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Conserved domains on  [gi|530398937|ref|XP_005253871|]
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CD9 antigen isoform X1 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 11992924)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

CATH:  1.10.1450.10
Gene Ontology:  GO:0016020
PubMed:  11756464|19709882|16024509|12575999
SCOP:  4001512
TCDB:  8.A.40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
10-128 5.65e-25

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 97.39  E-value: 5.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398937   10 IKYLLFGFNFIFWLAGIAVLAIGLWLrfdsqtKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCML 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL------LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLL 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 530398937   90 GLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDT 128
Cdd:pfam00335  75 LTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKS 113
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 111-149 8.38e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03152:

Pssm-ID: 351888  Cd Length: 84  Bit Score: 72.81  E-value: 8.38e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530398937 111 YSHKDEVIKEVQEFYKDTYNKLKTK-DEPQRETLKAIHYA 149
Cdd:cd03152    1 FSNKDKVVKEVQTFYRQTYAKYKQSrDPPLKETLKAIHFA 40
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
10-128 5.65e-25

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 97.39  E-value: 5.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398937   10 IKYLLFGFNFIFWLAGIAVLAIGLWLrfdsqtKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCML 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL------LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLL 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 530398937   90 GLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDT 128
Cdd:pfam00335  75 LTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKS 113
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 111-149 8.38e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 72.81  E-value: 8.38e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530398937 111 YSHKDEVIKEVQEFYKDTYNKLKTK-DEPQRETLKAIHYA 149
Cdd:cd03152    1 FSNKDKVVKEVQTFYRQTYAKYKQSrDPPLKETLKAIHFA 40
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
10-128 5.65e-25

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 97.39  E-value: 5.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398937   10 IKYLLFGFNFIFWLAGIAVLAIGLWLrfdsqtKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCML 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL------LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLL 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 530398937   90 GLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDT 128
Cdd:pfam00335  75 LTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKS 113
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 111-149 8.38e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 72.81  E-value: 8.38e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530398937 111 YSHKDEVIKEVQEFYKDTYNKLKTK-DEPQRETLKAIHYA 149
Cdd:cd03152    1 FSNKDKVVKEVQTFYRQTYAKYKQSrDPPLKETLKAIHFA 40
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 114-166 2.25e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 36.24  E-value: 2.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530398937 114 KDEVIKEVQEFYKDTYNK-LKTKDEPQRETLKAIHYAVCRLGKDTLLRFLRIVS 166
Cdd:cd03151    4 KDQIIKEVQNFYDSAYQDaVTDTRSKGTAVLKTFHSTLDCCGKGNLTALLSLLS 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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