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Conserved domains on  [gi|530365166|ref|XP_005245440|]
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coiled-coil domain-containing protein 181 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
338-500 2.82e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166  338 RQKELQKQLEEKRE----KLKREEERRKIEEEKEKKRENDIVFKAWLQKKREQVLEMRRIQraKEIEDMNSRQENRDPQQ 413
Cdd:pfam17380 366 RQEEIAMEISRMRElerlQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR--AEQEEARQREVRRLEEE 443
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166  414 AFRLWLKKKHEEQMKERQTEELRKQEECLF---FLKGTEGRERAFKQWLRRKRMEKMAE--QQAVRERTRQLRLEAKRSK 488
Cdd:pfam17380 444 RAREMERVRLEEQERQQQVERLRQQEEERKrkkLELEKEKRDRKRAEEQRRKILEKELEerKQAMIEEERKRKLLEKEME 523
                         170
                  ....*....|..
gi 530365166  489 QLQHHLYMSEAK 500
Cdd:pfam17380 524 ERQKAIYEEERR 535
 
Name Accession Description Interval E-value
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
338-500 2.82e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166  338 RQKELQKQLEEKRE----KLKREEERRKIEEEKEKKRENDIVFKAWLQKKREQVLEMRRIQraKEIEDMNSRQENRDPQQ 413
Cdd:pfam17380 366 RQEEIAMEISRMRElerlQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR--AEQEEARQREVRRLEEE 443
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166  414 AFRLWLKKKHEEQMKERQTEELRKQEECLF---FLKGTEGRERAFKQWLRRKRMEKMAE--QQAVRERTRQLRLEAKRSK 488
Cdd:pfam17380 444 RAREMERVRLEEQERQQQVERLRQQEEERKrkkLELEKEKRDRKRAEEQRRKILEKELEerKQAMIEEERKRKLLEKEME 523
                         170
                  ....*....|..
gi 530365166  489 QLQHHLYMSEAK 500
Cdd:pfam17380 524 ERQKAIYEEERR 535
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
335-491 6.48e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166   335 LSPRQKELQKQLEEKREKLKREEERRKIEEEKEKKRENDIVfkawlQKKREQVLEMRRIQRAK-EIEDMNSRQENRDPQQ 413
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVA-----QLELQIASLNNEIERLEaRLERLEDRRERLQQEI 423
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530365166   414 afRLWLKKKHEEQMKERQTEELRKQEEclffLKGTEGRERAFKQWLRRKRMEKMAEQQAVRERTRQLRLEAKRSKQLQ 491
Cdd:TIGR02168  424 --EELLKKLEEAELKELQAELEELEEE----LEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE 495
 
Name Accession Description Interval E-value
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
338-500 2.82e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166  338 RQKELQKQLEEKRE----KLKREEERRKIEEEKEKKRENDIVFKAWLQKKREQVLEMRRIQraKEIEDMNSRQENRDPQQ 413
Cdd:pfam17380 366 RQEEIAMEISRMRElerlQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR--AEQEEARQREVRRLEEE 443
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166  414 AFRLWLKKKHEEQMKERQTEELRKQEECLF---FLKGTEGRERAFKQWLRRKRMEKMAE--QQAVRERTRQLRLEAKRSK 488
Cdd:pfam17380 444 RAREMERVRLEEQERQQQVERLRQQEEERKrkkLELEKEKRDRKRAEEQRRKILEKELEerKQAMIEEERKRKLLEKEME 523
                         170
                  ....*....|..
gi 530365166  489 QLQHHLYMSEAK 500
Cdd:pfam17380 524 ERQKAIYEEERR 535
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
335-491 6.48e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365166   335 LSPRQKELQKQLEEKREKLKREEERRKIEEEKEKKRENDIVfkawlQKKREQVLEMRRIQRAK-EIEDMNSRQENRDPQQ 413
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVA-----QLELQIASLNNEIERLEaRLERLEDRRERLQQEI 423
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530365166   414 afRLWLKKKHEEQMKERQTEELRKQEEclffLKGTEGRERAFKQWLRRKRMEKMAEQQAVRERTRQLRLEAKRSKQLQ 491
Cdd:TIGR02168  424 --EELLKKLEEAELKELQAELEELEEE----LEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE 495
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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