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Conserved domains on  [gi|530368790|ref|XP_005264070|]
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sulfotransferase 1C2 isoform X1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-290 1.73e-117

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 337.78  E-value: 1.73e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790   39 PDDLLICTYPKaaSGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW----ARPPQPSGVEKAKAMPSPRILKTH 111
Cdd:pfam00685   1 DDDVLIVTYPK--SGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  112 LSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQI 191
Cdd:pfam00685  79 LPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  192 LFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGTVGDWKNHF 271
Cdd:pfam00685 159 LFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*....
gi 530368790  272 TVAQNERFDEIYRRKMEGT 290
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-290 1.73e-117

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 337.78  E-value: 1.73e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790   39 PDDLLICTYPKaaSGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW----ARPPQPSGVEKAKAMPSPRILKTH 111
Cdd:pfam00685   1 DDDVLIVTYPK--SGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  112 LSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQI 191
Cdd:pfam00685  79 LPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  192 LFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGTVGDWKNHF 271
Cdd:pfam00685 159 LFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*....
gi 530368790  272 TVAQNERFDEIYRRKMEGT 290
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-292 2.77e-34

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 127.34  E-value: 2.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  35 FEAKPDDLLICTYPKaaSGTTWIQEIVDMIEQNGDVEKCQRAIIQHR-H---PFIEWARPPQPS-GVEKAKAMPsprILK 109
Cdd:PLN02164  75 FQARPNDFLVCSYPK--TGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPSvDVLKDKGNT---LFS 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790 110 THLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MK 186
Cdd:PLN02164 150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKayQE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790 187 DRHQILFLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK-------ENPMTNRSTVSKSildqs 254
Cdd:PLN02164 230 NPDRILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLKnleankgEKDREDRPAVYAN----- 304

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530368790 255 iSSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSI 292
Cdd:PLN02164 305 -SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-290 1.73e-117

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 337.78  E-value: 1.73e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790   39 PDDLLICTYPKaaSGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW----ARPPQPSGVEKAKAMPSPRILKTH 111
Cdd:pfam00685   1 DDDVLIVTYPK--SGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  112 LSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQI 191
Cdd:pfam00685  79 LPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  192 LFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGTVGDWKNHF 271
Cdd:pfam00685 159 LFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*....
gi 530368790  272 TVAQNERFDEIYRRKMEGT 290
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-292 2.77e-34

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 127.34  E-value: 2.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  35 FEAKPDDLLICTYPKaaSGTTWIQEIVDMIEQNGDVEKCQRAIIQHR-H---PFIEWARPPQPS-GVEKAKAMPsprILK 109
Cdd:PLN02164  75 FQARPNDFLVCSYPK--TGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPSvDVLKDKGNT---LFS 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790 110 THLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MK 186
Cdd:PLN02164 150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKayQE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790 187 DRHQILFLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK-------ENPMTNRSTVSKSildqs 254
Cdd:PLN02164 230 NPDRILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLKnleankgEKDREDRPAVYAN----- 304

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530368790 255 iSSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSI 292
Cdd:PLN02164 305 -SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
52-215 6.18e-05

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 42.66  E-value: 6.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790   52 SGTTWIQEIVD-------MIEQNGDVEKCqRAIIQHRHPFIEWARP---PQPSGVEKakaMPS-----PRILKthlstqL 116
Cdd:pfam13469   9 SGTTLLHRLLAahpdvrpPEETWFVIPRI-LALLQAWGKSLEALARvpsYARWLCDK---SPShlfhlDLLLK------A 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530368790  117 LPpsfwenNCKFLYVARNAKDCMVSyyhfQRMNHMLPDPGTWEEYFETFINGKVVWgsWFDHVKGWWEMKDRH---QILF 193
Cdd:pfam13469  79 FP------DAKFIHLHRDPVDTVIS----SYCSLFGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARARVppgRFLD 146

                         170       180
                  ....*....|....*....|..
gi 530368790  194 LFYEDIKRDPKHEIRKVMQFMG 215
Cdd:pfam13469 147 VRYEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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