|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
46-886 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 654.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRDRhGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDL 125
Cdd:PLN02900 20 FLSFFESK-GHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTADPNTPLRKLPRATNTQKCIRAGGKHNDLDDVGKDT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFGgEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKagLDPDLETRDIWLSLgVPASRVLSFGP 205
Cdd:PLN02900 99 YHHTFFEMLGNWSFG-DYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEK--QAPDDEARAIWLDY-LPEERVLPFGC 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 206 QENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLV--------ELWNLVFMQHNRLVLRRILRR------------------ 259
Cdd:PLN02900 175 KDNFWEMGDTGPCGPCSEIHYDRIGERDAADLVnnddprfiEIWNLVFIQFNREADGSLKPLpakhvdtgmglerlasil 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 260 -------------------------------------------------------------------------------A 260
Cdd:PLN02900 255 qnkpsnydtdlfmpifdaiqeatgarpyagkvgaedddrvdmayrvvadhirtlsfaiadgvvpsnegrgyvlrrllrrA 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 261 VRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDmfpaeva 340
Cdd:PLN02900 335 VRYGRLLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIEKFKKALAAAKANG------- 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 341 wSLSLCGD--------LGLPLDMVELMLEEKGVQLDSAGLERlAQEEAQHRARQAE-PVQKQGLWLDVHALGELQRQGVP 411
Cdd:PLN02900 408 -GPVLSGKdafllydtYGFPVDLTELMAEERGVTVDMEGFEA-AMEEARERSRAAHlKAGGGAIELAAEATSWLQKQGVA 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 412 PTDDSPKYNySLRPSgsyefgtcEAQVLQLYTEDGtAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVraGQEDVLF 491
Cdd:PLN02900 486 ATDDFLKYD-WLSDH--------EAVVKAILTGGG-FVESVSEGDEVGIVLDKTSFYAESGGQIGDTGVLE--GSGGAVV 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 492 PVARAQVCGGFILHE-AVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVT 570
Cdd:PLN02900 554 EVSDVQKAGGFVLHIgTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFDFS 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 571 TQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSL-DEVYPDPVRVVSVGVPVahaldpasqaalqtSV 649
Cdd:PLN02900 634 HGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRINGLRAVfGEKYPDPVRVVSVGGVY--------------SM 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 650 ELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAAterlslgsrDVAEALRLSKDIGR 729
Cdd:PLN02900 700 ELCGGTHVSNTAEAEAFKLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSA---------LKVEGSDLEKKVAS 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 730 LIEAVETAVMPQWQRRELLATVKMLQRRANTAIRK---LQMGQAAKKTQELLERH-SKGPLIV-----DTVSAESLSvlv 800
Cdd:PLN02900 771 LKSRVDAAVIPAAKKEEIRARVSALQKELRAAQKEaaaLRAKLAVAKATELASKAlSAGKSVLvarldVGVDAAALK--- 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 801 KVVRQLCEQAPSTSVLLLSPQPM-GKVLCACQVAQGAMPT-FTAEAWALAVCSHMGGKAWGSRVVAQGTGS-TTDLEAAL 877
Cdd:PLN02900 848 EAAEKVIAKLGDPAAVVLSSDEEkGKVSLVAAVPPGVVKKgLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRdAEKLDAAL 927
|
....*....
gi 530382281 878 SIAQTYALS 886
Cdd:PLN02900 928 EKARAFAVA 936
|
|
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
46-888 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 578.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRdRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPrsemaGFRRVANSQKCVRAGGHHNDLEDVGRDL 125
Cdd:COG0013 11 FLDFFE-SKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKP-----PYPRATTSQKCVRTGGKHNDLENVGYTA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFgGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDpkaglDpdlETRDIWLSL-GVPASRVLSFG 204
Cdd:COG0013 85 RHHTFFEMLGNFSF-GDYFKEEAIAWAWELLTEVLGLPKERLWVTVYEDD-----D---EAYDIWKKEiGVPEERIIRLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 205 PQENFWEMGDTGPCGPCTEIHYDL--------AGGVGA--PQLVELWNLVFMQHNRLVL--------------------- 253
Cdd:COG0013 156 KKDNFWEMGDTGPCGPCSEIFYDRgpeygggpPGSPGEdgDRYIEIWNLVFMQFNRDEDgtltplpkknidtgmgleria 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 254 ------------------------------RRILRRAVRF----------SMEI-------------------------- 267
Cdd:COG0013 236 avlqgvhsnyetdlfrplieaaaeltgvkyGADEEDDVSLrviadhiravAFLIadgvlpsnegrgyvlrrilrravrhg 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 268 ----LKAPpgFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTL--GPSDMFPAEVAW 341
Cdd:COG0013 316 rllgIKEP--FLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLkaAGGKVLSGEDAF 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 342 SLSlcgD-LGLPLDMVELMLEEKGVQLDSAGLERlAQEEAQHRARQA----EPVQKQGLWLDVHALGElqrqgvpptdds 416
Cdd:COG0013 394 KLY---DtYGFPLDLTEEIARERGLTVDEEGFEA-AMEEQRERARAAakfsGDAAVDGVWRELLEEGG------------ 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 417 pkynyslrPS---GsYEFGTCEAQVLQLYtEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGqedVLFPV 493
Cdd:COG0013 458 --------PTefvG-YDTLEAEAKVLALV-KDGELVDSAKAGEEVEVVLDRTPFYAESGGQVGDTGTIEGDG---GVFEV 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 494 ARAQ-VCGGFILHEA-VAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTT 571
Cdd:COG0013 525 TDTQkPPGGLIVHIGkVEEGELKVGDTVTAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSH 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 572 QTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLAlTAQVPGLRSL-DEVYPDpvrvvsvgvpvahaldpasqaalqT--- 647
Cdd:COG0013 605 FEALTPEELAEIEDLVNEKIRENLPVETREMPLD-EAKALGAMALfGEKYGD------------------------Evrv 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 648 ------SVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQA----QQARELGQSLAQEVKAATErlslgsrdv 717
Cdd:COG0013 660 vsigdfSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAAleylREQEALLKELAELLKAPPE--------- 730
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 718 aealrlskdigRLIEAVEtavmpqwqrrELLATVKMLQRRantaIRKLQMGQAAKKTQELLE--RHSKG-PLIVDTVSAE 794
Cdd:COG0013 731 -----------ELPERVE----------ALLEELKELEKE----LEQLKAKLASAAADDLLAqaEEIGGvKVLAARVEGV 785
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 795 SLSVLVKVVRQLCEQAPSTSVLLLSPQPmGKVLCACQVAQGAMP-TFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTD- 872
Cdd:COG0013 786 DAKDLRDLADDLKDKLGSGVVVLASVAD-GKVSLVAGVTKDLVKkGLKAGDLVKEVAKIVGGGGGGRPDMAQAGGKDPSk 864
|
970
....*....|....*.
gi 530382281 873 LEAALSIAQTYALSQL 888
Cdd:COG0013 865 LDEALAAVKEWLAEKL 880
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
46-868 |
1.80e-155 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 477.26 E-value: 1.80e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRDRhGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSemagfRRVANSQKCVRAgghhNDLEDVGRDL 125
Cdd:TIGR00344 6 FLDFFKEK-GHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPS-----NRLTNAQPCIRL----NDLENVGRTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFGgEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLdpdletrdIWLSLGVPASRVLSFGP 205
Cdd:TIGR00344 76 RHHTLFEMLGNFSFG-DYFKEEAIAFAWELLTEVLGLDKERLYVTVYEDDEEAYK--------IWEKIGIPADRIIKCDA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 206 QENFWEMGDtGPCGPCTEIHYDLAGG-VGAP-----QLVELWNLVFMQHN------------------------------ 249
Cdd:TIGR00344 147 KDNFWDMGD-GPCGPCTEIYYDFVGGkPGEPleendRYLEVWNLVFMQFNrdpdgnytplpkknidtgmglerfvavlqg 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 250 --------------------------------RLVLRRILRRAVR------------------FS--------------- 264
Cdd:TIGR00344 226 vptnydtdiflpliekieeitgvkydsnnagiMDEKRVEDLRSLRviadhtraiafmladgvvPSnegrgyvlrrlirra 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 265 ---MEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGpSDMFPAEVAW 341
Cdd:TIGR00344 306 lrhGKKLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKLLKKTG-KKELDGEDAF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 342 SLSlcGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEaQHRARQAEPVQKQGlwldvhalGELQRqgVPPTDDSPKYNY 421
Cdd:TIGR00344 385 KLY--DTYGFPVELTKEIAEERGLTVDMPGFEALMAEQ-RERSKQNSQFQEQE--------IALVN--VYPATEFLGYDD 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 422 SlrpsgsyefgTCEAQVLQLYtEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVragQEDVLFPVARAQVCGG 501
Cdd:TIGR00344 452 L----------EFEAKVIGLF-DDGYLVEQALAGQSVYVILDQTPFYAESGGQIGDTGYLI---ANDGKFRVVDVQKPNG 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 502 FILHEA-VAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQL 580
Cdd:TIGR00344 518 VVFHFGeVEGGSLKVGDKVIAVIDEKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREEL 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 581 RAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAhaldpasqaalqtSVELCCGTHLLRT 660
Cdd:TIGR00344 598 EEIEDLANEQILANIPIKVIFMDLDEAKRKGAFALFGEKYVPGEKVRVVSVGDF-------------SVELCGGTHVRNT 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 661 GAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAaterlslgsrdvaealRLSKDIGRLIEAVEtavmp 740
Cdd:TIGR00344 665 GEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNEQEDKLKELAD----------------ILKVTPNELPKKVE----- 723
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 741 qwqrrELLATVKMLQRRantaIRKLQMGQAAKKTQELLERHSK---GPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLL 817
Cdd:TIGR00344 724 -----RFFEEWKALQKE----LESLKLKIADQKIDELKDKAETingVKVLVEVVDAKDMKSLKTMADRLKSKLGSAIYVL 794
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 530382281 818 LSpQPMGKVLCACQVAQGAMPT-FTAEAWALAVCSHMGGKAWGSRVVAQGTG 868
Cdd:TIGR00344 795 AS-FAEGKVKLVCGVSNDVLTKkIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
46-527 |
1.24e-150 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 454.81 E-value: 1.24e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRdRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSemagFRRVANSQKCVRAGghhnDLEDVGRDL 125
Cdd:pfam01411 6 FLDFFE-KKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVAKPP----YNRATNSQKCIRAG----DLENVGRTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFgGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPkagldpdlETRDIWLSL-GVPASRVLSFG 204
Cdd:pfam01411 77 RHHTFFEMLGNFSF-GDYFKEEAIEYAWELLTKELGLPPERLYVTVFEWDD--------EAGPIWEKIvGGPEERILRFG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 205 PQENFWEMGDTGPCGPCTEIHYD--LAGGVGAPQ---------LVELWNLVFMQHN------------------------ 249
Cdd:pfam01411 148 DKDNFWEMGDTGPCGPCSEIDYDrgEEIGGWDSGgtptadddrFLEIWNLVFMQFNrendgtlkplpkksidtgmglerl 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 250 -----------------------------RLVLRRILRRAVR----------F--------------------------S 264
Cdd:pfam01411 228 vavlqdvrsnydtdvfipvielieeisgaRYYTVDETDEAYRviadhtraltFaladgvvpsnegrgyvlrrilrravrH 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 265 MEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLG-PSDMFPAEVAWSL 343
Cdd:pfam01411 308 AKKLGLKEPFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKkGKKTLPGEDAFKL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 344 SlcgD-LGLPLDMVELMLEEKGVQLDSAGLERlAQEEAQHRARQAepVQKQGLWLDVHALGELqrqgvPPTDDSPKYNYS 422
Cdd:pfam01411 388 Y---DtYGFPVDLTKEIAEERGLKVDMPGFEY-AMVEQRERSKQA--VKEKGEKLDVSALKEL-----PATTEFLGYDDL 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 423 LrpsgsyefgtCEAQVLQLYTeDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVragQEDVLFPVARAQVCGGF 502
Cdd:pfam01411 457 E----------SEAKILALPK-DGEFVAEVLAGQEGGVILDRTPFYAESGGQIGDTGYII---GDGGEFRVTDVQKYGGV 522
|
570 580
....*....|....*....|....*.
gi 530382281 503 ILHEAVAPE-CLRLGDQVQLHVDEAW 527
Cdd:pfam01411 523 VVHKGKLESgKLKVGDKVIAVIDEDR 548
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
46-249 |
8.50e-91 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 286.95 E-value: 8.50e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRdRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSemagfRRVANSQKCVRAGGHHNdledVGRDL 125
Cdd:cd00673 8 FLSFFE-KKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPA-----NRLVNSQKCIRAGDIDN----VGKTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFGgEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDpkagldpDLETRDIWLSLGVPASRVLSFGP 205
Cdd:cd00673 78 RHHTFFEMLGNFSFG-DYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEGD-------DEEEAIWWWKIGLPGIRIERIGF 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 530382281 206 QENFWEMGDTGPCGPCTEIHYDLAGGVGA--------PQLVELWNLVFMQHN 249
Cdd:cd00673 150 KDNFWEMGGNGPCGPCSEIFYDRGEERDAaslpneddDRYLEIWNLVFMQYN 201
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
648-681 |
4.16e-06 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 44.30 E-value: 4.16e-06
10 20 30
....*....|....*....|....*....|....
gi 530382281 648 SVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRL 681
Cdd:smart00863 10 SVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
46-886 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 654.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRDRhGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDL 125
Cdd:PLN02900 20 FLSFFESK-GHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTADPNTPLRKLPRATNTQKCIRAGGKHNDLDDVGKDT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFGgEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKagLDPDLETRDIWLSLgVPASRVLSFGP 205
Cdd:PLN02900 99 YHHTFFEMLGNWSFG-DYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEK--QAPDDEARAIWLDY-LPEERVLPFGC 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 206 QENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLV--------ELWNLVFMQHNRLVLRRILRR------------------ 259
Cdd:PLN02900 175 KDNFWEMGDTGPCGPCSEIHYDRIGERDAADLVnnddprfiEIWNLVFIQFNREADGSLKPLpakhvdtgmglerlasil 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 260 -------------------------------------------------------------------------------A 260
Cdd:PLN02900 255 qnkpsnydtdlfmpifdaiqeatgarpyagkvgaedddrvdmayrvvadhirtlsfaiadgvvpsnegrgyvlrrllrrA 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 261 VRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDmfpaeva 340
Cdd:PLN02900 335 VRYGRLLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIEKFKKALAAAKANG------- 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 341 wSLSLCGD--------LGLPLDMVELMLEEKGVQLDSAGLERlAQEEAQHRARQAE-PVQKQGLWLDVHALGELQRQGVP 411
Cdd:PLN02900 408 -GPVLSGKdafllydtYGFPVDLTELMAEERGVTVDMEGFEA-AMEEARERSRAAHlKAGGGAIELAAEATSWLQKQGVA 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 412 PTDDSPKYNySLRPSgsyefgtcEAQVLQLYTEDGtAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVraGQEDVLF 491
Cdd:PLN02900 486 ATDDFLKYD-WLSDH--------EAVVKAILTGGG-FVESVSEGDEVGIVLDKTSFYAESGGQIGDTGVLE--GSGGAVV 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 492 PVARAQVCGGFILHE-AVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVT 570
Cdd:PLN02900 554 EVSDVQKAGGFVLHIgTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFDFS 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 571 TQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSL-DEVYPDPVRVVSVGVPVahaldpasqaalqtSV 649
Cdd:PLN02900 634 HGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRINGLRAVfGEKYPDPVRVVSVGGVY--------------SM 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 650 ELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAAterlslgsrDVAEALRLSKDIGR 729
Cdd:PLN02900 700 ELCGGTHVSNTAEAEAFKLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSA---------LKVEGSDLEKKVAS 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 730 LIEAVETAVMPQWQRRELLATVKMLQRRANTAIRK---LQMGQAAKKTQELLERH-SKGPLIV-----DTVSAESLSvlv 800
Cdd:PLN02900 771 LKSRVDAAVIPAAKKEEIRARVSALQKELRAAQKEaaaLRAKLAVAKATELASKAlSAGKSVLvarldVGVDAAALK--- 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 801 KVVRQLCEQAPSTSVLLLSPQPM-GKVLCACQVAQGAMPT-FTAEAWALAVCSHMGGKAWGSRVVAQGTGS-TTDLEAAL 877
Cdd:PLN02900 848 EAAEKVIAKLGDPAAVVLSSDEEkGKVSLVAAVPPGVVKKgLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRdAEKLDAAL 927
|
....*....
gi 530382281 878 SIAQTYALS 886
Cdd:PLN02900 928 EKARAFAVA 936
|
|
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
46-888 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 578.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRdRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPrsemaGFRRVANSQKCVRAGGHHNDLEDVGRDL 125
Cdd:COG0013 11 FLDFFE-SKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKP-----PYPRATTSQKCVRTGGKHNDLENVGYTA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFgGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDpkaglDpdlETRDIWLSL-GVPASRVLSFG 204
Cdd:COG0013 85 RHHTFFEMLGNFSF-GDYFKEEAIAWAWELLTEVLGLPKERLWVTVYEDD-----D---EAYDIWKKEiGVPEERIIRLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 205 PQENFWEMGDTGPCGPCTEIHYDL--------AGGVGA--PQLVELWNLVFMQHNRLVL--------------------- 253
Cdd:COG0013 156 KKDNFWEMGDTGPCGPCSEIFYDRgpeygggpPGSPGEdgDRYIEIWNLVFMQFNRDEDgtltplpkknidtgmgleria 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 254 ------------------------------RRILRRAVRF----------SMEI-------------------------- 267
Cdd:COG0013 236 avlqgvhsnyetdlfrplieaaaeltgvkyGADEEDDVSLrviadhiravAFLIadgvlpsnegrgyvlrrilrravrhg 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 268 ----LKAPpgFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTL--GPSDMFPAEVAW 341
Cdd:COG0013 316 rllgIKEP--FLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLkaAGGKVLSGEDAF 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 342 SLSlcgD-LGLPLDMVELMLEEKGVQLDSAGLERlAQEEAQHRARQA----EPVQKQGLWLDVHALGElqrqgvpptdds 416
Cdd:COG0013 394 KLY---DtYGFPLDLTEEIARERGLTVDEEGFEA-AMEEQRERARAAakfsGDAAVDGVWRELLEEGG------------ 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 417 pkynyslrPS---GsYEFGTCEAQVLQLYtEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGqedVLFPV 493
Cdd:COG0013 458 --------PTefvG-YDTLEAEAKVLALV-KDGELVDSAKAGEEVEVVLDRTPFYAESGGQVGDTGTIEGDG---GVFEV 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 494 ARAQ-VCGGFILHEA-VAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTT 571
Cdd:COG0013 525 TDTQkPPGGLIVHIGkVEEGELKVGDTVTAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSH 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 572 QTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLAlTAQVPGLRSL-DEVYPDpvrvvsvgvpvahaldpasqaalqT--- 647
Cdd:COG0013 605 FEALTPEELAEIEDLVNEKIRENLPVETREMPLD-EAKALGAMALfGEKYGD------------------------Evrv 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 648 ------SVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQA----QQARELGQSLAQEVKAATErlslgsrdv 717
Cdd:COG0013 660 vsigdfSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAAleylREQEALLKELAELLKAPPE--------- 730
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 718 aealrlskdigRLIEAVEtavmpqwqrrELLATVKMLQRRantaIRKLQMGQAAKKTQELLE--RHSKG-PLIVDTVSAE 794
Cdd:COG0013 731 -----------ELPERVE----------ALLEELKELEKE----LEQLKAKLASAAADDLLAqaEEIGGvKVLAARVEGV 785
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 795 SLSVLVKVVRQLCEQAPSTSVLLLSPQPmGKVLCACQVAQGAMP-TFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTD- 872
Cdd:COG0013 786 DAKDLRDLADDLKDKLGSGVVVLASVAD-GKVSLVAGVTKDLVKkGLKAGDLVKEVAKIVGGGGGGRPDMAQAGGKDPSk 864
|
970
....*....|....*.
gi 530382281 873 LEAALSIAQTYALSQL 888
Cdd:COG0013 865 LDEALAAVKEWLAEKL 880
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
46-868 |
1.80e-155 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 477.26 E-value: 1.80e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRDRhGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSemagfRRVANSQKCVRAgghhNDLEDVGRDL 125
Cdd:TIGR00344 6 FLDFFKEK-GHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPS-----NRLTNAQPCIRL----NDLENVGRTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFGgEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLdpdletrdIWLSLGVPASRVLSFGP 205
Cdd:TIGR00344 76 RHHTLFEMLGNFSFG-DYFKEEAIAFAWELLTEVLGLDKERLYVTVYEDDEEAYK--------IWEKIGIPADRIIKCDA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 206 QENFWEMGDtGPCGPCTEIHYDLAGG-VGAP-----QLVELWNLVFMQHN------------------------------ 249
Cdd:TIGR00344 147 KDNFWDMGD-GPCGPCTEIYYDFVGGkPGEPleendRYLEVWNLVFMQFNrdpdgnytplpkknidtgmglerfvavlqg 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 250 --------------------------------RLVLRRILRRAVR------------------FS--------------- 264
Cdd:TIGR00344 226 vptnydtdiflpliekieeitgvkydsnnagiMDEKRVEDLRSLRviadhtraiafmladgvvPSnegrgyvlrrlirra 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 265 ---MEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGpSDMFPAEVAW 341
Cdd:TIGR00344 306 lrhGKKLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKLLKKTG-KKELDGEDAF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 342 SLSlcGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEaQHRARQAEPVQKQGlwldvhalGELQRqgVPPTDDSPKYNY 421
Cdd:TIGR00344 385 KLY--DTYGFPVELTKEIAEERGLTVDMPGFEALMAEQ-RERSKQNSQFQEQE--------IALVN--VYPATEFLGYDD 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 422 SlrpsgsyefgTCEAQVLQLYtEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVragQEDVLFPVARAQVCGG 501
Cdd:TIGR00344 452 L----------EFEAKVIGLF-DDGYLVEQALAGQSVYVILDQTPFYAESGGQIGDTGYLI---ANDGKFRVVDVQKPNG 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 502 FILHEA-VAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQL 580
Cdd:TIGR00344 518 VVFHFGeVEGGSLKVGDKVIAVIDEKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREEL 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 581 RAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAhaldpasqaalqtSVELCCGTHLLRT 660
Cdd:TIGR00344 598 EEIEDLANEQILANIPIKVIFMDLDEAKRKGAFALFGEKYVPGEKVRVVSVGDF-------------SVELCGGTHVRNT 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 661 GAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAaterlslgsrdvaealRLSKDIGRLIEAVEtavmp 740
Cdd:TIGR00344 665 GEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNEQEDKLKELAD----------------ILKVTPNELPKKVE----- 723
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 741 qwqrrELLATVKMLQRRantaIRKLQMGQAAKKTQELLERHSK---GPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLL 817
Cdd:TIGR00344 724 -----RFFEEWKALQKE----LESLKLKIADQKIDELKDKAETingVKVLVEVVDAKDMKSLKTMADRLKSKLGSAIYVL 794
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 530382281 818 LSpQPMGKVLCACQVAQGAMPT-FTAEAWALAVCSHMGGKAWGSRVVAQGTG 868
Cdd:TIGR00344 795 AS-FAEGKVKLVCGVSNDVLTKkIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
46-527 |
1.24e-150 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 454.81 E-value: 1.24e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRdRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSemagFRRVANSQKCVRAGghhnDLEDVGRDL 125
Cdd:pfam01411 6 FLDFFE-KKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVAKPP----YNRATNSQKCIRAG----DLENVGRTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFgGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPkagldpdlETRDIWLSL-GVPASRVLSFG 204
Cdd:pfam01411 77 RHHTFFEMLGNFSF-GDYFKEEAIEYAWELLTKELGLPPERLYVTVFEWDD--------EAGPIWEKIvGGPEERILRFG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 205 PQENFWEMGDTGPCGPCTEIHYD--LAGGVGAPQ---------LVELWNLVFMQHN------------------------ 249
Cdd:pfam01411 148 DKDNFWEMGDTGPCGPCSEIDYDrgEEIGGWDSGgtptadddrFLEIWNLVFMQFNrendgtlkplpkksidtgmglerl 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 250 -----------------------------RLVLRRILRRAVR----------F--------------------------S 264
Cdd:pfam01411 228 vavlqdvrsnydtdvfipvielieeisgaRYYTVDETDEAYRviadhtraltFaladgvvpsnegrgyvlrrilrravrH 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 265 MEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLG-PSDMFPAEVAWSL 343
Cdd:pfam01411 308 AKKLGLKEPFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKkGKKTLPGEDAFKL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 344 SlcgD-LGLPLDMVELMLEEKGVQLDSAGLERlAQEEAQHRARQAepVQKQGLWLDVHALGELqrqgvPPTDDSPKYNYS 422
Cdd:pfam01411 388 Y---DtYGFPVDLTKEIAEERGLKVDMPGFEY-AMVEQRERSKQA--VKEKGEKLDVSALKEL-----PATTEFLGYDDL 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 423 LrpsgsyefgtCEAQVLQLYTeDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVragQEDVLFPVARAQVCGGF 502
Cdd:pfam01411 457 E----------SEAKILALPK-DGEFVAEVLAGQEGGVILDRTPFYAESGGQIGDTGYII---GDGGEFRVTDVQKYGGV 522
|
570 580
....*....|....*....|....*.
gi 530382281 503 ILHEAVAPE-CLRLGDQVQLHVDEAW 527
Cdd:pfam01411 523 VVHKGKLESgKLKVGDKVIAVIDEDR 548
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
46-249 |
8.50e-91 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 286.95 E-value: 8.50e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRdRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSemagfRRVANSQKCVRAGGHHNdledVGRDL 125
Cdd:cd00673 8 FLSFFE-KKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPA-----NRLVNSQKCIRAGDIDN----VGKTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFGgEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDpkagldpDLETRDIWLSLGVPASRVLSFGP 205
Cdd:cd00673 78 RHHTFFEMLGNFSFG-DYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEGD-------DEEEAIWWWKIGLPGIRIERIGF 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 530382281 206 QENFWEMGDTGPCGPCTEIHYDLAGGVGA--------PQLVELWNLVFMQHN 249
Cdd:cd00673 150 KDNFWEMGGNGPCGPCSEIFYDRGEERDAaslpneddDRYLEIWNLVFMQYN 201
|
|
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
46-687 |
5.08e-57 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 206.55 E-value: 5.08e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 46 FLNFFRDRhGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPrsemAGFRRVaNSQKCVRAGghhnDLEDVGrDL 125
Cdd:PRK01584 10 YIDFFKSK-GHVEIAGKSLIPENDPTVLFTTAGMHPLVPYLLGEPHP----SGTRLV-DVQKCLRTG----DIDEVG-DL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 126 SHHTFFEMLGNWAFgGEYFKEEACNMAWELLT--QVYGIPEERLWISYFDGDPKAgldP-DLETRDIWLSLGVPASRVLS 202
Cdd:PRK01584 79 SHLTFFEMLGNWSL-GAYFKEESIKYSFEFLTspDYLNIPKDKLYVTVFEGDEEI---PrDEETASVWESLGIPKDRIFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 203 FGPQENFW-EMGDTGPCGPCTEIHYDLAG---------GVGAPQLVELWNLVFMQHNRLVLRRILRRA------------ 260
Cdd:PRK01584 155 LSREHNWWgPVGETGPCGPDTEIFVDTGKpkcsvncrpTCSCGKYFEIWNNVFMQYNKDEDGNYEELKrkcvdtgmgier 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 261 ------------------------------------------------VRFSMEILKAPPG------------------- 273
Cdd:PRK01584 235 tiaflqgkssvydteaftpiikriekisgkiygqneeddrsiriiadhIRAACFILGDPFVvlpsnvgqgyvlrrlirrs 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 274 ------------FLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAW 341
Cdd:PRK01584 315 irhakklgieshFLADLVDSVEEIYGSFYPELTEKKDFIKEELNKEEEKFFKTLRKGEQEFIKLIPNLGSSKIIPGDIAF 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 342 SLSlcGDLGLPLDMVELMLEEKGVQLDSAGLErlaQEEAQHRarqaepvqkqglwldvhalgELQRQGvpptddspkyny 421
Cdd:PRK01584 395 KLY--DTYGFPYEITEELASEYGFTVDREGFD---EHFKKHQ--------------------KVSKKG------------ 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 422 slrpsgsyefgtceaqvlqlytedgtavasvgkgqrcgllldrtnfyaeqggqasdrgylvragqEDVLFPvaraqvcGG 501
Cdd:PRK01584 438 -----------------------------------------------------------------ADKVFK-------GG 445
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 502 filheavapeclrLGDqvqlHVDEAWRLgcmakHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLR 581
Cdd:PRK01584 446 -------------LAD----HSYETTKL-----HTATHLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIK 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 582 AVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDpvrvvsvgVPVAHALDpasqaalQTSVELCCGTHLLRTG 661
Cdd:PRK01584 504 KVEDIVNLQIKNDLSVKKEVMSLEEAREKGAMALFGEKYED--------IVKVYEID-------GFSKEVCGGPHVENTG 568
|
730 740
....*....|....*....|....*.
gi 530382281 662 AVGDLVIIGDRQLSKGTTRLLAVTGE 687
Cdd:PRK01584 569 ELGTFKIQKEQSSSSGVRRIRAILID 594
|
|
| AlaX |
COG2872 |
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis] ... |
433-681 |
3.42e-30 |
|
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442119 [Multi-domain] Cd Length: 238 Bit Score: 119.53 E-value: 3.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 433 TCEAQVLQLyTEDGtavasvgkgqrcGLLLDRTNFYAEQGGQASDRGYLVRAGQEdvlFPVARAQVCGGFILHEAVAPEC 512
Cdd:COG2872 14 EFEATVTAV-TEEG------------GVVLDRTAFYPTGGGQPGDTGTLVWDGKE---IRVVDVRKEDGEIVHVLEGAPL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 513 LRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEqqGSHLNPEQLRLDVTTQTPlTPEQLRAVENTVQEAVG 592
Cdd:COG2872 78 PEVGDEVTGEIDWERRYRHMRLHTALHLLSAVVYREYGAPVT--GGQIGEDRARIDFDLPEF-DEEDLEEIEAEANELIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 593 QDEAVYMEEVPLALTAQVPGLRSLDEVYPdpvrvvsvgvpvahaldPASQAALQTsVEL-------CCGTHLLRTGAVGD 665
Cdd:COG2872 155 ADLPVRIYWITREELEAIPGLVRTMSVLP-----------------PPGVGRVRI-VEIggvdlqpCGGTHVANTGEIGR 216
|
250
....*....|....*.
gi 530382281 666 LVIIGDRQLSKGTTRL 681
Cdd:COG2872 217 IKITKIEKKGKGNRRV 232
|
|
| PLN02961 |
PLN02961 |
alanine-tRNA ligase |
457-681 |
1.04e-10 |
|
alanine-tRNA ligase
Pssm-ID: 178546 [Multi-domain] Cd Length: 223 Bit Score: 62.41 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 457 RCGLLLDRTNFYAEQGGQASDRGYLVRAGqEDVLFPVARAQVCGGFILH----EAVAPEC---LRLGDQVQLHVDEAWRL 529
Cdd:PLN02961 2 RIALVLDRTIFHPQGGGQPSDTGRIVISG-GDTKFSVQDVRRKDGVVYHygvfEGSNPESaspFEAGDEVTVTVDESRRK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 530 GCMAKHTATHLLNWALRQT-LGPGTEQQGSHLnPEQLRLDVTTQTPltPEQLRAVENTVQEA----VGQDEAVYMEEVPL 604
Cdd:PLN02961 81 LHSRLHSAGHLLDVCMARVgLGPLEPGKGYHF-PDGPFVEYKGKIP--QGELDSKQDELEAEanelIAEGGKVSAAVLPY 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530382281 605 ALTAQVPGlRSLDEvYPDPVRVVSVGVPVAHALDPasqaalqtsvelCCGTHLLRTGAVGDLVIIGDRqLSKGTTRL 681
Cdd:PLN02961 158 DEAAELCG-GSLPD-YIAKDSTPRIVKIGDSPGCP------------CGGTHVADVSEITSVKVTQIR-VKKGVTRV 219
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
648-681 |
4.16e-06 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 44.30 E-value: 4.16e-06
10 20 30
....*....|....*....|....*....|....
gi 530382281 648 SVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRL 681
Cdd:smart00863 10 SVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
97-249 |
1.67e-04 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 43.65 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382281 97 AGFRRVANSQKCVRAGGHHndledvgRDLSHHTFFEMLGNWAFGGEYFKEEacnmawelltqvygipEERLWISYfdgdp 176
Cdd:cd00768 73 KLPLRLAEIGPAFRNEGGR-------RGLRRVREFTQLEGEVFGEDGEEAS----------------EFEELIEL----- 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530382281 177 kagldpdleTRDIWLSLGVPASRVLSFGPQENFWEmgdtGPCGPCTEIHYDLAGGVGapqlVELWNLVFMQHN 249
Cdd:cd00768 125 ---------TEELLRALGIKLDIVFVEKTPGEFSP----GGAGPGFEIEVDHPEGRG----LEIGSGGYRQDE 180
|
|
| tRNA_SAD |
pfam07973 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of ... |
648-681 |
1.82e-04 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 429764 [Multi-domain] Cd Length: 43 Bit Score: 39.74 E-value: 1.82e-04
10 20 30
....*....|....*....|....*....|....
gi 530382281 648 SVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRL 681
Cdd:pfam07973 10 DVDLCGGTHVPNTGEIGAFKILKGESKNKGLRRI 43
|
|
| |
