NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530412779|ref|XP_005257689|]
View 

DNA topoisomerase 2-alpha isoform X1 [Homo sapiens]

Protein Classification

type II topoisomerase( domain architecture ID 11488025)

type II topoisomerase is a DNA topoisomerase that controls and alters the topological states of DNA by transient breakage and subsequent rejoining of DNA strands

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
13-1485 0e+00

DNA topoisomerase 2-like protein; Provisional


:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 1699.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   13 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 88
Cdd:PTZ00108    1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   89 KMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 168
Cdd:PTZ00108   81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  169 TASREYKKMFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 247
Cdd:PTZ00108  161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  248 NKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD 327
Cdd:PTZ00108  241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  328 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 407
Cdd:PTZ00108  321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  408 QVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 487
Cdd:PTZ00108  401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  488 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 566
Cdd:PTZ00108  481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  567 KVSK-NKQEMAFYSLPEFEEWKSSTPNhKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQ 645
Cdd:PTZ00108  558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  646 IDDRKEWLTNFME----DRRQRKllglpedylygqtttyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 721
Cdd:PTZ00108  637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  722 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSL 801
Cdd:PTZ00108  701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  802 ARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYK 881
Cdd:PTZ00108  781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  882 NFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEpmlNGTEKTPPLITDYREYHTDTTVKFVVKMT 961
Cdd:PTZ00108  861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  962 EEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQAR 1041
Cdd:PTZ00108  937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1042 FILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPL 1121
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPI 1096
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1122 WYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVglpgkggkakgkktqmaevlps 1201
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAK---------------------- 1154
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1202 prgqrvipritiemkaeaekknkkkiknentegspqedgveleglKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNP 1281
Cdd:PTZ00108 1155 ---------------------------------------------EQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1282 WSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQK 1361
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEG 1269
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1362 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQ 1441
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQS 1349
                        1450      1460      1470      1480
                  ....*....|....*....|....*....|....*....|....
gi 530412779 1442 KPdpaKTKNRRKRKPSTSDDSDsnFEKIVSKAVTSKKSKGESDD 1485
Cdd:PTZ00108 1350 SR---LLRRPRKKKSDSSSEDD--DDSEVDDSEDEDDEDDEDDD 1388
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
13-1485 0e+00

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 1699.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   13 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 88
Cdd:PTZ00108    1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   89 KMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 168
Cdd:PTZ00108   81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  169 TASREYKKMFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 247
Cdd:PTZ00108  161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  248 NKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD 327
Cdd:PTZ00108  241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  328 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 407
Cdd:PTZ00108  321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  408 QVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 487
Cdd:PTZ00108  401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  488 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 566
Cdd:PTZ00108  481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  567 KVSK-NKQEMAFYSLPEFEEWKSSTPNhKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQ 645
Cdd:PTZ00108  558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  646 IDDRKEWLTNFME----DRRQRKllglpedylygqtttyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 721
Cdd:PTZ00108  637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  722 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSL 801
Cdd:PTZ00108  701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  802 ARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYK 881
Cdd:PTZ00108  781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  882 NFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEpmlNGTEKTPPLITDYREYHTDTTVKFVVKMT 961
Cdd:PTZ00108  861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  962 EEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQAR 1041
Cdd:PTZ00108  937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1042 FILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPL 1121
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPI 1096
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1122 WYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVglpgkggkakgkktqmaevlps 1201
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAK---------------------- 1154
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1202 prgqrvipritiemkaeaekknkkkiknentegspqedgveleglKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNP 1281
Cdd:PTZ00108 1155 ---------------------------------------------EQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1282 WSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQK 1361
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEG 1269
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1362 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQ 1441
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQS 1349
                        1450      1460      1470      1480
                  ....*....|....*....|....*....|....*....|....
gi 530412779 1442 KPdpaKTKNRRKRKPSTSDDSDsnFEKIVSKAVTSKKSKGESDD 1485
Cdd:PTZ00108 1350 SR---LLRRPRKKKSDSSSEDD--DDSEVDDSEDEDDEDDEDDD 1388
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
68-657 0e+00

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 776.73  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779     68 GLYKIFDEILVNAADNKQRDPkMSCIRVTIDPENnLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 147
Cdd:smart00433    1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    148 GGRNGYGAKLCNIFSTKFTVETASReyKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSldKDIVALM 227
Cdd:smart00433   79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    228 VRRAYDIAGSTKDVKVFLNGNK-------LPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKG-FQQI 299
Cdd:smart00433  155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    300 SFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVA-VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFG- 377
Cdd:smart00433  235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    378 ----STCQLSEKFIKAAIGCGIVESILNWVKFKAQVQ-LNKKCSAVKHNRIKGIPKLDDANDAGGRnstECTLILTEGDS 452
Cdd:smart00433  315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    453 AKTLAVSGLgvvGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYededSLKTLRYGKIMIMTDQDQ 532
Cdd:smart00433  392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    533 DGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQ--EMAFYSLPEFEEWKSSTPNHK-KWKVKYYKGLGTSTS 609
Cdd:smart00433  465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
                           570       580       590       600
                    ....*....|....*....|....*....|....*....|....*....
gi 530412779    610 KEAKEYFADMKRHRIQFKYSGPEDDA-AISLAFSKKQIDDRKEWLTNFM 657
Cdd:smart00433  545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
699-1162 8.52e-171

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 519.82  E-value: 8.52e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  699 NERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSsYHHGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 854
Cdd:cd00187    78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  855 FDVREIVNNIRRLMDGEEP-------LPMLPSYKNFkGTIEELA---------PNQYVISGEVAIL---NSTTIEISELP 915
Cdd:cd00187   156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEddeGRNTIEITELP 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  916 VRTWTQTYKEQVLEPMlngTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNsMVLFDHVG 995
Cdd:cd00187   235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  996 CLKKYdTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKID--GKIIIENKPKKELIKVLIQRGYDSD 1073
Cdd:cd00187   311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFSEI 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1074 pvkawkeaqqkvpdeeeneesdneketeksdsvtdsgpTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS--- 1150
Cdd:cd00187   390 --------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILase 431
                         490
                  ....*....|....
gi 530412779 1151 --PSDLWKEDLATF 1162
Cdd:cd00187   432 erPKDLWKEELDEF 445
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
701-1159 3.10e-158

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 485.90  E-value: 3.10e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   701 RSIPSMVDGLKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFVGsnNLNLLQPIGQ 777
Cdd:pfam00521    1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   778 FGTRLHGGKDsASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFD 856
Cdd:pfam00521   77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   857 VREIVNNIRRLMDGEEP-----LPMLPSYKNFKGTIEELAP--------NQYVISGEVAILNSTTIEISELPVRTWTQTY 923
Cdd:pfam00521  156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGIkeayktgrGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   924 KEQvLEPMLNgtEKTPPLITDYREYhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVgclKKYDTV 1003
Cdd:pfam00521  236 IEK-IEELVK--NGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  1004 LDILRDFFELRLKYYGLRKEWLLGMLGAESAKLN------NQARFILEKIDGKiIIENKPKKELIKVLiqrgydsdpvka 1077
Cdd:pfam00521  309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGS-IDRKKAKKNLIEEL------------ 375
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  1078 wKEAQqkvpdeeeneesdneketeksdsvtdsgptFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS----- 1152
Cdd:pfam00521  376 -SEIQ------------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekkln 424

                   ....*..
gi 530412779  1153 DLWKEDL 1159
Cdd:pfam00521  425 DLWIEEL 431
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
28-605 2.84e-40

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 159.42  E-value: 2.84e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   28 LEHILLRPDTYIGSVelvtqqmwvyDEDvginyrevtfvpGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDp 99
Cdd:COG0187    17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  100 ENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFK 179
Cdd:COG0187    65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RD-GKIYR 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  180 QTWMDnmGRAGEmELKpfNGEDY----TCITFQPDLSKFKMQSLDKDIVALMVRRaydiagstkdvKVFLNGN------- 248
Cdd:COG0187   143 QRFER--GKPVG-PLE--KIGKTdrtgTTVRFKPDPEIFETTEFDYETLAERLRE-----------LAFLNKGltitltd 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  249 ---KLPVK-------GFRSYVDMYLKDKldetgnslKVIHEQV--------NHRWEVCLTMSEKGFQQI-SFVNSIATSK 309
Cdd:COG0187   207 ereEEPKEetfhyegGIKDFVEYLNEDK--------EPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPE 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  310 GGRHV------------DYVadqivtKLVDVVKKKNK---------GGVAVkahqvknhmwifVNALIENPTFDSQTKEn 368
Cdd:COG0187   279 GGTHEtgfrtaltrvinDYA------RKNGLLKEKDKnltgddvreGLTAV------------ISVKLPEPQFEGQTKT- 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  369 mtlqpksfgstcQLSEKFIKaaigcGIVESILN----------------WVKF-----------KAQVQLNKKCSAVKHN 421
Cdd:COG0187   340 ------------KLGNSEAR-----GIVESVVSeklehyleenpaeakkILEKailaarareaaRKARELVRRKSALESS 402
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  422 RIKGipKLDDANDaggRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENAEI 495
Cdd:COG0187   403 GLPG--KLADCSS---KDPEESELFIVEGDSAggsaKQ---------GRDrEFqAILPLRGKILNVEKARLDKILKNEEI 468
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  496 NNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI--TPIVKVSKNKQ 573
Cdd:COG0187   469 RDLITALGTGIGDDFDLEK----LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKK 542
                         650       660       670
                  ....*....|....*....|....*....|..
gi 530412779  574 EMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLG 605
Cdd:COG0187   543 TYYAYSDAELDELLKELKGKKKVEIQRYKGLG 574
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
701-1077 1.01e-18

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 92.76  E-value: 1.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:TIGR01063   25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   777 QFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 854
Cdd:TIGR01063  101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   855 FDVREIVNNIRRLMDGEE----------PLPMLP-------------SYKNFKGTIeelapnqyVISGEVAILNS----T 907
Cdd:TIGR01063  178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSI--------VIRARAEIEEDskgrE 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   908 TIEISELPVRTWTQTYKEQVLEpMLNgtEKTPPLITDYREYHTDTTVKFVVkmtEEKLAEAERVGLHKVFK---LQTSLT 984
Cdd:TIGR01063  250 AIIVTEIPYQVNKARLIEKIAE-LVR--EKKIEGISDIRDESDREGIRIVI---ELKRDAVAEVVLNNLYKqtqLQVSFG 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   985 CNSMVLFDHvgcLKKYDTVLDILRDFFELRLK------YYGLRK-----EWLLGMLGAesakLNNqarfilekIDGKI-I 1052
Cdd:TIGR01063  324 INMLALVKG---LPKVLNLKELLEAFVEHRKDvitrrtIFELRKaeeraHILEGLLIA----LDN--------IDEVIaL 388
                          410       420
                   ....*....|....*....|....*
gi 530412779  1053 IENKPKKELIKVLIQRGYDSDPVKA 1077
Cdd:TIGR01063  389 IRASQNTEEAKTRLVERFSLSEIQA 413
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
13-1485 0e+00

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 1699.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   13 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 88
Cdd:PTZ00108    1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   89 KMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 168
Cdd:PTZ00108   81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  169 TASREYKKMFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 247
Cdd:PTZ00108  161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  248 NKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD 327
Cdd:PTZ00108  241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  328 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 407
Cdd:PTZ00108  321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  408 QVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 487
Cdd:PTZ00108  401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  488 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 566
Cdd:PTZ00108  481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  567 KVSK-NKQEMAFYSLPEFEEWKSSTPNhKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQ 645
Cdd:PTZ00108  558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  646 IDDRKEWLTNFME----DRRQRKllglpedylygqtttyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 721
Cdd:PTZ00108  637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  722 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSL 801
Cdd:PTZ00108  701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  802 ARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYK 881
Cdd:PTZ00108  781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  882 NFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEpmlNGTEKTPPLITDYREYHTDTTVKFVVKMT 961
Cdd:PTZ00108  861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  962 EEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQAR 1041
Cdd:PTZ00108  937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1042 FILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPL 1121
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPI 1096
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1122 WYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVglpgkggkakgkktqmaevlps 1201
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAK---------------------- 1154
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1202 prgqrvipritiemkaeaekknkkkiknentegspqedgveleglKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNP 1281
Cdd:PTZ00108 1155 ---------------------------------------------EQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1282 WSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQK 1361
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEG 1269
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1362 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQ 1441
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQS 1349
                        1450      1460      1470      1480
                  ....*....|....*....|....*....|....*....|....
gi 530412779 1442 KPdpaKTKNRRKRKPSTSDDSDsnFEKIVSKAVTSKKSKGESDD 1485
Cdd:PTZ00108 1350 SR---LLRRPRKKKSDSSSEDD--DDSEVDDSEDEDDEDDEDDD 1388
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
17-1167 0e+00

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 1663.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   17 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYdEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVT 96
Cdd:PLN03128    2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   97 IDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 176
Cdd:PLN03128   81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  177 MFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG-STKDVKVFLNGNKLPVKG 254
Cdd:PLN03128  161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  255 FRSYVDMYLKDKLDEtgNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNK 334
Cdd:PLN03128  241 FQDYVGLYLGPNSRE--DPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  335 GGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLnKK 414
Cdd:PLN03128  319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  415 CSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAE 494
Cdd:PLN03128  398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  495 INNIIKIVGLQYKKNYeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLEEFITPIVKVSKNKQ 573
Cdd:PLN03128  478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  574 EMAFYSLPEFEEWKSST-PNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEW 652
Cdd:PLN03128  557 SLSFYTMPEYEAWKESLeGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  653 LTNFMEDrrqrkllglpeDYLyGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKV 732
Cdd:PLN03128  637 LNNYEPG-----------TFL-DQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  733 AQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDH 812
Cdd:PLN03128  705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  813 TLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAP 892
Cdd:PLN03128  785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVST 864
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  893 ---NQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE 969
Cdd:PLN03128  865 srsGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  970 RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDG 1049
Cdd:PLN03128  944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1050 KIIIENKPKKELIKVLIQRGYDSDPvkawKEAQQKVPDEEENEESDNEKETEKSDSvtDSGPTFNYLLDMPLWYLTKEKK 1129
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFP----KTAKISETNVVGDRDGEASEEEEASDN--ELAKSYDYLLGMPISSLTLEKV 1097
                        1130      1140      1150
                  ....*....|....*....|....*....|....*...
gi 530412779 1130 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE 1167
Cdd:PLN03128 1098 DELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
3-1468 0e+00

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 1489.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    3 VNKIKKNEDAKKrlSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINyREVTFVPGLYKIFDEILVNAAD 82
Cdd:PLN03237   15 VAAAPAASSGGK--TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQ-RSVTYVPGLYKIFDEILVNAAD 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   83 NKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFS 162
Cdd:PLN03237   92 NKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFS 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  163 TKFTVETASREYKKMFKQTWMDNMGRAGE-MELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGST-KD 240
Cdd:PLN03237  172 TEFVIETADGKRQKKYKQVFSNNMGKKSEpVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDIAGCLgKT 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  241 VKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQ 320
Cdd:PLN03237  252 VKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQ 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  321 IVTKLVDVVKKKNKGGvAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESIL 400
Cdd:PLN03237  332 IANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVMKSGIVENLL 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  401 NWVKFKAQVQLnKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILN 480
Cdd:PLN03237  411 SWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFPLRGKLLN 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  481 VREASHKQIMENAEINNIIKIVGLQYKKNYEdedSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLE 559
Cdd:PLN03237  490 VREASHKQIMNNAEIENIKQILGLQHGKQYE---SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKvPSFLV 566
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  560 EFITPIVKVSK-NKQEMAFYSLPEFEEWKSS-TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAI 637
Cdd:PLN03237  567 EFITPIVKATRrGKKVLSFYSMPEYEEWKESlGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDGDAI 646
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  638 SLAFSKKQIDDRKEWLTNFMedrrqrkllglPEDYLyGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKV 717
Cdd:PLN03237  647 ELAFSKKKIEARKNWLRQYE-----------PGTHL-DQTQKDVKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKI 714
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  718 LFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTM 797
Cdd:PLN03237  715 LFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTR 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  798 LSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPML 877
Cdd:PLN03237  795 LSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMH 874
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  878 PSYKNFKGTIEELAPNQ----YVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEPMLNGTEKTP-PLITDYREYHTDT 952
Cdd:PLN03237  875 PWYRGFKGTIEKTASKEggctYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKdPFIKDVKAYNDDT 953
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  953 TVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAE 1032
Cdd:PLN03237  954 TVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFE 1033
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1033 SAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAwKEAQQKVPDEEENEESDNEKETEKSDSVTDsGPT 1112
Cdd:PLN03237 1034 LLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKA-KSVEAAVAGATDDAAEEEEEIDVSSSSGVR-GSD 1111
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1113 FNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAkgkk 1192
Cdd:PLN03237 1112 YDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEEAREKLQRAAA---- 1187
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1193 tqMAEVLPSPRGQRVIPRitiemkaeaekknKKKIKNENTEGSPQEDGVELEGlKQRLEKKQKREPGTKTKKQTTLAFKP 1272
Cdd:PLN03237 1188 --RGESGAAKKVSRQAPK-------------KPAPKKTTKKASESETTEETYG-SSAMETENVAEVVKPKGRAGAKKKAP 1251
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1273 IKKGKKRNPWSDSESDRSSDESNFDVPP-----RETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTK 1347
Cdd:PLN03237 1252 AAAKEKEEEDEILDLKDRLAAYNLDSAPaqsakMEETVKAVPARRAAARKKPLASVSVISDSDDDDDDFAVEVSLAERLK 1331
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1348 ---------------TSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPpathfpdETEI----TNPVPKKNVTVKKTA 1408
Cdd:PLN03237 1332 kkggrkpaaankkaaKPPAAAKKRGPATVQSGQKLLTEMLKPAEAIGISP-------EKKVrkmrASPFNKKSGSVLGRA 1404
                        1450      1460      1470      1480      1490      1500
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1409 AKSQSSTSTTGAkkrAAPKGTKRDPAlnsGVSQKPDPAktknRRKRKPSTSDDSDSNFEK 1468
Cdd:PLN03237 1405 ATNKETESSENV---SGSSSSEKDEI---DVSAKPRPQ----RANRKQTTYVLSDSESES 1454
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
68-657 0e+00

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 776.73  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779     68 GLYKIFDEILVNAADNKQRDPkMSCIRVTIDPENnLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 147
Cdd:smart00433    1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    148 GGRNGYGAKLCNIFSTKFTVETASReyKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSldKDIVALM 227
Cdd:smart00433   79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    228 VRRAYDIAGSTKDVKVFLNGNK-------LPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKG-FQQI 299
Cdd:smart00433  155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    300 SFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVA-VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFG- 377
Cdd:smart00433  235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    378 ----STCQLSEKFIKAAIGCGIVESILNWVKFKAQVQ-LNKKCSAVKHNRIKGIPKLDDANDAGGRnstECTLILTEGDS 452
Cdd:smart00433  315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    453 AKTLAVSGLgvvGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYededSLKTLRYGKIMIMTDQDQ 532
Cdd:smart00433  392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    533 DGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQ--EMAFYSLPEFEEWKSSTPNHK-KWKVKYYKGLGTSTS 609
Cdd:smart00433  465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
                           570       580       590       600
                    ....*....|....*....|....*....|....*....|....*....
gi 530412779    610 KEAKEYFADMKRHRIQFKYSGPEDDA-AISLAFSKKQIDDRKEWLTNFM 657
Cdd:smart00433  545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
681-1157 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 566.81  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    681 LTYNDFINKELILFSNS-DNERSIPSMVDGLKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSSYH-HGEMSLMMTII 757
Cdd:smart00434    1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    758 NLAQNFVgsNNLNLLQPIGQFGTRLhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMV 836
Cdd:smart00434   81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    837 LINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEP----LPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEIS 912
Cdd:smart00434  158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDAsideLMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    913 ELPVRTWTQTYKEQVLEPMLNGteKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFD 992
Cdd:smart00434  238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    993 HvGCLKKYDTVlDILRDFFELRLKYYGLRKEWLLGMLGAEsAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDS 1072
Cdd:smart00434  316 N-GRPKKYNLK-EILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   1073 dpvkawkeaqqkvpdeeeneesdneketeksdsVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS 1152
Cdd:smart00434  393 ---------------------------------FELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILAS 439

                    ....*
gi 530412779   1153 DLWKE 1157
Cdd:smart00434  440 EEWLN 444
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
699-1162 8.52e-171

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 519.82  E-value: 8.52e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  699 NERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSsYHHGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 854
Cdd:cd00187    78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  855 FDVREIVNNIRRLMDGEEP-------LPMLPSYKNFkGTIEELA---------PNQYVISGEVAIL---NSTTIEISELP 915
Cdd:cd00187   156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEddeGRNTIEITELP 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  916 VRTWTQTYKEQVLEPMlngTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNsMVLFDHVG 995
Cdd:cd00187   235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  996 CLKKYdTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKID--GKIIIENKPKKELIKVLIQRGYDSD 1073
Cdd:cd00187   311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFSEI 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1074 pvkawkeaqqkvpdeeeneesdneketeksdsvtdsgpTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS--- 1150
Cdd:cd00187   390 --------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILase 431
                         490
                  ....*....|....
gi 530412779 1151 --PSDLWKEDLATF 1162
Cdd:cd00187   432 erPKDLWKEELDEF 445
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
701-1159 3.10e-158

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 485.90  E-value: 3.10e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   701 RSIPSMVDGLKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFVGsnNLNLLQPIGQ 777
Cdd:pfam00521    1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   778 FGTRLHGGKDsASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFD 856
Cdd:pfam00521   77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   857 VREIVNNIRRLMDGEEP-----LPMLPSYKNFKGTIEELAP--------NQYVISGEVAILNSTTIEISELPVRTWTQTY 923
Cdd:pfam00521  156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGIkeayktgrGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   924 KEQvLEPMLNgtEKTPPLITDYREYhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVgclKKYDTV 1003
Cdd:pfam00521  236 IEK-IEELVK--NGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  1004 LDILRDFFELRLKYYGLRKEWLLGMLGAESAKLN------NQARFILEKIDGKiIIENKPKKELIKVLiqrgydsdpvka 1077
Cdd:pfam00521  309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGS-IDRKKAKKNLIEEL------------ 375
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  1078 wKEAQqkvpdeeeneesdneketeksdsvtdsgptFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS----- 1152
Cdd:pfam00521  376 -SEIQ------------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekkln 424

                   ....*..
gi 530412779  1153 DLWKEDL 1159
Cdd:pfam00521  425 DLWIEEL 431
HATPase_TopII-like cd16930
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ...
65-210 5.44e-96

Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.


Pssm-ID: 340407 [Multi-domain]  Cd Length: 147  Bit Score: 305.03  E-value: 5.44e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   65 FVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEK 144
Cdd:cd16930     1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530412779  145 KVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPF-NGEDYTCITFQPD 210
Cdd:cd16930    81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
TopoIIA_Trans_ScTopoIIA cd03481
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ...
253-405 7.11e-89

TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.


Pssm-ID: 239563 [Multi-domain]  Cd Length: 153  Bit Score: 285.33  E-value: 7.11e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  253 KGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKK 332
Cdd:cd03481     1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530412779  333 NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKF 405
Cdd:cd03481    81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
39 PHA02569
DNA topoisomerase II large subunit; Provisional
29-654 9.60e-85

DNA topoisomerase II large subunit; Provisional


Pssm-ID: 177398 [Multi-domain]  Cd Length: 602  Bit Score: 290.50  E-value: 9.60e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   29 EHILLRPDTYIGSVELVTQQMWVYDedvgiNYREVTFVPGLYKIFDEILVNAADNKQR-DPKMS-CIRVTIDpeNNLISI 106
Cdd:PHA02569   11 EHILKRPGMYIGSVAYEAHERFLFG-----KFTQVEYVPGLVKIIDEIIDNSVDEAIRtNFKFAnKIDVTIK--NNQVTV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  107 WNNGKGIP---VVEHKVEKMYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQT-W 182
Cdd:PHA02569   84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCSnG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  183 MDNMGrageMELKPfNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKgFRSYVDMY 262
Cdd:PHA02569  163 AENIS----WSTKP-GKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYAKQF 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  263 LKDKldetgnslkVIHEqvNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKggVAVKAH 342
Cdd:PHA02569  237 GDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTKA 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  343 QVKN--HMWIFVNALIeNPTFDSQTKENMTLQPKSFGSTCQLSEKFI------KAAIGCGIVESIL--NWVKFKAQVQLN 412
Cdd:PHA02569  304 RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakqilkTEAIIMPIIEAALarKLAAEKAAETKA 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  413 KKcSAVKHNRIKGIPklddANDAGgrNSTECTLILTEGDSAKTLAVSglgVVGRDKYGVFPLRGKILNVREASHKQIMEN 492
Cdd:PHA02569  383 AK-KAKKAKVAKHIK----ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILKN 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  493 AEINNIIKIVGLQYKknyEDEDSLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLL---RHRFLEefiTPIVKV 568
Cdd:PHA02569  453 KELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFeqgRIRFVK---TPVIIA 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  569 SKNKQEMAFYSLPEFEEWKSStpnHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEddaAISLAFSKKQiDD 648
Cdd:PHA02569  523 QVGKETKWFYSLDEFEKAKDS---LKKWSIRYIKGLGSLRKSEYRRVINNPVYDVVVLPDDWKE---LFEMLFGDDA-DL 595

                  ....*.
gi 530412779  649 RKEWLT 654
Cdd:PHA02569  596 RKDWMS 601
TOPRIM_TopoIIA cd03365
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ...
443-563 1.92e-77

TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173785 [Multi-domain]  Cd Length: 120  Bit Score: 251.07  E-value: 1.92e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  443 CTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKnyEDEDSLKTLRYG 522
Cdd:cd03365     1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGK--SDYESTKSLRYG 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530412779  523 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFIT 563
Cdd:cd03365    79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
52 PHA02592
DNA topisomerase II medium subunit; Provisional
679-1167 3.12e-77

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 263.46  E-value: 3.12e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  679 TYLTYNDFINKELILFSNSD-NERSIPSMVDGLKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSsYHHGEMSLMM 754
Cdd:PHA02592    4 KERSLKSIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  755 TIINLAQNFvgSNNLNLLQPIGQFGTRLhgGKDSASPRYIFTMLSSLARLLFppKDDHtLKFLYDDNQRVEPEWYIPIIP 834
Cdd:PHA02592   83 AGALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY--KDED-LAPVHEDPEHIPPAFYLPIIP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  835 MVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISEL 914
Cdd:PHA02592  156 MVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEI 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  915 PVRTWTQTYKEqVLEPMLngtEKTppLITDYREYHTDtTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLfDHV 994
Cdd:PHA02592  236 PVKYDRETYVA-VLDPLE---EKG--KIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NEN 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  995 GCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLiqrgydsdp 1074
Cdd:PHA02592  308 GKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL--------- 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1075 vKAWKeaqqkvpdeeeneesdneketeksdsvtDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDL 1154
Cdd:PHA02592  379 -SDNK----------------------------DFGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKE 429
                         490
                  ....*....|...
gi 530412779 1155 WKEDLatfiEELE 1167
Cdd:PHA02592  430 YIKDL----EELK 438
TOPRIM_C pfam16898
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ...
561-699 1.74e-75

C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.


Pssm-ID: 465302 [Multi-domain]  Cd Length: 127  Bit Score: 245.89  E-value: 1.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   561 FITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLA 640
Cdd:pfam16898    1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 530412779   641 FSKKQIDDRKEWLTNFMedrrqrkllglPEDYLYgQTTTYLTYNDFINKELILFSNSDN 699
Cdd:pfam16898   81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
TOPRIM_TopoIIA_like cd01030
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ...
443-563 2.95e-63

TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173780 [Multi-domain]  Cd Length: 115  Bit Score: 210.44  E-value: 2.95e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  443 CTLILTEGDSAKTLAVSGLGVVgrdKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYG 522
Cdd:cd01030     1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFD---LDKLRYG 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 530412779  523 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFIT 563
Cdd:cd01030    75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
PRK05559 PRK05559
DNA topoisomerase IV subunit B; Reviewed
28-605 1.06e-53

DNA topoisomerase IV subunit B; Reviewed


Pssm-ID: 235501 [Multi-domain]  Cd Length: 631  Bit Score: 199.94  E-value: 1.06e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   28 LEHILLRPDTYIGSvelvtqqmwvYDEDvginyrevtfvpGLYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpE 100
Cdd:PRK05559   19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLH-A 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  101 NNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQ 180
Cdd:PRK05559   68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RD-GKVYRQ 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  181 TWmDNMGRAGEMEL--KPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRR-AYDIAGstkdVKVFLNGNKLPVKgFRS 257
Cdd:PRK05559  146 RF-EGGDPVGPLEVvgTAGKRKTGTRVRFWPDPKIFDSPKFSPERLKERLRSkAFLLPG----LTITLNDERERQT-FHY 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  258 yvDMYLKDKLDETGNSLKVIHEQVNHRW---------EVCLTMSEKGFQQI-SFVNSIATSKGGRHVDYVADQIVTKLVD 327
Cdd:PRK05559  220 --ENGLKDYLAELNEGKETLPEEFVGSFegeaegeavEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLKAVRE 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  328 VVKKKN--KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMtlqpksfGST-CQ-LSEKFIKAAIG------CGIVE 397
Cdd:PRK05559  298 FAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKL-------GSReARrFVSGVVKDAFDlwlnqnPELAE 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  398 SILNWVKFKAQVQLNKKCSAVKHNRIKGI---PKLddaNDAGGRNSTECTLILTEGDSAktlavSGLGVVGRDKY--GVF 472
Cdd:PRK05559  371 KLAEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAIL 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  473 PLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 552
Cdd:PRK05559  443 PLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFDLED----LRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPL 518
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530412779  553 LR--HRFLEEfiTPIVKVSKNKQEMAFYSLPEFEEW-KSSTPNHKKWKVKYYKGLG 605
Cdd:PRK05559  519 VEagHVYIAL--PPLYRVDKGKKKIYALDEEEKEELlKKLGKKGGKPEIQRFKGLG 572
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
28-605 2.84e-40

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 159.42  E-value: 2.84e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   28 LEHILLRPDTYIGSVelvtqqmwvyDEDvginyrevtfvpGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDp 99
Cdd:COG0187    17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  100 ENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFK 179
Cdd:COG0187    65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RD-GKIYR 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  180 QTWMDnmGRAGEmELKpfNGEDY----TCITFQPDLSKFKMQSLDKDIVALMVRRaydiagstkdvKVFLNGN------- 248
Cdd:COG0187   143 QRFER--GKPVG-PLE--KIGKTdrtgTTVRFKPDPEIFETTEFDYETLAERLRE-----------LAFLNKGltitltd 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  249 ---KLPVK-------GFRSYVDMYLKDKldetgnslKVIHEQV--------NHRWEVCLTMSEKGFQQI-SFVNSIATSK 309
Cdd:COG0187   207 ereEEPKEetfhyegGIKDFVEYLNEDK--------EPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPE 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  310 GGRHV------------DYVadqivtKLVDVVKKKNK---------GGVAVkahqvknhmwifVNALIENPTFDSQTKEn 368
Cdd:COG0187   279 GGTHEtgfrtaltrvinDYA------RKNGLLKEKDKnltgddvreGLTAV------------ISVKLPEPQFEGQTKT- 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  369 mtlqpksfgstcQLSEKFIKaaigcGIVESILN----------------WVKF-----------KAQVQLNKKCSAVKHN 421
Cdd:COG0187   340 ------------KLGNSEAR-----GIVESVVSeklehyleenpaeakkILEKailaarareaaRKARELVRRKSALESS 402
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  422 RIKGipKLDDANDaggRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENAEI 495
Cdd:COG0187   403 GLPG--KLADCSS---KDPEESELFIVEGDSAggsaKQ---------GRDrEFqAILPLRGKILNVEKARLDKILKNEEI 468
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  496 NNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI--TPIVKVSKNKQ 573
Cdd:COG0187   469 RDLITALGTGIGDDFDLEK----LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKK 542
                         650       660       670
                  ....*....|....*....|....*....|..
gi 530412779  574 EMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLG 605
Cdd:COG0187   543 TYYAYSDAELDELLKELKGKKKVEIQRYKGLG 574
gyrB PRK05644
DNA gyrase subunit B; Validated
28-605 7.25e-35

DNA gyrase subunit B; Validated


Pssm-ID: 235542 [Multi-domain]  Cd Length: 638  Bit Score: 142.93  E-value: 7.25e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   28 LEHILLRPDTYIGSvelvtqqmwvydedvginyrevTFVPGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDP 99
Cdd:PRK05644   19 LEAVRKRPGMYIGS----------------------TGERGLHHLVYEIVDNSidealagyCDH---------IEVTINE 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  100 eNNLISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETaSREYKKm 177
Cdd:PRK05644   68 -DGSITVTDNGRGIPVDIHPKTG--KPAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV-KRDGKI- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  178 FKQTWMDnmGR-AGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAGSTKDVKVFL----NGNKLPV 252
Cdd:PRK05644  143 YYQEYER--GVpVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEE 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  253 K-----GFRSYVDmYL-KDKldetgnslKVIHEQV--------NHRWEVCLTMSEkGFQQ--ISFVNSIATSKGGRHVD- 315
Cdd:PRK05644  218 TfhyegGIKEYVE-YLnRNK--------EPLHEEPiyfegekdGIEVEVAMQYND-GYSEniLSFANNINTHEGGTHEEg 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  316 -YVAdqiVTKLV-DVVKKKNK---------------GGVAVKAhqVKnhmwifvnalIENPTFDSQTK------ENMTLQ 372
Cdd:PRK05644  288 fKTA---LTRVInDYARKNKLlkekddnltgedvreGLTAVIS--VK----------HPEPQFEGQTKtklgnsEVRGIV 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  373 PKSFGStcQLSEKF------IKAaigcgIVESILNwvKFKAQVqlnkkcsAVKHNR----------IKGIP-KLDDANDa 435
Cdd:PRK05644  353 DSVVSE--ALSEFLeenpnvAKK-----IVEKAIL--AARARE-------AARKAReltrrksaleSSSLPgKLADCSS- 415
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  436 ggRNSTECTLILTEGDSAKTLAVSGlgvvgRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKknyeDE 513
Cdd:PRK05644  416 --KDPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG----DD 484
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  514 DSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT---------PIVKVSKNKQEMAfYSLPEFE 584
Cdd:PRK05644  485 FDISKLRYHKIIIMTDADVDGAHIRTLLLTFF---------YRYMRPLIEagyvyiaqpPLYKIKKGGKEYA-YSDEELD 554
                         650       660
                  ....*....|....*....|...
gi 530412779  585 EWKSSTPNH--KKWKVKYYKGLG 605
Cdd:PRK05644  555 EILAELKLKgnPKYGIQRYKGLG 577
DTHCT pfam08070
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ...
1423-1510 8.57e-34

DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.


Pssm-ID: 462355 [Multi-domain]  Cd Length: 97  Bit Score: 125.64  E-value: 8.57e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  1423 RAAPKGTKR------DPALNSGVSQKPDPAKTKNRRKRKPSTS-DDSDSNFEKIVSKAVTSKKSKG--ESDDFHMDFDSA 1493
Cdd:pfam08070    1 KAAPKAAKAadksssDSDSDAGASKKPAPPKGRKARKRKPSSSsDDSDSDFGKKPSKAVAKKKSKKvsDDDDFSVDLDSE 80
                           90
                   ....*....|....*..
gi 530412779  1494 VAPRAKSVRAKKPIKYL 1510
Cdd:pfam08070   81 VAPRARPGRAKKPVKYL 97
DNA_gyraseB pfam00204
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ...
254-414 2.48e-31

DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.


Pssm-ID: 425522 [Multi-domain]  Cd Length: 173  Bit Score: 121.57  E-value: 2.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   254 GFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTM---SEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVK 330
Cdd:pfam00204    1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   331 KKN---KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGC-GIVESILNWVKFK 406
Cdd:pfam00204   81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKALQA 160

                   ....*...
gi 530412779   407 AQVQLNKK 414
Cdd:pfam00204  161 AKARLAAR 168
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
700-1061 5.69e-24

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 109.03  E-value: 5.69e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  700 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSSYH-HGEMSLMMTIINLAqnfvgsNNLNLLQPIGQF 778
Cdd:PRK09631   22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  779 GTRLHGgkDSAS-PRYIFTMLSSLARLLFPPKDDHTLKFLYdDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDV 857
Cdd:PRK09631   93 GNLFTG--DPASaARYIECRLTPLAKEVLYNKEITEYEPSY-DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  858 REIVNNIRRLMDGeEPLPMLPSYKNfkGTIEELapNQY-------VISGEVAILNSTTIEISELPVRTWTQTYKEQVLEP 930
Cdd:PRK09631  170 NEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYadgngkvLVRAKIETKDEKTIVIREIPFGTTTESLIASIEKA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  931 MLNGTEKTPPlITDYreyhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHvgcLKKYDTVLDILRdF 1010
Cdd:PRK09631  245 ARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK-F 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530412779 1011 FELRLKYYgLRKEwllgmLGAESAKLnnqarfiLEKIDGK----IIIENKPKKEL 1061
Cdd:PRK09631  316 HAEHLQKV-LKME-----LELERAKL-------LEKIFAKtleqIFIEERIYKRI 357
TOPRIM_TopoIIA_GyrB cd03366
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ...
443-553 6.03e-24

TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173786 [Multi-domain]  Cd Length: 114  Bit Score: 98.11  E-value: 6.03e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  443 CTLILTEGDSAktlavSGLGVVGRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedsLKTLR 520
Cdd:cd03366     1 SELYIVEGDSA-----GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
                          90       100       110
                  ....*....|....*....|....*....|...
gi 530412779  521 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 553
Cdd:cd03366    72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
PTZ00109 PTZ00109
DNA gyrase subunit b; Provisional
254-643 5.15e-19

DNA gyrase subunit b; Provisional


Pssm-ID: 240272 [Multi-domain]  Cd Length: 903  Bit Score: 93.79  E-value: 5.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  254 GFRSYVDMYLKDKL----DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSkGGRHVDYVADQIvTKLVDVV 329
Cdd:PTZ00109  376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDGFKYAI-TRCVNGN 453
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  330 KKKN---KGG-VAVKAHQVKNHMWIFVNALIENPTFDSQTKEnmtlqpksfgstcQLSEKFIKAaigcgIVESILNWvKF 405
Cdd:PTZ00109  454 IKKNgyfKGNfVNIPGEFIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE-QL 514
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  406 KAQVQLNKKCSAVKHNRIKGIPKLDDANDAG-----GRNS-----------TECT--------LILTEGDSAktlAVSGL 461
Cdd:PTZ00109  515 SEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirQKNNqyystilpgklVDCIsddierneLFIVEGESA---AGNAK 591
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  462 GVVGRDKYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK----------------------- 517
Cdd:PTZ00109  592 QARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtkaskdesvqnnnstltkkkn 671
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  518 -----TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQemafyslpefEEWKSSTPN 592
Cdd:PTZ00109  672 slfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNRM----------KQFNVSTKN 741
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530412779  593 HKKWKVKYYKGLGTSTSKE-AKEYFADMKRHRIQFKYSGPEDDAAISLAFSK 643
Cdd:PTZ00109  742 SKKYIYTWSDEELNVLIKLlNKDYSSKETTRSVEEKGNAPDLDNEYEDEKLD 793
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
701-1077 1.01e-18

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 92.76  E-value: 1.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:TIGR01063   25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   777 QFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 854
Cdd:TIGR01063  101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   855 FDVREIVNNIRRLMDGEE----------PLPMLP-------------SYKNFKGTIeelapnqyVISGEVAILNS----T 907
Cdd:TIGR01063  178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSI--------VIRARAEIEEDskgrE 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   908 TIEISELPVRTWTQTYKEQVLEpMLNgtEKTPPLITDYREYHTDTTVKFVVkmtEEKLAEAERVGLHKVFK---LQTSLT 984
Cdd:TIGR01063  250 AIIVTEIPYQVNKARLIEKIAE-LVR--EKKIEGISDIRDESDREGIRIVI---ELKRDAVAEVVLNNLYKqtqLQVSFG 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   985 CNSMVLFDHvgcLKKYDTVLDILRDFFELRLK------YYGLRK-----EWLLGMLGAesakLNNqarfilekIDGKI-I 1052
Cdd:TIGR01063  324 INMLALVKG---LPKVLNLKELLEAFVEHRKDvitrrtIFELRKaeeraHILEGLLIA----LDN--------IDEVIaL 388
                          410       420
                   ....*....|....*....|....*
gi 530412779  1053 IENKPKKELIKVLIQRGYDSDPVKA 1077
Cdd:TIGR01063  389 IRASQNTEEAKTRLVERFSLSEIQA 413
gyrB PRK14939
DNA gyrase subunit B; Provisional
93-574 1.43e-18

DNA gyrase subunit B; Provisional


Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 92.08  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   93 IRVTIDPENNlISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVeTA 170
Cdd:PRK14939   61 ITVTIHADGS-VSVSDNGRGIPTDIHPEEG--VSAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLEL-TI 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  171 SREyKKMFKQTWmdNMGRA-------GEMELKpfnGedyTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAgstkdvkv 243
Cdd:PRK14939  137 RRD-GKIHEQEF--EHGVPvaplkvvGETDKT---G---TEVRFWPSPEIFENTEFDYDILA---KRLRELA-------- 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  244 FLNgnklpvkgfrSYVDMYLKDKLDETGNSL-----------------KVIHEQVNH--------RWEVCL----TMSEK 294
Cdd:PRK14939  197 FLN----------SGVRIRLKDERDGKEEEFhyeggikafveylnrnkTPLHPNIFYfsgekdgiGVEVALqwndSYQEN 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  295 GFqqiSFVNSIATSKGGRHV------------DYVADQIVTKlvdvvKKKNK--------GGVAVKAhqVKnhmwifvna 354
Cdd:PRK14939  267 VL---CFTNNIPQRDGGTHLagfraaltrtinNYIEKEGLAK-----KAKVSltgddareGLTAVLS--VK--------- 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  355 lIENPTFDSQTKENMtlqpksfGStcqlSEkfIKaaigcGIVESILN--WVKF------KAQVQLNKKCSAVKH------ 420
Cdd:PRK14939  328 -VPDPKFSSQTKDKL-------VS----SE--VR-----PAVESLVNekLSEFleenpnEAKIIVGKIIDAARAreaark 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  421 ----NRIKGIpkLDDAN------DAGGRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREA 484
Cdd:PRK14939  389 arelTRRKGA--LDIAGlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDrKFqAILPLKGKILNVEKA 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  485 SHKQIMENAEINNIIKIVGLQYKKnyeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI-- 562
Cdd:PRK14939  458 RFDKMLSSQEIGTLITALGCGIGR---DEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHL--YIaq 532
                         570
                  ....*....|..
gi 530412779  563 TPIVKVSKNKQE 574
Cdd:PRK14939  533 PPLYKVKKGKQE 544
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
700-922 2.09e-17

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 87.26  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  700 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSSYHHGEMSLMMTIINLAqnfvgsNNLNLLQPIGQFG 779
Cdd:PRK09630   22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  780 TRLHGGKDSASpRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVRE 859
Cdd:PRK09630   94 NPLTGDPHAAA-RYIEARLSPLAKEVLFNTDLMTFHDSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCE 171
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530412779  860 IVN-NIRRLMDgeEPLPMLPSYKNfKGTIEelaPNQY-------VISGEVAILNSTTIEISELPVRTWTQT 922
Cdd:PRK09630  172 LLEaQIAILND--QPFTLLPDFPS-GGTMD---ASEYqdglgsiTLRASIDIINDKTLLIKEICPSTTTET 236
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
700-852 2.04e-12

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 72.34  E-value: 2.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  700 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEmssYH-HGEMSLMMTIINLAQnfvgsNNLnLLQPIGQF 778
Cdd:PRK12758   41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQ---YHpHGDASIGDALVQLGQ-----KDL-LIDTQGNW 111
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530412779  779 GTRLhGGKDSASPRYIFTMLSSLA-RLLFPPKDDHtLKFLYDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 852
Cdd:PRK12758  112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFNPKTTE-WQLSYDGRKK-EPV-TLPVkFPLLLAQGAEGIAVGLSTKI 183
TopoII_MutL_Trans cd00329
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ...
255-367 2.82e-11

MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.


Pssm-ID: 238202 [Multi-domain]  Cd Length: 107  Bit Score: 61.89  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  255 FRSYVDMYLKDKLDEtgnslKVIHEQVNH---RWEVCLTMSE----KGFQQISFVNSIATSKGGRHVDYVADQIVTKLvd 327
Cdd:cd00329     1 LKDRLAEILGDKVAD-----KLIYVEGESdgfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 530412779  328 vvkkknkggvavKAHQVKNHMWIFVNALIEN--PTFD-SQTKE 367
Cdd:cd00329    74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
HATPase_GyrB-like cd16928
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ...
69-246 1.75e-10

Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.


Pssm-ID: 340405 [Multi-domain]  Cd Length: 180  Bit Score: 61.40  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   69 LYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDD 141
Cdd:cd16928     1 LHHLVWEIVDNSIDealagyaTE--------IEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  142 DEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQTWMDNmGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDK 221
Cdd:cd16928    72 GSYKVSGGLHGVGVSVVNALSERLEVEVK-RD-GKIYRQEFSRG-GPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDF 148
                         170       180
                  ....*....|....*....|....*
gi 530412779  222 DIVAlmvRRAYDIAGSTKDVKVFLN 246
Cdd:cd16928   149 DTLK---RRLRELAFLNKGLKIVLE 170
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
700-946 2.40e-10

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 65.51  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  700 ERSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:PRK05561   33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 853
Cdd:PRK05561  109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  854 NFDVREIVNNIRRLMDGEE----------PLPMLPS--------------YKNFKG--------TIEELAPNQYVisgev 901
Cdd:PRK05561  186 PHNLREVIDAAIHLIDNPDatleelmefvPGPDFPTggeiitgrdgirkaYETGRGsirvrarwEIEDLAGGRWQ----- 260
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 530412779  902 ailnsttIEISELPVrtwtQTYKEQVLEPMLNGT-EKTPPLITDYR 946
Cdd:PRK05561  261 -------IVITELPY----QVSKAKLIEQIAELMnAKKLPGIADVR 295
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
68-175 3.15e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 53.14  E-value: 3.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779    68 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENNL-ISIWNNGKGIPVVEHKvekmyvpaLIFGQLLTSSnydddekKV 146
Cdd:pfam02518    5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
                           90       100       110
                   ....*....|....*....|....*....|.
gi 530412779   147 TGGRNGYGAKLCNIFSTKF--TVETASREYK 175
Cdd:pfam02518   67 GGGGTGLGLSIVRKLVELLggTITVESEPGG 97
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
700-872 4.92e-08

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 57.81  E-value: 4.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  700 ERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:PRK13979   36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 853
Cdd:PRK13979  112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
                         170
                  ....*....|....*....
gi 530412779  854 NFDVREIVNNIRRLMDGEE 872
Cdd:PRK13979  189 PHNLKEVIDGTLAYIDNNE 207
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
701-869 1.87e-07

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 55.82  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:COG0188    34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  777 QFGTRlhGGkDS-ASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIP-IIPMVLINGAEGIGTGWSCKI 852
Cdd:COG0188   110 NFGSI--DG-DPaAAMRYTEARLAKIAEELLADIDKDTVDFVpnYDGSEQ-EPT-VLPaRFPNLLVNGSSGIAVGMATNI 184
                         170
                  ....*....|....*....
gi 530412779  853 P--NfdVREIVNNIRRLMD 869
Cdd:COG0188   185 PphN--LGEVIDACIALID 201
PRK05560 PRK05560
DNA gyrase subunit A; Validated
701-890 2.62e-07

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 55.42  E-value: 2.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:PRK05560   29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  777 QFGTRlhGGkDS-ASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 852
Cdd:PRK05560  105 NFGSI--DG-DPaAAMRYTEARMSKIAHELLADIDKETVDFVpnYDGSEQ-EPT-VLPArFPNLLVNGSSGIAVGMATNI 179
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 530412779  853 PNFDVREIVNNIRRLMDGEEplpmlpsyknfkGTIEEL 890
Cdd:PRK05560  180 PPHNLGEVIDACLALIDNPD------------ITIEEL 205
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
68-168 1.44e-06

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 48.41  E-value: 1.44e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779     68 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENN--LISIWNNGKGIPvvEHKVEKMYVPaliFGQLltssnyddDEKK 145
Cdd:smart00387    5 RLRQVLSNLLDNAIKYT---PEGGRITVTLERDGDhvEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRS 68
                            90       100
                    ....*....|....*....|...
gi 530412779    146 VTGGRNGYGAKLCNIFSTKFTVE 168
Cdd:smart00387   69 RKIGGTGLGLSIVKKLVELHGGE 91
Toprim pfam01751
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ...
444-544 1.64e-06

Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.


Pssm-ID: 396354 [Multi-domain]  Cd Length: 93  Bit Score: 47.74  E-value: 1.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779   444 TLILTEGDS-AKTLAvsglGVVGRDKYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKnyededslktlryg 522
Cdd:pfam01751    1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
                           90       100
                   ....*....|....*....|..
gi 530412779   523 kIMIMTDQDQDGSHIKGLLINF 544
Cdd:pfam01751   57 -VILATDPDREGEAIALKLLEL 77
TOPRIM cd00188
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ...
443-554 5.87e-04

Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173773 [Multi-domain]  Cd Length: 83  Bit Score: 40.10  E-value: 5.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779  443 CTLILTEGDS-AKTLAVSGlgvvgRDKYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykknyededslktlRY 521
Cdd:cd00188     1 KKLIIVEGPSdALALAQAG-----GYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
                          90       100       110
                  ....*....|....*....|....*....|...
gi 530412779  522 GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR 554
Cdd:cd00188    48 KEVIIATDADREGEAIALRLLELLKSLGKKVRR 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH