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Conserved domains on  [gi|767932631|ref|XP_005263275|]
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centromere protein U isoform X1 [Homo sapiens]

Protein Classification

CENP-U and Mplasa_alph_rch domain-containing protein( domain architecture ID 10586794)

CENP-U and Mplasa_alph_rch domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 174-350 1.08e-78

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


:

Pssm-ID: 463785  Cd Length: 180  Bit Score: 241.92  E-value: 1.08e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631  174 ESDTRRKVKSAEKISTQRHEVIRTT--ASSELSEKPAESVTSKKTGPLSAQPSVEKENLA-IESQSKTQKKGKISHDKRK 250
Cdd:pfam13097   1 ESDVRRKVQSAEKISTQQREAVPATasASSELSEKPAESVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631  251 KSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLT 330
Cdd:pfam13097  81 KSRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLK 160

                         170       180
                  ....*....|....*....|
gi 767932631  331 NLKRKNAKMISDIEKKRQRM 350
Cdd:pfam13097 161 NLKRKNAKVISDIEKKRQRL 180
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 174-350 1.08e-78

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 241.92  E-value: 1.08e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631  174 ESDTRRKVKSAEKISTQRHEVIRTT--ASSELSEKPAESVTSKKTGPLSAQPSVEKENLA-IESQSKTQKKGKISHDKRK 250
Cdd:pfam13097   1 ESDVRRKVQSAEKISTQQREAVPATasASSELSEKPAESVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631  251 KSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLT 330
Cdd:pfam13097  81 KSRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLK 160

                         170       180
                  ....*....|....*....|
gi 767932631  331 NLKRKNAKMISDIEKKRQRM 350
Cdd:pfam13097 161 NLKRKNAKVISDIEKKRQRL 180
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
 278-394 3.10e-04

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 43.46  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631 278 IKELNIVLPEfEKTHLEHQQRIESKVCKAAIAtfYVNVKEqFIKMLKESQMLTNLKRKNAKMISDIEKKrqrmIEVQDEL 357
Cdd:PTZ00419 887 IGSVSVIPPI-EEEAEVPKGCGFDVVDNKVII--YLNLDE-FIDLKKELAKLEKKLAKLQKSLESYLKK----ISIPNYE 958

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767932631 358 LRLEPQLKQLQT-KYDELKERKSSLRNAayfLSNLKQL 394
Cdd:PTZ00419 959 DKVPEDVRKLNDeKIDELNEEIKQLEQA---IEELKSL 993
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 174-350 1.08e-78

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 241.92  E-value: 1.08e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631  174 ESDTRRKVKSAEKISTQRHEVIRTT--ASSELSEKPAESVTSKKTGPLSAQPSVEKENLA-IESQSKTQKKGKISHDKRK 250
Cdd:pfam13097   1 ESDVRRKVQSAEKISTQQREAVPATasASSELSEKPAESVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631  251 KSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLT 330
Cdd:pfam13097  81 KSRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLK 160

                         170       180
                  ....*....|....*....|
gi 767932631  331 NLKRKNAKMISDIEKKRQRM 350
Cdd:pfam13097 161 NLKRKNAKVISDIEKKRQRL 180
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
 278-394 3.10e-04

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 43.46  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932631 278 IKELNIVLPEfEKTHLEHQQRIESKVCKAAIAtfYVNVKEqFIKMLKESQMLTNLKRKNAKMISDIEKKrqrmIEVQDEL 357
Cdd:PTZ00419 887 IGSVSVIPPI-EEEAEVPKGCGFDVVDNKVII--YLNLDE-FIDLKKELAKLEKKLAKLQKSLESYLKK----ISIPNYE 958

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767932631 358 LRLEPQLKQLQT-KYDELKERKSSLRNAayfLSNLKQL 394
Cdd:PTZ00419 959 DKVPEDVRKLNDeKIDELNEEIKQLEQA---IEELKSL 993
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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