|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
25-1251 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 1924.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917 1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917 80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917 154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLF 339
Cdd:TIGR00917 234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 340 TRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHi 419
Cdd:TIGR00917 314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 420 yqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTILSVLNYFQNSHSVLDHKK 499
Cdd:TIGR00917 393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 500 GDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917 462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 580 AQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLG 657
Cdd:TIGR00917 531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 658 IAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE---------TLDQQLGRVL 728
Cdd:TIGR00917 611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 729 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDG- 807
Cdd:TIGR00917 691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 808 ----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL 883
Cdd:TIGR00917 771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 884 HAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNIT 963
Cdd:TIGR00917 851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 964 DQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILlGHGTRVGATYFMTYHT 1043
Cdd:TIGR00917 925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ-GYATIIQASSFRTYHT 1001
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1044 VLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWS 1123
Cdd:TIGR00917 1002 PLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALS 1076
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGIT 1203
Cdd:TIGR00917 1077 VVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGIT 1156
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|....*...
gi 530413816 1204 LTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYI 1251
Cdd:TIGR00917 1157 LTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVL 1204
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
23-267 |
3.02e-94 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 302.22 E-value: 3.02e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 23 QSCVWYGECGI-AYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414 1 GRCAWYGECGKkSLFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 102 YNLLNLFCELTCSPRQSQFLNVTATEdyvdpVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKda 181
Cdd:pfam16414 81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 182 dACNATNWIEYMFNKDNGQAPFTITPVF-SDFPVHGMEPMNNATKGCDESVDEvTAPCSCQDCSIVCGPKPQP-PPPPAP 259
Cdd:pfam16414 154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231
|
....*...
gi 530413816 260 WTILGLDA 267
Cdd:pfam16414 232 CKVGGLDG 239
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
524-1249 |
1.58e-74 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 264.99 E-value: 1.58e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 524 NDTSLLHDPCLGTFGGPVFPWLVLGG---YDDQNYNNATALVITFPVNnyYNDTEKLQRAQAWEKEFINFVKN-YKNPNL 599
Cdd:pfam02460 117 NTRIDITYPIMPVLGTPIYLGPHFGGvdfEPPGNISYAKAIVLWYFLK--FDEEEVEEDSKEWEDELSQLLHNkYASEHI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 600 TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIG 679
Cdd:pfam02460 195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 680 LPLTLIVIeVIPFLVLAVGVDNIFILVQAYQRDERLQgeTLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHT 759
Cdd:pfam02460 275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATL--SVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQL 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 760 FSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRG----AEDGTSV----QASESCLFRFFKNSYSPLLLK 831
Cdd:pfam02460 352 FCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSspqrIDSEGSEpdksHNIEQLKSRFFLDIYCPFLLN 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 832 DWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDYTSSKgqnmvcg 910
Cdd:pfam02460 432 PSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNNPPNLTIPE------- 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 911 gmgcNNDSLvQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQssccrvdnitdqfcNASVVDpacvrcrpltpEGKQRP 990
Cdd:pfam02460 505 ----SRDRM-NEMVDEFENTPYSLGPNSTLFWLREYENFLSTL--------------NMEEEE-----------DEEKEW 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 991 QGGDfmrfLPMFLSDNPNPKCGKGGHAAYSsavnillghGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNvtetmg 1070
Cdd:pfam02460 555 SYGN----LPSFLKAPGNSHWAGDLVWDDN---------TTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIADQ------ 615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1071 ingsaYRVFPYSVF---YVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCAtIAMVLVNMFGVMWLWGI 1147
Cdd:pfam02460 616 -----YPEFNVTVFdedAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLA-IASIDIGVFGFLSLWGV 689
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1148 SLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTkFGGIVVLAFAKSQIFQIFYFR 1227
Cdd:pfam02460 690 DLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKT 768
|
730 740
....*....|....*....|..
gi 530413816 1228 MYLaMVLLGATHGLIFLPVLLS 1249
Cdd:pfam02460 769 VFL-VVAIGLLHGLFILPIILS 789
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
649-803 |
1.36e-64 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 215.53 E-value: 1.36e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 649 LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGEtlDQQLGRVL 728
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530413816 729 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRG 803
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
581-1251 |
4.02e-62 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 232.46 E-value: 4.02e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 581 QAWEKEFINFVKNY--KNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALghmksCRRLLVDSKVSLGI 658
Cdd:TIGR00918 357 EAWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTM-----LRWDCAKSQGSVGL 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 659 AGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQrdERLQGETLDQQLGRVLGEVAPSMFLS 738
Cdd:TIGR00918 432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIPFEERTGECLKRTGASVVLT 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 739 SFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGA-------------- 804
Cdd:TIGR00918 510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPcsarviqiepqaya 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 805 --------------------EDGTSVQASESC------------------------------------------------ 816
Cdd:TIGR00918 590 dgsappvysshmqstvqlrtEYDPGTQHYYTTneprshlsvqpsdplscqspdiagstrdllsqfedskaaclslpcarw 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 817 -LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLhAGPPVYFVLEE 895
Cdd:TIGR00918 670 tLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYF-SFYNMYAVTQG 748
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 896 GHDYTSSKgqnmvcggmgcnndslvQQIFNAAQldNYTRI--------GFAPSSWIDDYFDWV----KPQSSCCRVDNIT 963
Cdd:TIGR00918 749 NFDYPTQQ-----------------QLLYDLHQ--SFSSVkyvlkednGQLPRMWLHYFRDWLqglqKAFDEDWRDGRIT 809
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 964 -DQFCNASvvDPACVRCRPLTPEGkQRPQGGDFMRFLPMFLSDNP---NPKCGKGGHAAYSSavNILLGHGTRVGATY-- 1037
Cdd:TIGR00918 810 kENYRNGS--DDAVLAYKLLVQTG-HRDKPVDKEQLTTQRLVNADgiiNPNAFYIYLSAWVS--NDPVAYAASQANIYph 884
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1038 ----------------------------FMTYHTVLQTSADFIDALKKARLIASNVtETMGINGsayrvFPYSVFYVFYE 1089
Cdd:TIGR00918 885 ppewlhdkndydpenlripaaepleyaqFPFYLNGLRETSQFVEAIEHVRAICNNY-EGFGLPS-----YPSGYPFLFWE 958
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1090 QYLTIIDDTIFNLGVSLGAIFLVTMVLLgCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCS 1169
Cdd:TIGR00918 959 QYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTV 1037
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1170 HITRAFTVSMkGSRVERAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQI-FQIFYFRMYLAMV-LLGATHGLIFLPVL 1247
Cdd:TIGR00918 1038 HIALGFLTAI-GDRNRRAVLALEHMFAPVLDGALSTLLG---VLMLAGSEFdFIVRYFFAVLAVLtCLGVLNGLVLLPVL 1113
|
....
gi 530413816 1248 LSYI 1251
Cdd:TIGR00918 1114 LSMF 1117
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
336-1258 |
3.92e-34 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 141.54 E-value: 3.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 336 RRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPffrTEQLIIraplt 415
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 416 dkhIYQPYPsgaDVpfgppLDIQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQnshsvl 495
Cdd:COG1033 72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRA------ 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 496 DHKKGDDFFVYADYHTHFLYCVRAPASLNDtSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNYYN 572
Cdd:COG1033 113 TEGTEDGLTVEPLIPDELPASPEELAELRE-KVLSSP----------------LYVGRLVSPdgkATLIVVTL---DPDP 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 573 DTEKLQRAQAWEkEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVV-ISYAIMFLYISLALGHmkscrrllvd 651
Cdd:COG1033 173 LSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRS---------- 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 652 skVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVDNIFILVQAYqRDERLQGETLDQQLGRVLGEV 731
Cdd:COG1033 242 --LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALRKL 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 732 APSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQIT---CFVSLLGLDIKRQEKNRldifccvrgaedgt 808
Cdd:COG1033 318 GPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK-------------- 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 809 svqaSESCLFRFFKNsyspllLKDWMRP---IVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDS-YMVDyFKSISQYLH 884
Cdd:COG1033 384 ----KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpIRQD-LDFIEENFG 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 885 AGPPVYFVLEEGHDYtsskgqnmvcggmGCNNDSLVQQIFNAAQ-LDNYTRIGFAPSswIDDYFDWVkpqssccrvdnit 963
Cdd:COG1033 453 GSDPLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKEL------------- 504
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 964 dqfcNASVVDPAcvrcrpltPEGKQRPQGGDFMRFLPMFLSDNPNpkcgkgghaaySSAVNILLGHGTRVGATYFMTYHT 1043
Cdd:COG1033 505 ----NQALNEGD--------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDEDYSAARVTVRLKDLD 561
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1044 VlQTSADFIDALKKArlIASNvtetmgINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGcELWS 1123
Cdd:COG1033 562 S-EEIKALVEEVRAF--LAEN------FPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRL 631
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1124 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMK--GSRVERAEEALAHMGSSV-FS 1200
Cdd:COG1033 632 GLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkgGDLEEAIRRALRTTGKAIlFT 711
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1201 GITLtkFGGIVVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIAKLLERT 1258
Cdd:COG1033 712 SLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKK 766
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
335-783 |
5.85e-15 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 79.90 E-value: 5.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 335 LRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPFFRTEqLIIRAPl 414
Cdd:COG1033 388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGSDPLE-VVVDTG- 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 415 TDKHIYQPypsgadvpfgppldiQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQNSHSV 494
Cdd:COG1033 465 EPDGLKDP---------------EVLKEIDRLQDYLESL------PEVG----------------KVLSLADLVKELNQA 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 495 LDhkkGDDFFVYAdyhthflycvrapasLNDTSLLHDPCLGTFGGPvfPWLVLGGYDDQNYNNAtalVITFPVNNyyNDT 574
Cdd:COG1033 508 LN---EGDPKYYA---------------LPESRELLAQLLLLLSSP--PGDDLSRFVDEDYSAA---RVTVRLKD--LDS 562
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 575 EKLQRAQAWEKEFINfvKNYKNPNLTISFTAERSIEDELNRESDSD-VFTVVISYAIMFLYISLALGhmkscrrllvdsK 653
Cdd:COG1033 563 EEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAINESVIESqIRSLLLALLLIFLLLLLAFR------------S 628
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 654 VSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPfLVLAVGVDN-IFILvqAYQRDERLQGETLDQQLGRVLGEVA 732
Cdd:COG1033 629 LRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL--SRYREERRKGGDLEEAIRRALRTTG 705
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 530413816 733 PSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLL 783
Cdd:COG1033 706 KAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALL 756
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
571-800 |
1.14e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 62.93 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 571 YNDTEKlqraqawEKEFINFVKNYK---NPNLTISFTAERSIEDELNResdsdvfTVVISYAIMFLYIslalghmkscrr 647
Cdd:TIGR00921 157 YNDVER-------SLERTNPPSGKFldvTGSPAINYDIEREFGKDMGT-------TMAISGILVVLVL------------ 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 648 LLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPfLVLAVGVDNIFILVQAYQrDERLQGETLDQQLGRV 727
Cdd:TIGR00921 211 LLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYGIQTLNRYE-EERDIGRAKGEAIVTA 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530413816 728 LGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
Cdd:TIGR00921 289 VRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVKKEIIAI 361
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
658-785 |
6.77e-09 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 59.23 E-value: 6.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 658 IAGILIVLS---SVACSLG---VFSYI-GLPLTLIVIEVIPFLVLAVGVD-NIFiLVQAYqRDERLQGETLDQQLGRVLG 729
Cdd:pfam03176 167 VAALLPLLTvglSLGAAQGlvaILAHIlGIGLSTFALNLLVVLLIAVGTDyALF-LVSRY-REELRAGEDREEAVIRAVR 244
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 530413816 730 EVAPSMFLSSFseTVAFFLGALSV--MPAVHTFSLFAGLAVFIDFLLQITCFVSLLGL 785
Cdd:pfam03176 245 GTGKVVTAAGL--TVAIAMLALSFarLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1095-1253 |
3.36e-08 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 58.19 E-value: 3.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1095 IDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISV-------Ef 1167
Cdd:COG0841 330 IEEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVddaivvvE- 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1168 csHITRafTVSMKGSRVERAEEALAHMGSSVFSgITLTKfggIVV---LAFAKSQIFQIFYfrmYLAMVLLGAT-----H 1239
Cdd:COG0841 408 --NIER--HMEEGLSPLEAAIKGAREVAGAVIA-STLTL---VAVflpLAFMGGITGQLFR---QFALTVAIALlislfV 476
|
170
....*....|....
gi 530413816 1240 GLIFLPVLLSYIAK 1253
Cdd:COG0841 477 ALTLTPALCARLLK 490
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
619-792 |
2.87e-06 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 51.78 E-value: 2.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 619 SDVFTVVISYAIMFLYISLALGHMkscRRLlvDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIViEVIPFLVLAVG 698
Cdd:TIGR00920 60 SDVIVMTITRCIAVLYIYYQFCNL---RQL--GSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN-EALPFFLLLID 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 699 VDNIFILVQaYQRDERLQGETLDqQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITC 778
Cdd:TIGR00920 134 LSKASALAK-FALSSNSQDEVRD-NIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTF 211
|
170
....*....|....*..
gi 530413816 779 F---VSLLgLDIKRQEK 792
Cdd:TIGR00920 212 FpacLSLV-LELSRSGR 227
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1079-1253 |
9.83e-06 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 49.99 E-value: 9.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1079 FPYSVFY-VFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSL 1154
Cdd:pfam00873 310 FPQGVEIvVVYDTTPFIrasIEEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTL 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1155 VNLVMSCGISV-------EFCSHITRA-----FTVSMKGSR-VERAEEALAHMGSSVFsgITLTKFGGIVvlafakSQIF 1221
Cdd:pfam00873 389 GGLVLAIGLVVddaivvvENIERVLEEnglkpLEAAYKSMGeIGGALVAIALVLSAVF--LPILFLGGLT------GRIF 460
|
170 180 190
....*....|....*....|....*....|..
gi 530413816 1222 QIFYFRMYLAMvLLGATHGLIFLPVLLSYIAK 1253
Cdd:pfam00873 461 RQFAITIVLAI-LLSVLVALTLTPALCATLLK 491
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
626-774 |
1.32e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 49.47 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 626 ISYAIMFLYISLALGhmkSCRRLLVdskvslgiagILIV-LSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVD-NIF 703
Cdd:COG4258 647 LALLLILLLLLLRLR---SLRRALR----------VLLPpLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALF 712
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530413816 704 ILVQAYQRDERLqgetldqqlgRVLgevaPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLL 774
Cdd:COG4258 713 FTEGLLDKGELA----------RTL----LSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1095-1215 |
5.74e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.72 E-value: 5.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1095 IDDTIFNLGVSL--GAIfLVTMVL---LGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCG------- 1162
Cdd:COG3696 330 IDRAIHTVTKNLleGAL-LVILVLflfLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGiivdgav 407
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 530413816 1163 ISVEFC-SHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITltkfggIVVLAF 1215
Cdd:COG3696 408 VMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
1046-1166 |
1.28e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 46.55 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1046 QTSADFIDALKKARLIASNVTETMGingSAYRVfpysvfYVFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELW 1122
Cdd:NF033617 286 QPGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLR 355
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 530413816 1123 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1166
Cdd:NF033617 356 ATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1087-1252 |
1.81e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.00 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1087 FYEQYLtiiDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1166
Cdd:COG4258 633 LFGRYR---NDALWLLLLALLLILLLLLLRLR-SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID 708
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1167 FCSHITRAFTvsmkgsrveRAEEALAHMGSSVFSGI-TLTKFGgivVLAFAKSQIFQIFYfrmylAMVLLGathglIFLP 1245
Cdd:COG4258 709 YALFFTEGLL---------DKGELARTLLSILLAALtTLLGFG---LLAFSSTPALRSFG-----LTVLLG-----ILLA 766
|
....*..
gi 530413816 1246 VLLSYIA 1252
Cdd:COG4258 767 LLLAPLL 773
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
597-785 |
3.66e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 597 PNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALghmksCRRLLVdskvslGIAGILIVLSSVACSLGVFS 676
Cdd:TIGR00921 545 PGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAV-----FRNPIK------AVFPLIAIGSGILWAIGLMG 613
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 677 YIGLPLTLIVIEVIPfLVLAVGVDNIFILVQAY--QRDERLQGETLDQQLGRVlgevAPSMFLSSFseTVAFFLGAL--S 752
Cdd:TIGR00921 614 LRGIPSFLAMATTIS-IILGLGMDYSIHLAERYfeERKEHGPKEAITHTMERT----GPGILFSGL--TTAGGFLSLllS 686
|
170 180 190
....*....|....*....|....*....|...
gi 530413816 753 VMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGL 785
Cdd:TIGR00921 687 HFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
597-777 |
4.38e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 44.76 E-value: 4.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 597 PNLTISFTAERSIEDELNRESDSD-----VFTVVISYAIMFLyislALGhmkscrrllvdskvSLGIAG--ILIVLSSVA 669
Cdd:COG2409 147 PGLTVYVTGPAALAADLNEAFEEDlgraeLITLPVALVVLLL----VFR--------------SLVAALlpLLTAGLAVG 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 670 CSLGVFSYIG--LPLTLIVIEVIPFLVLAVGVD-NIFILvqAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFseTVAF 746
Cdd:COG2409 209 VALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLV--SRYREELRAGEDREEAVARAVATAGRAVLFSGL--TVAI 284
|
170 180 190
....*....|....*....|....*....|...
gi 530413816 747 FLGALSV--MPAVHTFSLFAGLAVFIDFLLQIT 777
Cdd:COG2409 285 ALLGLLLagLPFLRSMGPAAAIGVAVAVLAALT 317
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1100-1251 |
5.61e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.98 E-value: 5.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413816 1100 FNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNM-FGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAF--T 1176
Cdd:TIGR00921 195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeE 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530413816 1177 VSMKGSRVERAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQIFQIFYFRMYLAM-VLLGATHGLIFLPVLLSYI 1251
Cdd:TIGR00921 275 RDIGRAKGEAIVTAVRRTGRAVLIALLTTSAG---FAALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALLQSI 347
|
|
|