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Conserved domains on  [gi|530392554|ref|XP_005252703|]
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sperm-associated antigen 6 isoform X1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
14-365 1.98e-15

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 78.39  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  14 QKARTQFVQMVAELATrpQNIEtLQNAGVMSLLRTLLLDVVPTIQQtaalalgrlanynddlaeaVVKCDILPQLVYSLA 93
Cdd:COG5064   67 QQFYSELPQLTQQLFS--DDIE-QQLQAVYKFRKLLSKETSPPIQP-------------------VIDAGVVPRFVEFMD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  94 E-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
Cdd:COG5064  125 EiQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 173 VLCIQE--PEIALKRIAASALSD-------------IAKHSPELA--------QTVVDA-GAVAHLAqmilnpDAKLKLS 228
Cdd:COG5064  205 LGLLLSsaIHISMLRNATWTLSNlcrgknpppdwsnISQALPILAkliysrdpEVLVDAcWAISYLS------DGPNEKI 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 229 QLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSEnLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRH 308
Cdd:COG5064  279 QAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD-DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAG 357

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530392554 309 TPEHARAVAVTNTLPVLLSLYmsteSSEDLQVKSKK--AIKNILQKCTYLPALEPFLYD 365
Cdd:COG5064  358 NTEQIQAVIDANLIPPLIHLL----SSAEYKIKKEAcwAISNATSGGLNRPDIIRYLVS 412
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
14-365 1.98e-15

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 78.39  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  14 QKARTQFVQMVAELATrpQNIEtLQNAGVMSLLRTLLLDVVPTIQQtaalalgrlanynddlaeaVVKCDILPQLVYSLA 93
Cdd:COG5064   67 QQFYSELPQLTQQLFS--DDIE-QQLQAVYKFRKLLSKETSPPIQP-------------------VIDAGVVPRFVEFMD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  94 E-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
Cdd:COG5064  125 EiQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 173 VLCIQE--PEIALKRIAASALSD-------------IAKHSPELA--------QTVVDA-GAVAHLAqmilnpDAKLKLS 228
Cdd:COG5064  205 LGLLLSsaIHISMLRNATWTLSNlcrgknpppdwsnISQALPILAkliysrdpEVLVDAcWAISYLS------DGPNEKI 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 229 QLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSEnLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRH 308
Cdd:COG5064  279 QAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD-DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAG 357

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530392554 309 TPEHARAVAVTNTLPVLLSLYmsteSSEDLQVKSKK--AIKNILQKCTYLPALEPFLYD 365
Cdd:COG5064  358 NTEQIQAVIDANLIPPLIHLL----SSAEYKIKKEAcwAISNATSGGLNRPDIIRYLVS 412
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 2.32e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530392554  114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 9.06e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.42  E-value: 9.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530392554   114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
114-317 2.40e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 43.69  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 114 SPQLAQAI-VDCGALDTLVICLEDFDPGVKEAAAwalryiarhnAELSQAVVDaGAVPLLVLCIQEPEIALKRIAASALS 192
Cdd:PRK13800 609 SPRILAVLaLDAPSVAELAPYLADPDPGVRRTAV----------AVLTETTPP-GFGPALVAALGDGAAAVRRAAAEGLR 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 193 diakhspELAQTVVDAGAVA-HLAQmilnPDAKLKLSQLVV----NAGGVAAVIDCIGSCKGNTRLPGIMMLGYV----- 262
Cdd:PRK13800 678 -------ELVEVLPPAPALRdHLGS----PDPVVRAAALDVlralRAGDAALFAAALGDPDHRVRIEAVRALVSVddves 746

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530392554 263 ---AAHSENLAMAVIISKGVPQLSV----------CLSEEPEDHIKAAAAWALGQIGRHTPEHARAVA 317
Cdd:PRK13800 747 vagAATDENREVRIAVAKGLATLGAggapagdavrALTGDPDPLVRAAALAALAELGCPPDDVAAATA 814
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
14-365 1.98e-15

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 78.39  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  14 QKARTQFVQMVAELATrpQNIEtLQNAGVMSLLRTLLLDVVPTIQQtaalalgrlanynddlaeaVVKCDILPQLVYSLA 93
Cdd:COG5064   67 QQFYSELPQLTQQLFS--DDIE-QQLQAVYKFRKLLSKETSPPIQP-------------------VIDAGVVPRFVEFMD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  94 E-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
Cdd:COG5064  125 EiQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 173 VLCIQE--PEIALKRIAASALSD-------------IAKHSPELA--------QTVVDA-GAVAHLAqmilnpDAKLKLS 228
Cdd:COG5064  205 LGLLLSsaIHISMLRNATWTLSNlcrgknpppdwsnISQALPILAkliysrdpEVLVDAcWAISYLS------DGPNEKI 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 229 QLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSEnLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRH 308
Cdd:COG5064  279 QAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD-DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAG 357

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530392554 309 TPEHARAVAVTNTLPVLLSLYmsteSSEDLQVKSKK--AIKNILQKCTYLPALEPFLYD 365
Cdd:COG5064  358 NTEQIQAVIDANLIPPLIHLL----SSAEYKIKKEAcwAISNATSGGLNRPDIIRYLVS 412
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
42-230 3.39e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 58.75  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  42 VMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAafvLRAVGK---HSPQLA 118
Cdd:COG5064  244 ALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPA---LRSVGNivtGSDDQT 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 119 QAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
Cdd:COG5064  321 QVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGG 400

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530392554 199 ---PELAQTVVDAGAVAHLAQMILNPDAKLKLSQL 230
Cdd:COG5064  401 lnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVAL 435
HEAT COG1413
HEAT repeat [General function prediction only];
37-195 1.02e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.78  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  37 LQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANynddlAEAVvkcdilPQLVYSLAEQNRFYKKAAAFVLRAVGkhspq 116
Cdd:COG1413   12 LGDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPDPEVRAAAAEALGRIG----- 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530392554 117 laqaivDCGALDTLVICLEDFDPGVKEAAAWALRYIArhnaelsqavvDAGAVPLLVLCIQEPEIALKRIAASALSDIA 195
Cdd:COG1413   76 ------DPEAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALGRLG 137
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 2.32e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530392554  114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 9.06e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.42  E-value: 9.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530392554   114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
114-317 2.40e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 43.69  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 114 SPQLAQAI-VDCGALDTLVICLEDFDPGVKEAAAwalryiarhnAELSQAVVDaGAVPLLVLCIQEPEIALKRIAASALS 192
Cdd:PRK13800 609 SPRILAVLaLDAPSVAELAPYLADPDPGVRRTAV----------AVLTETTPP-GFGPALVAALGDGAAAVRRAAAEGLR 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554 193 diakhspELAQTVVDAGAVA-HLAQmilnPDAKLKLSQLVV----NAGGVAAVIDCIGSCKGNTRLPGIMMLGYV----- 262
Cdd:PRK13800 678 -------ELVEVLPPAPALRdHLGS----PDPVVRAAALDVlralRAGDAALFAAALGDPDHRVRIEAVRALVSVddves 746

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530392554 263 ---AAHSENLAMAVIISKGVPQLSV----------CLSEEPEDHIKAAAAWALGQIGRHTPEHARAVA 317
Cdd:PRK13800 747 vagAATDENREVRIAVAKGLATLGAggapagdavrALTGDPDPLVRAAALAALAELGCPPDDVAAATA 814
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 4.36e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 4.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 530392554  156 NAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIA 195
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 121-223 2.31e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.47  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530392554  121 IVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL--------CIQ-EPEIALKRIAASA 190
Cdd:PLN03200  227 VLDAGAVKQLLKLLgQGNEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALINatvapskeFMQgEFAQALQENAMGA 306

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 530392554  191 LSDI-------------AKHSPELAQTVVDA-GAVAHlAQMILNPDA 223
Cdd:PLN03200  307 LANIcggmsalilylgeLSESPRSPAPIADTlGALAY-ALMVFDSSA 352
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 139-194 3.57e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 3.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530392554  139 PGVKEAAAWALRYIARHNAELSQAVVDAgAVPLLVLCIQEPEIALKRIAASALSDI 194
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-196 6.66e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.33  E-value: 6.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530392554   156 NAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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