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Conserved domains on  [gi|530371977|ref|XP_005264966|]
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xin actin-binding repeat-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

Xin and PHA03247 domain-containing protein( domain architecture ID 10547186)

Xin and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 948-1444 7.88e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 7.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  948 PPADPSPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQ 1027
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP 2680

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1028 KGM-------AVLGKSEGATTTPPGPG---APDLLAAMQSLRMATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAG 1097
Cdd:PHA03247 2681 QRPrrraarpTVGSLTSLADPPPPPPTpepAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1098 ATQSNirPGGGSDPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQRePQSRHRETALSVQA 1177
Cdd:PHA03247 2761 PTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1178 PRPLQGGPGQSTGPgreePGGctqmaWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAgASPHPHNAFVPPP 1257
Cdd:PHA03247 2838 APPPPPGPPPPSLP----LGG-----SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRS-TESFALPPDQPER 2907

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1258 PTLPAAVTGPDFPAGAHRAE-DSIQQASEPLKDPLLHSHSSPAGQRTPGGSQTktpklDPTMPPKKKPQLPPKPAHLTQS 1336
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP-----QPWLGALVPGRVAVPRFRVPQP 2982

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1337 HPPQRLPKPLPLSP--SFSSEVGQREHQRGERDTAIPQPAKVPTTVdqgHIP--LARCPSGHSQPSLQHGLSTTAPRPTK 1412
Cdd:PHA03247 2983 APSREAPASSTPPLtgHSLSRVSSWASSLALHEETDPPPVSLKQTL---WPPddTEDSDADSLFDSDSERSDLEALDPLP 3059

                         490       500       510
                  ....*....|....*....|....*....|..
gi 530371977 1413 NQATGSNAQSSEPPKLNALNHDPTSPQWGPGP 1444
Cdd:PHA03247 3060 PEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 507-522 2.05e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 42.71  E-value: 2.05e-05
                           10
                   ....*....|....*.
gi 530371977   507 GDVQGYRWMFETQPLD 522
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 545-560 1.19e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 40.40  E-value: 1.19e-04
                           10
                   ....*....|....*.
gi 530371977   545 GDVGTARWLFETQPLE 560
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 151-166 1.32e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 40.40  E-value: 1.32e-04
                           10
                   ....*....|....*.
gi 530371977   151 GDVRAARWLFETKPLD 166
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 589-603 2.55e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.63  E-value: 2.55e-04
                           10
                   ....*....|....*
gi 530371977   589 GDVQTIRWLFETCPM 603
Cdd:pfam08043    1 GDVKTTRWLFETQPL 15
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 376-391 3.77e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.25  E-value: 3.77e-04
                           10
                   ....*....|....*.
gi 530371977   376 GDVRSTLWLFETKPLD 391
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 303-317 4.28e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 38.86  E-value: 4.28e-04
                           10
                   ....*....|....*
gi 530371977   303 DVSATRWIFETQPLD 317
Cdd:pfam08043    2 DVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 89-104 3.37e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.55  E-value: 3.37e-03
                           10
                   ....*....|....*.
gi 530371977    89 GDVQCMRWIFENWRLD 104
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 186-201 4.48e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.16  E-value: 4.48e-03
                           10
                   ....*....|....*.
gi 530371977   186 GDVQGTRMLFETRPLD 201
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 948-1444 7.88e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 7.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  948 PPADPSPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQ 1027
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP 2680

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1028 KGM-------AVLGKSEGATTTPPGPG---APDLLAAMQSLRMATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAG 1097
Cdd:PHA03247 2681 QRPrrraarpTVGSLTSLADPPPPPPTpepAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1098 ATQSNirPGGGSDPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQRePQSRHRETALSVQA 1177
Cdd:PHA03247 2761 PTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1178 PRPLQGGPGQSTGPgreePGGctqmaWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAgASPHPHNAFVPPP 1257
Cdd:PHA03247 2838 APPPPPGPPPPSLP----LGG-----SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRS-TESFALPPDQPER 2907

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1258 PTLPAAVTGPDFPAGAHRAE-DSIQQASEPLKDPLLHSHSSPAGQRTPGGSQTktpklDPTMPPKKKPQLPPKPAHLTQS 1336
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP-----QPWLGALVPGRVAVPRFRVPQP 2982

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1337 HPPQRLPKPLPLSP--SFSSEVGQREHQRGERDTAIPQPAKVPTTVdqgHIP--LARCPSGHSQPSLQHGLSTTAPRPTK 1412
Cdd:PHA03247 2983 APSREAPASSTPPLtgHSLSRVSSWASSLALHEETDPPPVSLKQTL---WPPddTEDSDADSLFDSDSERSDLEALDPLP 3059

                         490       500       510
                  ....*....|....*....|....*....|..
gi 530371977 1413 NQATGSNAQSSEPPKLNALNHDPTSPQWGPGP 1444
Cdd:PHA03247 3060 PEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 507-522 2.05e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 42.71  E-value: 2.05e-05
                           10
                   ....*....|....*.
gi 530371977   507 GDVQGYRWMFETQPLD 522
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 893-1275 1.07e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977   893 TGLVMQETEQGLVALTaySLQPRLTSKASERSSVQL--LASCIDKGDLSGlhslrwEPPADPSPVPASEGAQSLHPTESI 970
Cdd:pfam05109  437 TGFAAPNTTTGLPSST--HVPTNLTAPASTGPTVSTadVTSPTPAGTTSG------ASPVTPSPSPRDNGTESKAPDMTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977   971 IHVPPLDPSMGMGHLRASGATPCP---PQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQKGMAVLGKSE--GATTTP-P 1044
Cdd:pfam05109  509 PTSAVTTPTPNATSPTPAVTTPTPnatSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSptSAVTTPtP 588

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1045 GPGAPDLlaamqslrmataeAQSLHQQVLNKHKQG---PTPTATSNPiQDGLRKAGATQSNIRPGGGSDPRIpaapRKVS 1121
Cdd:pfam05109  589 NATSPTV-------------GETSPQANTTNHTLGgtsSTPVVTSPP-KNATSAVTTGQHNITSSSTSSMSL----RPSS 650

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1122 REEQALPrglpggwvTIQDGIYTAHPVRT-FDPPGGVQLSQREPQSRHREtALSVQAPRPLQGGPGQSTGPGRE----EP 1196
Cdd:pfam05109  651 ISETLSP--------STSDNSTSHMPLLTsAHPTGGENITQVTPASTSTH-HVSTSSPAPRPGTTSQASGPGNSststKP 721

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1197 GGCTQMAWGPPGKAMAEVCPGGLQAAETTL-------KTAPLGRHILASGPQAA--------GASPHP---HNA--FVPP 1256
Cdd:pfam05109  722 GEVNVTKGTPPKNATSPQAPSGQKTAVPTVtstggkaNSTTGGKHTTGHGARTStepttdygGDSTTPrtrYNAttYLPP 801

                          410       420       430
                   ....*....|....*....|....*....|...
gi 530371977  1257 --------------PPTLPAAVTGPDFPAGAHR 1275
Cdd:pfam05109  802 stssklrprwtftsPPVTTAQATVPVPPTSQPR 834
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 545-560 1.19e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 40.40  E-value: 1.19e-04
                           10
                   ....*....|....*.
gi 530371977   545 GDVGTARWLFETQPLE 560
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 151-166 1.32e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 40.40  E-value: 1.32e-04
                           10
                   ....*....|....*.
gi 530371977   151 GDVRAARWLFETKPLD 166
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 589-603 2.55e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.63  E-value: 2.55e-04
                           10
                   ....*....|....*
gi 530371977   589 GDVQTIRWLFETCPM 603
Cdd:pfam08043    1 GDVKTTRWLFETQPL 15
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 376-391 3.77e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.25  E-value: 3.77e-04
                           10
                   ....*....|....*.
gi 530371977   376 GDVRSTLWLFETKPLD 391
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 303-317 4.28e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 38.86  E-value: 4.28e-04
                           10
                   ....*....|....*
gi 530371977   303 DVSATRWIFETQPLD 317
Cdd:pfam08043    2 DVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 89-104 3.37e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.55  E-value: 3.37e-03
                           10
                   ....*....|....*.
gi 530371977    89 GDVQCMRWIFENWRLD 104
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 186-201 4.48e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.16  E-value: 4.48e-03
                           10
                   ....*....|....*.
gi 530371977   186 GDVQGTRMLFETRPLD 201
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 948-1444 7.88e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 7.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  948 PPADPSPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQ 1027
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP 2680

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1028 KGM-------AVLGKSEGATTTPPGPG---APDLLAAMQSLRMATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAG 1097
Cdd:PHA03247 2681 QRPrrraarpTVGSLTSLADPPPPPPTpepAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1098 ATQSNirPGGGSDPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQRePQSRHRETALSVQA 1177
Cdd:PHA03247 2761 PTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1178 PRPLQGGPGQSTGPgreePGGctqmaWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAgASPHPHNAFVPPP 1257
Cdd:PHA03247 2838 APPPPPGPPPPSLP----LGG-----SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRS-TESFALPPDQPER 2907

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1258 PTLPAAVTGPDFPAGAHRAE-DSIQQASEPLKDPLLHSHSSPAGQRTPGGSQTktpklDPTMPPKKKPQLPPKPAHLTQS 1336
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP-----QPWLGALVPGRVAVPRFRVPQP 2982

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1337 HPPQRLPKPLPLSP--SFSSEVGQREHQRGERDTAIPQPAKVPTTVdqgHIP--LARCPSGHSQPSLQHGLSTTAPRPTK 1412
Cdd:PHA03247 2983 APSREAPASSTPPLtgHSLSRVSSWASSLALHEETDPPPVSLKQTL---WPPddTEDSDADSLFDSDSERSDLEALDPLP 3059

                         490       500       510
                  ....*....|....*....|....*....|..
gi 530371977 1413 NQATGSNAQSSEPPKLNALNHDPTSPQWGPGP 1444
Cdd:PHA03247 3060 PEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1080-1447 1.87e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1080 PTPTATSNPIQDGLRKAGATQSNIRPGGGS-------DPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTahpvRTFD 1152
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPPSPSPAANEPDPHPPptvpppeRPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR----RAAR 2689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1153 PPGGVQLSQREPQSRHRETAlsvqaPRPLQGGPGQSTGPGREEPGGC---TQMAWGPPGKAMAEVCPGGlqaaETTLKTA 1229
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPE-----PAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGG----PARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1230 PLGRHILASGPQAAGASPHPHNAfvPPPPTLPAAVTGPDFPAGAHRAEDSiqqASEPLKDPLLHSHSSPAGQRTPGGSQT 1309
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRL--TRPAVASLSESRESLPSPWDPADPP---AAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1310 KTPKLDPTMPPKKKPQLPPKPA--HLTQSHPPQRLPKPLPLSPSfssevgqreHQRGERdTAIPQPAKVPTTVDQGHIPL 1387
Cdd:PHA03247 2836 PTAPPPPPGPPPPSLPLGGSVApgGDVRRRPPSRSPAAKPAAPA---------RPPVRR-LARPAVSRSTESFALPPDQP 2905

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1388 ARCPsghsQPSLQhglsttaPRPTKNQATGSNAQSSEPPKLNALNHDPTSPQWGPGPSGE 1447
Cdd:PHA03247 2906 ERPP----QPQAP-------PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954
PHA03247 PHA03247
large tegument protein UL36; Provisional
 948-1426 6.88e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  948 PPADPSPVPASEGaQSLHPTESIIHvpPLDPSMGMGHLRASgatpCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHsgq 1027
Cdd:PHA03247 2553 PPLPPAAPPAAPD-RSVPPPRPAPR--PSEPAVTSRARRPD----APPQSARPRAPVDDRGDPRGPAPPSPLPPDTH--- 2622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1028 kgmavlgksegatttPPGPGAPDLLAAMQSLRMATAEAQSLHQQVLNkhkqGPTPTATSNPiQDGLRKAGATQSNIRPGG 1107
Cdd:PHA03247 2623 ---------------APDPPPPSPSPAANEPDPHPPPTVPPPERPRD----DPAPGRVSRP-RRARRLGRAAQASSPPQR 2682

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1108 gsdPRIPAAPRKVSR--------EEQALPRGLPGGWVTiqdgiytAHPVrtfdPPGGVQLSQREPqsrhreTALSVQAPR 1179
Cdd:PHA03247 2683 ---PRRRAARPTVGSltsladppPPPPTPEPAPHALVS-------ATPL----PPGPAAARQASP------ALPAAPAPP 2742

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1180 PLQGGPgqsTGPGREEPGGCTQMAWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHiLASGPQAAGASPHPhNAFVPPPPT 1259
Cdd:PHA03247 2743 AVPAGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLPSPWDPADPP-AAVLAPAAA 2817

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1260 LPAAVTgpdfPAGAHRAEDSIQQASEPLKDPLLHSHSSPAGQRTPGG---------SQTKTPKLDPTMPPKKKPQLPPKP 1330
Cdd:PHA03247 2818 LPPAAS----PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvrrrppsrSPAAKPAAPARPPVRRLARPAVSR 2893

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1331 AHLTQSHPPQRLPKP----LPLSPSFSSEVGQREH-QRGERDTAIPQPAKVPTTVDQGhiplARCPSGhSQPSLQHGLST 1405
Cdd:PHA03247 2894 STESFALPPDQPERPpqpqAPPPPQPQPQPPPPPQpQPPPPPPPRPQPPLAPTTDPAG----AGEPSG-AVPQPWLGALV 2968

                         490       500
                  ....*....|....*....|.
gi 530371977 1406 TAPRPTKNQATGSNAQSSEPP 1426
Cdd:PHA03247 2969 PGRVAVPRFRVPQPAPSREAP 2989
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 507-522 2.05e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 42.71  E-value: 2.05e-05
                           10
                   ....*....|....*.
gi 530371977   507 GDVQGYRWMFETQPLD 522
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 947-1286 9.11e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 9.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  947 EPPADPSPVPASEGAQSlhptesiihvppldPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSG 1026
Cdd:PRK07764  424 APAAAPQPAPAPAPAPA--------------PPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPA 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1027 QKGMAvlgKSEGATTTPPGPGA--------PDLLAAMQSLRMATAEAQSLHQQVLNKHKQG-----PTPTATSNPIQDG- 1092
Cdd:PRK07764  490 PAAAP---AAPAAPAAPAGADDaatlrerwPEILAAVPKRSRKTWAILLPEATVLGVRGDTlvlgfSTGGLARRFASPGn 566

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1093 ---LRKAGATQSNIR----------PGGGSDPRIPAAPRKVSREEQALPRGlPGGWVTiQDGIYTAHPVRTFDPPGGVQL 1159
Cdd:PRK07764  567 aevLVTALAEELGGDwqveavvgpaPGAAGGEGPPAPASSGPPEEAARPAA-PAAPAA-PAAPAPAGAAAAPAEASAAPA 644

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1160 SQREPQSRHRETALSVQAPRPLQGGPGQSTGPGREEPGGCTQ--MAWGPPGKAMAEVCPGGLQAAETTLKTAPLGRhilA 1237
Cdd:PRK07764  645 PGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPApaAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQ---P 721

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 530371977 1238 SGPQAAGASPHPHNAFVPPPPTLPAAVTGPDFPAGAHRAEDSIQQASEP 1286
Cdd:PRK07764  722 PQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 893-1275 1.07e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977   893 TGLVMQETEQGLVALTaySLQPRLTSKASERSSVQL--LASCIDKGDLSGlhslrwEPPADPSPVPASEGAQSLHPTESI 970
Cdd:pfam05109  437 TGFAAPNTTTGLPSST--HVPTNLTAPASTGPTVSTadVTSPTPAGTTSG------ASPVTPSPSPRDNGTESKAPDMTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977   971 IHVPPLDPSMGMGHLRASGATPCP---PQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQKGMAVLGKSE--GATTTP-P 1044
Cdd:pfam05109  509 PTSAVTTPTPNATSPTPAVTTPTPnatSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSptSAVTTPtP 588

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1045 GPGAPDLlaamqslrmataeAQSLHQQVLNKHKQG---PTPTATSNPiQDGLRKAGATQSNIRPGGGSDPRIpaapRKVS 1121
Cdd:pfam05109  589 NATSPTV-------------GETSPQANTTNHTLGgtsSTPVVTSPP-KNATSAVTTGQHNITSSSTSSMSL----RPSS 650

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1122 REEQALPrglpggwvTIQDGIYTAHPVRT-FDPPGGVQLSQREPQSRHREtALSVQAPRPLQGGPGQSTGPGRE----EP 1196
Cdd:pfam05109  651 ISETLSP--------STSDNSTSHMPLLTsAHPTGGENITQVTPASTSTH-HVSTSSPAPRPGTTSQASGPGNSststKP 721

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1197 GGCTQMAWGPPGKAMAEVCPGGLQAAETTL-------KTAPLGRHILASGPQAA--------GASPHP---HNA--FVPP 1256
Cdd:pfam05109  722 GEVNVTKGTPPKNATSPQAPSGQKTAVPTVtstggkaNSTTGGKHTTGHGARTStepttdygGDSTTPrtrYNAttYLPP 801

                          410       420       430
                   ....*....|....*....|....*....|...
gi 530371977  1257 --------------PPTLPAAVTGPDFPAGAHR 1275
Cdd:pfam05109  802 stssklrprwtftsPPVTTAQATVPVPPTSQPR 834
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 545-560 1.19e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 40.40  E-value: 1.19e-04
                           10
                   ....*....|....*.
gi 530371977   545 GDVGTARWLFETQPLE 560
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 151-166 1.32e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 40.40  E-value: 1.32e-04
                           10
                   ....*....|....*.
gi 530371977   151 GDVRAARWLFETKPLD 166
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 589-603 2.55e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.63  E-value: 2.55e-04
                           10
                   ....*....|....*
gi 530371977   589 GDVQTIRWLFETCPM 603
Cdd:pfam08043    1 GDVKTTRWLFETQPL 15
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 376-391 3.77e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.25  E-value: 3.77e-04
                           10
                   ....*....|....*.
gi 530371977   376 GDVRSTLWLFETKPLD 391
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 303-317 4.28e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 38.86  E-value: 4.28e-04
                           10
                   ....*....|....*
gi 530371977   303 DVSATRWIFETQPLD 317
Cdd:pfam08043    2 DVKTTRWLFETQPLD 16
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
1331-1485 1.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.61  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1331 AHLTQ---SHPPQRLPKPlPLSPSFSSEVGQREHQRGERDTAIPQPAKVPTTVDQGhiPLARCPSGHSQPslqhgLSTTA 1407
Cdd:PRK14971  360 AQLTQkgdDASGGRGPKQ-HIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAP--QSATQPAGTPPT-----VSVDP 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1408 PRPTKNQATGSNAQSSEPPKLNALNHDPTSPQWGPGPSGEQPMEGSHQG-------APESPDSLQRNQKELQGLLNQVQA 1480
Cdd:PRK14971  432 PAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEKAEQatgnikeAPTGTQKEIFTEEDLQYYWQEFAG 511


                  ....*
gi 530371977 1481 LEKEA 1485
Cdd:PRK14971  512 TRPQE 516
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 89-104 3.37e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.55  E-value: 3.37e-03
                           10
                   ....*....|....*.
gi 530371977    89 GDVQCMRWIFENWRLD 104
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1163-1464 3.74e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1163 EPQSRHRETALSVQAPRPLQGGPGQ---STGPGREEPGGCTQMAW-------GPPGKAMAEVCPGGLQA----AETTLKT 1228
Cdd:PHA03307   18 GEFFPRPPATPGDAADDLLSGSQGQlvsDSAELAAVTVVAGAAACdrfepptGPPPGPGTEAPANESRStptwSLSTLAP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1229 APLGRHIlASGPQAAGASPHPHNAFVP--PPPTLPAAVTGPDFPAGAHRAEDSIQQASEPLKDPllhshSSPAGQRTPGG 1306
Cdd:PHA03307   98 ASPAREG-SPTPPGPSSPDPPPPTPPPasPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA-----AVASDAASSRQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1307 S---QTKTPKLDPTMPPKKKPQLPPKPAHLTqSHPPQRLPKPLPLSPSFSSEVGQREHQRGERDTAIPQPAKVPTTVDQG 1383
Cdd:PHA03307  172 AalpLSSPEETARAPSSPPAEPPPSTPPAAA-SPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977 1384 hiPLARCPSGHSQPSLQHGLSTTAPRPTknqATGSNAQSSEPPKLNALNHDPTSPQWGPGPSGEQPMEGSHQGAPESPDS 1463
Cdd:PHA03307  251 --PENECPLPRPAPITLPTRIWEASGWN---GPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS 325


                  .
gi 530371977 1464 L 1464
Cdd:PHA03307  326 S 326
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 186-201 4.48e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.16  E-value: 4.48e-03
                           10
                   ....*....|....*.
gi 530371977   186 GDVQGTRMLFETRPLD 201
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1061-1423 4.65e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 4.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1061 ATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAGATQSNIRPGGGSDPRIPAAPRKVSREEQALPRGLpggwvtIQD 1140
Cdd:pfam03154  160 SSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL------IQQ 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1141 GIyTAHPVRTFDPPGGVQL-------SQREPQSrHRETALSVQAP---RPLQGGP------------------GQST--- 1189
Cdd:pfam03154  234 TP-TLHPQRLPSPHPPLQPmtqppppSQVSPQP-LPQPSLHGQMPpmpHSLQTGPshmqhpvppqpfpltpqsSQSQvpp 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1190 GPGREEPGGCTQMAWGPPGKAMAevcPGGLQAAETTLKTAPLGR-HILA---------SGPQA-------AGASPHPHNA 1252
Cdd:pfam03154  312 GPSPAAPGQSQQRIHTPPSQSQL---QSQQPPREQPLPPAPLSMpHIKPppttpipqlPNPQShkhpphlSGPSPFQMNS 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1253 FVPPPPTL-PAAVTGPDFPAGAHRAEDSIQQASEPLKDPLLH--------SHSSPAGQRTPGGSQTKTPKLDPTMPPKkk 1323
Cdd:pfam03154  389 NLPPPPALkPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQppvltqsqSLPPPAASHPPTSGLHQVPSQSPFPQHP-- 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530371977  1324 pqlppkpahLTQSHPPQRLPKPLPLSPSFSSEVGQREHQRGERDTAIPQPAKVPTTVDQGHI---PLARCPSGHSQPSLQ 1400
Cdd:pfam03154  467 ---------FVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeeALDEAEEPESPPPPP 537

                          410       420
                   ....*....|....*....|...
gi 530371977  1401 HGLSttaPRPTKNQATGSNAQSS 1423
Cdd:pfam03154  538 RSPS---PEPTVVNTPSHASQSA 557
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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