 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQ 215
Cdd:cd18464    1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                         90
                 ....*....|....*.
gi 767922822 216 RGPYLPELLSNIRLPL 231
Cdd:cd18464   81 RHEVLPELLRSVRLAL 96

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

136-231

2.90e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 88.49 E-value: 2.90e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 136 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQ 215
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*.
gi 767922822 216 RGPYLPELLSNIRLPL 231
Cdd:cd18515   81 RHCYLSELLQTVRLAL 96

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-141

9.74e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 88.52 E-value: 9.74e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIR---RQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAI 103
Cdd:cd18270   13 LLEQLKffyEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAI 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767922822 104 DQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL 141
Cdd:cd18270   93 NDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

139-216

3.39e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 85.07 E-value: 3.39e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEdVLELV-SRDELNVKSEEQVFEAALAWVRYDREQR 216
Cdd:cd18480    5 NCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFE-VLEKIlEADELNVPDEEAVLKAVLRWTKHDLEAR 82

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

133-231

5.08e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 85.19 E-value: 5.08e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 133 ERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 212
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90
                 ....*....|....*....
gi 767922822 213 REQRGPYLPELLSNIRLPL 231
Cdd:cd18469   81 PQARAAHLPELLSLVHLSL 99

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-141

1.53e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 84.88 E-value: 1.53e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18271   14 VLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL 141
Cdd:cd18271   94 NVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-141

6.12e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 83.09 E-value: 6.12e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:cd18261   23 RNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDV 102

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 112 LMGASFLQLQSIKDACCTFLRERLHPKNCL 141
Cdd:cd18261  103 LAAGSHLQLLELLSLCSHYLIQELNSFNYL 132

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-131

6.20e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 82.94 E-value: 6.20e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQS 110
Cdd:cd18251   17 LRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQE 96

                         90       100
                 ....*....|....*....|.
gi 767922822 111 LLMGASFLQLQSIKDACCTFL 131
Cdd:cd18251   97 TLTAACQLQIPEVIGFCCDFL 117

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-140

7.34e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 82.93 E-value: 7.34e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGD--HKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18239   14 FDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNM 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 106 QNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18239   94 DNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

135-234

1.91e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 80.56 E-value: 1.91e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELnVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 767922822 215 QRGPYLPELLSNIRLPLCRP 234
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

135-231

2.66e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 80.27 E-value: 2.66e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*..
gi 767922822 215 QRGPYLPELLSNIRLPL 231
Cdd:cd18477   81 NRQKALPTVFESIRFRL 97

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-138

4.34e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 80.47 E-value: 4.34e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmqgMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18222   16 LNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVI---KNPTVFEQLLSFCYTGRICLQLAD 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLrERLHPK 138
Cdd:cd18222   93 IISYLTAASFLQMQHIIDKCTQIL-EGIHFK 122

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

4.87e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 80.07 E-value: 4.87e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  13 VHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmqgMDPSALEAL 92
Cdd:cd18220    1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVI---KNPNVFEQL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767922822  93 INFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLrERLH 136
Cdd:cd18220   78 LSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL-ESIH 120

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

135-231

1.35e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 78.27 E-value: 1.35e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*..
gi 767922822 215 QRGPYLPELLSNIRLPL 231
Cdd:cd18517   81 NRVKSLGEIFDCIRFRL 97

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

135-229

2.02e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 77.79 E-value: 2.02e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 767922822 215 QRGPYLPELLSNIRL 229
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

18-140

2.17e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 78.75 E-value: 2.17e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  18 SELPSRgygvMEEIRRQGKLCDVTLKIGD---HKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ------GMDPSA 88
Cdd:cd18241    8 SELSWR----QNEQRKQGLFCDITLAFGGaggREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPDPDT 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767922822  89 LEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18241   84 VEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-131

2.31e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 78.44 E-value: 2.31e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18326   14 SSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVST 93

                         90       100
                 ....*....|....*....|....*.
gi 767922822 106 QNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18326   94 SNVGDILSAARLLEIPAVSHVCADLL 119

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-126

2.56e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 77.91 E-value: 2.56e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTnDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18212   14 FEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA-DEGEVGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKS 92

                         90
                 ....*....|....*....
gi 767922822 108 VQSLLMGASFLQLQSIKDA 126
Cdd:cd18212   93 LEQILATAQFLKVNDLVKA 111

PHA02790

Kelch-like protein; Provisional

55-514

4.84e-17

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 83.94 E-value: 4.84e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  55 VLAASIPYFHAMFTNDMMECKqDEI--VMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLR 132
Cdd:PHA02790  39 ILKKLSPYFRTHLRQKYTKNK-DPVtrVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFIL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 133 ERLHPKNCLgvrqfaETMMCAVLYDAAN------SFIHQHFVEVS--MSEEFLALPLEDVLElvsRDELNVKSEEQVFEA 204
Cdd:PHA02790 118 RDFRKEYCV------ECYMMGIEYGLSNllchtkDFIAKHFLELEddIIDNFDYLSMKLILE---SDELNVPDEDYVVDF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 205 ALAWVRYDREQRGPYLpELLSNIrlplCRPQFLSDrvqqddlvRCCHKCRDLVDEAKDYHLMPE-RRPHLPAFRTRP--- 280
Cdd:PHA02790 189 VIKWYMKRRNRLGNLL-LLIKNV----IRSNYLSP--------RGINNVKWILDCTKIFHCDKQpRKSYKYPFIEYPmnm 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 281 -------RCCTS--IAGLIYAVGG-LNSAANFYAgDSLNVVevfdpiANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD 350
Cdd:PHA02790 256 dqiidifHMCTSthVGEVVYLIGGwMNNEIHNNA-IAVNYI------SNNWIPIPPMNSPRLYASGVPANNKLYVVGGLP 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 351 GQlrlSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTVvldgqIYVCGGYdgNSSLSSVETYSPETDKWTVVTSMSSNR 430
Cdd:PHA02790 329 NP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNV-----IYVIGGH--SETDTTTEYLLPNHDQWQFGPSTYYPH 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 431 SAAGVTVFEGRIYVSGghdglqifSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSV 510
Cdd:PHA02790 399 YKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNR 470


                 ....
gi 767922822 511 ADQW 514
Cdd:PHA02790 471 TYSW 474

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-140

8.44e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 77.14 E-value: 8.44e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQS 110
Cdd:cd18264   22 LRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLED 101

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 111 LLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18264  102 TLEAASYLQVTEAIGLCSQYLINNLAPENC 131

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

28-141

1.53e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 76.00 E-value: 1.53e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18263    4 IEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWEN 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL 141
Cdd:cd18263   84 LFEATCTALQLQISGALALCLDFLQREISPARCL 117

Kelch

Kelch domain;

394-440

2.00e-16

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 72.98 E-value: 2.00e-16

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767922822   394 QIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEG 440
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

39-127

3.07e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 74.30 E-value: 3.07e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFL 118
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                 ....*....
gi 767922822 119 QLQSIKDAC 127
Cdd:cd18314   88 QVPDLEKLC 96

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

21-131

3.20e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 74.88 E-value: 3.20e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  21 PSRGYGVMEEIRRQ---GKLCDVTLKIGDHKFSAHRIVLAASIPYFHamftNDMMECKQDEIVMQG-MDPSALEALINFA 96
Cdd:cd18210    2 PEITSSLLESLNQQrmeGKLCDISIHVQGRVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGvMDPGAFESVLASA 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822  97 YNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18210   78 YTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

139-231

3.29e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 74.41 E-value: 3.29e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 218
Cdd:cd18516    5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTK 84

                         90
                 ....*....|...
gi 767922822 219 YLPELLSNIRLPL 231
Cdd:cd18516   85 ALPVLLESIRFRL 97

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

135-209

3.34e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 73.58 E-value: 3.34e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWV 209
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

135-230

4.62e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 73.74 E-value: 4.62e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 767922822 215 QRGPYLPELLSN-IRLP 230
Cdd:cd18483   81 KREMHLPEIFAKcIRMP 97

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

37-119

6.06e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 72.97 E-value: 6.06e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTnDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGAS 116
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                 ...
gi 767922822 117 FLQ 119
Cdd:cd18315   80 LLQ 82

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-135

9.48e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 73.74 E-value: 9.48e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMF----------TNDMMECKQD--EIVMQGMDPsaleaLI 93
Cdd:cd18228    8 GKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvlVSPAGKCVLDlhHVTVTGFAP-----LL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767922822  94 NFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERL 135
Cdd:cd18228   83 EYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-132

1.34e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 73.43 E-value: 1.34e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYfhamFTNDMMECKQDEIVMQG-MDPSALEALINFAYNGNLAIDQQNVQS 110
Cdd:cd18227   20 RQQGQLCDISVVVQGHLFRAHKAVLAASSPY----FCDQVLLKNSRRIVLPDvMNPRVFENILLSCYTGRLVLPAPEIVS 95

                         90       100
                 ....*....|....*....|..
gi 767922822 111 LLMGASFLQLQSIKDACCTFLR 132
Cdd:cd18227   96 YLTAASFLQMWHVVDKCTELLE 117

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

139-231

1.46e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 72.46 E-value: 1.46e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 218
Cdd:cd18462    5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                         90
                 ....*....|...
gi 767922822 219 YLPELLSNIRLPL 231
Cdd:cd18462   85 CAYDLLSSIKLDL 97

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

138-229

1.51e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 72.22 E-value: 1.51e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 138 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDrEQRG 217
Cdd:cd18470    4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRV 82

                         90
                 ....*....|..
gi 767922822 218 PYLPELLSNIRL 229
Cdd:cd18470   83 KYAADLLSNIRF 94

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

135-226

1.64e-15

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 72.27 E-value: 1.64e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALP---LEDVLElvSRDELNVKSEEQVFEAALAWVRY 211
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPrlqIEVILE--SNQELESINERKLCQLVLEWVQR 78

                         90
                 ....*....|....*
gi 767922822 212 DREQRGPYLPELLSN 226
Cdd:cd18502   79 SIEEGGLDLDDLTEK 93

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

330-375

1.65e-15

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 70.33 E-value: 1.65e-15

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767922822  330 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMN 375
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

2.02e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 72.79 E-value: 2.02e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTN----DMMECKQDEIVMQGMDPsaleaLINFAYNGNLAI 103
Cdd:cd18277   18 LNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGqadaELNITLPEEVTVKGFEP-----LIQFAYTAKLIL 92

                         90       100
                 ....*....|....*....|....*...
gi 767922822 104 DQQNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18277   93 SKDNVDEVCKCVEFLSVHNIEESCFQFL 120

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

465-567

2.27e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 76.73 E-value: 2.27e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 465 ATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHT-RRSRVSLVASCGRLYAVGGYD 543
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFT 80

                         90       100
                 ....*....|....*....|....*...
gi 767922822 544 GQSN----LSSVEMYDPETDCWTFMAPM 567
Cdd:COG3055   81 GANPsstpLNDVYVYDPATNTWTKLAPM 108

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-131

2.91e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 72.27 E-value: 2.91e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  33 RQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA---IDQQNVQ 109
Cdd:cd18287   18 LNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTltdLKEDVLL 97

                         90       100
                 ....*....|....*....|....*
gi 767922822 110 SLLMGA---SFLQLQSikdACCTFL 131
Cdd:cd18287   98 DVLGLAhqyGFEELEA---AISDYL 119

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-130

2.99e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 72.38 E-value: 2.99e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  19 ELPSRGYGVME---EIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQgmdPSALEALINF 95
Cdd:cd18290    6 EIPNFGNSILEclnEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQ---PQSFQQILSF 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822  96 AYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTF 130
Cdd:cd18290   83 CYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEF 117

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

34-136

3.89e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 71.91 E-value: 3.89e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAI-DQQNVQSLL 112
Cdd:cd18286   14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELL 93

                         90       100
                 ....*....|....*....|....*
gi 767922822 113 MGASFLQLQSIKD-ACCTFLRERLH 136
Cdd:cd18286   94 SLADMYGLDGLKDvVAYTLRRDYCH 118

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-131

5.78e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 70.58 E-value: 5.78e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFT----NDMMECKQDEIVMQGMDPsaleaLINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVC 75

                         90
                 ....*....|....*....
gi 767922822 113 MGASFLQLQSIKDACCTFL 131
Cdd:cd18955   76 RCAEFLGVHNIEKACFDFL 94

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-118

8.36e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 70.67 E-value: 8.36e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18209    7 SALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENE-SQSVFQLDFCEPDAFENVLNYIYSSSLFVEK 85

                         90
                 ....*....|....*...
gi 767922822 106 QN---VQSL--LMGASFL 118
Cdd:cd18209   86 SSlaaVQELgySLGISFL 103

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

136-190

8.78e-15

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 68.84 E-value: 8.78e-15

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767922822 136 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSR 190
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

8.95e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 71.13 E-value: 8.95e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFT----NDMMECKQDEIVMQGMDPsaleaLINFAYNGNLAI 103
Cdd:cd18278   22 LNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVgqteNDLVVSLPEEVTARGFGP-----LLQFAYTAKLLL 96

                         90       100
                 ....*....|....*....|....*...
gi 767922822 104 DQQNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18278   97 SRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

9.13e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 71.05 E-value: 9.13e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18198   16 LNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTAN 95

                         90       100
                 ....*....|....*....|....
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18198   96 VGDILSAARLLEIPCVSHVCAEIL 119

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-127

1.13e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 70.68 E-value: 1.13e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18328   16 LNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSN 95

                         90       100
                 ....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDAC 127
Cdd:cd18328   96 VKHILNAAQMLEIQCIINVC 115

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

2.13e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 69.87 E-value: 2.13e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECK-------QDEIVMQGMDPSALEALINFAYNGN 100
Cdd:cd18327   16 LNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgagggQDVCELDFVGPEALGALLEFAYTAT 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767922822 101 LAIDQQNVQSLLMGASFLQLQSIKDACCTFLR 132
Cdd:cd18327   96 LTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-134

2.52e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 69.84 E-value: 2.52e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  19 ELPSRGYGVMEEIRRQ---GKLCDVTLKIGDHKFSAHRIVLAASIPYFHaMFTNDMMECKQDEIVMQG--MDPSALEALI 93
Cdd:cd18956    2 EFPEHGGRLLGRLRQQrelGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGdiVTAPAFGRLL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767922822  94 NFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18956   81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLREK 121

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-134

3.16e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 69.47 E-value: 3.16e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHaMFTNDMME-----CKQDEIVMqgmdPSALEALINFAYNGNLA 102
Cdd:cd18323   14 LREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDkrdlvCINNEIVT----APAFSLLLEFMYEGRLS 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767922822 103 IDQQNVQSLLMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18323   89 FNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120

PHA02713

hypothetical protein; Provisional

37-412

3.37e-14

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 75.43 E-value: 3.37e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGD-HKFSAHRIVLAASIPYFHAMFTNDM-MECKQDEIVMQGMDPSALEALINFAYNGNlaIDQQNVQSLLMG 114
Cdd:PHA02713  25 LCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKC 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 115 ASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS-RDEL 193
Cdd:PHA02713 103 ADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIIStNDNV 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 194 NVKSEEQVFEAALAWVRYDreqrgpYLPE----------------------LLSNIRL---PLCrPQFLSDRVQQDDLV- 247
Cdd:PHA02713 183 YLYREGYKVTILLKWLEYN------YITEeqllcilscidiqnldkksrllLYSNKTInmyPSC-IQFLLDNKQNRNIIp 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 248 -RCCHKCRD----------LVDE--AKDYHLMPERRPHLPAFRTrprccTSIAGLIYAVGGLNsaanfYAGDSLNVVEVF 314
Cdd:PHA02713 256 rQLCLVCHDtkynvcnpciLVYNinTMEYSVISTIPNHIINYAS-----AIVDNEIIIAGGYN-----FNNPSLNKVYKI 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 315 DPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMnskrsSVCFSAMGTVVLDGQ 394
Cdd:PHA02713 326 NIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDM-----PIALSSYGMCVLDQY 400

                        410
                 ....*....|....*...
gi 767922822 395 IYVCGGYDGNSSLSSVET 412
Cdd:PHA02713 401 IYIIGGRTEHIDYTSVHH 418

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-133

4.30e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 68.73 E-value: 4.30e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFH-AMFTNDmmeckQDEIVMQG-MDPSALEALINFAYNGNLAIDQQNVQ 109
Cdd:cd18200   13 RLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLND-----TNCLVLPSvIEAAAFENLLQLIYSGRLTLCMDALP 87

                         90       100
                 ....*....|....*....|....
gi 767922822 110 SLLMGASFLQLQSIKDACCTFLRE 133
Cdd:cd18200   88 SHLLVASGLQMWQVVDRCSELLKE 111

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

139-212

4.33e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 67.53 E-value: 4.33e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD 212
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-134

4.74e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 68.80 E-value: 4.74e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKIGDHK--FSAHRIVLAASIPYFHAMFTNDMmECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:cd18231   11 QPDLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDV 89

                         90       100
                 ....*....|....*....|...
gi 767922822 112 LMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18231   90 LNAAAVLQMNDIAASCQELIDSR 112

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

523-567

5.57e-14

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 66.10 E-value: 5.57e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767922822  523 RRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 567
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-141

6.47e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 68.30 E-value: 6.47e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMmecKQDEIVMQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18260    8 GLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDP---SLQRVELNDISPLGLATVITYAYTGKLTLSLY 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL 141
Cdd:cd18260   85 TIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-134

6.81e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 69.30 E-value: 6.81e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHaMFTNDMMEcKQDeIVMQGMD---PSALEALINFAYNGNLAID 104
Cdd:cd18324   14 LSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFH-LFYKDQLD-KRD-IVHLNSDivtAPAFALLLEFMYEGKLQFK 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 105 QQNVQSLLMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18324   91 DLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-127

7.00e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 67.86 E-value: 7.00e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFtndmmECKQDEIVMqgMDPS-----ALEALINFAYNGNLAIDQQ 106
Cdd:cd18217   13 REAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVF--LDQSqvsadGFQKLLEFIYTGNLNLDSW 85

                         90       100
                 ....*....|....*....|.
gi 767922822 107 NVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18217   86 NVAEIHQAASYLGMEEVVAKC 106

Kelch

Kelch domain;

342-387

7.05e-14

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 66.04 E-value: 7.05e-14

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767922822   342 LLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMG 387
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

Kelch

Kelch domain;

535-576

1.24e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 65.27 E-value: 1.24e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767922822   535 RLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGV 576
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGV 42

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-135

1.50e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 67.54 E-value: 1.50e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHaMFTNDMMEcKQDEIVMQG--MDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18194   14 LREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLD-KRDLVRLNSdiVTAPAFGLLLDFMYEGRLALRD 91

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 106 QNVQSLLMGASFLQLQSIKDACCTFLRERL 135
Cdd:cd18194   92 LPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-134

2.17e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 66.81 E-value: 2.17e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHamftnDMMECKQDEIVMQGMDPS-ALEALINFAYNGNLAIDQQNVQS 110
Cdd:cd18229   13 RLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFH-----DKLLLGHSEIEVPPVVPAqTVRQLVEFMYSGSLVVAQSEALQ 87

                         90       100
                 ....*....|....*....|....
gi 767922822 111 LLMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18229   88 ILTAASILQIKTVIDECTQIISQS 111

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-142

2.54e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 66.92 E-value: 2.54e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMF---TNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNV 108
Cdd:cd18258   12 RRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANA 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 109 QSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Cdd:cd18258   92 KTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-130

2.65e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 66.49 E-value: 2.65e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  19 ELPSRGYGVMEEIRRQ---GKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNdmmecKQDEIVMQGMDPSALEALINF 95
Cdd:cd18206    1 DFPQHSQHVLEQLNQQrqlGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD-----QKDVVHLDISNAAGLGQVLEF 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822  96 AYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTF 130
Cdd:cd18206   76 MYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

40-118

3.29e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 65.00 E-value: 3.29e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922822  40 VTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFL 118
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

384-427

3.29e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 64.17 E-value: 3.29e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767922822  384 SAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMS 427
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

138-231

3.45e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 65.70 E-value: 3.45e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 138 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRg 217
Cdd:cd18465    4 ETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRR- 82

                         90
                 ....*....|....
gi 767922822 218 PYLPELLSNIRLPL 231
Cdd:cd18465   83 ASASHVLCHIRFPL 96

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-97

3.76e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 66.20 E-value: 3.76e-13

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  38 CDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAY 97
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIY 74

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-134

6.51e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 65.83 E-value: 6.51e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHaMFTNDMMEckQDEIVMQGMD---PSALEALINFAYNGNLAID 104
Cdd:cd18325   14 LSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLD--KRDIVHLNSDivtAPAFSLLLEFMYEGKLEFS 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 105 QQNVQSLLMGASFLQLQSIKDACCTFLRER 134
Cdd:cd18325   91 SLPVEDVLAAASYLHMYDIVKVCKGKLKDK 120

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-130

8.14e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 65.00 E-value: 8.14e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  26 GVMEEIRR---QGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTND-MMECKQDEIVMQgMDP---SALEALINFAYN 98
Cdd:cd18292    3 EFLQDIAQlynNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELV-EDPecaAVFEKFLRYLYT 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767922822  99 GNLAIDQQNVQSLLMGASFLQLQSIKDACCTF 130
Cdd:cd18292   82 GQISVNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-133

1.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 64.22 E-value: 1.56e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKIGDHKFSAHRIVLAASiPYFHAMFTNDMMECKQDEIVMQGMDPSAL-EAL-INFA--YNGNLAIDQQNVQ 109
Cdd:cd18305   12 NGENSDITICALGREWKLHKIYLCQS-GYFASMFSGSWKESKETVINLEIPDDNITvEALnVVFGslYRDEIEIKPSRVV 90

                         90       100
                 ....*....|....*....|....
gi 767922822 110 SLLMGASFLQLQSIKDACCTFLRE 133
Cdd:cd18305   91 SILAAATLLQLDGLIQQCSEVMKE 114

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-127

1.97e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 64.60 E-value: 1.97e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  35 GKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD-EIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLM 113
Cdd:cd18207   25 GRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPrELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMT 104

                         90
                 ....*....|....
gi 767922822 114 GASFLQLQSIKDAC 127
Cdd:cd18207  105 AAKFLLMRSVIDIC 118

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

2.31e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 63.76 E-value: 2.31e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18233    9 LHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQ-KNDVFHLDIKNVGGIGQILDFMYTSHLDLNQDN 87

                         90       100
                 ....*....|....*....|....*
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLR 132
Cdd:cd18233   88 VQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-143

3.15e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 64.15 E-value: 3.15e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18272   21 SIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRV 100

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767922822 106 QNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18272  101 EELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-135

5.79e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 63.16 E-value: 5.79e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQ------DEIVMQGmdpsaLEALINFAYNGNL 101
Cdd:cd18230   12 LNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQatvthlDIVTAQG-----FKAIIDFMYSAHL 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822 102 AIDQQNVQSLLMGASFLQLQSIKDACCTFLRERL 135
Cdd:cd18230   87 ALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120

Kelch

Kelch domain;

441-486

7.02e-12

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 60.26 E-value: 7.02e-12

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767922822   441 RIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLG 486
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-131

8.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 62.55 E-value: 8.39e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  36 KLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGA 115
Cdd:cd18279   17 RFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAA 96

                         90       100
                 ....*....|....*....|
gi 767922822 116 SFLQLQSIK----DACCTFL 131
Cdd:cd18279   97 DKYALERLKvmceDALCSNL 116

Kelch

Kelch domain;

289-341

1.06e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 59.88 E-value: 1.06e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767922822   289 LIYAVGGLNSaanfyaGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNG 341
Cdd:smart00612   1 KIYVVGGFDG------GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

1.14e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 61.76 E-value: 1.14e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIV-MQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18329   12 LDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVAtFDVFSPDTFTIILDFVYSGKLSLTSQ 91

                         90       100
                 ....*....|....*....|....*
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18329   92 NVIEVMSAASYLQMTDVISVCKTFI 116

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

139-211

1.14e-11

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 60.82 E-value: 1.14e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRY 211
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

25-130

1.80e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 61.43 E-value: 1.80e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  25 YGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAID 104
Cdd:cd18215    7 LLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSRLNLR 86

                         90       100
                 ....*....|....*....|....*.
gi 767922822 105 QQNVQSLLMGASFLQLQSIKDACCTF 130
Cdd:cd18215   87 EGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-124

2.47e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 60.79 E-value: 2.47e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFtndmMECKQDEIV-MQGMDPSALEALINFAYNGNLAI-DQ 105
Cdd:cd18221    9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF----QDFTQEPLVeIEGVSNMAFRHLIEFTYTAKLMVqGE 84

                         90       100
                 ....*....|....*....|
gi 767922822 106 QNVQSLLMGASFLQLQ-SIK 124
Cdd:cd18221   85 EEANDVWKAAEYLQMQeAIK 104

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-137

2.51e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 61.22 E-value: 2.51e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQG--MDPSALEALINFAYNGNLAIDQQNVQ 109
Cdd:cd18196   16 RLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVM 95

                         90       100
                 ....*....|....*....|....*...
gi 767922822 110 SLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18196   96 DVLLAASHLHLNSVVKACKHYLTTRTLP 123

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-136

2.73e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 61.13 E-value: 2.73e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEA---LINFAYNGNLAID 104
Cdd:cd18201   12 LNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKE-SCDQTTVTHLDVVAVQGfsvILDFMYSGNLVLT 90

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767922822 105 QQNVQSLLMGASFLQLQSIKDACCTFLRERLH 136
Cdd:cd18201   91 SQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

2.94e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 60.64 E-value: 2.94e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18332   10 LNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPRT 89

                         90       100
                 ....*....|....*....|....*
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLR 132
Cdd:cd18332   90 VPAVLAAATYLQMEHVVETCRRFIQ 114

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-139

4.38e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 60.53 E-value: 4.38e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIG----DHKFSAHRIVLAASIPYFHAMFtNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18281   22 LSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTL 100

                         90       100
                 ....*....|....*....|....*..
gi 767922822 113 MGASFLQLQSIKDACCTFLRERLHPKN 139
Cdd:cd18281  101 YTAKKYAVPALESACVEFLKKNLSSDN 127

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-131

4.82e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 59.95 E-value: 4.82e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  36 KLCDVTLKIGDHKF--SAHRIVLAASIPYFHAMF-TNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18294   13 EFSDVKFLVGPERQeiFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92

                         90
                 ....*....|....*....
gi 767922822 113 MGASFLQLQSIKDACCTFL 131
Cdd:cd18294   93 AAAVEYGLDELRKLCERFI 111

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-135

5.65e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 59.98 E-value: 5.65e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNG---NLAIDQQNVQSLLM 113
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDALELLR 91

                         90       100
                 ....*....|....*....|..
gi 767922822 114 GASFLQLQSIKDACCTFLRERL 135
Cdd:cd18297   92 AASFFQLDGLKRHCEILLSQQI 113

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-127

5.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 60.02 E-value: 5.71e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  36 KLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGA 115
Cdd:cd18343   20 RFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAA 99

                         90
                 ....*....|..
gi 767922822 116 SFLQLQSIKDAC 127
Cdd:cd18343  100 DKYALERLKVMC 111

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-131

5.88e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 59.86 E-value: 5.88e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  36 KLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGA 115
Cdd:cd18345   17 AFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAA 96

                         90       100
                 ....*....|....*....|
gi 767922822 116 SFLQLQSIKDAC----CTFL 131
Cdd:cd18345   97 DKYALERLKVMCeealCSNL 116

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-127

7.57e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 59.60 E-value: 7.57e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmqgmDPSALEALINFAYNGN-LAIDQ- 105
Cdd:cd18334   12 LNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMV----NPTVFRQILDFIYTGKlLTSDQp 87

                         90       100
                 ....*....|....*....|....
gi 767922822 106 --QNVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18334   88 geQNFNALLTAASYLQLHDLAALC 111

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-127

7.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 59.87 E-value: 7.64e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDH----KFSAHRIVLAASIPYFHAMFTNDM-MECKQDEIVMQGMDPSALEALINFAYNGNLA 102
Cdd:cd18211   16 MHKLRLLGHLCDVTVQVEHQgskeEFSAHKAVLAASSKYFKEVFLNEKiSDGKNTNVMLNEIYTADFASFLEFVYTAKVE 95

                         90       100
                 ....*....|....*....|....*
gi 767922822 103 IDQQNVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18211   96 VEEDRVQRMLEIAEKLKCLDLSETC 120

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

9-123

8.32e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 60.04 E-value: 8.32e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822   9 LEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDmmeCKQDEIVMQGMDPSA 88
Cdd:cd18289    1 MSQMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPATVPPAC 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767922822  89 LEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSI 123
Cdd:cd18289   78 FQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHI 112

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-127

9.23e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 59.31 E-value: 9.23e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  14 HFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHamftNDMMECKQDEIVMQGMDPSALEALI 93
Cdd:cd18208    2 SINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQ----DKLLLGYSDIEIPSVVSVQSVQKLI 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767922822  94 NFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18208   78 DFMYSGVLRVSQSEALQILTAASILQIKTVIDEC 111

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-143

1.44e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 58.27 E-value: 1.44e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEckqdeivMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFL 118
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILK-------VKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                         90       100
                 ....*....|....*....|....*
gi 767922822 119 QLQSIKDACCTFLRERLHPKNCLGV 143
Cdd:cd18275   79 QMPCAAQCAVDAVRAQLCLGNCYEV 103

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-127

1.50e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 58.41 E-value: 1.50e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  29 EEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNdmmECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNV 108
Cdd:cd18218   10 ARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGEL 86

                         90
                 ....*....|....*....
gi 767922822 109 QSLLMGASFLQLQSIKDAC 127
Cdd:cd18218   87 RPLLEAARALEVESLEEAC 105

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

139-230

1.58e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 57.82 E-value: 1.58e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDrEQRGP 218
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                         90
                 ....*....|..
gi 767922822 219 YLPELLSNIRLP 230
Cdd:cd18449   84 FAAKLMENIRFP 95

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-127

2.64e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 58.26 E-value: 2.64e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  29 EEIRRQ---GKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMM-ECKQDEIVMQGMDPSALEALINFAYNGNLAID 104
Cdd:cd18293    4 LQLHRQqnsGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVS 83

                         90       100
                 ....*....|....*....|...
gi 767922822 105 QQNVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18293   84 SEEAQDVLAAARRLQISELESLC 106

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

34-135

2.82e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 57.63 E-value: 2.82e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIdQQNVQS--L 111
Cdd:cd18300    6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPI-LEDGDCvgL 84

                         90       100
                 ....*....|....*....|....
gi 767922822 112 LMGASFLQLQSIKDACCTFLRERL 135
Cdd:cd18300   85 IVLANRLCLPRLVALCEQYIVKEL 108

BACK_KLHL22

cd18461

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...

139-231

3.37e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.

Pssm-ID: 350536 Cd Length: 104 Bit Score: 57.46 E-value: 3.37e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWvRYDREQ--- 215
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQvek 83

                         90
                 ....*....|....*....
gi 767922822 216 -RGPYL--PELLSNIRLPL 231
Cdd:cd18461   84 dQVSLQepPKLLEAVRFPL 102

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

135-222

6.84e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 56.12 E-value: 6.84e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 135 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 767922822 215 QRGPYLPE 222
Cdd:cd18451   81 ERERYFEE 88

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

430-473

1.02e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 54.16 E-value: 1.02e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767922822  430 RSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGM 473
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-130

1.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 55.92 E-value: 1.10e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMmeckQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:cd18232   13 REEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESFAEVFGLLLDFFYTGELALTRENRDRV 88

                         90
                 ....*....|....*....
gi 767922822 112 LMGASFLQLQSIKDACCTF 130
Cdd:cd18232   89 LLAAKELRVPEAVELCQRF 107

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-131

1.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 55.89 E-value: 1.15e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  22 SRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIV-MQGMDPSALEALINFAYNGN 100
Cdd:cd18199    3 SRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTAsFDVFSSDAFSIILDFVYSGK 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767922822 101 LAIDQQNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18199   83 LSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

21-125

1.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 55.98 E-value: 1.22e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  21 PSRGYGVMEEIRRQ---GKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAY 97
Cdd:cd18192    2 PSHSSYVLQQLNNQrewGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMY 81

                         90       100
                 ....*....|....*....|....*...
gi 767922822  98 NGNLAIDQQNVQSLLMGASFLQLQSIKD 125
Cdd:cd18192   82 LGKIMTAPSDFEQLKVAMNYLQLYYIPE 109

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

18-127

2.07e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 55.61 E-value: 2.07e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  18 SELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmQGMDPSALEALINFAY 97
Cdd:cd18224    7 SDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVV-DFITPANFEKVLSFIY 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822  98 NGNLAIDQQNVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18224   86 TSELFTDLINVGVIYEVAEKLGMEDLLKAC 115

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

2.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 55.25 E-value: 2.63e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTnDMMECKQDEIVMQ-GMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18331   15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFT-DQLKCNLSVINLDpEINPEGFNILLDFMYTSRLNLREG 93

                         90       100
                 ....*....|....*....|....*
gi 767922822 107 NVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18331   94 NIMAVMATAMYLQMEHVVDTCRKFI 118

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

34-103

3.45e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 55.09 E-value: 3.45e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767922822  34 QGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS--ALEALINFAYNGNLAI 103
Cdd:cd18309   17 GGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSrqAFDSLLRYIYYGDVTM 88

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

139-228

3.83e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 54.05 E-value: 3.83e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRG 217
Cdd:cd18482    5 NCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELCeLSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKERA 84

                         90
                 ....*....|.
gi 767922822 218 PYLPELLSNIR 228
Cdd:cd18482   85 ASAAEVLKCVR 95

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

37-127

4.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 54.41 E-value: 4.20e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGAS 116
Cdd:cd18352   13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92

                         90
                 ....*....|.
gi 767922822 117 FLQLQSIKDAC 127
Cdd:cd18352   93 QYLLEGLKRLC 103

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

477-520

5.80e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 51.84 E-value: 5.80e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767922822  477 RCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPM 520
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-137

6.30e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 54.06 E-value: 6.30e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTndMMECKQDEIVMQgMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18214   16 MNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISIL-QNSEVGRQLLLSCYTGVLEFPEME 92

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18214   93 LVNYLTAASFLQMSHIVERCTQALWKFIKP 122

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

29-125

6.67e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 54.18 E-value: 6.67e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  29 EEIRR---QGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNdmmECK-QDEIVMQG--MDPSALEALINFAYNGNLA 102
Cdd:cd18295    8 EFLRRlleQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFET---KWKdKREINLKHplVNPDAFRALLQYLYTGRLE 84

                         90       100
                 ....*....|....*....|...
gi 767922822 103 IDQQNVQSLLMGASFLQLQSIKD 125
Cdd:cd18295   85 IHVDDVEDCKRLAKQCRLEELIE 107

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-103

1.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 53.74 E-value: 1.07e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS-------------ALEALIN 94
Cdd:cd18195    9 LNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSpervlelpgvkagVFSDVLN 88


                 ....*....
gi 767922822  95 FAYNGNLAI 103
Cdd:cd18195   89 FIYSSRVAL 97

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-127

1.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 53.32 E-value: 1.17e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIV-MQGMDPSALEALINFAYNGNLAIDQQ 106
Cdd:cd18202   10 LNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVdLSGFCKSSFLPLLEFAYTSELTFDFC 89

                         90       100
                 ....*....|....*....|.
gi 767922822 107 NVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18202   90 SMAEVAMLARHLFMNEVLEIC 110

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

155-231

1.49e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 52.62 E-value: 1.49e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767922822 155 LYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVkSEEQVFEAALAWVRYdREQRGPYLPELLSNIRLPL 231
Cdd:cd14822   21 LCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEH-NPDSKEDAKEILEAVRLPL 95

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-127

1.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 52.92 E-value: 1.51e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAM-FTNDMMECKQDeivmqGMDPSALEALINFAYNGNLA---IDQQN 107
Cdd:cd18216   15 RTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLvLHDNLIHLDQD-----MVSPTVFQQILDFIYTGKLLdslFEEPN 89

                         90       100
                 ....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDAC 127
Cdd:cd18216   90 LSEVLAAANYLQLPDLAALC 109

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-99

1.61e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 53.42 E-value: 1.61e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767922822  39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNG 99
Cdd:cd18344   25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTG 85

PLN02193

nitrile-specifier protein

271-447

2.12e-08

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 56.89 E-value: 2.12e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 271 PHLPAFRTRprcCTSIAGLIYAVGGLNSAANFyagdslNVVEVFDPIANCWERCRPMT---TARSRVGVAVVNGLLYAIG 347
Cdd:PLN02193 215 PHLSCLGVR---MVSIGSTLYVFGGRDASRQY------NGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFG 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 348 GYDGQLRLSTVEAYNPETDTW----TRVGSMNSKrssvcfSAMGTVVLDGQIYVCGGYDGnSSLSSVETYSPETDKWTVV 423
Cdd:PLN02193 286 GVSATARLKTLDSYNIVDKKWfhcsTPGDSFSIR------GGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQV 358

                        170       180
                 ....*....|....*....|....*..
gi 767922822 424 TSMS---SNRSAAGVTVFEGRIYVSGG 447
Cdd:PLN02193 359 ETFGvrpSERSVFASAAVGKHIVIFGG 385

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

21-118

2.65e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 51.82 E-value: 2.65e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  21 PSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAAsipyFHAMFTNDMMECKQDEIVMQG-MDPSALEALINFAYNG 99
Cdd:cd18262    2 PSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAA----VSSLFRERLLGSNGPLPPLSLeVTPVGWEAVLTFAYTG 77

                         90
                 ....*....|....*....
gi 767922822 100 NLAIDQQNVQSLLMGASFL 118
Cdd:cd18262   78 VLGRNPATVGDILVAAEAL 96

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-139

2.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 52.38 E-value: 2.93e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGD----HKFSAHRIVLAASIPYFHAMFtNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18347   22 LSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                         90       100
                 ....*....|....*....|....*..
gi 767922822 113 MGASFLQLQSIKDACCTFLRERLHPKN 139
Cdd:cd18347  101 YTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-127

3.34e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 52.21 E-value: 3.34e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmqgmDPSALEALINFAYNGNLA----IDQQN 107
Cdd:cd18333   16 RTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMV----SPGIFRLILDYIYTGRLSegdpGSEQN 91

                         90       100
                 ....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDAC 127
Cdd:cd18333   92 LGAVLAAASYLQIPDLVALC 111

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-139

3.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 52.41 E-value: 3.41e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  36 KLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGA 115
Cdd:cd18342   21 RFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAA 100

                         90       100
                 ....*....|....*....|....
gi 767922822 116 SFLQLQSIKDACCTFLRERLHPKN 139
Cdd:cd18342  101 DKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-139

3.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 52.37 E-value: 3.98e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  45 GDHKFSAHRIVLAASIPYFHAMFtNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIK 124
Cdd:cd18346   40 GAQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                         90
                 ....*....|....*
gi 767922822 125 DACCTFLRERLHPKN 139
Cdd:cd18346  119 AHCVEFLTKHLRADN 133

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

39-131

4.31e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 51.91 E-value: 4.31e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEC-----KQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLM 113
Cdd:cd18296   19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESeenngSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                         90
                 ....*....|....*...
gi 767922822 114 GASFLQLQSIKDACCTFL 131
Cdd:cd18296   99 VADMYLLPGLKRLCGTVL 116

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-119

4.94e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 51.33 E-value: 4.94e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMeCKQDEiVMQGMDPSA--LEALINFAYNGNLAIDQ 105
Cdd:cd18223    9 LNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEI-WISSH-VLELPDLKAevFAEILNFIYSSKVVVKR 86

                         90       100
                 ....*....|....*....|
gi 767922822 106 QNVQSLL------MGASFLQ 119
Cdd:cd18223   87 QETVTDLvaagkkLGITFLE 106

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-131

5.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 51.47 E-value: 5.12e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  22 SRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEC-KQDEIVMQGMDPSALEALINFAYNGN 100
Cdd:cd18330    3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGK 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767922822 101 LAIDQQNVQSLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18330   83 LDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-127

5.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 51.41 E-value: 5.55e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTndMMECKQDEI-VMQGMDPSalEALINFAYNGNLAIDQQ 106
Cdd:cd18197   16 MNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRItILQSAEVG--RKLLLSCYTGALEVKKK 91

                         90       100
                 ....*....|....*....|.
gi 767922822 107 NVQSLLMGASFLQLQSIKDAC 127
Cdd:cd18197   92 ELLKYLTAASYLQMVHIVEKC 112

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

39-99

6.17e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 50.75 E-value: 6.17e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767922822  39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEC----KQDEIVMQGMDPSALEALINFAYNG 99
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSedavGCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

39-116

6.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 50.21 E-value: 6.98e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ--GMDPSALEALINFAYNGNL-AIDQQNVQSLLMGA 115
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLdLFSVENVHEVLELA 80


                 .
gi 767922822 116 S 116
Cdd:cd18190   81 S 81

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-133

9.59e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 50.81 E-value: 9.59e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNdmMECKQDEIV-MQGMDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18204    8 TLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKK--LEVDSSSVIeIDFLRSDIFEEVLNYMYTAKISVKK 85

                         90       100
                 ....*....|....*....|....*...
gi 767922822 106 QNVQSLLMGASFLQLQSIkDACCTFLRE 133
Cdd:cd18204   86 EDVNLMMSSGQILGIRFL-DKLCSQKRD 112

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

277-328

1.53e-07

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 47.99 E-value: 1.53e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767922822  277 RTRPRCCTSIAGLIYAVGGLNSaanfyaGDSLNVVEVFDPIANCWERCRPMT 328
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG------NQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-118

1.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 49.80 E-value: 1.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  33 RQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMmecKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18226   18 KQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNP---NTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVL 94


                 ....*.
gi 767922822 113 MGASFL 118
Cdd:cd18226   95 EAAKFL 100

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-131

2.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 49.65 E-value: 2.05e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  30 EIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDmmeckQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQ 109
Cdd:cd18205   11 QMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN-----SQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLD 85

                         90       100
                 ....*....|....*....|..
gi 767922822 110 SLLMGASFLQLQSIKDACCTFL 131
Cdd:cd18205   86 DLLYAAEILEIEYLEEQCLKIL 107

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-139

2.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 49.65 E-value: 2.99e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  33 RQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTndmmeckQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18243   28 RKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 100

                         90       100
                 ....*....|....*....|....*..
gi 767922822 113 MGASFLQLQSIKDACCTFLRERLHPKN 139
Cdd:cd18243  101 SVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-137

3.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 49.11 E-value: 3.65e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFtndMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN 107
Cdd:cd18203   16 MNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQF---LLNPSSELQVSLMHSSRVVADLLLSCYTGALEFSVRD 92

                         90       100       110
                 ....*....|....*....|....*....|
gi 767922822 108 VQSLLMGASFLQLQSIKDACCTFLRERLHP 137
Cdd:cd18203   93 IVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

Kelch

Kelch domain;

488-531

5.81e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 46.40 E-value: 5.81e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767922822   488 KMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVA 531
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAV 44

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-140

6.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 48.47 E-value: 6.73e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  34 QGKLCDVTLKIGDHKFSAHRIVLAASIPYFHamFTNDmmeCKQDEIVMQGMDPSALEALINFAYNGNLAI--DQQNVQSL 111
Cdd:cd18303   15 KELYSDITIKLADKSIPAHKFVLAARSEKWS--NENL---ASTNELDLSDISYEVVLALLRWLYTDELDLtlDDEFLLEL 89

                         90       100
                 ....*....|....*....|....*....
gi 767922822 112 LMGASFLQLQSIKDACCTFLRERLHPKNC 140
Cdd:cd18303   90 MKAAKRFQLTDLVERCERALMSSVNVDNC 118

BTB_POZ_ZBTB2

cd18193

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-119

7.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349502 [Multi-domain] Cd Length: 115 Bit Score: 48.06 E-value: 7.40e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQdeIVMQGMDPSALEALINFAYNGNLAIDQQNVQSL 111
Cdd:cd18193   16 REFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVR--LKPTDIQPDIFSYLLHLMYTGKMAPQLIDPVRL 93


                 ....*...
gi 767922822 112 LMGASFLQ 119
Cdd:cd18193   94 EQGIKFLH 101

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

37-139

1.08e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 47.74 E-value: 1.08e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIGDHK-FSAHRIVLAASIPYFHAMFTNDMME-CKQDEIVMQGmdPS-ALEALINFAY-NGNLAIDQ-QNVQSL 111
Cdd:cd18302    5 LYDVTIVSEDGKeFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPI--PSdILEIILDYLYtDEASAVKEsQNVEFL 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767922822 112 ---LMGASFLQLQSIKDACCTFLRERLHPKN 139
Cdd:cd18302   83 cnvLVIADQLLITRLKEICEVALVELLSLKN 113

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

139-231

1.09e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 47.21 E-value: 1.09e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 139 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEV--SMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDreQR 216
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELlkSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN--CR 82

                         90
                 ....*....|....*
gi 767922822 217 GPYLPELLSNIRLPL 231
Cdd:cd18471   83 YQYMDELLQYVRFGL 97

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

28-119

1.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 47.58 E-value: 1.17e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  28 MEEIRRQGKLCDVTLKIGDH-KFSAHRIVLAASIPYFHAMftNDMMECKQDEIVMQG-MDPSALEALINFAYNGNLAIDQ 105
Cdd:cd18311    5 LQNLFNKTEYCDLTLQFRDNeQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQLEFEE 82

                         90
                 ....*....|....
gi 767922822 106 QNVQSLLMGASFLQ 119
Cdd:cd18311   83 KSYGKLLRTAKELN 96

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

39-131

1.30e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 47.21 E-value: 1.30e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  39 DVTLKI-GDHKFSAHRIVLAASIPYFHAMFTNdMMECKQDEIVmqgmDPSALEALINFAYNGNLAIDQQNVQSLLMGASF 117
Cdd:cd18299   14 DVVFILqGGVRIFAHRIVLAAASSVFADLFLM-MTVVTLDSDI----TPEAFRRVLEFLYTGVLDENEDDLKELKDAAEL 88

                         90
                 ....*....|....
gi 767922822 118 LQLQSIKDACCTFL 131
Cdd:cd18299   89 LELFDLVMMCTNVL 102

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-68

1.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 47.13 E-value: 1.54e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFT 68
Cdd:cd18219   12 LNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS 52

PRK14131

N-acetylneuraminate epimerase;

295-447

1.62e-06

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 50.40 E-value: 1.62e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 295 GLNSAA-NFYAGDSLNVVEVFDPIANCwercrpMTTARSRVGVAVVNGLLYAIGGY-----DGQLRL-STVEAYNPETDT 367
Cdd:PRK14131  44 GLGSAGtSWYKLDLNAPSKGWTKIAAF------PGGPREQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNS 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 368 WTRVGSmnskRSSVCFSAMGTVVLDG-QIYVCGGY---------------DGNSSLSS-------------------VET 412
Cdd:PRK14131 118 WQKLDT----RSPVGLAGHVAVSLHNgKAYITGGVnknifdgyfedlaaaGKDKTPKDkindayfdkkpedyffnkeVLS 193

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767922822 413 YSPETDKWTVV-TSMSSNRSAAGVTVFEGRIYVSGG 447
Cdd:PRK14131 194 YDPSTNQWKNAgESPFLGTAGSAVVIKGNKLWLING 229

Kelch_6

Kelch motif;

330-378

1.86e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 45.02 E-value: 1.86e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767922822  330 ARSRVGVAVVNGLLYAIGGYDGQL-RLSTVEAYNPETDTWTRVGSMNSKR 378
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-133

2.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 46.74 E-value: 2.24e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  19 ELPSRGYGVMEEI---RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNdmmeckQDEIVMQG--MDPSALEALI 93
Cdd:cd18225    2 ELPNYSRQLLQQLhtlRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDS------TDTISIDAsvVSPEEFALLL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767922822  94 NFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRE 133
Cdd:cd18225   76 EMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115

BTB2_POZ_RHOBTB1

cd18358

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

28-102

2.24e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349667 [Multi-domain] Cd Length: 126 Bit Score: 46.88 E-value: 2.24e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767922822  28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA 102
Cdd:cd18358   11 IKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLS 85

BTB_POZ_ZBTB25_ZNF46_KUP

cd18213

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-99

2.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349522 [Multi-domain] Cd Length: 128 Bit Score: 47.20 E-value: 2.27e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  32 RRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECkqdeIVMQGMD--PSALEALINFAYNG 99
Cdd:cd18213   16 REFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSEC----IKIQPTDiqPDIFSYLLHIMYTG 81

BACK_KLHL14

cd18453

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...

141-245

2.66e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.

Pssm-ID: 350528 Cd Length: 102 Bit Score: 46.16 E-value: 2.66e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 141 LGVRQFAETMMCAVLY--DAANSFIHQHFVEvsmseEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP 218
Cdd:cd18453    1 ISVQNYKQVCKIAALHglEETKKLANKYLVE-----DVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQ 75

                         90       100
                 ....*....|....*....|....*..
gi 767922822 219 YLPELLSNIRLPLCRPQFLSDRVQQDD 245
Cdd:cd18453   76 YAPDLMKRLRFALIPAPELVERVQSVD 102

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-135

2.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 46.51 E-value: 2.66e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  37 LCDVTLKIG----DHKFSAHRIVLAASIPYFHAMFTNDMMECKQdEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLL 112
Cdd:cd18349    8 MADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATL 86

                         90       100
                 ....*....|....*....|...
gi 767922822 113 MGASFLQLQSIKDACCTFLRERL 135
Cdd:cd18349   87 YAAKKYIVPALAKACVNFLETSL 109

BTB_POZ_KLHL42

cd18319

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-119

3.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 45.63 E-value: 3.09e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  40 VTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQN----------VQ 109
Cdd:cd18319    4 VQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDstdtleenelLE 83

                         90
                 ....*....|
gi 767922822 110 SLLMGASFLQ 119
Cdd:cd18319   84 DLVEAASFLQ 93

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-139

4.35e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 46.55 E-value: 4.35e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  45 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKqDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIK 124
Cdd:cd18348   33 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 111

                         90
                 ....*....|....*
gi 767922822 125 DACCTFLRERLHPKN 139
Cdd:cd18348  112 RACVNFLETSLSAKN 126

Kelch_3

pfam13415

Galactose oxidase, central domain;

340-385

5.16e-06

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 43.82 E-value: 5.16e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767922822  340 NGLLYAIGGYD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSsvCFSA 385
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRS--GHSA 46

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

523-567

5.52e-06

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 43.48 E-value: 5.52e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767922822  523 RRSRVSLVASCGRLYAVGGYDGQSNLSSVEM--YDPETDCWTFMAPM 567
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVlvYDPETNVWTEVPRL 47

Kelch_6

Kelch motif;

382-426

6.05e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 43.48 E-value: 6.05e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767922822  382 CFSAMGTVVLDGQIYVCGGY-DGNSSLSSVETYSPETDKWTVVTSM 426
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

51-135

6.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 45.08 E-value: 6.47e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  51 AHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTF 130
Cdd:cd18282   25 AHKYVLATGSSVFYAMFYGGLAE-NKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQF 103


                 ....*
gi 767922822 131 LRERL 135
Cdd:cd18282  104 LETSL 108

PLN02153

epithiospecifier protein

331-514

6.94e-06

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 48.44 E-value: 6.94e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 331 RSRVGVAVVNGLLYAIGG-------YDGQLRLstveaYNPETDTWTrVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDG 403
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGelkpnehIDKDLYV-----FDFNTHTWS-IAPANGDVPRISCLGVRMVAVGTKLYIFGGRDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 404 NSSLSSVETYSPETDKWTVVTSMSSN-----RSAAGVTVFEGRIYVSGG--HDGLQI----FSSVEHYNHHTATWH--PA 470
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvsKGGLMKtperFRTIEAYNIADGKWVqlPD 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767922822 471 AG-MLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQW 514
Cdd:PLN02153 177 PGeNFEKRGGAGFAVVQGKIWVVYGFATSILPGGKSDYESNAVQF 221

BACK_KBTBD4

cd18481

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

138-225

1.14e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.

Pssm-ID: 350556 Cd Length: 88 Bit Score: 44.11 E-value: 1.14e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 138 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRdelNVKSEEQVFEAALAWVRYDREQRG 217
Cdd:cd18481    4 RNCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEERE 80


                 ....*...
gi 767922822 218 pYLPELLS 225
Cdd:cd18481   81 -GFSETLT 87

PLN02193

nitrile-specifier protein

280-494

2.52e-05

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 46.87 E-value: 2.52e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 280 PRCCTSIAGL---IYAVGGlnsaaNFYAGDSLNV-VEVFDPIANCWErCRPMT---TARSRVGVAVVN--GLLYAIGGYD 350
Cdd:PLN02193 165 LRCSHGIAQVgnkIYSFGG-----EFTPNQPIDKhLYVFDLETRTWS-ISPATgdvPHLSCLGVRMVSigSTLYVFGGRD 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822 351 GQLRLSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTVvlDGQIYVCGGYDGNSSLSSVETYSPETDKW----TVVTSM 426
Cdd:PLN02193 239 ASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAAD--EENVYVFGGVSATARLKTLDSYNIVDKKWfhcsTPGDSF 316

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767922822 427 SSnRSAAGVTVFEGRIYVSGGHDGLQIfSSVEHYNHHTATWHPAAGM---LNKRCRHGAASLGSKMFVCGG 494
Cdd:PLN02193 317 SI-RGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFgvrPSERSVFASAAVGKHIVIFGG 385

DUF6242

pfam19755

Domain of unknown function (DUF6242); This presumed domain is functionally uncharacterized. ...

361-456

2.94e-05

Domain of unknown function (DUF6242); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 290 amino acids in length. It contains a BNR/Asp box motif at the C-terminal, which contains the characteriztic sequence motif SxDxGxT/xW of the BNR family, present as repeats in sialidases and others glycosyl hydrolases.

Pssm-ID: 437587 Cd Length: 218 Bit Score: 45.53 E-value: 2.94e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922822  361 YNPETDTWTRVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDGNSSLssVETYSPETDKWTVVTSMSSNrSAAGVTVFEG 440
Cdd:pfam19755 122 QDPDSLVWTKLVTNSALPNGAALTEQKAVALNGKLYVFGTDGGGTLV--YSTASTDGKTWTLLGTLSAA-DYSSVTAFDG 198

                          90
                  ....*....|....*.
gi 767922822  441 RIYVSGGhDGlQIFSS 456
Cdd:pfam19755 199 KLYALDA-DG-KLYSS 212

BACK_KLHL15

cd18454

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...

160-234

3.63e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.

Pssm-ID: 350529 Cd Length: 108 Bit Score: 42.96 E-value: 3.63e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767922822 160 NSFIHQHFVEVSMSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDReQRGPYLPELLSNIRLPLCRP 234
Cdd:cd18454   28 DSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDR-RRWRHTDTIIQNIRFCLMTP 102

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

388-426

3.75e-05

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 41.17 E-value: 3.75e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767922822  388 TVVLDGQIYVCGGYD--GNSSLSSVETYSPETDKWTVVTSM 426
Cdd:pfam07646   7 SSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWTEVPRL 47

Kelch_6

Kelch motif;

283-331

4.03e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.17 E-value: 4.03e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767922822  283 CTSIAGLIYAVGGLNsaanfYAGDSLNVVEVFDPIANCWERCRPMTTAR 331
Cdd:pfam13964   7 VVSVGGYIYVFGGYT-----NASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_KBTBD13

cd18320

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-84

5.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349629 [Multi-domain] Cd Length: 83 Bit Score: 42.03 E-value: 5.58e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767922822  34 QGKLCdvtLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGM 84
Cdd:cd18320    1 MQKVK---VWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGL 48

BACK_KLHL36

cd18475

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...

160-231

6.60e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pssm-ID: 350550 Cd Length: 100 Bit Score: 42.14 E-value: 6.60e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922822 160 NSFIHQHFVEVSMSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREqRGPYLPELLSNIRLPL 231
Cdd:cd18475   26 DSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPE-RENEAYQVLSNIHFPL 97

Kelch_6