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Conserved domains on  [gi|530411003|ref|XP_005258020|]
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WD repeat and SOCS box-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-183 1.92e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEFGHlfppptpifaggaNDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSV 160
Cdd:COG2319  278 GELLRTLTG-------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVRSVAFSPDGKT 344

                        170       180
                 ....*....|....*....|....*
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQ 183
Cdd:COG2319  345 LASGSDDGTVRLWdlATGELLRTLT 369
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 177-216 2.21e-24

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239715  Cd Length: 40  Bit Score: 90.64  E-value: 2.21e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 216
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-183 1.92e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEFGHlfppptpifaggaNDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSV 160
Cdd:COG2319  278 GELLRTLTG-------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVRSVAFSPDGKT 344

                        170       180
                 ....*....|....*....|....*
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQ 183
Cdd:COG2319  345 LASGSDDGTVRLWdlATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-173 1.42e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.42e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEF-GHL-------FPPPTPIFAGGANDR---------------------WVRSVSFSHDGLHVASLADDKMVRFW 133
Cdd:cd00200   83 GECVRTLtGHTsyvssvaFSPDGRILSSSSRDKtikvwdvetgkclttlrghtdWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530411003 134 RIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 173
Cdd:cd00200  163 DLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTIKLW 204
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 177-216 2.21e-24

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 90.64  E-value: 2.21e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 216
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 173-215 3.90e-16

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.25  E-value: 3.90e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 530411003   173 WATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 215
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 178-212 2.00e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.40  E-value: 2.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530411003  178 QVPSLQHLCRMSIRRVMPT---QEVQELPIPSKLLEFL 212
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 44-79 7.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 7.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530411003    44 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 79
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
44-79 8.72e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 8.72e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530411003   44 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 79
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 5-86 4.69e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   5 LRGHQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 83
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200


                 ...
gi 530411003  84 DIL 86
Cdd:PTZ00421 201 TIV 203
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-183 1.92e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEFGHlfppptpifaggaNDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSV 160
Cdd:COG2319  278 GELLRTLTG-------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVRSVAFSPDGKT 344

                        170       180
                 ....*....|....*....|....*
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQ 183
Cdd:COG2319  345 LASGSDDGTVRLWdlATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
4-184 4.32e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 4.32e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   4 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 83
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  84 DILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSV 160
Cdd:COG2319  195 KLLRTLtGH--------------TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRL 260

                        170       180
                 ....*....|....*....|....*.
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQH 184
Cdd:COG2319  261 LASGSADGTVRLWdlATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
3-183 5.33e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 5.33e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEFGHlfppptpifaggaNDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSV 160
Cdd:COG2319  236 GKLLRTLTG-------------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKL 302

                        170       180
                 ....*....|....*....|....*
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQ 183
Cdd:COG2319  303 LASGSDDGTVRLWdlATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
3-173 2.70e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGS 159
Cdd:COG2319  320 GKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGavTSVAFSPDGR 385

                        170
                 ....*....|....
gi 530411003 160 VLAAGTHDGSVYFW 173
Cdd:COG2319  386 TLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-173 1.42e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.42e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEF-GHL-------FPPPTPIFAGGANDR---------------------WVRSVSFSHDGLHVASLADDKMVRFW 133
Cdd:cd00200   83 GECVRTLtGHTsyvssvaFSPDGRILSSSSRDKtikvwdvetgkclttlrghtdWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530411003 134 RIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 173
Cdd:cd00200  163 DLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-183 2.09e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 2.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   4 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 83
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  84 DILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSV 160
Cdd:cd00200  168 KCVATLtGH--------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYL 233

                        170       180
                 ....*....|....*....|....*
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQ 183
Cdd:cd00200  234 LASGSEDGTIRVWdlRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-174 3.47e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 3.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  83 GDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGS 159
Cdd:cd00200  209 GKCLGTLrGH--------------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGK 274

                        170
                 ....*....|....*
gi 530411003 160 VLAAGTHDGSVYFWA 174
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-184 4.70e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 4.70e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   4 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 83
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  84 DILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSV 160
Cdd:COG2319  153 KLLRTLtGH--------------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavRSVAFSPDGKL 218

                        170       180
                 ....*....|....*....|....*.
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQH 184
Cdd:COG2319  219 LASGSADGTVRLWdlATGKLLRTLTG 244
WD40 COG2319
WD40 repeat [General function prediction only];
3-136 3.50e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 3.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 82
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530411003  83 GDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRID 136
Cdd:COG2319  362 GELLRTLtGH--------------TGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-134 4.53e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 4.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   2 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPH 81
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530411003  82 NGDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWR 134
Cdd:cd00200  250 TGECVQTLsGH--------------TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-183 3.86e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 3.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   4 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 83
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  84 DILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSV 160
Cdd:COG2319  111 LLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGavTSVAFSPDGKL 176

                        170       180
                 ....*....|....*....|....*
gi 530411003 161 LAAGTHDGSVYFW--ATPRQVPSLQ 183
Cdd:COG2319  177 LASGSDDGTVRLWdlATGKLLRTLT 201
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 177-216 2.21e-24

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 90.64  E-value: 2.21e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 216
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 177-215 3.75e-22

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 84.78  E-value: 3.75e-22
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 215
Cdd:cd03733    1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
WD40 COG2319
WD40 repeat [General function prediction only];
2-82 5.95e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 5.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   2 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPH 81
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                 .
gi 530411003  82 N 82
Cdd:COG2319  403 T 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 43-173 6.78e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 6.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  43 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GH-------LFPPPTPIFAGGANDR------- 107
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHtgpvrdvAASADGTYLASGSSDKtirlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003 108 --------------WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVY 171
Cdd:cd00200   81 etgecvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTFVASSSQDGTIK 160


                 ..
gi 530411003 172 FW 173
Cdd:cd00200  161 LW 162
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 173-215 3.90e-16

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.25  E-value: 3.90e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 530411003   173 WATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 215
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 178-215 2.81e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.02  E-value: 2.81e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 530411003 178 QVPSLQHLCRMSIRRVM---PTQEVQELPIPSKLLEFLSYR 215
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 178-215 1.12e-10

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 54.52  E-value: 1.12e-10
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 530411003 178 QVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 215
Cdd:cd03717    2 SVRSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 177-215 2.54e-10

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 53.75  E-value: 2.54e-10
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 215
Cdd:cd03745    1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 177-215 1.42e-09

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 51.73  E-value: 1.42e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQ---EVQELPIPSKLLEFLSYR 215
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 180-215 1.85e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 1.85e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530411003   180 PSLQHLCRMSIRRVMPTqeVQELPIPSKLLEFLSYR 215
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--IDKLPLPPRLKDYLLYY 34
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 178-212 2.00e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.40  E-value: 2.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530411003  178 QVPSLQHLCRMSIRRVMPT---QEVQELPIPSKLLEFL 212
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 180-215 3.20e-08

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 48.31  E-value: 3.20e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530411003 180 PSLQHLCRMSIRRVmpTQEVQELPIPSKLLEFLS-YR 215
Cdd:cd03736    4 PSLQHLCRITINKC--TRQIQELPLPTRLKDYLTeYT 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 44-79 7.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 7.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530411003    44 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 79
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
44-79 8.72e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 8.72e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530411003   44 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 79
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 177-214 3.74e-07

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 45.47  E-value: 3.74e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 530411003 177 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSY 214
Cdd:cd03741    1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYLRE 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 3-37 1.60e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 1.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 530411003     3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 37
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 5-86 4.69e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   5 LRGHQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 83
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200


                 ...
gi 530411003  84 DIL 86
Cdd:PTZ00421 201 TIV 203
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 50-79 1.12e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.06  E-value: 1.12e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530411003   50 HHHDVVAC-DFSPDGALLATASYDTRVYIWD 79
Cdd:pfam20426 122 QHKDVVSCvAVTSDGSILATGSYDTTVMVWE 152
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 178-212 1.34e-05

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 40.86  E-value: 1.34e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530411003 178 QVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFL 212
Cdd:cd03740    2 QVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
WD40 pfam00400
WD domain, G-beta repeat;
3-37 1.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530411003    3 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 37
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 179-212 2.05e-05

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 40.72  E-value: 2.05e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 530411003 179 VPSLQHLCRMSIRRVmpTQEVQELPIPSKLLEFL 212
Cdd:cd03734    3 ARSLQHLCRLVINRL--VTDVDCLPLPRRMADYL 34
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-37 6.92e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 6.92e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530411003   1 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 37
Cdd:cd00200  253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 181-215 9.14e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 38.82  E-value: 9.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 530411003 181 SLQHLCRMSIRRVM---PTQEVQELPIPSKLLEFLSYR 215
Cdd:cd03718    5 PLMDLCRRRVRVALgrdRLEEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 175-212 1.35e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.58  E-value: 1.35e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 530411003 175 TPRqvpSLQHLCRMSIRRVMPTQ---EVQELPIPSKLLEFL 212
Cdd:cd03723    2 TPR---SLQHLCRCAIRKLLGSRchkLVPQLSLPTSLKNYL 39
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 175-215 1.95e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 37.84  E-value: 1.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 530411003 175 TPRqvpSLQHLCRMSIRRVMPTQEVQ---ELPIPSKLLEFLSYR 215
Cdd:cd03729    2 TPL---SLQQLCRINLRKALGTRALEkiaKLNIPNRIIDYLSYN 42
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 179-214 2.52e-04

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 37.85  E-value: 2.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 530411003 179 VPSLQHLCRMSIRRVMPTQE------VQELPIPSKLLEFLSY 214
Cdd:cd03722    3 VPSLTHLCRLEIRSSLKSERlrsdsfICQLPLPRSLQDYLLY 44
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 5-173 3.11e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   5 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW--------NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 76
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFecesiikdGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003  77 IWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSFSH-DGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA-F 154
Cdd:PLN00181 559 VWDVARSQLVTEMKE-------------HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVqF 625

                        170       180
                 ....*....|....*....|
gi 530411003 155 STD-GSVLAAGTHDGSVYFW 173
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYY 645
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 17-93 9.81e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.79  E-value: 9.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411003   17 FSPDSSMLCSVG---ASKAVFLWNMDKYTMIRKLEghHHDVVACDFSPDGALLATAS------YDTRVYIWDpHNGDILM 87
Cdd:pfam08662 108 WSPFGRLVLLAGfgnLAGDIEFWDVVNKKKIATAE--ASNATLCEWSPDGRYFLTATtaprlrVDNGFKIWH-YNGALVY 184


                  ....*...
gi 530411003   88 E--FGHLF 93
Cdd:pfam08662 185 KydFDELY 192
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 181-215 9.88e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 36.35  E-value: 9.88e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 530411003 181 SLQHLCRMSIRRVMPTQEVQE------LPIPSKLLEFLSYR 215
Cdd:cd03731    5 PLKHLCRLKIRKLMGLQKLQQpssmkkLPLPPALKRYILYK 45
SOCS_SOCS5 cd03739
SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the ...
 181-212 3.63e-03

SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting IL-4 signaling. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239708  Cd Length: 57  Bit Score: 34.58  E-value: 3.63e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 530411003 181 SLQHLCRMSIRRVMPTQEVQELPIPSKLLEFL 212
Cdd:cd03739    5 SLQYICRAVICRCTTYDGIDALPLPSMLQDFL 36
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 120-197 4.89e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.36  E-value: 4.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530411003  120 HVASLADDKMVRFWRIDEDYpvqVAplsnglCCAFSTDGSVLAAGTHDGSVYFWATPRQvpslqhlcRMSIRRVMPTQ 197
Cdd:pfam20426 107 QVISLNDGRMVQSIRQHKDV---VS------CVAVTSDGSILATGSYDTTVMVWEVLRG--------RSSEKRSRNTQ 167
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-133 5.62e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.62e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 530411003   104 ANDRWVRSVSFSHDGLHVASLADDKMVRFW 133
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-173 5.68e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.68e-03
                           10        20
                   ....*....|....*....|....
gi 530411003   150 LCCAFSTDGSVLAAGTHDGSVYFW 173
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 174-215 6.40e-03

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 33.70  E-value: 6.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 530411003 174 ATPRqvpSLQHLCRMSIRRVMPTQE---VQELPIPSKLLEFLSYR 215
Cdd:cd03724    1 ATPS---SLCQLCRLCIRNYIGRSRlhlIPQLQLPTLLKNFLQYR 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 181-215 7.36e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 33.67  E-value: 7.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 530411003 181 SLQHLCRMSIRRVMPTQEVQE------LPIPSKLLEFLSYR 215
Cdd:cd03730    5 SLKHLCRLKIRACMGRLRLRCpvfmsfLPLPNRLKAYILYK 45
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 140-173 8.31e-03

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 36.66  E-value: 8.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530411003  140 PVQVAPLSNGL----------CCAFSTDGSVLAAGTHDGSVYFW 173
Cdd:pfam16529 170 PLQPAALESGYieieehsllvDAAFSPDGTALATASLDGEVKFF 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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