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Conserved domains on  [gi|530374274|ref|XP_005247344|]
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target of Nesh-SH3 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 635-1025 2.89e-14

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 79.21  E-value: 2.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  635 PKSKPALEPATiqPEPLVPTT--ASKPSERPKTT--HRPDAPQIQ--------PGSKPPKQLLPKPQTTAEPDMPPTKSV 702
Cdd:PHA03247 2553 PPLPPAAPPAA--PDRSVPPPrpAPRPSEPAVTSraRRPDAPPQSarprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  703 SEPVPFETEAPSMTIVPttdiEPVTVRTEATVTTLA-PKTSQRTRTRRPRPKHKTTPRPETLQTkldfgPITPGTSSA-- 779
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVP----PPERPRDDPAPGRVSrPRRARRLGRAAQASSPPQRPRRRAARP-----TVGSLTSLAdp 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  780 PTTTTKRTRRPHPKPKTTPHPEVPQT--KLVPATILEPVLRTEASGTT--------AAPKVPQRTHRPHPK--PKTTLSP 847
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAarQASPALPAAPAPPAVPAGPAtpggparpARPPTTAGPPAPAPPaaPAAGPPR 2781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  848 EELQTELVPATIFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATv 927
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG- 2860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  928 lePVTLRPEASTTlASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTlrtetwvTTQAPKTSQRTRRPRPKTKTT 1007
Cdd:PHA03247 2861 --DVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP-------QPQAPPPPQPQPQPPPPPQPQ 2930

                         410       420
                  ....*....|....*....|.
gi 530374274 1008 PSPEV---PQTKLVPSTDLEP 1025
Cdd:PHA03247 2931 PPPPPpprPQPPLAPTTDPAG 2951
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 382-800 7.79e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 7.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  382 PLSTLAPKSLPEFPEAKTPFPFE-KPRGTLASSEKPWIVPTAKISED----SKVLQPQTATYD----VFSSPTTSDEPEI 452
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRDdpapGRVSRPRRARRLgraaQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  453 SDSYTATSDRILDsiPPKTSRTLE-QPRATLAPSETPFVPQKL-EIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRT 530
Cdd:PHA03247 2688 ARPTVGSLTSLAD--PPPPPPTPEpAPHALVSATPLPPGPAAArQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG 2765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  531 KPERTTSAGTITPkiskspePTWTTPAPGKTQFISLKPKIPLSPEvthtkPAPEPQTLLPSQSTigpETPGTKPSTTLAP 610
Cdd:PHA03247 2766 PPAPAPPAAPAAG-------PPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAA---LPPAASPAGPLPP 2830

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  611 RKTKRPGRRPRPRPRPKTTPSPE--VPKSKPALEPATIQPEPLVPTTASKPSER-------PKTTHRPDAPQIQPGSKPP 681
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGgsVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarpavSRSTESFALPPDQPERPPQ 2910

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  682 KQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPsmtIVPTTDIEPVtvrteatvttlapktsqrtrtrrprpkhkttPRPE 761
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP---LAPTTDPAGA-------------------------------GEPS 2956

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 530374274  762 TLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHP 800
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1535-1626 1.03e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1535 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNP 1612
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 530374274 1613 LGEGPVSNTVAFST 1626
Cdd:cd00063    80 GGESPPSESVTVTT 93
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1115-1362 1.94e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.69  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1115 PVTSPSLEMTESQPVSDVLESvtlstESPKETIAPAKTDYVYPTAKaPLWPEEPKTEVVESITYVSEPPETTLAPK---- 1190
Cdd:PTZ00449  520 PPKAPGDKEGEEGEHEDSKES-----DEPKEGGKPGETKEGEVGKK-PGPAKEHKPSKIPTLSKKPEFPKDPKHPKdpee 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1191 ----QTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTA--KPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPvlqpvtf 1264
Cdd:PTZ00449  594 pkkpKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESpkSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPP------- 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1265 rFEPPKTTiapletrgiPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPhrfYTTVRPRTSDKPH 1344
Cdd:PTZ00449  667 -FDPKFKE---------KFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRP---LPPKLPRDEEFPF 733

                         250
                  ....*....|....*...
gi 530374274 1345 IRPvlnrttTRPTRPKPS 1362
Cdd:PTZ00449  734 EPI------GDPDAEQPD 745
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-202 5.64e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 5.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   123 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPND-RFYTIRYREKDKEKKWIFQICPATET--IVENLKPNTVYEF 199
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 530374274   200 GVK 202
Cdd:pfam00041   72 RVQ 74
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1352-1631 6.77e-04

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1352 TTTRPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGI 1431
Cdd:COG3401    48 TKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1432 ISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNS--- 1508
Cdd:COG3401   128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTyyy 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1509 -PCSITDSVKRFPKEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQMT 1587
Cdd:COG3401   208 rVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATV 282

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 530374274 1588 NQTFSTVENLKPNTSYEFQVKPKNPLG-EGPVSNTVAFSTESADP 1631
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 635-1025 2.89e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 79.21  E-value: 2.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  635 PKSKPALEPATiqPEPLVPTT--ASKPSERPKTT--HRPDAPQIQ--------PGSKPPKQLLPKPQTTAEPDMPPTKSV 702
Cdd:PHA03247 2553 PPLPPAAPPAA--PDRSVPPPrpAPRPSEPAVTSraRRPDAPPQSarprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  703 SEPVPFETEAPSMTIVPttdiEPVTVRTEATVTTLA-PKTSQRTRTRRPRPKHKTTPRPETLQTkldfgPITPGTSSA-- 779
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVP----PPERPRDDPAPGRVSrPRRARRLGRAAQASSPPQRPRRRAARP-----TVGSLTSLAdp 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  780 PTTTTKRTRRPHPKPKTTPHPEVPQT--KLVPATILEPVLRTEASGTT--------AAPKVPQRTHRPHPK--PKTTLSP 847
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAarQASPALPAAPAPPAVPAGPAtpggparpARPPTTAGPPAPAPPaaPAAGPPR 2781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  848 EELQTELVPATIFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATv 927
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG- 2860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  928 lePVTLRPEASTTlASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTlrtetwvTTQAPKTSQRTRRPRPKTKTT 1007
Cdd:PHA03247 2861 --DVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP-------QPQAPPPPQPQPQPPPPPQPQ 2930

                         410       420
                  ....*....|....*....|.
gi 530374274 1008 PSPEV---PQTKLVPSTDLEP 1025
Cdd:PHA03247 2931 PPPPPpprPQPPLAPTTDPAG 2951
PHA03247 PHA03247
large tegument protein UL36; Provisional
 382-800 7.79e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 7.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  382 PLSTLAPKSLPEFPEAKTPFPFE-KPRGTLASSEKPWIVPTAKISED----SKVLQPQTATYD----VFSSPTTSDEPEI 452
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRDdpapGRVSRPRRARRLgraaQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  453 SDSYTATSDRILDsiPPKTSRTLE-QPRATLAPSETPFVPQKL-EIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRT 530
Cdd:PHA03247 2688 ARPTVGSLTSLAD--PPPPPPTPEpAPHALVSATPLPPGPAAArQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG 2765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  531 KPERTTSAGTITPkiskspePTWTTPAPGKTQFISLKPKIPLSPEvthtkPAPEPQTLLPSQSTigpETPGTKPSTTLAP 610
Cdd:PHA03247 2766 PPAPAPPAAPAAG-------PPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAA---LPPAASPAGPLPP 2830

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  611 RKTKRPGRRPRPRPRPKTTPSPE--VPKSKPALEPATIQPEPLVPTTASKPSER-------PKTTHRPDAPQIQPGSKPP 681
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGgsVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarpavSRSTESFALPPDQPERPPQ 2910

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  682 KQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPsmtIVPTTDIEPVtvrteatvttlapktsqrtrtrrprpkhkttPRPE 761
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP---LAPTTDPAGA-------------------------------GEPS 2956

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 530374274  762 TLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHP 800
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1535-1626 1.03e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1535 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNP 1612
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 530374274 1613 LGEGPVSNTVAFST 1626
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1536-1616 1.43e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.43e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   1536 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQMTNQTFS-TVENLKPNTSYEFQVKPKNPL 1613
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 530374274   1614 GEG 1616
Cdd:smart00060   81 GEG 83
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1115-1362 1.94e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.69  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1115 PVTSPSLEMTESQPVSDVLESvtlstESPKETIAPAKTDYVYPTAKaPLWPEEPKTEVVESITYVSEPPETTLAPK---- 1190
Cdd:PTZ00449  520 PPKAPGDKEGEEGEHEDSKES-----DEPKEGGKPGETKEGEVGKK-PGPAKEHKPSKIPTLSKKPEFPKDPKHPKdpee 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1191 ----QTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTA--KPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPvlqpvtf 1264
Cdd:PTZ00449  594 pkkpKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESpkSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPP------- 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1265 rFEPPKTTiapletrgiPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPhrfYTTVRPRTSDKPH 1344
Cdd:PTZ00449  667 -FDPKFKE---------KFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRP---LPPKLPRDEEFPF 733

                         250
                  ....*....|....*...
gi 530374274 1345 IRPvlnrttTRPTRPKPS 1362
Cdd:PTZ00449  734 EPI------GDPDAEQPD 745
fn3 pfam00041
Fibronectin type III domain;
1536-1619 4.30e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 4.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  1536 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQMTNQTFS-TVENLKPNTSYEFQVKPKNP 1612
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 530374274  1613 LGEGPVS 1619
Cdd:pfam00041   79 GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
123-202 5.64e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 5.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   123 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPND-RFYTIRYREKDKEKKWIFQICPATET--IVENLKPNTVYEF 199
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 530374274   200 GVK 202
Cdd:pfam00041   72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 124-202 5.68e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.68e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274    124 PLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPNDRFYTIRYREKDKEKKWIFQICPA----TETIVENLKPNTVYEF 199
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTEYEF 72


                    ...
gi 530374274    200 GVK 202
Cdd:smart00060   73 RVR 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1352-1631 6.77e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1352 TTTRPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGI 1431
Cdd:COG3401    48 TKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1432 ISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNS--- 1508
Cdd:COG3401   128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTyyy 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1509 -PCSITDSVKRFPKEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQMT 1587
Cdd:COG3401   208 rVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATV 282

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 530374274 1588 NQTFSTVENLKPNTSYEFQVKPKNPLG-EGPVSNTVAFSTESADP 1631
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1530-1674 7.89e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1530 TSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqmtNQTFSTVENLKPNTSYEFQV 1607
Cdd:COG3401   324 LTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKV 397

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530374274 1608 KPKNPLG-EGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1674
Cdd:COG3401   398 TAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-202 2.83e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  123 KPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpndrFYTIRYREKDKE--KKWIFQICPATETIVENLKPNTVYEFG 200
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFR 73


                  ..
gi 530374274  201 VK 202
Cdd:cd00063    74 VR 75
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 565-1009 4.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 4.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   565 SLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEP- 643
Cdd:pfam03154  143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTq 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   644 ATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTksvsePVPFETEAPSMtivpttdi 723
Cdd:pfam03154  223 STAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPM-----PHSLQTGPSHM-------- 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   724 ePVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETlqtkldfgpiTPGTSSAPTTTTKRTRRPHPKPKTTPHPEVP 803
Cdd:pfam03154  290 -QHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHT----------PPSQSQLQSQQPPREQPLPPAPLSMPHIKPP 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   804 QtklvpatilepvlrteasgTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVPATIFEPVSPIK-EAPGTTFVPVTDLEP 882
Cdd:pfam03154  359 P-------------------TTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLStHHPPSAHPPPLQLMP 419

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   883 VTFRTEIPATT--LATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTlRPEASTTLASKTSQRTRRPRLRTKTTP 960
Cdd:pfam03154  420 QSQQLPPPPAQppVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGG-PPPITPPSGPPTSTSSAMPGIQPPSSA 498

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530374274   961 RPEAPESKP-VPTAELKPVTLRTETWVTTQAPKT---SQRTRRPRPKTKTTPS 1009
Cdd:pfam03154  499 SVSSSGPVPaAVSCPLPPVQIKEEALDEAEEPESpppPPRSPSPEPTVVNTPS 551
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 635-1025 2.89e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 79.21  E-value: 2.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  635 PKSKPALEPATiqPEPLVPTT--ASKPSERPKTT--HRPDAPQIQ--------PGSKPPKQLLPKPQTTAEPDMPPTKSV 702
Cdd:PHA03247 2553 PPLPPAAPPAA--PDRSVPPPrpAPRPSEPAVTSraRRPDAPPQSarprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  703 SEPVPFETEAPSMTIVPttdiEPVTVRTEATVTTLA-PKTSQRTRTRRPRPKHKTTPRPETLQTkldfgPITPGTSSA-- 779
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVP----PPERPRDDPAPGRVSrPRRARRLGRAAQASSPPQRPRRRAARP-----TVGSLTSLAdp 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  780 PTTTTKRTRRPHPKPKTTPHPEVPQT--KLVPATILEPVLRTEASGTT--------AAPKVPQRTHRPHPK--PKTTLSP 847
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAarQASPALPAAPAPPAVPAGPAtpggparpARPPTTAGPPAPAPPaaPAAGPPR 2781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  848 EELQTELVPATIFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATv 927
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG- 2860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  928 lePVTLRPEASTTlASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTlrtetwvTTQAPKTSQRTRRPRPKTKTT 1007
Cdd:PHA03247 2861 --DVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP-------QPQAPPPPQPQPQPPPPPQPQ 2930

                         410       420
                  ....*....|....*....|.
gi 530374274 1008 PSPEV---PQTKLVPSTDLEP 1025
Cdd:PHA03247 2931 PPPPPpprPQPPLAPTTDPAG 2951
PHA03247 PHA03247
large tegument protein UL36; Provisional
 778-1269 4.04e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 4.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  778 SAPTTTTKRTRRPHPKPKTTPHPEVPQTKLVP-ATILEPV-------------LRTEASG-------TTAAPKVPQR--- 833
Cdd:PHA03247 2490 FAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPdEPVGEPVhprmltwirgleeLASDDAGdpppplpPAAPPAAPDRsvp 2569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  834 THRPHPKPKTTLSPEELQTELVP---ATIFEPVSPIKEAPGTTfvPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPK 910
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPpqsARPRAPVDDRGDPRGPA--PPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  911 TtpsPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTP-----RPEAPESKPVPtaelkpvtlRTETW 985
Cdd:PHA03247 2648 P---PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSltslaDPPPPPPTPEP---------APHAL 2715

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  986 VT-TQAPKTSQRTRRPRPKTKTTPSPevpqtklvPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPETTLAPKTQRTR 1064
Cdd:PHA03247 2716 VSaTPLPPGPAAARQASPALPAAPAP--------PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1065 RPRPRPKTTS--SPEVPQNKSVSVTGFEPVVHSTDAPGTTFALTELQTLILKPVTSPSLEMTESqPVSDVLESVTLSTES 1142
Cdd:PHA03247 2788 VASLSESRESlpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP-LGGSVAPGGDVRRRP 2866

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1143 PKETIAPAKTDYVYPTAKAPLWPEepktevvesityVSEPPETTLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTA 1222
Cdd:PHA03247 2867 PSRSPAAKPAAPARPPVRRLARPA------------VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 530374274 1223 KPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPVLQPVTFRFEPP 1269
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981
PHA03247 PHA03247
large tegument protein UL36; Provisional
 478-980 1.31e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.43  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  478 PRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPE--RTTSAGTITPKISKSPEPTWTT 555
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGdpRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  556 PAPGKTQfiSLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVP 635
Cdd:PHA03247 2631 PSPAANE--PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  636 KSKPalePATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPP--KQLLPKPQTTAEPD--MPPTKSVSEPVPFETE 711
Cdd:PHA03247 2709 EPAP---HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPapAPPAAPAAGPPRRLTR 2785

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  712 APSMTIVPTTDIEP-----------VTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDfGPITPGtssAP 780
Cdd:PHA03247 2786 PAVASLSESRESLPspwdpadppaaVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPG---GD 2861

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  781 TTTTKRTRRPHPKPKTTPHPEV-----PQTKLVPATILEPVLRTEASGTTAAPKVPQRTHRPHPKPKTTLSPEE------ 849
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVrrlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPpprpqp 2941

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  850 -LQTELVPATIFEPvSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAP-----ETKPV 923
Cdd:PHA03247 2942 pLAPTTDPAGAGEP-SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSlalheETDPP 3020

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530374274  924 PATVLEpvTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTL 980
Cdd:PHA03247 3021 PVSLKQ--TLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATP 3075
PHA03247 PHA03247
large tegument protein UL36; Provisional
 382-800 7.79e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 7.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  382 PLSTLAPKSLPEFPEAKTPFPFE-KPRGTLASSEKPWIVPTAKISED----SKVLQPQTATYD----VFSSPTTSDEPEI 452
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRDdpapGRVSRPRRARRLgraaQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  453 SDSYTATSDRILDsiPPKTSRTLE-QPRATLAPSETPFVPQKL-EIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRT 530
Cdd:PHA03247 2688 ARPTVGSLTSLAD--PPPPPPTPEpAPHALVSATPLPPGPAAArQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG 2765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  531 KPERTTSAGTITPkiskspePTWTTPAPGKTQFISLKPKIPLSPEvthtkPAPEPQTLLPSQSTigpETPGTKPSTTLAP 610
Cdd:PHA03247 2766 PPAPAPPAAPAAG-------PPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAA---LPPAASPAGPLPP 2830

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  611 RKTKRPGRRPRPRPRPKTTPSPE--VPKSKPALEPATIQPEPLVPTTASKPSER-------PKTTHRPDAPQIQPGSKPP 681
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGgsVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarpavSRSTESFALPPDQPERPPQ 2910

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  682 KQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPsmtIVPTTDIEPVtvrteatvttlapktsqrtrtrrprpkhkttPRPE 761
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP---LAPTTDPAGA-------------------------------GEPS 2956

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 530374274  762 TLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHP 800
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1535-1626 1.03e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1535 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNP 1612
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 530374274 1613 LGEGPVSNTVAFST 1626
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1536-1616 1.43e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.43e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   1536 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQMTNQTFS-TVENLKPNTSYEFQVKPKNPL 1613
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 530374274   1614 GEG 1616
Cdd:smart00060   81 GEG 83
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1115-1362 1.94e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.69  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1115 PVTSPSLEMTESQPVSDVLESvtlstESPKETIAPAKTDYVYPTAKaPLWPEEPKTEVVESITYVSEPPETTLAPK---- 1190
Cdd:PTZ00449  520 PPKAPGDKEGEEGEHEDSKES-----DEPKEGGKPGETKEGEVGKK-PGPAKEHKPSKIPTLSKKPEFPKDPKHPKdpee 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1191 ----QTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTA--KPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPvlqpvtf 1264
Cdd:PTZ00449  594 pkkpKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESpkSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPP------- 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1265 rFEPPKTTiapletrgiPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPhrfYTTVRPRTSDKPH 1344
Cdd:PTZ00449  667 -FDPKFKE---------KFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRP---LPPKLPRDEEFPF 733

                         250
                  ....*....|....*...
gi 530374274 1345 IRPvlnrttTRPTRPKPS 1362
Cdd:PTZ00449  734 EPI------GDPDAEQPD 745
fn3 pfam00041
Fibronectin type III domain;
1536-1619 4.30e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 4.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  1536 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQMTNQTFS-TVENLKPNTSYEFQVKPKNP 1612
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 530374274  1613 LGEGPVS 1619
Cdd:pfam00041   79 GGEGPPS 85
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 533-980 5.18e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 5.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  533 ERTTSAGTITPKISKSPEPTWTT-----PAPGKTQFISLKPKIPLSPEVTHTKPAP-EPQTLLPSQSTIGPETPGTKPST 606
Cdd:PTZ00449  533 EHEDSKESDEPKEGGKPGETKEGevgkkPGPAKEHKPSKIPTLSKKPEFPKDPKHPkDPEEPKKPKRPRSAQRPTRPKSP 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  607 TLaprktkrpgrrprprprpktTPSPEVPKSKPALEPATIQPEPLVPTtaskpseRPKTTHRPDAPQIQPGSKPPKQllP 686
Cdd:PTZ00449  613 KL--------------------PELLDIPKSPKRPESPKSPKRPPPPQ-------RPSSPERPEGPKIIKSPKPPKS--P 663

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  687 KPqttaepdmpptksvsepvPFEteaPSMTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPrpetLQTK 766
Cdd:PTZ00449  664 KP------------------PFD---PKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTP----FTTP 718

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  767 LDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLVPATILEPVLRTEASGTTAAPKVPQRTHRPHPKPKTTLS 846
Cdd:PTZ00449  719 RPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDS 798

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  847 PEELQTElvpATIFEPVSPIKEAPGTTF-VPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVpa 925
Cdd:PTZ00449  799 PSEHEDK---PPGDHPSLPKKRHRLDGLaLSTTDLESDAGRIAKDASGKIVKLKRSKSFDDLTTVEEAEEMGAEARKI-- 873

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530374274  926 tVLEPVTLRPEASTTLASKTSQ----RTRRPRLRTKTTPRPEAPESKPVPTAELKPVTL 980
Cdd:PTZ00449  874 -VVDDDGTEADDEDTHPPEEKHksevRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSII 931
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1161-1557 2.20e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1161 APLWPEEPKTEVVESITYVSEPPETTLAPKQTPRAPPKPKTSPRP-----RIPQTQPVPKVPQRVTAKPKTSPSPEVSYT 1235
Cdd:PHA03247 2591 APPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRL 2670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1236 TPAPKDVLLPHKPYPEVSQsePVLQPVTFRFEPP-----------------KTTIAPLETRGIPFIPMISPSPSQEELQT 1298
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAAR--PTVGSLTSLADPPpppptpepaphalvsatPLPPGPAAARQASPALPAAPAPPAVPAGP 2748

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1299 TLEETDQSTQEPFTTKIPRTTelakttqAPHRFYTTVRPRTSDKPHIRPVLNRTTTRPTRPKPSGMP---SGNGVGTGVK 1375
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAP-------APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPaavLAPAAALPPA 2821

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1376 QAPRPSGADRNVSVDSTHPTKKPGTRRPPLP-----------------PRPTHPRRKPLPPNNVTGKPGSAGIISSGPIT 1438
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALP 2901

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1439 TPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRfkgPHVRYIQKPDNSPCSITDSVKR 1518
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS---GAVPQPWLGALVPGRVAVPRFR 2978

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 530374274 1519 FPkEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 1557
Cdd:PHA03247 2979 VP-QPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
fn3 pfam00041
Fibronectin type III domain;
123-202 5.64e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 5.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   123 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPND-RFYTIRYREKDKEKKWIFQICPATET--IVENLKPNTVYEF 199
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 530374274   200 GVK 202
Cdd:pfam00041   72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 124-202 5.68e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.68e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274    124 PLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPNDRFYTIRYREKDKEKKWIFQICPA----TETIVENLKPNTVYEF 199
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTEYEF 72


                    ...
gi 530374274    200 GVK 202
Cdd:smart00060   73 RVR 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1352-1631 6.77e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1352 TTTRPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGI 1431
Cdd:COG3401    48 TKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1432 ISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNS--- 1508
Cdd:COG3401   128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTyyy 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1509 -PCSITDSVKRFPKEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQMT 1587
Cdd:COG3401   208 rVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATV 282

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 530374274 1588 NQTFSTVENLKPNTSYEFQVKPKNPLG-EGPVSNTVAFSTESADP 1631
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1530-1674 7.89e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1530 TSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqmtNQTFSTVENLKPNTSYEFQV 1607
Cdd:COG3401   324 LTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKV 397

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530374274 1608 KPKNPLG-EGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1674
Cdd:COG3401   398 TAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 831-1216 8.09e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 8.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  831 PQRTHRPHPKPKTTLSPEELQTELVPATIFEPVSPikEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPK 910
Cdd:PTZ00449  563 PAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKP--KRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ 640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  911 TTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTprpeapeskpVPTAELKPVTLRTETWVTTQA 990
Cdd:PTZ00449  641 RPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKET----------KTTVVLDESFESILKETLPET 710

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  991 PKTSQRTRRPRPktkttpsPEVPQTKLVPSTDLEPGTlrteAPKTMVVTTVLEPDTFRTKFPETT----LAPKTQRTRRP 1066
Cdd:PTZ00449  711 PGTPFTTPRPLP-------PKLPRDEEFPFEPIGDPD----AEQPDDIEFFTPPEEERTFFHETPadtpLPDILAEEFKE 779

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1067 RPRPKTTSSPEVPQNKSVSVTGFEPVVHST---------DAPGTTFALTELQT---LILKPVTSPSLEMTESQPVSDvle 1134
Cdd:PTZ00449  780 EDIHAETGEPDEAMKRPDSPSEHEDKPPGDhpslpkkrhRLDGLALSTTDLESdagRIAKDASGKIVKLKRSKSFDD--- 856

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1135 svtLSTESPKETIAPAKTDYVYptakaplwpEEPKTEVVESITYVSEPPETTLA----PKQTPRAPPKPKTSPRPRIPQT 1210
Cdd:PTZ00449  857 ---LTTVEEAEEMGAEARKIVV---------DDDGTEADDEDTHPPEEKHKSEVrrrrPPKKPSKPKKPSKPKKPKKPDS 924


                  ....*.
gi 530374274 1211 QPVPKV 1216
Cdd:PTZ00449  925 AFIPSI 930
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 657-1028 1.18e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  657 SKPSERPKTTHRPDAPQIQPGSKPPKqllpkPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVTvrTEATVTT 736
Cdd:PTZ00449  537 SKESDEPKEGGKPGETKEGEVGKKPG-----PAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRS--AQRPTRP 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  737 LAPKTSQRTRTRRPRPKHKTTPRPETlqtkldfgPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEV-PQTK-LVPATILE 814
Cdd:PTZ00449  610 KSPKLPELLDIPKSPKRPESPKSPKR--------PPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFdPKFKeKFYDDYLD 681

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  815 PVLRTEASGTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVP------ATIFEPV-SPIKEAPGTTFVPVTDLEPVTFRT 887
Cdd:PTZ00449  682 AAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPklprdeEFPFEPIgDPDAEQPDDIEFFTPPEEERTFFH 761

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  888 EIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPvpatvLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRpEAPES 967
Cdd:PTZ00449  762 ETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRP-----DSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL-ESDAG 835

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  968 KPVPTAELKPVTLR-----------------------------------TETWVTTQAPKTSQRTRRPRPKTKTTPSPEV 1012
Cdd:PTZ00449  836 RIAKDASGKIVKLKrsksfddlttveeaeemgaearkivvdddgteaddEDTHPPEEKHKSEVRRRRPPKKPSKPKKPSK 915

                         410
                  ....*....|....*.
gi 530374274 1013 PQTKLVPSTDLEPGTL 1028
Cdd:PTZ00449  916 PKKPKKPDSAFIPSII 931
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 639-707 1.25e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.64  E-value: 1.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530374274  639 PALEPATIQPEPLVPTtASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVP 707
Cdd:PRK14950  362 PVPAPQPAKPTAAAPS-PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAP 429
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1085-1275 1.58e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1085 SVTgfEPVVHSTDAPGTTFALTELQTLILKPVTSPSLEMTESQPVSDVLESVTLSTESPkeTIAPAKTDyvYPTAKAPLW 1164
Cdd:PRK10263  315 PIT--EPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEP--VIAPAPEG--YPQQSQYAQ 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1165 PEEPKTEVVESiTYVSEPPETTLAPKQTPRAPPKPKTSPRPrIPQTQPVPKVPQRVTAKPKTSPSPEVSYttpAPKDVLL 1244
Cdd:PRK10263  389 PAVQYNEPLQQ-PVQPQQPYYAPAAEQPAQQPYYAPAPEQP-AQQPYYAPAPEQPVAGNAWQAEEQQSTF---APQSTYQ 463

                         170       180       190
                  ....*....|....*....|....*....|..
gi 530374274 1245 PHKPYPE-VSQSEPVLQPvtfRFEPPKTTIAP 1275
Cdd:PRK10263  464 TEQTYQQpAAQEPLYQQP---QPVEQQPVVEP 492
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 992-1366 1.60e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  992 KTSQRTRRPRPKTKTTPSPEVPQTKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPETTLAPKTQRTRRPRPRPK 1071
Cdd:PTZ00449  528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1072 TTSSPEVPQNKSVSVTGFEPvvHSTDAPgttfaltelqtlilKPVTSPSLEMTESQPVSDVLESVTLSTESPKETIAPAK 1151
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRP--ESPKSP--------------KRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKF 671

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1152 TDYVYPT-AKAPLWPEEPKTEVVESITYVSEPPETTLAPKQTPRAPPKPKTSPRPRIPQT--QPV--PKVPQRVTAKPKT 1226
Cdd:PTZ00449  672 KEKFYDDyLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFpfEPIgdPDAEQPDDIEFFT 751

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1227 SPSPEVSYTTPAPKDVLLPHKPYPEVsQSEPVLQPVTFRFEPPKTTIAPLE-----TRGIPFIPMISPSPSQEELQTTLE 1301
Cdd:PTZ00449  752 PPEEERTFFHETPADTPLPDILAEEF-KEEDIHAETGEPDEAMKRPDSPSEhedkpPGDHPSLPKKRHRLDGLALSTTDL 830

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1302 ETD------QSTQEPFTTKIPRT-TELAKTTQAPH---------------------------RFYTTVRPRTSDKPHIRP 1347
Cdd:PTZ00449  831 ESDagriakDASGKIVKLKRSKSfDDLTTVEEAEEmgaearkivvdddgteaddedthppeeKHKSEVRRRRPPKKPSKP 910

                         410
                  ....*....|....*....
gi 530374274 1348 VLNRTTTRPTRPKPSGMPS 1366
Cdd:PTZ00449  911 KKPSKPKKPKKPDSAFIPS 929
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
890-1058 2.20e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  890 PATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEA-----STTLASKTSQRTRRPRLRTKTTPRPEA 964
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAaparrSPAPEALAAARQASARGPGGAPAPAPA 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  965 PESKPVPTAELKPVTLRTETWVTTQAPKTSQRTRRPRPKTKTTPS-PEVPQTKLVPS-TDLEPGTLRTEAPKTMVVTTVL 1042
Cdd:PRK12323  454 PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPwEELPPEFASPApAQPDAAPAGWVAESIPDPATAD 533

                         170
                  ....*....|....*.
gi 530374274 1043 EPDTFRTKFPETTLAP 1058
Cdd:PRK12323  534 PDDAFETLAPAPAAAP 549
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 692-1242 2.24e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  692 AEPDMPptksvSEPVPFETEAPSMtivPTTDIEPVT-VRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFG 770
Cdd:PRK10263  337 VEPVTQ-----TPPVASVDVPPAQ---PTVAWQPVPgPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYY 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  771 PITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPqtklvpatILEPVLRTEASGTTAAPKVPQRTHRPHPKPKTTLSPEEL 850
Cdd:PRK10263  409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQP--------VAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQ 480

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  851 QTELVPATIFEPVsPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATktskrTRPPRPRPKTTPSPQAPETKPVPATVLEP 930
Cdd:PRK10263  481 PQPVEQQPVVEPE-PVVEETKPARPPLYYFEEVEEKRAREREQLAA-----WYQPIPEPVKEPEPIKSSLKAPSVAAVPP 554

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  931 VTLRPeASTTLASKTSQRTrrprLRTKTTPRPEAPESKPVPTAELKPvtlRTETWVTTQAPKtSQRTRRPRPKTKTTPSP 1010
Cdd:PRK10263  555 VEAAA-AVSPLASGVKKAT----LATGAAATVAAPVFSLANSGGPRP---QVKEGIGPQLPR-PKRIRVPTRRELASYGI 625

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1011 EVPQTKLVPSTDLEPGTLRTEAPKTMVVTTV--LEPDTFRTKFPETTLAP--KTQRTRRPRPRPKTTSSPEVPQNKSVSV 1086
Cdd:PRK10263  626 KLPSQRAAEEKAREAQRNQYDSGDQYNDDEIdaMQQDELARQFAQTQQQRygEQYQHDVPVNAEDADAAAEAELARQFAQ 705

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1087 TGFEPVVHSTDAPGTTFALTELQTLILK---------PVTSPSLeMTESQPVSDVlesVTLSTESPKETIAPAKTDYVYP 1157
Cdd:PRK10263  706 TQQQRYSGEQPAGANPFSLDDFEFSPMKallddgphePLFTPIV-EPVQQPQQPV---APQQQYQQPQQPVAPQPQYQQP 781

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1158 TAKAPLWPEEPKTEVVESITYVSEPPETTLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKP------------- 1224
Cdd:PRK10263  782 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLHPllmrngdsrplhk 861

                         570
                  ....*....|....*...
gi 530374274 1225 KTSPSPEVSYTTPAPKDV 1242
Cdd:PRK10263  862 PTTPLPSLDLLTPPPSEV 879
PHA03247 PHA03247
large tegument protein UL36; Provisional
 264-587 2.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  264 DSAKSPEKAPlggvilvHLIIPGLNETTVKLPASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVP 343
Cdd:PHA03247 2703 PPPPTPEPAP-------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  344 RSTKPTTSSALDVSETTLVL----SKRTPETLQTILIPQFELPLSTLAPKSLPEFPEAKTPFPFEKPRGTLASSEKP--W 417
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESReslpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggS 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  418 IVPTAKISEDSKVLQPQTatydvfsSPTTSDEPEISdsytatsdRILDSIPPKTSRTLEQPRATLAPSETPFVPQKleif 497
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAA-------KPAAPARPPVR--------RLARPAVSRSTESFALPPDQPERPPQPQAPPP---- 2916

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  498 tsPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKperTTSAGTITPKIsksPEPTWTTPAPGKTQFISLKpkiplSPEVT 577
Cdd:PHA03247 2917 --PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---PAGAGEPSGAV---PQPWLGALVPGRVAVPRFR-----VPQPA 2983

                         330
                  ....*....|
gi 530374274  578 HTKPAPEPQT 587
Cdd:PHA03247 2984 PSREAPASST 2993
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-202 2.83e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  123 KPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpndrFYTIRYREKDKE--KKWIFQICPATETIVENLKPNTVYEFG 200
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFR 73


                  ..
gi 530374274  201 VK 202
Cdd:cd00063    74 VR 75
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1103-1291 3.54e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1103 FALTELQTLILKPVTSPSlemtESQPVSDVLESVTLSTE--SPKETIAPAKTDYVYPTAKAPLwPEEPKTEVVESITYVS 1180
Cdd:PRK12323  353 FTMTLLRMLAFRPGQSGG----GAGPATAAAAPVAQPAPaaAAPAAAAPAPAAPPAAPAAAPA-AAAAARAVAAAPARRS 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1181 EPPETTLAPKQ------------TPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKP 1248
Cdd:PRK12323  428 PAPEALAAARQasargpggapapAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA 507

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530374274 1249 YPEVSQSEPVLQPV---------------TFRFEPPKTTIAPLETRGIPFIPMISPSP 1291
Cdd:PRK12323  508 SPAPAQPDAAPAGWvaesipdpatadpddAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 565-1009 4.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 4.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   565 SLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEP- 643
Cdd:pfam03154  143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTq 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   644 ATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTksvsePVPFETEAPSMtivpttdi 723
Cdd:pfam03154  223 STAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPM-----PHSLQTGPSHM-------- 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   724 ePVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETlqtkldfgpiTPGTSSAPTTTTKRTRRPHPKPKTTPHPEVP 803
Cdd:pfam03154  290 -QHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHT----------PPSQSQLQSQQPPREQPLPPAPLSMPHIKPP 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   804 QtklvpatilepvlrteasgTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVPATIFEPVSPIK-EAPGTTFVPVTDLEP 882
Cdd:pfam03154  359 P-------------------TTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLStHHPPSAHPPPLQLMP 419

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   883 VTFRTEIPATT--LATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTlRPEASTTLASKTSQRTRRPRLRTKTTP 960
Cdd:pfam03154  420 QSQQLPPPPAQppVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGG-PPPITPPSGPPTSTSSAMPGIQPPSSA 498

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530374274   961 RPEAPESKP-VPTAELKPVTLRTETWVTTQAPKT---SQRTRRPRPKTKTTPS 1009
Cdd:pfam03154  499 SVSSSGPVPaAVSCPLPPVQIKEEALDEAEEPESpppPPRSPSPEPTVVNTPS 551
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 582-1021 6.15e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 6.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   582 APEPQTLLPSQSTIGPETPGTK---PSTTLAPRKTKRPGRRPRPRPRPKTTpSPEVPKSKPALEPATIQPEPLVPTTASK 658
Cdd:pfam05109  424 APESTTTSPTLNTTGFAAPNTTtglPSSTHVPTNLTAPASTGPTVSTADVT-SPTPAGTTSGASPVTPSPSPRDNGTESK 502

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   659 PSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEP--DMPPTKSVSEPVPFETEAPSMTIVPTTDiepvtvrteATVTT 736
Cdd:pfam05109  503 APDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTlgKTSPTSAVTTPTPNATSPTPAVTTPTPN---------ATIPT 573

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   737 LApKTSqrtrtrrprpkhkttprpetlqtkldfgPITPGTSSAPTTTTKRTRRPHPKPKTTPHPevpqtklVPATILEPV 816
Cdd:pfam05109  574 LG-KTS----------------------------PTSAVTTPTPNATSPTVGETSPQANTTNHT-------LGGTSSTPV 617

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   817 LRTEASGTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVPATIFEPVSPIkeaPGTTFVPVTDLEPVTFRTEIPATTLAT 896
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHM---PLLTSAHPTGGENITQVTPASTSTHHV 694

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   897 KTSkRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTK------------TTPRPEA 964
Cdd:pfam05109  695 STS-SPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTggkansttggkhTTGHGAR 773

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 530374274   965 PESKPVPTAELKPVTLRTETWVTTQAPKTSQRTRRPRPKTKTTPSPEVPQTKLVPST 1021
Cdd:pfam05109  774 TSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPT 830
PRK11633 PRK11633
cell division protein DedD; Provisional
 1179-1240 6.62e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 6.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530374274 1179 VSEPPETTLAPKQTPRAPPKPKtsPRPRiPQTQPVPKVPQRVTAKPKTSPSPEVSyTTPAPK 1240
Cdd:PRK11633   89 TVAPPNTPVEPEPAPVEPPKPK--PVEK-PKPKPKPQQKVEAPPAPKPEPKPVVE-EKAAPT 146
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
568-794 6.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  568 PKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRktkrpgrrprprprpKTTPSPEVPKSKPALEPATIQ 647
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR---------------AVAAAPARRSPAPEALAAARQ 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  648 PEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVT 727
Cdd:PRK12323  439 ASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAP 518

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530374274  728 VRTEAtvttlapktsqrtrtrrprpkhKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKP 794
Cdd:PRK12323  519 AGWVA----------------------ESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 1183-1261 7.88e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.08  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274 1183 PETTLAPKQTPRAPPKPKTSPRP-RIPQTQPVPKVPQRVTAKPKTSPSPEVSYT----TPAPKDVLLPHKPYPEVSQSEP 1257
Cdd:PRK14954  376 NDGGVAPSPAGSPDVKKKAPEPDlPQPDRHPGPAKPEAPGARPAELPSPASAPTpeqqPPVARSAPLPPSPQASAPRNVA 455


                  ....
gi 530374274 1258 VLQP 1261
Cdd:PRK14954  456 SGKP 459
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 726-1039 8.18e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.71  E-value: 8.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   726 VTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKldfGPITPGTSSAPTTTTKRTRRPH-PKPKTTPHPEVPQ 804
Cdd:pfam17823   86 VTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSSA---AQSLPAAIAALPSEAFSAPRAAaCRANASAAPRAAI 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   805 TKLVPATILEPVLRTEASGTTAAPKVPQRTHRPHPKPKTTlspeelqtelvPATIFePVSPIKEAPGTTFVPVTDlepvT 884
Cdd:pfam17823  163 AAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSA-----------PATLT-PARGISTAATATGHPAAG----T 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   885 FRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVL---EPVTLRPEASTTLASKTSQRTRRPRLRTK---- 957
Cdd:pfam17823  227 ALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTInmgDPHARRLSPAKHMPSDTMARNPAAPMGAQaqgp 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   958 ------------TTPRPE-APESKPVPTAELKPVTLRTETWVTTQAPKTSQRTRRPRPKTKTTPSPEVPQTKLVPSTDLE 1024
Cdd:pfam17823  307 iiqvstdqpvhnTAGEPTpSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPL 386

                          330
                   ....*....|....*
gi 530374274  1025 PGTLRTEAPKTMVVT 1039
Cdd:pfam17823  387 LPTQGAAGPGILLAP 401
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 540-774 8.48e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  540 TITPKIskSPEPTWTTPAPGKTQfislkpkiplsPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRR 619
Cdd:PRK10263  368 TGEPVI--APAPEGYPQQSQYAQ-----------PAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  620 PRPRPRPKTTPSPEVPKSKPALEP-ATIQPEPLV--PTTASKPSERPKTTHRPDAPQIQPG------SKPP--------- 681
Cdd:PRK10263  435 APAPEQPVAGNAWQAEEQQSTFAPqSTYQTEQTYqqPAAQEPLYQQPQPVEQQPVVEPEPVveetkpARPPlyyfeevee 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274  682 ------KQLLPKPQTTAEPDMPPtksvsEPVPFETEAPSMTIVPTTDIEPVTVRTEATV--TTLAPKTSQRTRTRRPRPK 753
Cdd:PRK10263  515 krarerEQLAAWYQPIPEPVKEP-----EPIKSSLKAPSVAAVPPVEAAAAVSPLASGVkkATLATGAAATVAAPVFSLA 589

                         250       260
                  ....*....|....*....|.
gi 530374274  754 HKTTPRPetlQTKLDFGPITP 774
Cdd:PRK10263  590 NSGGPRP---QVKEGIGPQLP 607
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 467-839 9.61e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 9.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   467 IPPKTSRTLEQPRATLAP-SETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKI 545
Cdd:pfam03154  182 SPPSPPPPGTTQAATAGPtPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   546 SKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAprKTKRPGRRPRPRPR 625
Cdd:pfam03154  262 SPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRI--HTPPSQSQLQSQQP 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   626 PKTTPSPEVPKSKPALEPATIQPEPLVPTTASKpsERPKTTHRPDAPQIQPGSKPPKQLlpKPQTTAEPDMPPTksvSEP 705
Cdd:pfam03154  340 PREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSH--KHPPHLSGPSPFQMNSNLPPPPAL--KPLSSLSTHHPPS---AHP 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374274   706 VPFETEAPSMTIVPTTDIEPVTVRTEATVTTLA----PKTSQRTRTRRPRPKHKTTPRPETLQTKldfgPITPGTSSAPT 781
Cdd:pfam03154  413 PPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAAshppTSGLHQVPSQSPFPQHPFVPGGPPPITP----PSGPPTSTSSA 488

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530374274   782 TTTKRTRRPHPKPKTTPHPEVPQTKLVPATILEPVLrtEASGTTAAPKVPQRTHRPHP 839
Cdd:pfam03154  489 MPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEAL--DEAEEPESPPPPPRSPSPEP 544
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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