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Conserved domains on  [gi|530410650|ref|XP_005256857|]
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glucose-induced degradation protein 4 homolog isoform X1 [Homo sapiens]

Protein Classification

GID4/VID24 family protein( domain architecture ID 10561119)

GID4/VID24 family protein similar to human glucose-induced degradation protein 4 homolog, also called vacuolar import and degradation protein 24 homolog, the substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
 121-236 1.79e-55

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


:

Pssm-ID: 462897  Cd Length: 162  Bit Score: 175.03  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410650  121 LLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTR--KWDADEDVD 198
Cdd:pfam09783   1 FLRPGSRFVGTQQSGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPEITTFFEGEIIDGKYGFLTRkpEWGADEETD 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530410650  199 RKHWGKFLAFyqyaKSFNSDDFdyeelKNGDYVFMRWK 236
Cdd:pfam09783  81 LEHWSKFPPF----RPLFAKDL-----LNFRYIFMRWK 109
 
Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
 121-236 1.79e-55

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


Pssm-ID: 462897  Cd Length: 162  Bit Score: 175.03  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410650  121 LLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTR--KWDADEDVD 198
Cdd:pfam09783   1 FLRPGSRFVGTQQSGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPEITTFFEGEIIDGKYGFLTRkpEWGADEETD 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530410650  199 RKHWGKFLAFyqyaKSFNSDDFdyeelKNGDYVFMRWK 236
Cdd:pfam09783  81 LEHWSKFPPF----RPLFAKDL-----LNFRYIFMRWK 109
VID24 COG5073
Vacuolar import and degradation protein [Intracellular trafficking and secretion];
108-236 5.22e-24

Vacuolar import and degradation protein [Intracellular trafficking and secretion];


Pssm-ID: 227405  Cd Length: 272  Bit Score: 96.87  E-value: 5.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410650 108 PPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVD------TGNSYLCGYLKIKGLTEEYPTLTTFFEGEIIS 181
Cdd:COG5073   65 KRRLFSSYTRRSGFLRNGAQFGGVQISGYPPLTVEVNIDTVDlpkkddYSLPHLCGTLNIQNLTDPSSTLTTYFEGEIIG 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530410650 182 -KKHPFLTRKW---DADEDVDRKHWGKFLAFYQYAKSFNSDDF---DYEELKNGDYVFMRWK 236
Cdd:COG5073  145 fNKLPFATEKWsmaPASEEIDVCHWKRFPPFRMDNGTFIERIFnqkSKDYKINQRYIYMKWK 206
 
Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
 121-236 1.79e-55

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


Pssm-ID: 462897  Cd Length: 162  Bit Score: 175.03  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410650  121 LLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTR--KWDADEDVD 198
Cdd:pfam09783   1 FLRPGSRFVGTQQSGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPEITTFFEGEIIDGKYGFLTRkpEWGADEETD 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530410650  199 RKHWGKFLAFyqyaKSFNSDDFdyeelKNGDYVFMRWK 236
Cdd:pfam09783  81 LEHWSKFPPF----RPLFAKDL-----LNFRYIFMRWK 109
VID24 COG5073
Vacuolar import and degradation protein [Intracellular trafficking and secretion];
108-236 5.22e-24

Vacuolar import and degradation protein [Intracellular trafficking and secretion];


Pssm-ID: 227405  Cd Length: 272  Bit Score: 96.87  E-value: 5.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410650 108 PPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVD------TGNSYLCGYLKIKGLTEEYPTLTTFFEGEIIS 181
Cdd:COG5073   65 KRRLFSSYTRRSGFLRNGAQFGGVQISGYPPLTVEVNIDTVDlpkkddYSLPHLCGTLNIQNLTDPSSTLTTYFEGEIIG 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530410650 182 -KKHPFLTRKW---DADEDVDRKHWGKFLAFYQYAKSFNSDDF---DYEELKNGDYVFMRWK 236
Cdd:COG5073  145 fNKLPFATEKWsmaPASEEIDVCHWKRFPPFRMDNGTFIERIFnqkSKDYKINQRYIYMKWK 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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