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Conserved domains on  [gi|530385411|ref|XP_005250165|]
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leucine-rich repeat-containing protein 17 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471162)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
272-328 5.26e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 5.26e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530385411  272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSL 328
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-351 4.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 4.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  98 NNMFSKFKKLKSLDLQQNEISKIEsEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLlSYLRLYDNpwhctcEIETLism 177
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTNL-KSLDLSNN------QLTDL--- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 178 lqiprNRNLGNyakcespqeqkNKKLRqikseqlcneeekeqldpkpqvsgrppvikpevdstfchnyvfpiqTLDCKRK 257
Cdd:COG4886  175 -----PEELGN-----------LTNLK----------------------------------------------ELDLSNN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 258 ELKKVPNNI--PPDIVKLDLSYNKINQLrPKEFEDVHELKKLNLSSNGIEfiDPAAFLGLTHLEELDLSNNSLQNFDygV 335
Cdd:COG4886  193 QITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLP--P 267

                        250
                 ....*....|....*.
gi 530385411 336 LEDLYFLKLLWLRDNP 351
Cdd:COG4886  268 LANLTNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
272-328 5.26e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 5.26e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530385411  272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSL 328
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-350 3.72e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 249 IQTLDCKRKELKKVPNNIP--PDIVKLDLSYNKINQLrPKEFEDVHELKKLNLSSNGIEFIdPAAFLGLTHLEELDLSNN 326
Cdd:COG4886  115 LESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN 192

                         90       100
                 ....*....|....*....|....
gi 530385411 327 SLQNFDYgVLEDLYFLKLLWLRDN 350
Cdd:COG4886  193 QITDLPE-PLGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-351 4.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 4.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  98 NNMFSKFKKLKSLDLQQNEISKIEsEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLlSYLRLYDNpwhctcEIETLism 177
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTNL-KSLDLSNN------QLTDL--- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 178 lqiprNRNLGNyakcespqeqkNKKLRqikseqlcneeekeqldpkpqvsgrppvikpevdstfchnyvfpiqTLDCKRK 257
Cdd:COG4886  175 -----PEELGN-----------LTNLK----------------------------------------------ELDLSNN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 258 ELKKVPNNI--PPDIVKLDLSYNKINQLrPKEFEDVHELKKLNLSSNGIEfiDPAAFLGLTHLEELDLSNNSLQNFDygV 335
Cdd:COG4886  193 QITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLP--P 267

                        250
                 ....*....|....*.
gi 530385411 336 LEDLYFLKLLWLRDNP 351
Cdd:COG4886  268 LANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
84-141 1.00e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.00e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530385411   84 LHML-LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
Cdd:pfam13855   3 LRSLdLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 294-351 9.23e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 9.23e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 294 LKKLNLSSNGIEFIDPaaFLGLTHLEELDLSNNSLQNFDY--GVLEDLYFLKLLWLRDNP 351
Cdd:cd21340  122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-326 9.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 9.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  59 YLHEKYLDCQErklvyvLPGWPQDLLHMLLARNKIRTLKNnmFSKFKKLKSLDLQQNEISKIESeaFFGLNKLTTLLLQH 138
Cdd:cd21340    8 YLNDKNITKID------NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 139 NQIKVLTeevfiytpllsylrlydnpwhctceietlismlqiprnrNLGNyakCESPQEqknkkLRQikseqlcneeEKE 218
Cdd:cd21340   78 NRISVVE---------------------------------------GLEN---LTNLEE-----LHI----------ENQ 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 219 QLDPkpqvsgrppvikpevDSTFChnyvFPIQTLDCKRKELKKvpnnippdivkLDLSYNKINQLRPkeFEDVHELKKLN 298
Cdd:cd21340  101 RLPP---------------GEKLT----FDPRSLAALSNSLRV-----------LNISGNNIDSLEP--LAPLRNLEQLD 148

                        250       260       270
                 ....*....|....*....|....*....|
gi 530385411 299 LSSNGIEFIDPAAFL--GLTHLEELDLSNN 326
Cdd:cd21340  149 ASNNQISDLEELLDLlsSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 249-328 3.36e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 249 IQTLDCKRKELKK-VPNNIP--PDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSN 325
Cdd:PLN00113 477 LENLDLSRNQFSGaVPRKLGslSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556


                 ...
gi 530385411 326 NSL 328
Cdd:PLN00113 557 NQL 559
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
272-328 5.26e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 5.26e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530385411  272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSL 328
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-350 3.72e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 249 IQTLDCKRKELKKVPNNIP--PDIVKLDLSYNKINQLrPKEFEDVHELKKLNLSSNGIEFIdPAAFLGLTHLEELDLSNN 326
Cdd:COG4886  115 LESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN 192

                         90       100
                 ....*....|....*....|....
gi 530385411 327 SLQNFDYgVLEDLYFLKLLWLRDN 350
Cdd:COG4886  193 QITDLPE-PLGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
293-351 7.09e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 7.09e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530385411  293 ELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNP 351
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-350 1.56e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 249 IQTLDCKRKELKKVPNNIP--PDIVKLDLSYNKINQLrPKEFEDVHELKKLNLSSNGIEFIdPAAFLGLTHLEELDLSNN 326
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                         90       100
                 ....*....|....*....|....
gi 530385411 327 SLQNFDYgvLEDLYFLKLLWLRDN 350
Cdd:COG4886  239 QLTDLPE--LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-351 4.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 4.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  98 NNMFSKFKKLKSLDLQQNEISKIEsEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLlSYLRLYDNpwhctcEIETLism 177
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTNL-KSLDLSNN------QLTDL--- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 178 lqiprNRNLGNyakcespqeqkNKKLRqikseqlcneeekeqldpkpqvsgrppvikpevdstfchnyvfpiqTLDCKRK 257
Cdd:COG4886  175 -----PEELGN-----------LTNLK----------------------------------------------ELDLSNN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 258 ELKKVPNNI--PPDIVKLDLSYNKINQLrPKEFEDVHELKKLNLSSNGIEfiDPAAFLGLTHLEELDLSNNSLQNFDygV 335
Cdd:COG4886  193 QITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLP--P 267

                        250
                 ....*....|....*.
gi 530385411 336 LEDLYFLKLLWLRDNP 351
Cdd:COG4886  268 LANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-345 8.03e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 8.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  88 LARNKIRTLKNNmFSKFKKLKSLDLQQNEISKIeSEAFFGLNKLTTLLLQHNQIKVLTEEvFIYTPLLSYLRLYDNPwhc 167
Cdd:COG4886  120 LSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ--- 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 168 tceIETLISMLQiprnrnlgnyakcespqeqKNKKLrqikseqlcneeekeqldpkpqvsgrppvikpevdstfchnyvf 247
Cdd:COG4886  194 ---ITDLPEPLG-------------------NLTNL-------------------------------------------- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 248 piQTLDCKRKELKKVPNNIP--PDIVKLDLSYNKINQLrpKEFEDVHELKKLNLSSNGIEFIDPAAflGLTHLEELDLSN 325
Cdd:COG4886  208 --EELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281

                        250       260
                 ....*....|....*....|
gi 530385411 326 NSLQNFDYGVLEDLYFLKLL 345
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSL 301
LRR_8 pfam13855
Leucine rich repeat;
84-141 1.00e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.00e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530385411   84 LHML-LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
Cdd:pfam13855   3 LRSLdLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
106-164 5.60e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 5.60e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530385411  106 KLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNP 164
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 294-351 9.23e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 9.23e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 294 LKKLNLSSNGIEFIDPaaFLGLTHLEELDLSNNSLQNFDY--GVLEDLYFLKLLWLRDNP 351
Cdd:cd21340  122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-182 4.53e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 4.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  84 LHML-LARNKIRTLKNNmFSKFKKLKSLDLQQNEISKIeSEAFFGLNKLTTLLLQHNQIKVLTEEvFIYTPLLSYLRLYD 162
Cdd:COG4886  161 LKSLdLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237

                         90       100
                 ....*....|....*....|
gi 530385411 163 NpwhctcEIETLISMLQIPR 182
Cdd:COG4886  238 N------QLTDLPELGNLTN 251
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-326 9.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 9.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411  59 YLHEKYLDCQErklvyvLPGWPQDLLHMLLARNKIRTLKNnmFSKFKKLKSLDLQQNEISKIESeaFFGLNKLTTLLLQH 138
Cdd:cd21340    8 YLNDKNITKID------NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 139 NQIKVLTeevfiytpllsylrlydnpwhctceietlismlqiprnrNLGNyakCESPQEqknkkLRQikseqlcneeEKE 218
Cdd:cd21340   78 NRISVVE---------------------------------------GLEN---LTNLEE-----LHI----------ENQ 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 219 QLDPkpqvsgrppvikpevDSTFChnyvFPIQTLDCKRKELKKvpnnippdivkLDLSYNKINQLRPkeFEDVHELKKLN 298
Cdd:cd21340  101 RLPP---------------GEKLT----FDPRSLAALSNSLRV-----------LNISGNNIDSLEP--LAPLRNLEQLD 148

                        250       260       270
                 ....*....|....*....|....*....|
gi 530385411 299 LSSNGIEFIDPAAFL--GLTHLEELDLSNN 326
Cdd:cd21340  149 ASNNQISDLEELLDLlsSWPSLRELDLTGN 178
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 294-326 2.78e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.78e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 530385411  294 LKKLNLSSNGIEFIDPaaFLGLTHLEELDLSNN 326
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 249-328 3.36e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 249 IQTLDCKRKELKK-VPNNIP--PDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSN 325
Cdd:PLN00113 477 LENLDLSRNQFSGaVPRKLGslSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556


                 ...
gi 530385411 326 NSL 328
Cdd:PLN00113 557 NQL 559
PLN03150 PLN03150
hypothetical protein; Provisional
 285-350 5.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 5.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530385411 285 PKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 267-351 1.82e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 267 PPDIVKLDLSYNKINQ--LRP--KEFEDVHELKKLNLSSNGI-EFIDPAAFLGL---THLEELDLSNNSLQN----FDYG 334
Cdd:cd00116  136 PPALEKLVLGRNRLEGasCEAlaKALRANRDLKELNLANNGIgDAGIRALAEGLkanCNLEVLDLNNNGLTDegasALAE 215

                         90
                 ....*....|....*..
gi 530385411 335 VLEDLYFLKLLWLRDNP 351
Cdd:cd00116  216 TLASLKSLEVLNLGDNN 232
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
270-351 3.51e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530385411 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNgiefidpAAFLGLTHLEELDLSNNSLQNFDYGvLEDLYFLKLLWLRD 349
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSN 145


                 ..
gi 530385411 350 NP 351
Cdd:COG4886  146 NQ 147
LRR_8 pfam13855
Leucine rich repeat;
81-117 5.47e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 5.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530385411   81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEI 117
Cdd:pfam13855  25 SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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