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Conserved domains on  [gi|530409316|ref|XP_005255709|]
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voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
Gene Ontology:  GO:0034220|GO:0005216|GO:0005886|GO:0034702
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 792-1019 1.74e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.53  E-value: 1.74e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316   947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1293-1565 6.28e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.28e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 530409316  1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1621-1852 6.59e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 183.62  E-value: 6.59e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1621 SHYLDLFITFIICVNVITMSMEHYNQPKS-LDEALKYCNYVFTIVFVFEAALKLVAFGF-RRFFKDRWNQLDLAIVLLSL 1698
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1699 MGITLEEIEmsaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1778
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316  1779 LECSEDNPCEGlsrHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSredkhclsylPALSPVYFVTFVLVA 1852
Cdd:pfam00520  154 KLKTWENPDNG---RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILG 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-430 8.74e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 163.21  E-value: 8.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316    99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223

                          330
                   ....*....|....*
gi 530409316   416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1890-2346 2.13e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1890 AQGPGSARRVDADRPP---------LPQESPGARDAPNLVARKVSVSRMLS---------LPNDSYMFRP--VVPASAPH 1949
Cdd:PHA03247 2495 APDPGGGGPPDPDAPPapsrlapaiLPDEPVGEPVHPRMLTWIRGLEELASddagdppppLPPAAPPAAPdrSVPPPRPA 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1950 PRPLQ-EVEMETYGAGTPLEScASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDT 2028
Cdd:PHA03247 2575 PRPSEpAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2029 LDPAEPGEKTPVRPVTQGGSLQ--SPPRSPRPASVRTrkhTFGQRCVSSRPAAPGGEEAEASDPADEEV--------SHI 2098
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAARP---TVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2099 TSSACPWQPtAEPHGPEASPVAGGERDLRRLYSVDAqgfldkPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRK 2178
Cdd:PHA03247 2731 ASPALPAAP-APPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2179 KkmSPPCISVEPPAEDE-GSARPSAAEGGSTTLRRRTPSCEATPHRDSLePTEGSGAGGDPAAKGERWGQASC------- 2250
Cdd:PHA03247 2804 P--ADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAkpaapar 2880

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2251 -RAEHLTVPSFAFEPLDLGVPSGDPfldgSHSVTPESRASSsgaivplEPPESEPPMPVGDPPEKRRGLyltvPQCPLEK 2329
Cdd:PHA03247 2881 pPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP-------QPQPQPPPPPQPQPPPPPPPR----PQPPLAP 2945

                         490
                  ....*....|....*..
gi 530409316 2330 PGSPSATPAPGGGADDP 2346
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 792-1019 1.74e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.53  E-value: 1.74e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316   947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1293-1565 6.28e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.28e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 530409316  1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1621-1852 6.59e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 183.62  E-value: 6.59e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1621 SHYLDLFITFIICVNVITMSMEHYNQPKS-LDEALKYCNYVFTIVFVFEAALKLVAFGF-RRFFKDRWNQLDLAIVLLSL 1698
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1699 MGITLEEIEmsaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1778
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316  1779 LECSEDNPCEGlsrHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSredkhclsylPALSPVYFVTFVLVA 1852
Cdd:pfam00520  154 KLKTWENPDNG---RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILG 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-430 8.74e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 163.21  E-value: 8.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316    99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223

                          330
                   ....*....|....*
gi 530409316   416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1890-2346 2.13e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1890 AQGPGSARRVDADRPP---------LPQESPGARDAPNLVARKVSVSRMLS---------LPNDSYMFRP--VVPASAPH 1949
Cdd:PHA03247 2495 APDPGGGGPPDPDAPPapsrlapaiLPDEPVGEPVHPRMLTWIRGLEELASddagdppppLPPAAPPAAPdrSVPPPRPA 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1950 PRPLQ-EVEMETYGAGTPLEScASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDT 2028
Cdd:PHA03247 2575 PRPSEpAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2029 LDPAEPGEKTPVRPVTQGGSLQ--SPPRSPRPASVRTrkhTFGQRCVSSRPAAPGGEEAEASDPADEEV--------SHI 2098
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAARP---TVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2099 TSSACPWQPtAEPHGPEASPVAGGERDLRRLYSVDAqgfldkPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRK 2178
Cdd:PHA03247 2731 ASPALPAAP-APPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2179 KkmSPPCISVEPPAEDE-GSARPSAAEGGSTTLRRRTPSCEATPHRDSLePTEGSGAGGDPAAKGERWGQASC------- 2250
Cdd:PHA03247 2804 P--ADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAkpaapar 2880

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2251 -RAEHLTVPSFAFEPLDLGVPSGDPfldgSHSVTPESRASSsgaivplEPPESEPPMPVGDPPEKRRGLyltvPQCPLEK 2329
Cdd:PHA03247 2881 pPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP-------QPQPQPPPPPQPQPPPPPPPR----PQPPLAP 2945

                         490
                  ....*....|....*..
gi 530409316 2330 PGSPSATPAPGGGADDP 2346
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQP 2962
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 2024-2180 7.42e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 44.37  E-value: 7.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2024 SPRDtlDPA----EPGEKTPVRPVTQGGSLQSPPRSPRPASVrtrkhtfgqrcvsSRPAAPGGEEAEASDPADEEVSHIT 2099
Cdd:NF040712  178 TALD--DEArwliDPDFGRPLRPLATVPRLAREPADARPEEV-------------EPAPAAEGAPATDSDPAEAGTPDDL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2100 SSA-----CPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQW-RPSAELGSGEPGEAKAWGPEAEPAL 2173
Cdd:NF040712  243 ASArrrraGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPApAPAAPAAPAAPEAEEPARPEPPPAP 322


                  ....*..
gi 530409316 2174 GARRKKK 2180
Cdd:NF040712  323 KPKRRRR 329
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 792-1019 1.74e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.53  E-value: 1.74e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316   947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1293-1565 6.28e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.28e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 530409316  1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1621-1852 6.59e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 183.62  E-value: 6.59e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1621 SHYLDLFITFIICVNVITMSMEHYNQPKS-LDEALKYCNYVFTIVFVFEAALKLVAFGF-RRFFKDRWNQLDLAIVLLSL 1698
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1699 MGITLEEIEmsaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1778
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316  1779 LECSEDNPCEGlsrHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSredkhclsylPALSPVYFVTFVLVA 1852
Cdd:pfam00520  154 KLKTWENPDNG---RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILG 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-430 8.74e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 163.21  E-value: 8.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316    99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223

                          330
                   ....*....|....*
gi 530409316   416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1890-2346 2.13e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1890 AQGPGSARRVDADRPP---------LPQESPGARDAPNLVARKVSVSRMLS---------LPNDSYMFRP--VVPASAPH 1949
Cdd:PHA03247 2495 APDPGGGGPPDPDAPPapsrlapaiLPDEPVGEPVHPRMLTWIRGLEELASddagdppppLPPAAPPAAPdrSVPPPRPA 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1950 PRPLQ-EVEMETYGAGTPLEScASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDT 2028
Cdd:PHA03247 2575 PRPSEpAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2029 LDPAEPGEKTPVRPVTQGGSLQ--SPPRSPRPASVRTrkhTFGQRCVSSRPAAPGGEEAEASDPADEEV--------SHI 2098
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAARP---TVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2099 TSSACPWQPtAEPHGPEASPVAGGERDLRRLYSVDAqgfldkPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRK 2178
Cdd:PHA03247 2731 ASPALPAAP-APPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2179 KkmSPPCISVEPPAEDE-GSARPSAAEGGSTTLRRRTPSCEATPHRDSLePTEGSGAGGDPAAKGERWGQASC------- 2250
Cdd:PHA03247 2804 P--ADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAkpaapar 2880

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2251 -RAEHLTVPSFAFEPLDLGVPSGDPfldgSHSVTPESRASSsgaivplEPPESEPPMPVGDPPEKRRGLyltvPQCPLEK 2329
Cdd:PHA03247 2881 pPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP-------QPQPQPPPPPQPQPPPPPPPR----PQPPLAP 2945

                         490
                  ....*....|....*..
gi 530409316 2330 PGSPSATPAPGGGADDP 2346
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQP 2962
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1940-2274 6.26e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 61.73  E-value: 6.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1940 RPVVPASAPHPRPLQEVEMETYGAGTPLESCASLQIPLAVSSPARSGEPlhalSPRGTARSPSLSrllcrQEAVHTdsle 2019
Cdd:PHA03307  119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA----SSRQAALPLSSP-----EETARA---- 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2020 gkIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPG----GEEAEASDPADEEV 2095
Cdd:PHA03307  186 --PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwGPENECPLPRPAPI 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2096 SHITS--SACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELG------SGEPGEAKAWGP 2167
Cdd:PHA03307  264 TLPTRiwEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSssstssSSESSRGAAVSP 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2168 EAEPALGARRKKKmSPPCISVEPPAEDEGSARPS--AAEGGSTTLRRRTPSC-EATPHRDSLEPTEGSGAGGDPAAKGER 2244
Cdd:PHA03307  344 GPSPSRSPSPSRP-PPPADPSSPRKRPRPSRAPSspAASAGRPTRRRARAAVaGRARRRDATGRFPAGRPRPSPLDAGAA 422

                         330       340       350
                  ....*....|....*....|....*....|
gi 530409316 2245 WGQASCRaehltvpsfafEPldLGVPSGDP 2274
Cdd:PHA03307  423 SGAFYAR-----------YP--LLTPSGEP 439
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1941-2345 2.55e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1941 PVVPASAPHPRPLQEvEMETYGAGTPLESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSlsrllcrqeavhtdsleg 2020
Cdd:PHA03307   54 TVVAGAAACDRFEPP-TGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSP------------------ 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2021 kiDSPRDTLDPAEPGEKTPVRpvtqggsLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVShitS 2100
Cdd:PHA03307  115 --DPPPPTPPPASPPPSPAPD-------LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEE---T 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2101 SACPWQPTAEPhgPEASPVAGGERDLRRLYSVDAQGFLD---KPGRADEQWRP-SAELGSGEPGEAKAWGPEAE-----P 2171
Cdd:PHA03307  183 ARAPSSPPAEP--PPSTPPAAASPRPPRRSSPISASASSpapAPGRSAADDAGaSSSDSSSSESSGCGWGPENEcplprP 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2172 ALGARRKKKM-----------SPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAA 2240
Cdd:PHA03307  261 APITLPTRIWeasgwngpssrPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2241 KGErwGQASCRAehltvpsfafepldlGVPSGDPfldGSHSVTPESRASSSGAIVPLEPPESeppmpvGDPPEKRRGLYL 2320
Cdd:PHA03307  341 VSP--GPSPSRS---------------PSPSRPP---PPADPSSPRKRPRPSRAPSSPAASA------GRPTRRRARAAV 394

                         410       420
                  ....*....|....*....|....*.
gi 530409316 2321 TVPQCPLEKPGS-PSATPAPGGGADD 2345
Cdd:PHA03307  395 AGRARRRDATGRfPAGRPRPSPLDAG 420
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1659-1851 6.15e-07

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 52.66  E-value: 6.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1659 YVFTIVFVFEAALKLVAFGfRRFFKDRWNQLDLAIVLLS----------------LMGITLEEIE--------------- 1707
Cdd:pfam08016   18 VVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSvvlivlniyrdfladrLIKSVEASPVtfidfdrvaqldnly 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316  1708 -MSAALPINPTIIRIMRVLRIARVLKLLKmatgmrallDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGrlecsednp 1786
Cdd:pfam08016   97 rIILAFLVFLTWLKLFKVLRFNKTMSLFT---------KTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------- 158

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530409316  1787 ceglSRHATFSNFGMAFLTLFRVSTGD-NWNGImkdtlRECSRedkhclsylpALSPVYFVTFVLV 1851
Cdd:pfam08016  159 ----TQAPNFSNFVKSILTLFRTILGDfGYNEI-----FSGNR----------VLGPLLFLTFVFL 205
dnaA PRK14086
chromosomal replication initiator protein DnaA;
2028-2233 1.06e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 47.51  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2028 TLDPA--EPGEKTPVRPVTQGGSLQSPPRSP------RPASVRTRKHTFGQRCVSSRPAAPggEEAEASDPAdeevshit 2099
Cdd:PRK14086   87 TVDPSagEPAPPPPHARRTSEPELPRPGRRPyegyggPRADDRPPGLPRQDQLPTARPAYP--AYQQRPEPG-------- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2100 ssacPWQPTAEPHGPEASPVAGGERDlrrLYSVDAQgfldkPGRADEQWRPSAelGSGEPGEAKAWGPEAEPALGARRKK 2179
Cdd:PRK14086  157 ----AWPRAADDYGWQQQRLGFPPRA---PYASPAS-----YAPEQERDREPY--DAGRPEYDQRRRDYDHPRPDWDRPR 222

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530409316 2180 KMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSlEPTEGSG 2233
Cdd:PRK14086  223 RDRTDRPEPPPGAGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQP-APAPGPG 275
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1890-2249 3.01e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1890 AQGPGSARRVDADRPPlPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLES 1969
Cdd:PRK07764  409 APAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAA 487

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1970 CASLQIPLAVSSPARSGEPLHALSPRG---------TARSPSLSRLLCRQEAVHT---DSLEGKIDSPRDTLDPAEPGEK 2037
Cdd:PRK07764  488 PAPAAAPAAPAAPAAPAGADDAATLRErwpeilaavPKRSRKTWAILLPEATVLGvrgDTLVLGFSTGGLARRFASPGNA 567

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2038 TPVRPVTQ---GGSLQ-----SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSH----ITSSACPW 2105
Cdd:PRK07764  568 EVLVTALAeelGGDWQveavvGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAApaeaSAAPAPGV 647

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2106 QPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRkkkmsppc 2185
Cdd:PRK07764  648 AAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAA-------- 719

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530409316 2186 isvEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQAS 2249
Cdd:PRK07764  720 ---QPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2031-2347 3.25e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2031 PAEPGEKTPVRPVT-QGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAA-PGGEEAEASDPADEEVSHITSSACPWQPT 2108
Cdd:PRK07764  415 AAPAAAAAPAPAAApQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAqPAPAPAAAPEPTAAPAPAPPAAPAPAAAP 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2109 AEPHGPEASPVAGGERDLRRL--------------------------------------YSVDAQGFLDkPGRAD----- 2145
Cdd:PRK07764  495 AAPAAPAAPAGADDAATLRERwpeilaavpkrsrktwaillpeatvlgvrgdtlvlgfsTGGLARRFAS-PGNAEvlvta 573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2146 ------EQWRPSAELGsGEPGEAKAWGPEAePALGARRKKKMSPPciSVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEA 2219
Cdd:PRK07764  574 laeelgGDWQVEAVVG-PAPGAAGGEGPPA-PASSGPPEEAARPA--APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAA 649

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2220 TPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAehlTVPSFAFEPLDLGVPSGDPfLDGSHSVTPESRASSSGAIVPLEP 2299
Cdd:PRK07764  650 PEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPP---PAPAPAAPAAPAGAAPAQP-APAPAATPPAGQADDPAAQPPQAA 725

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530409316 2300 PESEPPMPVGD-----------PPEKRRGLYLTVPQCPLEKPGSPSATPAPGGGADDPV 2347
Cdd:PRK07764  726 QGASAPSPAADdpvplppepddPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEE 784
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2071-2265 6.17e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 6.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2071 RCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLdKPGRADEQWRP 2150
Cdd:PRK12323  359 RMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARR-SPAPEALAAAR 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2151 SAELGSGEPGEAKAWGPEAEPALGARrkkkmsPPCISVEPPAEDEGSARPSAAEGGSttlrrRTPSCEATPHRDSLEPTE 2230
Cdd:PRK12323  438 QASARGPGGAPAPAPAPAAAPAAAAR------PAAAGPRPVAAAAAAAPARAAPAAA-----PAPADDDPPPWEELPPEF 506

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 530409316 2231 GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPL 2265
Cdd:PRK12323  507 ASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL 541
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 2024-2180 7.42e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 44.37  E-value: 7.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2024 SPRDtlDPA----EPGEKTPVRPVTQGGSLQSPPRSPRPASVrtrkhtfgqrcvsSRPAAPGGEEAEASDPADEEVSHIT 2099
Cdd:NF040712  178 TALD--DEArwliDPDFGRPLRPLATVPRLAREPADARPEEV-------------EPAPAAEGAPATDSDPAEAGTPDDL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2100 SSA-----CPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQW-RPSAELGSGEPGEAKAWGPEAEPAL 2173
Cdd:NF040712  243 ASArrrraGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPApAPAAPAAPAAPEAEEPARPEPPPAP 322


                  ....*..
gi 530409316 2174 GARRKKK 2180
Cdd:NF040712  323 KPKRRRR 329
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 875-1018 1.56e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 42.26  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316   875 QADGGLSVLRTFRLLRVLKLVRFlpalRRQLVVLVKTM----DNVATFCTLLMLFIFIFSILGMHLFGCKFSlktdtgdt 950
Cdd:pfam08016   95 LYRIILAFLVFLTWLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP-------- 162

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530409316   951 vpdrkNFDSLLWAIVTVFQILtqedWNVVLYNGMASTSSW-AALYFVALMTFGNYVLFNLLVAILVEGF 1018
Cdd:pfam08016  163 -----NFSNFVKSILTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 222
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2031-2227 2.00e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2031 PAEPGEktPVRPVTQGGslQSPPRSPRPASVRTRkhtfgqrcvSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAE 2110
Cdd:PRK07764  615 PAAPAA--PAAPAAPAP--AGAAAAPAEASAAPA---------PGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2111 PHGPEASPVAGGERDLRRlYSVDAQGFLDKPGRADEQW--RPSAELGSGEPGEAKAWG----PEAEPALGARRKKKMSPP 2184
Cdd:PRK07764  682 PPAPAPAAPAAPAGAAPA-QPAPAPAATPPAGQADDPAaqPPQAAQGASAPSPAADDPvplpPEPDDPPDPAGAPAQPPP 760

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 530409316 2185 CISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLE 2227
Cdd:PRK07764  761 PPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEE 803
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2024-2215 2.42e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2024 SPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQR--CVSSRPAAPGGEEAEASDPADEEVSHITSS 2101
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGpgGAPAPAPAPAAAPAAAARPAAAGPRPVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2102 ACPWQPTAEPhGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWR--PSAELGSGEPGEAKAWGPEAEPALGARRKK 2179
Cdd:PRK12323  476 AAAAPARAAP-AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVaeSIPDPATADPDDAFETLAPAPAAAPAPRAA 554

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 530409316 2180 KMSPPCISVEPPAEDEgSARPSAAEGGSTTLRRRTP 2215
Cdd:PRK12323  555 AATEPVVAPRPPRASA-SGLPDMFDGDWPALAARLP 589
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1993-2249 3.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1993 SPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPvRPVTQGGS--LQSPPRSPRPASVRTR--KHTF 2068
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAP-KAAAAAAAtrAEAPPAAPAPPATADRgdDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2069 GQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGfLDKPGRADE-- 2146
Cdd:PRK07003  445 GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA-PAAASREDApa 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2147 -QWRPSAELGSGEPGEAK--AWGPEAEPALGARRKKKMSppcISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHR 2223
Cdd:PRK07003  524 aAAPPAPEARPPTPAAAApaARAGGAAAALDVLRNAGMR---VSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPR 600

                         250       260
                  ....*....|....*....|....*.
gi 530409316 2224 DSLEPTEGSGAGGDPAAKGERWGQAS 2249
Cdd:PRK07003  601 ARAATGDAPPNGAARAEQAAESRGAP 626
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 1969-2312 3.74e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 42.92  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 1969 SCASLQIPLAVSSPARSGEPLHALSP--RGTARSPS-----------------LSRLLCRQEAVHTDSLEGKidsprDTL 2029
Cdd:PHA03309 1572 SSASHDRSPSSSSRRRDGRPSSRRRPsrRMSARPPSrppaavilraswryaeeVAREMLDAAASRFDEADGE-----DPL 1646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2030 DPAEPGEKtPVRPVT-------QGGSLQSPPRSPRPASvrtrkhtfGQRCVSSRPAApggeeaeASDPADEEVshitssa 2102
Cdd:PHA03309 1647 PPAACGGK-PIAPETlvalceqRGRGPTSLPRAPTPRS--------GEALAAPRRSG-------AKDPRQGQY------- 1703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2103 CPWQPTAE-PHGPEASPVAggERDLRRLYSVDAQGFLD----------KPGRADEQWRPSAELGSGEPGEAKAWGPEA-E 2170
Cdd:PHA03309 1704 CPSARRSEaPHSPSPRDVA--LRLLERQQELNRQLLLElrrgsceispSPRRRDAEGRRFGCRQDDDDGYDYEGGRESpE 1781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2171 PALGARRKKKMSPPC--------------ISV-EPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAG 2235
Cdd:PHA03309 1782 RVLGRRQSRRDSVPVrrrsgaancggrwmISAgRSSSSSSSSSSSSSSSPSSRPSRSATPSLSPSPSPPRRAPVDRSRSG 1861

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409316 2236 -----GDPAAKGERWG-QASCRAEHL---TVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPM 2306
Cdd:PHA03309 1862 rrrerDRPSANPFRWApRQRSRADHSpdgTAPGDAPLNLEDGPGRGRPIWTPSSATTLPSRSGPEDSVDETETEDSAPPA 1941


                  ....*.
gi 530409316 2307 PVGDPP 2312
Cdd:PHA03309 1942 RLAPSP 1947
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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