BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899   6 VLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVA 85
Cdd:cd18211    1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530425899  86 DFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899   6 VLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVA 85
Cdd:cd18211    1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530425899  86 DFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899    32 DVTVSVEYqgvrKDFMAHKAVLAATSKFFKEVFLNEKSVDGTrTNVYLNEVQVADFASFLEFVYTAKVQVEEDRVQRMLE 111
Cdd:smart00225   1 DVTLVVGG----KKFHAHKAVLAAHSPYFKALFSSDFKESDK-SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 530425899   112 VAEKLKCLDLSETCFQLKKQML 133
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 530425899  449 ALKTHMRIHTGEKPFVCDECGARFTQ 474
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899   6 VLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVA 85
Cdd:cd18211    1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530425899  86 DFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  30 LCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTnVYLNEVQVADFASFLEFVYTAKVQVEEDRVQRM 109
Cdd:cd18186    1 LCDVTLVVG----GREFPAHRAVLAARSPYFRAMFSSGMKESSSSE-IELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                 ....*..
gi 530425899 110 LEVAEKL 116
Cdd:cd18186   76 LAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899   8 LESKSSPFNLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTrtnVYLNEVQVAD- 86
Cdd:cd18212    1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVE----NVQFRAHKALLAASSEYFSMMFADEGEVGQS---IYMLEGMVAEt 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530425899  87 FASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDL 121
Cdd:cd18212   74 FGALLEFIYTGCLQVGEKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  21 MHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLN-----EKSVdgtrtnVYLNEVQVADFASFLEFVY 95
Cdd:cd18248   12 MNELRLSQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSglrecGMEV------VPIEGVHPCVMSRLIEFAY 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530425899  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLE 134
Cdd:cd18248   86 TASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSV-DGTRTNVYLNEVQVADFASFLEFVY 95
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVG----GEEIPVQKNVLAAASPYFRAKLNYNPPKdDGSTYKIELEGISVEVMEEILDYIY 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 530425899  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18245   77 TGQIKLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899   9 ESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEksVDGTRTNVYLNEVQVADFA 88
Cdd:cd18277    6 ESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQ----RFRAHRSVLAACSSYFHSRIVGQ--ADAELNITLPEEVTVKGFE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530425899  89 SFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQL 128
Cdd:cd18277   80 PLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQF 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  21 MHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSvdGTRTN-VYLNEVQVADFASFLEFVYTAKV 99
Cdd:cd18235   12 MNELRKQNLLCDVILVAD----GVEIPAHRVVLASCSPYFHAMFTGDLS--ESRANrVTLQDVDGKALLLLIDYVYTAEI 85

                         90       100
                 ....*....|....*....|....*.
gi 530425899 100 QVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18235   86 QVTEENVQVLLPAANLLQLTDVRDAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  21 MHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSvDGTRTNVYLNEVQVADFASFLEFVYTAKVQ 100
Cdd:cd18338   12 MNELRSQNLLCDVTIVAE----DVEIAAHRVVLAACSPYFHAMFTGEMS-ESRAKRVRIKEVDGWTLKMLIDYVYTAEIQ 86

                         90       100
                 ....*....|....*....|....*
gi 530425899 101 VEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18338   87 VTEENVQVLLPAAGLLQLQDVKKTC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSvDGTRTNVYLNEVQVADFASFLEFVYT 96
Cdd:cd18242    8 ILNTMNSLRKSNTLCDVTLRVE----GKEFPAHRIVLAACSDYFCAMFTSEMS-EKGKSEVELQGLTASTMEILLDFVYT 82

                         90       100
                 ....*....|....*....|....*....
gi 530425899  97 AKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  16 NLLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKSVDgtRTNVYLNEVQVAD-FASFLEFV 94
Cdd:cd18326   11 DILSSLNEQRTQGLLCDVVILVEGR----EFPTHRSVLAACSQYFKKLFTSGAVVD--QQNVYEIDFVSAEaLTALLDFA 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530425899  95 YTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQL 128
Cdd:cd18326   85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCADL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  16 NLLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTnVYLNEVQVADFASFLEFVY 95
Cdd:cd18306    4 SVLAKLNALRKNRQFCDVILQVGGH----EIPAHRAVLACASPYLFELFSSDSDGESILT-VKLDGLDPDAVEVLVNYAY 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 530425899  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18306   79 TSRLEVPADLVKSVYSAAKKLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  16 NLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVADFASFLEFVY 95
Cdd:cd18230    7 HLLRELNEQRQHGILCDVCIIVE----GKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530425899  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLE 134
Cdd:cd18230   83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  15 FNLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEV--FLNEKSVDGTrTNVYLNEVQVADFASFLE 92
Cdd:cd18201    6 YQLLQELNEQRKKGILCDVNIVVS----GKVFRAHKNILVAGSRFFKTLycFTNKESCDQT-TVTHLDVVAVQGFSVILD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530425899  93 FVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18201   81 FMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  21 MHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSvDGTRTNVYLNEVQVADFASFLEFVYTAKVQ 100
Cdd:cd18339   12 MNELRSKQLLCDVTIVAE----DVEIEAHRVVLAACSPYFCAMFTGDMS-ESKAKKIEIKDVDGQTLSKLIDYIYTAEIE 86

                         90       100
                 ....*....|....*....|....*
gi 530425899 101 VEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18339   87 VTEENVQVLLPAASLLQLMDVRQNC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  14 PFNLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSvDGTRTNVYLNEVQVADFASFLEF 93
Cdd:cd18253    2 SESILQVFNEFRDSRLFTDVIICVE----GREFPCHRAILSACSSYFRAMFCNDHR-ESREMLVEINGILAEAMDCFLQY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530425899  94 VYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLE 134
Cdd:cd18253   77 VYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSVeyqGVRKdFMAHKAVLAATSKFFKEVF---LNEKSvdgtRTNVYLNEVQVADFASFLEF 93
Cdd:cd18257    5 LLQGLNLLRQHHELCDVVLRV---GDVK-IHAHKVVLASCSPYFKAMFtgnLSEKE----NSEVEFQCIDETALQAIVEY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530425899  94 VYTAKVQVEEDRVQRMLEVAEKLKC-LDLSETCFQLKKQM 132
Cdd:cd18257   77 AYTGTVFISQATVESLLPAANLLQIkLVLKECCDFLESQL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  21 MHELRLLG-HLCDVTVSVEYQgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDgtRTNVYLNEVQVADFASFLEFVYTAKV 99
Cdd:cd18231    4 LNEQRLFQpDLCDVDIVLVRQ--RSTFPAHKGVLAAYSQFFHSLFTQNKQLQ--RVELSLEALTSQGLQQILNFIYTSKL 79

                         90       100
                 ....*....|....*....|....*....
gi 530425899 100 QVEEDRVQRMLEVAEKLKCLDLSETCFQL 128
Cdd:cd18231   80 LVNSCNVQDVLNAAAVLQMNDIAASCQEL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVADFASFLEFVYT 96
Cdd:cd18202    6 VLDQLNQQRLNNQFCDVTLLIEGE----EYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530425899  97 AKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQM 132
Cdd:cd18202   82 SELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQM 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  23 ELRLLGHLCDVTVSVeyQGVRkdFMAHKAVLAATSKFFKEVFLNEKSVdGTRTNVYLNEVQVADFASFLEFVYTAKVQVE 102
Cdd:cd18240   10 ELRLEGKLCDVVIRV--NGVE--FPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPGVSPEMMELIIEYAYTRTVPIT 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530425899 103 EDRVQRMLEVAEKLKCLDLSETCFQ-LKKQM 132
Cdd:cd18240   85 AENVEELLPAADQFNIMGIVKACCDfLEDQL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTN------------VYLNEVQV 84
Cdd:cd18195    5 LLLQLNEQRLRGLFCDVTLIAG----DTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAaapgatqspervLELPGVKA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530425899  85 ADFASFLEFVYTAKVQVEEDRVQRML-EVAEKL--KCL 119
Cdd:cd18195   81 GVFSDVLNFIYSSRVALPGSAAAKELgAAGKRLgiPFL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVdgtrtNVYLNEVQVADFASFLEFVYT 96
Cdd:cd18334    8 LLLQLNQQRAKGFLCDVIIVVE----NALFRAHKNILAASSMYFKSLVLHDNLI-----NLDTDMVNPTVFRQILDFIYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530425899  97 AKV----QVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18334   79 GKLltsdQPGEQNFNALLTAASYLQLHDLAALC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  10 SKSSPFNLLHEMHELRLLGHLCDVTVSVeyqGVRKDFmAHKAVLAATSKFFKEVFLNEKSvDGTRTNVYLNEVQVADFAS 89
Cdd:cd18249    3 SDKHPRQTLEAINLLRKHRELCDVVLVV---GAKKIY-AHRVILSACSPYFRAMFTGELA-ESRQTEVTIRDIDERAMEL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530425899  90 FLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQ-LKKQM 132
Cdd:cd18249   78 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEfLKRQL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  17 LLHEMHELRLLGHLCDVTVSV-EYQgvrkdFMAHKAVLAATSKFFKEVFlneksVDGTRTNVYLNEVQV--ADFASFLEF 93
Cdd:cd18217    5 LLERLNKQREAGFLCDCTIVIgQFQ-----FKAHRNVLAAFSEYFGAQY-----KDTEDNIVFLDQSQVsaDGFQKLLEF 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530425899  94 VYTAKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18217   75 IYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425899  14 PFNLLHEMHELrllGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKsVDGTRTNVYLNEVQVADFASFLEF 93
Cdd:cd18238    2 SFKVLHQFYEN---GELCDVTLKVG----EKSIHCHRLVLACVSPYFRAMFTSEM-AESKQDSITIKDIDEEAVELLVDF 73