|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1536-1649 |
1.25e-67 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 223.19 E-value: 1.25e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1536 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1615
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 578838741 1616 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1649
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1537-1651 |
6.10e-61 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 203.77 E-value: 6.10e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1537 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1616
Cdd:pfam16553 1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80
|
90 100 110
....*....|....*....|....*....|....*
gi 578838741 1617 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1651
Cdd:pfam16553 81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1364-1473 |
1.42e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1364 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1443
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|
gi 578838741 1444 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1370-1461 |
1.69e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.31 E-value: 1.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1370 LQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1449
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 578838741 1450 WLLLSYGADPTL 1461
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
198-636 |
7.69e-16 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 84.22 E-value: 7.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838741 577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1367-1458 |
3.89e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 63.92 E-value: 3.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1367 ETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1446
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 578838741 1447 ETIWLLLSYGAD 1458
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 |
8.01e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.00 E-value: 8.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPStp 370
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP-- 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 371 tliPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154 329 ---PSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154 391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154 449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154 524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1400-1428 |
6.65e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.12 E-value: 6.65e-06
10 20
....*....|....*....|....*....
gi 578838741 1400 GYTALHEACSRGWTDILNILLEHGANVNC 1428
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1359-1458 |
1.04e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.85 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1359 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHG---ANVNCSAQ--DG 1433
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 578838741 1434 TRPVHDAVVNDNLETIWLLLSYGAD 1458
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| rad23 |
TIGR00601 |
UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
272-337 |
9.44e-03 |
|
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 40.26 E-value: 9.44e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838741 272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601 75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1536-1649 |
1.25e-67 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 223.19 E-value: 1.25e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1536 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1615
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 578838741 1616 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1649
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1537-1651 |
6.10e-61 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 203.77 E-value: 6.10e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1537 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1616
Cdd:pfam16553 1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80
|
90 100 110
....*....|....*....|....*....|....*
gi 578838741 1617 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1651
Cdd:pfam16553 81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
|
|
| PUFD_like |
cd14259 |
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ... |
1538-1649 |
1.62e-42 |
|
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271222 Cd Length: 106 Bit Score: 150.93 E-value: 1.62e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1538 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPg 1617
Cdd:cd14259 1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79
|
90 100 110
....*....|....*....|....*....|..
gi 578838741 1618 glddrSPPGSSETVELVRYEPDLLRLLGSEVE 1649
Cdd:cd14259 80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
|
|
| PUFD |
cd14261 |
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ... |
1538-1649 |
1.32e-36 |
|
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271224 Cd Length: 117 Bit Score: 134.59 E-value: 1.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1538 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPG 1617
Cdd:cd14261 6 DVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSCPKDLE 85
|
90 100 110
....*....|....*....|....*....|..
gi 578838741 1618 GLDdrspPGSSETVELVRYEPDLLRLLGSEVE 1649
Cdd:cd14261 86 AFN----PDSKELLDLVEFTNELQTLLGSSLE 113
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1364-1473 |
1.42e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1364 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1443
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|
gi 578838741 1444 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1359-1475 |
2.94e-25 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 107.73 E-value: 2.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1359 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDsEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1438
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158
|
90 100 110
....*....|....*....|....*....|....*..
gi 578838741 1439 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS 1475
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1354-1473 |
9.82e-20 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 91.55 E-value: 9.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1354 PEARRLIVNKNA--------GETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGAN 1425
Cdd:COG0666 133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 578838741 1426 VNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:COG0666 212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1359-1473 |
7.64e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 83.08 E-value: 7.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1359 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1438
Cdd:COG0666 46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125
|
90 100 110
....*....|....*....|....*....|....*
gi 578838741 1439 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:COG0666 126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1370-1461 |
1.69e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.31 E-value: 1.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1370 LQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1449
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 578838741 1450 WLLLSYGADPTL 1461
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
198-636 |
7.69e-16 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 84.22 E-value: 7.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838741 577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1364-1470 |
4.93e-12 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 68.44 E-value: 4.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1364 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1443
Cdd:COG0666 184 NDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
|
90 100
....*....|....*....|....*..
gi 578838741 1444 DNLETIWLLLSYGADPTLATYSGQTAM 1470
Cdd:COG0666 263 GAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1361-1427 |
3.16e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 58.20 E-value: 3.16e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838741 1361 VNKNAGETLLQRAARLGYKDVVLYCLQKdsEDVNHRDNaGYTALHEACSRGWTDILNILLEHGANVN 1427
Cdd:pfam12796 25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1367-1458 |
3.89e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 63.92 E-value: 3.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1367 ETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1446
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 578838741 1447 ETIWLLLSYGAD 1458
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1404-1475 |
5.04e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 54.74 E-value: 5.04e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838741 1404 LHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASS 1475
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAAR 70
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1354-1473 |
5.28e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 57.37 E-value: 5.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1354 PEARRLIVNKNA--------GETLLQRAA--RLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEA--CSRGWTDILNILLE 1421
Cdd:PHA03100 86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEYLLDNGA-NVNIKNSDGENLLHLYleSNKIDLKILKLLID 164
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1422 HGANVNcsAQD------------------GTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:PHA03100 165 KGVDIN--AKNrvnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
205-435 |
1.90e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 56.04 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 205 PPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSvptlisdsnPLSVSASVLVP 284
Cdd:PRK12323 374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL---------AAARQASARGP 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 285 VPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAptlvlAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSS 364
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP-----AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838741 365 GPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPL 435
Cdd:PRK12323 520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPV 590
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
181-609 |
2.41e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.10 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 181 TGVPVEGTLPLVTTNFSPLP-APICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPvqvatsvPAPSPPLAPVPALA 259
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP-------AAGPPRRLTRPAVA 2789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 260 PAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPlaliqAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----GPPPPSLPLGGSVAPGGDVRR 2864
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 340 PMPASTPPAapappsvpmptptpssgppstptlipafaptpvpaptpapifTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PHA03247 2865 RPPSRSPAA------------------------------------------KPAAPARPPVRRLARPAVSRSTESFALPP 2902
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 420 VCFPAAQAPAMQKVPLSFQPgtvlTPSQPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPEL 499
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQ----PPPPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF 2977
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 500 RSYPYAFSVARPLTSDSKLVSLEVNRL------------PCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKV-LPTPQP 566
Cdd:PHA03247 2978 RVPQPAPSREAPASSTPPLTGHSLSRVsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSdLEALDP 3057
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 578838741 567 LLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLER 609
Cdd:PHA03247 3058 LPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSR 3100
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1355-1483 |
2.68e-07 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 54.19 E-value: 2.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1355 EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGT 1434
Cdd:COG0666 9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 578838741 1435 RPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLS 1483
Cdd:COG0666 89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYngnlEIVKLLLE 141
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 |
8.01e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.00 E-value: 8.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPStp 370
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP-- 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 371 tliPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154 329 ---PSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154 391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154 449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154 524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
197-419 |
9.41e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 53.73 E-value: 9.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 197 SPLPAPICPPAPgSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVpalapappsvptlisdsnPLS 276
Cdd:PRK12323 376 TAAAAPVAQPAP-AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL------------------AAA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 277 VSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPsaptlvlAPVPTPVLAPMPASTPPAAPAPPSVP 356
Cdd:PRK12323 437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-------APAAAPAPADDDPPPWEELPPEFASP 509
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838741 357 MPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PRK12323 510 APAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1400-1452 |
1.02e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 1.02e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 578838741 1400 GYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI-WLL 1452
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1392-1469 |
1.04e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 53.10 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1392 DVNHRDNAGYTALHeACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN--LETIWLLLSYGADPTLATYSG 1466
Cdd:PHA03095 109 DVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRF 187
|
...
gi 578838741 1467 QTA 1469
Cdd:PHA03095 188 RSL 190
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1347-1458 |
1.13e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.53 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1347 PTARQIPPEARRLIVNKNA----GETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRG-WTDILNILLE 1421
Cdd:PHA02876 284 PSLSRLVPKLLERGADVNAknikGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLE 363
|
90 100 110
....*....|....*....|....*....|....*..
gi 578838741 1422 HGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1458
Cdd:PHA02876 364 LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1418-1497 |
1.22e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 53.36 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1418 ILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSDHLSDLQGRA 1493
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEngfrEVVQLLSRHSQCHFELGA 179
|
....
gi 578838741 1494 EGDP 1497
Cdd:PTZ00322 180 NAKP 183
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1392-1470 |
2.40e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 51.89 E-value: 2.40e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838741 1392 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1470
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1401-1489 |
2.42e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 51.97 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1401 YTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH-----DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AM 1470
Cdd:PHA03100 36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaIS 115
|
90
....*....|....*....
gi 578838741 1471 KLASSDTMKRFLSDHLSDL 1489
Cdd:PHA03100 116 KKSNSYSIVEYLLDNGANV 134
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1378-1473 |
2.85e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 51.80 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1378 YKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWT-DILNILLEHGANVNC-SAQDGTRPVHDAVVNDnlETIWLLLSY 1455
Cdd:PHA02878 212 YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKLLLEY 289
|
90
....*....|....*...
gi 578838741 1456 GADPTLATYSGQTAMKLA 1473
Cdd:PHA02878 290 GADINSLNSYKLTPLSSA 307
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1368-1420 |
3.06e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 3.06e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 578838741 1368 TLLQRAARLGYKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILL 1420
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1386-1438 |
5.47e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.03 E-value: 5.47e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 578838741 1386 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1438
Cdd:pfam13857 2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1386-1458 |
6.19e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 50.79 E-value: 6.19e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838741 1386 LQKDSEDVNHRDNAGYTALHEACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1458
Cdd:PHA03095 33 LLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1400-1428 |
6.65e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.12 E-value: 6.65e-06
10 20
....*....|....*....|....*....
gi 578838741 1400 GYTALHEACSRGWTDILNILLEHGANVNC 1428
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
287-649 |
9.59e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 9.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 287 ASAPPSGPVPLSAPAPAPLSVPVSAPPlaliQAPVP-PSAPTlVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSG 365
Cdd:PHA03247 2544 ASDDAGDPPPPLPPAAPPAAPDRSVPP----PRPAPrPSEPA-VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP 2618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 366 PPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAA--QAPAMQKVPLSFQPGTVL 443
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSppQRPRRRAARPTVGSLTSL 2698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 444 T--PSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLTSDSKLVSL 521
Cdd:PHA03247 2699 AdpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 522 EVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQ----PLLPAPSGSSAPPHPAKMPSGTEQQTEGTSVT 597
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspagPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 578838741 598 FSPLKSPPQLEREMASP-----PECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTP 649
Cdd:PHA03247 2859 GGDVRRRPPSRSPAAKPaaparPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1400-1428 |
4.26e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 41.89 E-value: 4.26e-05
10 20 30
....*....|....*....|....*....|
gi 578838741 1400 GYTALHEACSR-GWTDILNILLEHGANVNC 1428
Cdd:pfam00023 2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1392-1455 |
4.35e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 48.36 E-value: 4.35e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 1392 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSY 1455
Cdd:PTZ00322 107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1400-1428 |
1.04e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 40.70 E-value: 1.04e-04
10 20
....*....|....*....|....*....
gi 578838741 1400 GYTALHEACSRGWTDILNILLEHGANVNC 1428
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1392-1475 |
1.36e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 46.41 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1392 DVNHRD-NAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1470
Cdd:PHA02878 159 DINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238
|
....*
gi 578838741 1471 KLASS 1475
Cdd:PHA02878 239 HISVG 243
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1386-1449 |
1.55e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 46.60 E-value: 1.55e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 1386 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI 1449
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1360-1427 |
3.44e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 45.04 E-value: 3.44e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838741 1360 IVNKNA-GETLLQRAARLGYKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVN 1427
Cdd:PHA03100 185 INIKDVyGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1392-1487 |
3.73e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 45.02 E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1392 DVNHRDNAGYTALHEA---CSRGWTDILNiLLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQT 1468
Cdd:PHA03095 214 DPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNT 292
|
90 100
....*....|....*....|...
gi 578838741 1469 AMKLA----SSDTMKRFLSDHLS 1487
Cdd:PHA03095 293 PLSLMvrnnNGRAVRAALAKNPS 315
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1386-1482 |
4.40e-04 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 45.24 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1386 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGA--DPTLAT 1463
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAG 623
|
90
....*....|....*....
gi 578838741 1464 YSGQTAMKLASSDTMKRFL 1482
Cdd:PLN03192 624 DLLCTAAKRNDLTAMKELL 642
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
197-336 |
1.00e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.93 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 197 SPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHsglvPVQVATSVPAPSPPLAPVPALApappsvptlisdSNPLS 276
Cdd:PRK14951 372 AAAPAEKKTPARPEAAAPAAAP----VAQAAAAPAPA----AAPAAAASAPAAPPAAAPPAPV------------AAPAA 431
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838741 277 VSASVLVPVPASAPPSGPVPLSAPAPAPLSVPV-SAPPLALIQAPVPPSAPTLVLAPVPTP 336
Cdd:PRK14951 432 AAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVrVAPEPAVASAAPAPAAAPAAARLTPTE 492
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1359-1458 |
1.04e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.85 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1359 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHG---ANVNCSAQ--DG 1433
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 578838741 1434 TRPVHDAVVNDNLETIWLLLSYGAD 1458
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1367-1473 |
1.12e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 43.41 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1367 ETLLQRAARLGYKDVVlYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1446
Cdd:PHA02874 125 KTFLHYAIKKGDLESI-KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
90 100
....*....|....*....|....*..
gi 578838741 1447 ETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNA 230
|
|
| PRK05641 |
PRK05641 |
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated |
271-322 |
1.22e-03 |
|
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
Pssm-ID: 235540 [Multi-domain] Cd Length: 153 Bit Score: 41.00 E-value: 1.22e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 578838741 271 DSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSApplALIQAPVP 322
Cdd:PRK05641 44 DLSAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPASAGE---NVVTAPMP 92
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1366-1458 |
1.36e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 43.32 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1366 GETLLQRAARLGYKDVVLYCLqKDSEDVNHRDNAGYTALHEACSRGWTDILNI--------------------------- 1418
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFRIlyhfasisdphaagdllctaakrndlt 636
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 578838741 1419 ----LLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1458
Cdd:PLN03192 637 amkeLLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1378-1460 |
1.81e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 42.70 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1378 YKDVVLyCLQKDSEDVNHRDNAGYTALH-EACSRGWTDILNILLEHGANVNCSAQDGTRPVHD--AVVNDNLETIWLLLS 1454
Cdd:PHA03095 62 VKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLR 140
|
....*.
gi 578838741 1455 YGADPT 1460
Cdd:PHA03095 141 KGADVN 146
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
274-569 |
2.21e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 274 PLSVSASVLVPVPASAPPSG--PVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPvptpvlapmpastppaapa 351
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAaaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA------------------- 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 352 ppsvpmptptpssgppstptlipafaptpvpaPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQ 431
Cdd:PRK12323 436 --------------------------------ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 432 KVPLSFQPGTVLTPsqPLVYIPPpscgqplsvatlpttlgvsstlTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARP 511
Cdd:PRK12323 484 APAAAPAPADDDPP--PWEELPP----------------------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 578838741 512 ltsdsklvSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLP 569
Cdd:PRK12323 540 --------TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
274-337 |
2.65e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.39 E-value: 2.65e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 274 PLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLAlIQAPVPPSAPTLVLAPVPTPV 337
Cdd:PRK14951 391 AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-APAAAPAAAPAAVALAPAPPA 453
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1419-1473 |
2.87e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.33 E-value: 2.87e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 578838741 1419 LLEHG-ANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1473
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA02795 |
PHA02795 |
ankyrin-like protein; Provisional |
1391-1433 |
3.06e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165157 [Multi-domain] Cd Length: 437 Bit Score: 41.90 E-value: 3.06e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 578838741 1391 EDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDG 1433
Cdd:PHA02795 212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
273-471 |
3.47e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.01 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 273 NPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPtpvlapmpastppaapap 352
Cdd:PRK14951 372 AAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA------------------ 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 353 psvpmptptpssgppstptlipafaptpvpaptpapiftPAPTPMPAATPAAIPTSAPIPAsfslsrvcfpaaqAPAMQK 432
Cdd:PRK14951 434 ---------------------------------------PAAAPAAAPAAVALAPAPPAQA-------------APETVA 461
|
170 180 190
....*....|....*....|....*....|....*....
gi 578838741 433 VPLSFQPGTVLTPSqplvyiPPPSCGQPLSVATLPTTLG 471
Cdd:PRK14951 462 IPVRVAPEPAVASA------APAPAAAPAAARLTPTEEG 494
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
206-335 |
3.53e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.14 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 206 PAPGSASVPHSVPDAfQVPLSVPAPVPHSGLVPvqvATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASvlVPV 285
Cdd:PRK07003 360 PAVTGGGAPGGGVPA-RVAGAVPAPGARAAAAV---GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAP--APP 433
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 578838741 286 PASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPT 335
Cdd:PRK07003 434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASD 483
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1414-1475 |
3.84e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 41.57 E-value: 3.84e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 1414 DILNILLEHGANVNCSAQDGTRPVHDAVVN--DNLETIWLLLSYGADPTLATYSGQTAMKLASS 1475
Cdd:PHA03100 87 EIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE 150
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
180-353 |
4.59e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 41.76 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 180 GTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALA 259
Cdd:PRK07003 363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTA----VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 260 PAPPSVPTLisdsnPLSVSASVLVPVPASAPPSGPVPLSAPAPAplSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PRK07003 439 GDDAADGDA-----PVPAKANARASADSRCDERDAQPPADSGSA--SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDAR 511
|
170
....*....|....
gi 578838741 340 PMPASTPPAAPAPP 353
Cdd:PRK07003 512 APAAASREDAPAAA 525
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
197-338 |
6.27e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 41.13 E-value: 6.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 197 SPLPAPICPPAPGSASVPHSVPDAFQ---------VPLSVPAPVPHSGLVPVQV-ATSVPAPSPPLAPVPALAPAPPSVP 266
Cdd:PRK12727 77 TKPAAPVHAPLKLSANANMSQRQRVAsaaedmiaaMALRQPVSVPRQAPAAAPVrAASIPSPAAQALAHAAAVRTAPRQE 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 267 TLISdSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLA-------------------LIQAPVPPSAPT 327
Cdd:PRK12727 157 HALS-AVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAyaqdddeqldddgfdlddaLPQILPPAALPP 235
|
170
....*....|.
gi 578838741 328 LVLAPVPTPVL 338
Cdd:PRK12727 236 IVVAPAAPAAL 246
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
74-336 |
6.46e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 6.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 74 ADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSwTPLNTQMSKQVD 153
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT-RPAVASLSESRE 2796
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 154 CSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPH 233
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 234 SGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPP 313
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
|
250 260
....*....|....*....|....*.
gi 578838741 314 LALIQAPVPPSAPTLVLAP---VPTP 336
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPrfrVPQP 2982
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
197-329 |
7.15e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 41.00 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 197 SPLPAPICPPA---PGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSN 273
Cdd:PRK07994 363 APLPEPEVPPQsaaPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSE 442
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838741 274 PLSVSASV--------LVPVPASAPPSGPVPLSAPA-------PAPLSVPVSAPPLALIQAPVPPSAPTLV 329
Cdd:PRK07994 443 PAAASRARpvnsalerLASVRPAPSALEKAPAKKEAyrwkatnPVEVKKEPVATPKALKKALEHEKTPELA 513
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1415-1484 |
7.67e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 40.82 E-value: 7.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838741 1415 ILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSD 1484
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDskniDTIKAIIDN 233
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
278-406 |
7.80e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.85 E-value: 7.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 278 SASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPM 357
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 578838741 358 PTPTPSSGPPSTPTLIPAFAPTPVPaptpapifTPAPTPMPAATPAAIP 406
Cdd:PRK14951 447 LAPAPPAQAAPETVAIPVRVAPEPA--------VASAAPAPAAAPAAAR 487
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
220-351 |
7.93e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.85 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 220 AFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSvptlisdsnPLSVSASVLVPVPASAPPSGPVPLSA 299
Cdd:PRK14951 363 AFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAP---------AAAASAPAAPPAAAPPAPVAAPAAAA 433
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 578838741 300 PAPAPLSVPVSAPPlalIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPA 351
Cdd:PRK14951 434 PAAAPAAAPAAVAL---APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAA 482
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
1382-1470 |
8.42e-03 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 41.05 E-value: 8.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 1382 VLYCLQKDSEDVNHRDNAGYTALHEACSRGW--TDILNILLEHGANVNCSAQDGTRPVHD-----AVVND---------N 1445
Cdd:PHA02716 299 VVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlSVVNIldpetdndiR 378
|
90 100
....*....|....*....|....*
gi 578838741 1446 LETIWLLLSYGADPTLATYSGQTAM 1470
Cdd:PHA02716 379 LDVIQCLISLGADITAVNCLGYTPL 403
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
214-337 |
9.15e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 40.62 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838741 214 PHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSG 293
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 578838741 294 PVPLSAPAPAPLSVPV----SAPPLALIQAPVPPSAPTLVLAPVPTPV 337
Cdd:PRK07994 441 SEPAAASRARPVNSALerlaSVRPAPSALEKAPAKKEAYRWKATNPVE 488
|
|
| rad23 |
TIGR00601 |
UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
272-337 |
9.44e-03 |
|
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 40.26 E-value: 9.44e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838741 272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601 75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
|
|
| |
