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Conserved domains on  [gi|530370327|ref|XP_005246599|]
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transcription factor Sp5 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SP5_N cd22541
N-terminal domain of transcription factor Specificity Protein (SP) 5; Specificity Proteins ...
 150-341 9.35e-21

N-terminal domain of transcription factor Specificity Protein (SP) 5; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. All of them contain clade SP5, which plays a potential role in human cancers and was found in several human tumors including hepatocellular carcinoma, gastric cancer, and colon cancer. Leukemia inhibitor factor/Stat3 and Wnt/beta-catenin signaling pathways converge on SP5 to promote mouse embryonic stem cell self-renewal. SP5 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP5.


:

Pssm-ID: 412096 [Multi-domain]  Cd Length: 143  Bit Score: 88.00  E-value: 9.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 150 GAAHELPLTPPADPS------YPYEFSPVKMLPSSMAALPASCAPAYVPYAAQaalppgysnllpppppppppPTCRQLS 223
Cdd:cd22541    1 MAPHELPLTPPAEPSfhqslaYSFELSPVKMLPTPAPAPAASAPPHPSPVSSP--------------------TQQPQQL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 224 PNPAPDDLPWWSIPQAGAGPGASGVPGsglsgacagaphaprfpasaaaaaaaaaalqrglvLGPSDFAQYQSQIAALLQ 303
Cdd:cd22541   61 PPNPADDIPWWSIQQSNPAHPPSTSTP-----------------------------------LGHPTFAGYQPQIAALLQ 105

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 530370327 304 TKAPLA--ATARRCRRCRCPNCQAAGGapEAEPGKKKQHV 341
Cdd:cd22541  106 TKSPAAslSTTRRCRRCRCPNCQNPST--SSEPGKKKQHI 143
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-409 1.11e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 1.11e-07
                          10        20
                  ....*....|....*....|....
gi 530370327  386 ELQRHLRTHTGEKRFACPECGKRF 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 19-267 1.95e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   19 DHGAGRGPSDASPShfAPASSKAGWRLSAPSSLARSARGPHVQDRTPSASPDLGKHSPLALLAATCSRIGQP-GAAAPPD 97
Cdd:PHA03247 2604 DRGDPRGPAPPSPL--PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaQASSPPQ 2681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   98 FLQVP-YDPALGSPSRLfhpwtADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTP--PADPSYPyefspvkM 174
Cdd:PHA03247 2682 RPRRRaARPTVGSLTSL-----ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPapPAVPAGP-------A 2749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  175 LPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLS 254
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829

                         250
                  ....*....|...
gi 530370327  255 GACAGAPHAPRFP 267
Cdd:PHA03247 2830 PPTSAQPTAPPPP 2842
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-428 3.83e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 355 SHLKAHLRW--HTGE--RPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACP--ECGKRFMRSDHLAKHVKTHQNKKLK 428
Cdd:COG5048  303 SPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLK 382
 
Name Accession Description Interval E-value
SP5_N cd22541
N-terminal domain of transcription factor Specificity Protein (SP) 5; Specificity Proteins ...
 150-341 9.35e-21

N-terminal domain of transcription factor Specificity Protein (SP) 5; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. All of them contain clade SP5, which plays a potential role in human cancers and was found in several human tumors including hepatocellular carcinoma, gastric cancer, and colon cancer. Leukemia inhibitor factor/Stat3 and Wnt/beta-catenin signaling pathways converge on SP5 to promote mouse embryonic stem cell self-renewal. SP5 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP5.


Pssm-ID: 412096 [Multi-domain]  Cd Length: 143  Bit Score: 88.00  E-value: 9.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 150 GAAHELPLTPPADPS------YPYEFSPVKMLPSSMAALPASCAPAYVPYAAQaalppgysnllpppppppppPTCRQLS 223
Cdd:cd22541    1 MAPHELPLTPPAEPSfhqslaYSFELSPVKMLPTPAPAPAASAPPHPSPVSSP--------------------TQQPQQL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 224 PNPAPDDLPWWSIPQAGAGPGASGVPGsglsgacagaphaprfpasaaaaaaaaaalqrglvLGPSDFAQYQSQIAALLQ 303
Cdd:cd22541   61 PPNPADDIPWWSIQQSNPAHPPSTSTP-----------------------------------LGHPTFAGYQPQIAALLQ 105

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 530370327 304 TKAPLA--ATARRCRRCRCPNCQAAGGapEAEPGKKKQHV 341
Cdd:cd22541  106 TKSPAAslSTTRRCRRCRCPNCQNPST--SSEPGKKKQHI 143
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-409 1.11e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 1.11e-07
                          10        20
                  ....*....|....*....|....
gi 530370327  386 ELQRHLRTHTGEKRFACPECGKRF 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA03247 PHA03247
large tegument protein UL36; Provisional
 19-267 1.95e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   19 DHGAGRGPSDASPShfAPASSKAGWRLSAPSSLARSARGPHVQDRTPSASPDLGKHSPLALLAATCSRIGQP-GAAAPPD 97
Cdd:PHA03247 2604 DRGDPRGPAPPSPL--PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaQASSPPQ 2681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   98 FLQVP-YDPALGSPSRLfhpwtADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTP--PADPSYPyefspvkM 174
Cdd:PHA03247 2682 RPRRRaARPTVGSLTSL-----ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPapPAVPAGP-------A 2749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  175 LPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLS 254
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829

                         250
                  ....*....|...
gi 530370327  255 GACAGAPHAPRFP 267
Cdd:PHA03247 2830 PPTSAQPTAPPPP 2842
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-428 3.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 355 SHLKAHLRW--HTGE--RPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACP--ECGKRFMRSDHLAKHVKTHQNKKLK 428
Cdd:COG5048  303 SPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLK 382
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-383 4.44e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.44e-05
                          10        20
                  ....*....|....*....|....*...
gi 530370327  356 HLKAHLRWHTGERPFVCNwlFCGKSFTR 383
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
SP1-4_N cd22545
N-terminal domain of transcription factor Specificity Proteins (SP) 1-4; Specificity Proteins ...
 75-95 2.52e-04

N-terminal domain of transcription factor Specificity Proteins (SP) 1-4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. SPs belong to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP1-4.


Pssm-ID: 411777 [Multi-domain]  Cd Length: 82  Bit Score: 39.73  E-value: 2.52e-04
                         10        20
                 ....*....|....*....|.
gi 530370327  75 SPLALLAATCSRIGQPGAAAP 95
Cdd:cd22545   10 SPLALLAATCSKIGSPAENST 30
ZnF_C2H2 smart00355
zinc finger;
400-422 1.43e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 530370327   400 FACPECGKRFMRSDHLAKHVKTH 422
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 369-422 1.92e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 1.92e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530370327 369 PFVCNwlFCGKSFTRSDELQRHLRTHTGEKrfACPECGKRFMRSDHLAKHV-KTH 422
Cdd:PHA00733  73 PYVCP--LCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVcKKH 123
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 368-428 1.94e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530370327 368 RPFvCnWlFCGKSFtrSDE--LQRHLRthtgEKRFACPECGKRFMRSDHLAKHVKTHQNKKLK 428
Cdd:cd20908    1 KPW-C-Y-YCDREF--DDEkiLIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQVHKETLT 54
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 15-264 5.77e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.13  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   15 PTLTDHGAGRGPSDASPSHFAPASSKAGWRLSAPSSLARS------ARGPHVQDRTPSA-SPDLGKHSPLALLAATcsri 87
Cdd:pfam05109 476 PTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTptpnatSPTPAVTTPTPNAtSPTLGKTSPTSAVTTP---- 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   88 gQPGAAAPPDFLQVPYD----PALGSPSRlfhpwTADMPAHSPGAlppPHPSLGLT-PQKTHLQPSFGAAHELPL--TPP 160
Cdd:pfam05109 552 -TPNATSPTPAVTTPTPnatiPTLGKTSP-----TSAVTTPTPNA---TSPTVGETsPQANTTNHTLGGTSSTPVvtSPP 622

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  161 ADPSYPY---EFSPVKMLPSSMAALPASCAPAYVPYAAQ----------AALPPGYSNLLPPPPPPPPPPTCRQLSPNPA 227
Cdd:pfam05109 623 KNATSAVttgQHNITSSSTSSMSLRPSSISETLSPSTSDnstshmplltSAHPTGGENITQVTPASTSTHHVSTSSPAPR 702

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 530370327  228 PddlpwwSIPQAGAGPGASGV---PGS-----GLSGACAGAPHAP 264
Cdd:pfam05109 703 P------GTTSQASGPGNSSTstkPGEvnvtkGTPPKNATSPQAP 741
 
Name Accession Description Interval E-value
SP5_N cd22541
N-terminal domain of transcription factor Specificity Protein (SP) 5; Specificity Proteins ...
 150-341 9.35e-21

N-terminal domain of transcription factor Specificity Protein (SP) 5; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. All of them contain clade SP5, which plays a potential role in human cancers and was found in several human tumors including hepatocellular carcinoma, gastric cancer, and colon cancer. Leukemia inhibitor factor/Stat3 and Wnt/beta-catenin signaling pathways converge on SP5 to promote mouse embryonic stem cell self-renewal. SP5 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP5.


Pssm-ID: 412096 [Multi-domain]  Cd Length: 143  Bit Score: 88.00  E-value: 9.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 150 GAAHELPLTPPADPS------YPYEFSPVKMLPSSMAALPASCAPAYVPYAAQaalppgysnllpppppppppPTCRQLS 223
Cdd:cd22541    1 MAPHELPLTPPAEPSfhqslaYSFELSPVKMLPTPAPAPAASAPPHPSPVSSP--------------------TQQPQQL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 224 PNPAPDDLPWWSIPQAGAGPGASGVPGsglsgacagaphaprfpasaaaaaaaaaalqrglvLGPSDFAQYQSQIAALLQ 303
Cdd:cd22541   61 PPNPADDIPWWSIQQSNPAHPPSTSTP-----------------------------------LGHPTFAGYQPQIAALLQ 105

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 530370327 304 TKAPLA--ATARRCRRCRCPNCQAAGGapEAEPGKKKQHV 341
Cdd:cd22541  106 TKSPAAslSTTRRCRRCRCPNCQNPST--SSEPGKKKQHI 143
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-409 1.11e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 1.11e-07
                          10        20
                  ....*....|....*....|....
gi 530370327  386 ELQRHLRTHTGEKRFACPECGKRF 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA03247 PHA03247
large tegument protein UL36; Provisional
 19-267 1.95e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   19 DHGAGRGPSDASPShfAPASSKAGWRLSAPSSLARSARGPHVQDRTPSASPDLGKHSPLALLAATCSRIGQP-GAAAPPD 97
Cdd:PHA03247 2604 DRGDPRGPAPPSPL--PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaQASSPPQ 2681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   98 FLQVP-YDPALGSPSRLfhpwtADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTP--PADPSYPyefspvkM 174
Cdd:PHA03247 2682 RPRRRaARPTVGSLTSL-----ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPapPAVPAGP-------A 2749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  175 LPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLS 254
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829

                         250
                  ....*....|...
gi 530370327  255 GACAGAPHAPRFP 267
Cdd:PHA03247 2830 PPTSAQPTAPPPP 2842
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-428 3.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 355 SHLKAHLRW--HTGE--RPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACP--ECGKRFMRSDHLAKHVKTHQNKKLK 428
Cdd:COG5048  303 SPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLK 382
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-383 4.44e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.44e-05
                          10        20
                  ....*....|....*....|....*...
gi 530370327  356 HLKAHLRWHTGERPFVCNwlFCGKSFTR 383
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 400-422 4.85e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 4.85e-05
                          10        20
                  ....*....|....*....|...
gi 530370327  400 FACPECGKRFMRSDHLAKHVKTH 422
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 370-394 7.17e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 7.17e-05
                          10        20
                  ....*....|....*....|....*
gi 530370327  370 FVCNwlFCGKSFTRSDELQRHLRTH 394
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-426 1.18e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530370327 372 CNWLFCGKSFTRSDELQRHLRT--HTGE--KRFACPE--CGKRFMRSDHLAKHVKTHQNKK 426
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
SP1-4_N cd22545
N-terminal domain of transcription factor Specificity Proteins (SP) 1-4; Specificity Proteins ...
 75-95 2.52e-04

N-terminal domain of transcription factor Specificity Proteins (SP) 1-4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. SPs belong to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP1-4.


Pssm-ID: 411777 [Multi-domain]  Cd Length: 82  Bit Score: 39.73  E-value: 2.52e-04
                         10        20
                 ....*....|....*....|.
gi 530370327  75 SPLALLAATCSRIGQPGAAAP 95
Cdd:cd22545   10 SPLALLAATCSKIGSPAENST 30
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
368-427 3.57e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530370327 368 RPFVCNwlFCGKSFTRSDELQRHLRTHTGEKRFAC--PECGKRFMRSDHLAKHVKTHQNKKL 427
Cdd:COG5048   32 RPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-418 7.55e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 7.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327 336 KKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTgEKRFACPECGKRFMRSDHL 415
Cdd:COG5048  383 NDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDL 461


                 ...
gi 530370327 416 AKH 418
Cdd:COG5048  462 SNH 464
SP1_N cd22539
N-terminal domain of transcription factor Specificity Protein (SP) 1; Specificity Proteins ...
 75-96 7.77e-04

N-terminal domain of transcription factor Specificity Protein (SP) 1; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP1 has been shown to interact with a variety of proteins including myogenin, SMAD3, SUMO1, SF1, TAL1, and UBC. Some 12,000 SP1 binding sites are found in the human genome. SP1 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLF bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP1.


Pssm-ID: 411775  Cd Length: 433  Bit Score: 41.81  E-value: 7.77e-04
                         10        20
                 ....*....|....*....|..
gi 530370327  75 SPLALLAATCSRIGQPGAAAPP 96
Cdd:cd22539   10 SPLALLAATCSRIESPNENSNS 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 15-266 1.31e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   15 PTLTDHGAGRGPSDASPSHFAPASSKAGwrLSAPSSLARSARGPHV---QDRTPSASPDLGKHSPLALLAATCSRIGQPG 91
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAG--PATPGGPARPARPPTTagpPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   92 AAAPPDFLQVPY--------DPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQ-----KTHLQPSFGAAHELPLT 158
Cdd:PHA03247 2798 LPSPWDPADPPAavlapaaaLPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAA 2877

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  159 PPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDdlpwwsipQ 238
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD--------P 2949

                         250       260
                  ....*....|....*....|....*...
gi 530370327  239 AGAGPGASGVPGSGLSGACAGAPHAPRF 266
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVPGRVAVPRF 2977
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
332-400 1.38e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530370327 332 AEPGKKKQHVChvPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRF 400
Cdd:COG5048   26 SLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSD 92
ZnF_C2H2 smart00355
zinc finger;
400-422 1.43e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 530370327   400 FACPECGKRFMRSDHLAKHVKTH 422
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 369-422 1.92e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 1.92e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530370327 369 PFVCNwlFCGKSFTRSDELQRHLRTHTGEKrfACPECGKRFMRSDHLAKHV-KTH 422
Cdd:PHA00733  73 PYVCP--LCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVcKKH 123
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 368-428 1.94e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530370327 368 RPFvCnWlFCGKSFtrSDE--LQRHLRthtgEKRFACPECGKRFMRSDHLAKHVKTHQNKKLK 428
Cdd:cd20908    1 KPW-C-Y-YCDREF--DDEkiLIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQVHKETLT 54
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 75-108 2.64e-03

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 40.29  E-value: 2.64e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530370327  75 SPLALLAATCSRIGQPGAAAPPDFL-QVPYDPALG 108
Cdd:cd22536   15 SPLALLAATCSKIGTPGENQGAGQQqQIIIDPSQG 49
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 400-422 3.15e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|...
gi 530370327  400 FACPECGKRFMRSDHLAKHVKTH 422
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
ZnF_C2H2 smart00355
zinc finger;
370-394 4.69e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 4.69e-03
                           10        20
                   ....*....|....*....|....*
gi 530370327   370 FVCNWlfCGKSFTRSDELQRHLRTH 394
Cdd:smart00355   1 YRCPE--CGKVFKSKSALREHMRTH 23
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 15-264 5.77e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.13  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   15 PTLTDHGAGRGPSDASPSHFAPASSKAGWRLSAPSSLARS------ARGPHVQDRTPSA-SPDLGKHSPLALLAATcsri 87
Cdd:pfam05109 476 PTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTptpnatSPTPAVTTPTPNAtSPTLGKTSPTSAVTTP---- 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   88 gQPGAAAPPDFLQVPYD----PALGSPSRlfhpwTADMPAHSPGAlppPHPSLGLT-PQKTHLQPSFGAAHELPL--TPP 160
Cdd:pfam05109 552 -TPNATSPTPAVTTPTPnatiPTLGKTSP-----TSAVTTPTPNA---TSPTVGETsPQANTTNHTLGGTSSTPVvtSPP 622

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  161 ADPSYPY---EFSPVKMLPSSMAALPASCAPAYVPYAAQ----------AALPPGYSNLLPPPPPPPPPPTCRQLSPNPA 227
Cdd:pfam05109 623 KNATSAVttgQHNITSSSTSSMSLRPSSISETLSPSTSDnstshmplltSAHPTGGENITQVTPASTSTHHVSTSSPAPR 702

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 530370327  228 PddlpwwSIPQAGAGPGASGV---PGS-----GLSGACAGAPHAP 264
Cdd:pfam05109 703 P------GTTSQASGPGNSSTstkPGEvnvtkGTPPKNATSPQAP 741
CLEC16A_C pfam19439
CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A ...
 35-170 7.48e-03

CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.


Pssm-ID: 466083  Cd Length: 762  Bit Score: 38.71  E-value: 7.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327   35 APASSKagwrlSAPSSLARSARGPHVQDRTPSASpdlGKHSPLALLAATcsrigqPGAAAPPDFLQVPYDPALGSPSRLF 114
Cdd:pfam19439 644 SPLSSP-----SPPSSSSGSGSTGRCDSVTASST---STPSPSDDGSTP------EQPQLPDELAFLDSTPAVSKPGKSS 709

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530370327  115 HPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSfgaAHELPLTPPADPSYPYEFS 170
Cdd:pfam19439 710 ASSETEPAALAPSLTPAPQPTISLLSDDSTDALS---VESLTLLPPADSPHLRSCS 762
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 75-148 7.87e-03

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 38.37  E-value: 7.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370327  75 SPLALLAATCSRIGQPGA------AAPPDFLQ---VPYDPAlgspsrlfhpwtadmpahsPGALPPPHPSLGLTPQKT-- 143
Cdd:cd22540   25 SPLALLAATCSKIGPPAVeaavtpPAPPQPTPrklVPIKPA-------------------PLPLGPGKNSIGFLSAKGni 85


                 ....*.
gi 530370327 144 -HLQPS 148
Cdd:cd22540   86 iQLQGS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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