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Conserved domains on  [gi|530390389|ref|XP_005251697|]
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rab9 effector protein with kelch motifs isoform X1 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-278 1.73e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 112.17  E-value: 1.73e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  21 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 94
Cdd:COG3055   45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  95 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvq 174
Cdd:COG3055  113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 175 dtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCIDISDMKWQKLNPTgaaPAGCAAH 254
Cdd:COG3055  180 ------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGH 245

                        250       260
                 ....*....|....*....|....
gi 530390389 255 SAVAMGKHVYIFGGMTPAGALDTM 278
Cdd:COG3055  246 AAVLTDGKVYVIGGETKPGVRTPL 269
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-278 1.73e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 112.17  E-value: 1.73e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  21 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 94
Cdd:COG3055   45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  95 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvq 174
Cdd:COG3055  113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 175 dtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCIDISDMKWQKLNPTgaaPAGCAAH 254
Cdd:COG3055  180 ------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGH 245

                        250       260
                 ....*....|....*....|....
gi 530390389 255 SAVAMGKHVYIFGGMTPAGALDTM 278
Cdd:COG3055  246 AAVLTDGKVYVIGGETKPGVRTPL 269
PLN02193 PLN02193
nitrile-specifier protein
 134-288 2.89e-20

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.94  E-value: 2.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 134 WTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVqDTKLHVFDANTLTWS-QPETLGNPPSPRHGHVMVAAGTK 212
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530390389 213 LFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 288
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
Kelch_3 pfam13415
Galactose oxidase, central domain;
157-209 1.08e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530390389  157 GNQLYVFGGGERGAQPVqDTKLHVFDANTLTWsqpETLGNPPSPRHGHVMVAA 209
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-LNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-278 1.73e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 112.17  E-value: 1.73e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  21 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 94
Cdd:COG3055   45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  95 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvq 174
Cdd:COG3055  113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 175 dtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCIDISDMKWQKLNPTgaaPAGCAAH 254
Cdd:COG3055  180 ------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGH 245

                        250       260
                 ....*....|....*....|....
gi 530390389 255 SAVAMGKHVYIFGGMTPAGALDTM 278
Cdd:COG3055  246 AAVLTDGKVYVIGGETKPGVRTPL 269
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
93-277 6.27e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 105.24  E-value: 6.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  93 PRYEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQ 171
Cdd:COG3055   12 PRSEAAAALLD---GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGfTGANPS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 172 PVQDTKLHVFDANTLTWSQpetLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGC 251
Cdd:COG3055   86 STPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                        170       180
                 ....*....|....*....|....*.
gi 530390389 252 AAhsAVAMGKHVYIFGGMTPAGALDT 277
Cdd:COG3055  163 AA--AVLPDGKILVIGGRNGSGFSNT 186
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
56-291 1.34e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 101.77  E-value: 1.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  56 GKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTckglLPRYEHASFIPSctpDRIWVFGGANQSGNRNCLQ----VL 127
Cdd:COG3055   23 GKVYVAGGLSGGSASNSFEVYDPATNTWselaPLPG----PPRHHAAAVAQD---GKLYVFGGFTGANPSSTPLndvyVY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 128 NPETRTWTTpevTSPPPSPRTFHTsSAAIGNQLYVFGggerGAQPVQDTKLH-VFDANTLTWSQpetLGNPPSPRHGH-V 205
Cdd:COG3055   96 DPATNTWTK---LAPMPTPRGGAT-ALLLDGKIYVVG----GWDDGGNVAWVeVYDPATGTWTQ---LAPLPTPRDHLaA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 206 MVAAGTKLFIHGGLAGDRFYDdlhcidisdmKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTpaGALDTMYQYHTEE 285
Cdd:COG3055  165 AVLPDGKILVIGGRNGSGFSN----------TWTTLAP---LPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPAT 229


                 ....*.
gi 530390389 286 QHWTLL 291
Cdd:COG3055  230 NTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 134-288 2.89e-20

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.94  E-value: 2.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 134 WTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVqDTKLHVFDANTLTWS-QPETLGNPPSPRHGHVMVAAGTK 212
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530390389 213 LFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 288
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
PLN02153 PLN02153
epithiospecifier protein
 144-287 1.18e-19

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 88.89  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 144 PSPRTFHtSSAAIGNQLYVFGGgERGAQPVQDTKLHVFDANTLTWSQPETLGNPPS-PRHGHVMVAAGTKLFIHGGLAGD 222
Cdd:PLN02153  20 PGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDEK 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530390389 223 RFYDDLHCIDISDMKWQ---KLNPTGAaPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 287
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAY 164
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
133-291 2.15e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.13  E-value: 2.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 133 TWTTpevTSPPPSPRTfHTSSAAIGNQLYVFGGGERGAQPvqdTKLHVFDANTLTWSQpetLGNPP-SPRHGHVMVAAGT 211
Cdd:COG3055    2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGLSGGSAS---NSFEVYDPATNTWSE---LAPLPgPPRHHAAAVAQDG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 212 KLFIHGGLAGD----RFYDDLHCIDISDMKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 287
Cdd:COG3055   72 KLYVFGGFTGAnpssTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGT 148


                 ....
gi 530390389 288 WTLL 291
Cdd:COG3055  149 WTQL 152
PLN02193 PLN02193
nitrile-specifier protein
 17-291 9.89e-19

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 87.32  E-value: 9.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  17 PGDKPRKATWYTLTVPGDSPCARVGHScsyLPPVGNakrgKVFIVGGA-NPNRSFSD-VHTMDLGKHQWDLDTCKGLLPr 94
Cdd:PLN02193 144 PSTPKLLGKWIKVEQKGEGPGLRCSHG---IAQVGN----KIYSFGGEfTPNQPIDKhLYVFDLETRTWSISPATGDVP- 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  95 yeHASFIPSC---TPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAq 171
Cdd:PLN02193 216 --HLSCLGVRmvsIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFH-SMAADEENVYVFGGVSATA- 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 172 pvqdtKLHVFDANTL---TWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFyDDLHCIDISDMKWQKLNPTGAAP 248
Cdd:PLN02193 292 -----RLKTLDSYNIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFGVRP 365

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530390389 249 AGCAAHSAVAMGKHVYIFGG---------MTPAGALDTMYQYHTEEQHWTLL 291
Cdd:PLN02193 366 SERSVFASAAVGKHIVIFGGeiamdplahVGPGQLTDGTFALDTETLQWERL 417
PLN02153 PLN02153
epithiospecifier protein
 33-268 1.44e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 73.87  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  33 GDSPCARVGHScsyLPPVGNakrgKVFIVGGA-NPNRSF-SDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIW 110
Cdd:PLN02153  17 GKGPGPRCSHG---IAVVGD----KLYSFGGElKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 111 VFGGANQSGNRNCLQVLNPETRTWT--TPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLT- 187
Cdd:PLN02153  90 IFGGRDEKREFSDFYSYDTVKNEWTflTKLDEEGGPEARTFH-SMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIAd 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 188 --WSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA------GDRFYDD--LHCIDISDMKWQKLNPTGAAPAGCAAHSAV 257
Cdd:PLN02153 169 gkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpgGKSDYESnaVQFFDPASGKWTEVETTGAKPSARSVFAHA 248

                        250
                 ....*....|.
gi 530390389 258 AMGKHVYIFGG 268
Cdd:PLN02153 249 VVGKYIIIFGG 259
PLN02153 PLN02153
epithiospecifier protein
 195-306 5.60e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 63.08  E-value: 5.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 195 GNPPSPRHGHVMVAAGTKLFIHGG-LAGDRFYD-DLHCIDISDMKWQKLNPTGAAPA-GCAAHSAVAMGKHVYIFGGMTP 271
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDE 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530390389 272 AGALDTMYQYHTEEQHWTLL-KFDTL-LPPGRLDHSM 306
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLtKLDEEgGPEARTFHSM 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
187-306 9.24e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.10  E-value: 9.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 187 TWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYIF 266
Cdd:COG3055    2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAA--AVAQDGKLYVF 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530390389 267 GGMTPA----GALDTMYQYHTEEQHWTLLkfdTLLPPGRLDHSM 306
Cdd:COG3055   77 GGFTGAnpssTPLNDVYVYDPATNTWTKL---APMPTPRGGATA 117
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-182 4.22e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.09  E-value: 4.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  21 PRKATWytlTVPGDSPCARVGHSCSYLPpvgnakRGKVFIVGGAN---PNRSFSDVHTMdlgkhqwdldtckgLLPRYEH 97
Cdd:COG3055  144 PATGTW---TQLAPLPTPRDHLAAAVLP------DGKILVIGGRNgsgFSNTWTTLAPL--------------PTARAGH 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  98 ASFIPSctpDRIWVFGGanQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSsAAIGNQLYVFGGG-ERGAQPVQDT 176
Cdd:COG3055  201 AAAVLG---GKILVFGG--ESGFSDEVEAYDPATNTWTA---LGELPTPRHGHAA-VLTDGKVYVIGGEtKPGVRTPLVT 271


                 ....*.
gi 530390389 177 KLHVFD 182
Cdd:COG3055  272 SAEVYD 277
PRK14131 PRK14131
N-acetylneuraminate epimerase;
153-268 5.46e-09

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 57.33  E-value: 5.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 153 SAAIGNQLYVfGGGERGaqpvqdTKLHVFDANTLT--WSQPETLgnPPSPRHGHVMVAAGTKLFIHGGL------AGDRF 224
Cdd:PRK14131  34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSkgWTKIAAF--PGGPREQAVAAFIDGKLYVFGGIgktnseGSPQV 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530390389 225 YDDLHCIDISDMKWQKLNPTgaAPAGCAAHSAVAM-GKHVYIFGG 268
Cdd:PRK14131 105 FDDVYKYDPKTNSWQKLDTR--SPVGLAGHVAVSLhNGKAYITGG 147
PRK14131 PRK14131
N-acetylneuraminate epimerase;
49-280 7.79e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 53.87  E-value: 7.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  49 PVGNAKRGKVFIVGG------ANPNRSFSDVHTMDLGKHQWD-LDTC--KGLLPryeHASFIPSctPDRIWVFGGANQS- 118
Cdd:PRK14131  78 AVAAFIDGKLYVFGGigktnsEGSPQVFDDVYKYDPKTNSWQkLDTRspVGLAG---HVAVSLH--NGKAYITGGVNKNi 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 119 ----------------------------------GNRNCLqVLNPETRTWTTPEVTsppPSPRTFHTSSAAIGNQLYVFG 164
Cdd:PRK14131 153 fdgyfedlaaagkdktpkdkindayfdkkpedyfFNKEVL-SYDPSTNQWKNAGES---PFLGTAGSAVVIKGNKLWLIN 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 165 G----GERGAQpvqdTKLHVFDANTLTWSQPETLgnPPSPR---------------HGHVMVAAGT------------KL 213
Cdd:PRK14131 229 GeikpGLRTDA----VKQGKFTGNNLKWQKLPDL--PPAPGgssqegvagafagysNGVLLVAGGAnfpgarenyqngKL 302

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530390389 214 FIHGGLAgDRFYDDLHCIDisDMKWQKLnptGAAPAGCAAHSAVAMGKHVYIFGGMTPAG-ALDTMYQ 280
Cdd:PRK14131 303 YAHEGLK-KSWSDEIYALV--NGKWQKV---GELPQGLAYGVSVSWNNGVLLIGGETAGGkAVSDVTL 364
PLN02153 PLN02153
epithiospecifier protein
 25-229 4.13e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 4.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  25 TWYTLTVPGDSPcaRVGHSCSYLPPVGNakrgKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTCKGLLPRYEHASf 100
Cdd:PLN02153  61 TWSIAPANGDVP--RISCLGVRMVAVGT----KLYIFGGRDEKREFSDFYSYDTVKNEWtfltKLDEEGGPEARTFHSM- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 101 ipSCTPDRIWVFGGANQSG------------------------------------------------------------- 119
Cdd:PLN02153 134 --ASDENHVYVFGGVSKGGlmktperfrtieayniadgkwvqlpdpgenfekrggagfavvqgkiwvvygfatsilpggk 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 120 ---NRNCLQVLNPETRTWTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGG-------GERGAQPVQDTKlHVFDANTLTWS 189
Cdd:PLN02153 212 sdyESNAVQFFDPASGKWTEVETTGAKPSARSVF-AHAVVGKYIIIFGGevwpdlkGHLGPGTLSNEG-YALDTETLVWE 289

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 530390389 190 QPETLGNPPSPRHGHVMVAA---GTK-LFIHGG-LAGDRFYDDLH 229
Cdd:PLN02153 290 KLGECGEPAMPRGWTAYTTAtvyGKNgLLMHGGkLPTNERTDDLY 334
PLN02153 PLN02153
epithiospecifier protein
 89-301 9.25e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 50.37  E-value: 9.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  89 KGLLPRYEHASfipSCTPDRIWVFGG---ANQSGNRNcLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG 165
Cdd:PLN02153  18 KGPGPRCSHGI---AVVGDKLYSFGGelkPNEHIDKD-LYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 166 GErgaQPVQDTKLHVFDANTLTW---SQPETLGNPPSpRHGHVMVAAGTKLFIHGGLAG-------DRFyDDLHCIDISD 235
Cdd:PLN02153  94 RD---EKREFSDFYSYDTVKNEWtflTKLDEEGGPEA-RTFHSMASDENHVYVFGGVSKgglmktpERF-RTIEAYNIAD 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530390389 236 MKWQKL-NPTGAAPAGCAAHSAVAMGKHVYIFGGMT---PAGALD----TMYQYHTEEQHWTLLKFDTLLPPGR 301
Cdd:PLN02153 169 GKWVQLpDPGENFEKRGGAGFAVVQGKIWVVYGFATsilPGGKSDyesnAVQFFDPASGKWTEVETTGAKPSAR 242
Kelch_3 pfam13415
Galactose oxidase, central domain;
157-209 1.08e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530390389  157 GNQLYVFGGGERGAQPVqDTKLHVFDANTLTWsqpETLGNPPSPRHGHVMVAA 209
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-LNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
107-155 2.74e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 2.74e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530390389  107 DRIWVFGGANQSGNR--NCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAA 155
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATYI 49
Kelch_6 pfam13964
Kelch motif;
146-201 7.06e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 7.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530390389  146 PRTFHtSSAAIGNQLYVFGGGERGAQPVQdtKLHVFDANTLTWsqpETLGNPPSPR 201
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PHA03098 PHA03098
kelch-like protein; Provisional
 49-238 1.52e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 46.68  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389  49 PVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTcKGLLPRYEHASFIpscTPDRIWVFGGANQSG-NRNCLQVL 127
Cdd:PHA03098 336 PGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEP-PLIFPRYNPCVVN---VNNLIYVIGGISKNDeLLKTVECF 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 128 NPETRTWTTPEvtsppPSPRTFHTSSAAI-GNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNppsPRHGHVM 206
Cdd:PHA03098 412 SLNTNKWSKGS-----PLPISHYGGCAIYhDGKIYVIGGISYIDNIKVYNIVESYNPVTNKWTELSSLNF---PRINASL 483

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530390389 207 VAAGTKLFIHGGLAGDRFYDDLHCIDISDMKW 238
Cdd:PHA03098 484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 251-291 2.46e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530390389  251 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 291
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
PHA03098 PHA03098
kelch-like protein; Provisional
 107-309 1.41e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 107 DRIWVFGGANQSGNR-NCLQVLNPETRTWTT-PEVTSPPPSPrtfhtSSAAIGNQLYVFGGgERGAQPVQDTKLHVFDAN 184
Cdd:PHA03098 295 NVIYFIGGMNKNNLSvNSVVSYDTKTKSWNKvPELIYPRKNP-----GVTVFNNRIYVIGG-IYNSISLNTVESWKPGES 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390389 185 TltWSQPETLgnpPSPRHGHVMVAAGTKLFIHGGLA-GDRFYDDLHCIDISDMKWQKLNPTgaaPAGCAAHSAVAMGKHV 263
Cdd:PHA03098 369 K--WREEPPL---IFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKI 440

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 530390389 264 YIFGGMTPA---GALDTMYQYHTEEQHWTLLKfdTLLPPgRLDHSMCII 309
Cdd:PHA03098 441 YVIGGISYIdniKVYNIVESYNPVTNKWTELS--SLNFP-RINASLCIF 486
Kelch_4 pfam13418
Galactose oxidase, central domain;
146-199 1.50e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.50e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530390389  146 PRTFHTSSAAIGNQLYVFGGgeRGAQPVQDTKLHVFDANTLTWSQpetLGNPPS 199
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG--EGEDGTLLSDLWVFDLSTNEWTR---LGSLPS 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 200-243 1.52e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 1.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530390389  200 PRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNP 243
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
93-144 3.00e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 3.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530390389   93 PRYEHASFipSCTPDRIWVFGGANQSGNR-NCLQVLNPETRTWTTpeVTSPPP 144
Cdd:pfam13418   1 PRAYHTST--SIPDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTR--LGSLPS 49
Kelch_6 pfam13964
Kelch motif;
93-147 3.75e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 3.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530390389   93 PRYEHASFIPSctpDRIWVFGGANQSGNR-NCLQVLNPETRTWttpEVTSPPPSPR 147
Cdd:pfam13964   1 PRTFHSVVSVG---GYIYVFGGYTNASPAlNKLEVYNPLTKSW---EELPPLPTPR 50
Kelch_4 pfam13418
Galactose oxidase, central domain;
200-241 4.80e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 4.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 530390389  200 PRHGHVMVA-AGTKLFIHGGLAGD-RFYDDLHCIDISDMKWQKL 241
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRL 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 198-229 5.14e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 5.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530390389  198 PSPRHGHVMVAAGTKLFIHGGLAGDR--FYDDLH 229
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVY 34
PLN02772 PLN02772
guanylate kinase
 152-222 9.10e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 9.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530390389 152 SSAAIGNQLYVFGGGERGAQPVQDTKLhvFDANTLTWSQPETLGNPPSPRHGH--VMVAAGTKLFIHGGLAGD 222
Cdd:PLN02772  29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPD 99
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 248-284 8.87e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 8.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530390389  248 PAGCAAHSAVAMGKHVYIFGGMTPAG--ALDTMYQYHTE 284
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVYVLSLP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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