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Conserved domains on  [gi|767909636|ref|XP_005245348|]
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protoporphyrinogen oxidase isoform X7 [Homo sapiens]

Protein Classification

protoporphyrinogen/coproporphyrinogen oxidase( domain architecture ID 11440906)

protoporphyrinogen/coproporphyrinogen oxidase is a FAD-dependent enzyme that catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX or the oxidation of coproporphyrinogen III to coproporphyrin III, respectively

CATH:  3.50.50.60|3.50.50.60|1.10.3110.10|3.90.660.20
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0006779|GO:0071949
PubMed:  10944103
SCOP:  4000128|3000055|4000128

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-416 1.07e-72

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 237.81  E-value: 1.07e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGAlgaRTLLLVSELGLDS 82
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFLTRDP---EVLELLRELGLGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  83 EVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRRLGPEVASL 161
Cdd:COG1232   76 ELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRRFGREVYER 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 162 AMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------WSLRGGLEM 235
Cdd:COG1232  150 LVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfGYLRGGLGT 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 236 LPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSV 314
Cdd:COG1232  212 LVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAALAGIPYASV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 315 AVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvLSQELFQQR 392
Cdd:COG1232  289 AVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----LSDEELVAL 362

                        410       420
                 ....*....|....*....|....
gi 767909636 393 AQEAAATQLGLKEMPSHCLVHLHK 416
Cdd:COG1232  363 ALADLRKLLGIDAEPVDTRVVRWP 386
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-416 1.07e-72

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 237.81  E-value: 1.07e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGAlgaRTLLLVSELGLDS 82
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFLTRDP---EVLELLRELGLGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  83 EVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRRLGPEVASL 161
Cdd:COG1232   76 ELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRRFGREVYER 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 162 AMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------WSLRGGLEM 235
Cdd:COG1232  150 LVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfGYLRGGLGT 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 236 LPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSV 314
Cdd:COG1232  212 LVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAALAGIPYASV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 315 AVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvLSQELFQQR 392
Cdd:COG1232  289 AVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----LSDEELVAL 362

                        410       420
                 ....*....|....*....|....
gi 767909636 393 AQEAAATQLGLKEMPSHCLVHLHK 416
Cdd:COG1232  363 ALADLRKLLGIDAEPVDTRVVRWP 386
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-372 1.31e-59

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 203.91  E-value: 1.31e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636    3 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlgaRTLLLVSELGL 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK---SAPDLVKDLGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   81 DsevlPVRGDHPAAQnRFLYV-GGALHALPTglrgllRPSPPFSKPLFWAG-----LRELTKPRGKEPDETVHSFAQRRL 154
Cdd:TIGR00562  79 E----HVLVSDATGQ-RYVLVnRGKLMPVPT------KIAPFVKTGLFSLGgklraGMDFIRPASPGKDESVEEFVRRRF 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  155 GPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW--SLRGG 232
Cdd:TIGR00562 148 GDEVVENLIEPLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfqTLATG 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  233 LEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAV 312
Cdd:TIGR00562 224 LETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLDKIHSP 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767909636  313 SVAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGS 372
Cdd:TIGR00562 302 PVANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA 362
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 3-356 6.80e-48

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 171.96  E-value: 6.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGAR--TLLLVSELGL 80
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKpsAPALVKELGL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  81 DSEVLpvrgdHPAAQNRFLYVGGALHALPTG-LRGLlrpsPPFSKPLFWAGL----------RELTKPRGK-EPDETVHS 148
Cdd:PRK11883  75 EDELV-----ANTTGQSYIYVNGKLHPIPPGtVMGI----PTSIAPFLFAGLvspigklraaADLRPPRWKpGQDQSVGA 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 149 FAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerwsqwS 228
Cdd:PRK11883 146 FFRRRFGDEVVENLIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG------T 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 229 LRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplARALS 307
Cdd:PRK11883 216 LKGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FALFK 290

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 767909636 308 AITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQ 356
Cdd:PRK11883 291 TIPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT 340
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-402 4.50e-41

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 153.42  E-value: 4.50e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   12 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGAlgaRTLLLVSELGLDSEVlpvRGDH 91
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQP---PLLALLKELGLEDRL---VLPD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   92 PAAQNRFLYVGG-----ALHALPTGLRGLLRPSPPFS---------KPLFWAGLRELtKPRGKEPDETVHSFAQRRLGP- 156
Cdd:pfam01593  72 PAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSipeklrlglAALASDALDEF-DLDDFSLAESLLFLGRRGPGDv 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  157 -------EVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglllgagrtpqpdsalirqalaerwsqWSL 229
Cdd:pfam01593 151 evwdrliDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL-----------------------------LLP 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  230 RGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARAL 306
Cdd:pfam01593 202 RGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPEKARAI 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  307 SAITAVSVAVVNLQYQGAHLPVQgfGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAsgcvLS 385
Cdd:pfam01593 279 RNLGYGPVNKVHLEFDRKFWPDL--GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG----LS 352

                         410
                  ....*....|....*..
gi 767909636  386 QELFQQRAQEAAATQLG 402
Cdd:pfam01593 353 DEELLQAVLRDLRKLFG 369
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-416 1.07e-72

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 237.81  E-value: 1.07e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGAlgaRTLLLVSELGLDS 82
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFLTRDP---EVLELLRELGLGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  83 EVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRRLGPEVASL 161
Cdd:COG1232   76 ELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRRFGREVYER 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 162 AMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------WSLRGGLEM 235
Cdd:COG1232  150 LVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfGYLRGGLGT 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 236 LPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSV 314
Cdd:COG1232  212 LVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAALAGIPYASV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 315 AVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvLSQELFQQR 392
Cdd:COG1232  289 AVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----LSDEELVAL 362

                        410       420
                 ....*....|....*....|....
gi 767909636 393 AQEAAATQLGLKEMPSHCLVHLHK 416
Cdd:COG1232  363 ALADLRKLLGIDAEPVDTRVVRWP 386
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-372 1.31e-59

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 203.91  E-value: 1.31e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636    3 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlgaRTLLLVSELGL 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK---SAPDLVKDLGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   81 DsevlPVRGDHPAAQnRFLYV-GGALHALPTglrgllRPSPPFSKPLFWAG-----LRELTKPRGKEPDETVHSFAQRRL 154
Cdd:TIGR00562  79 E----HVLVSDATGQ-RYVLVnRGKLMPVPT------KIAPFVKTGLFSLGgklraGMDFIRPASPGKDESVEEFVRRRF 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  155 GPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW--SLRGG 232
Cdd:TIGR00562 148 GDEVVENLIEPLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfqTLATG 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  233 LEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAV 312
Cdd:TIGR00562 224 LETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLDKIHSP 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767909636  313 SVAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGS 372
Cdd:TIGR00562 302 PVANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA 362
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 3-356 6.80e-48

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 171.96  E-value: 6.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGAR--TLLLVSELGL 80
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKpsAPALVKELGL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  81 DSEVLpvrgdHPAAQNRFLYVGGALHALPTG-LRGLlrpsPPFSKPLFWAGL----------RELTKPRGK-EPDETVHS 148
Cdd:PRK11883  75 EDELV-----ANTTGQSYIYVNGKLHPIPPGtVMGI----PTSIAPFLFAGLvspigklraaADLRPPRWKpGQDQSVGA 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 149 FAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerwsqwS 228
Cdd:PRK11883 146 FFRRRFGDEVVENLIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG------T 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 229 LRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplARALS 307
Cdd:PRK11883 216 LKGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FALFK 290

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 767909636 308 AITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQ 356
Cdd:PRK11883 291 TIPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT 340
PLN02576 PLN02576
protoporphyrinogen oxidase
 2-372 1.82e-45

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 166.34  E-value: 1.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   2 GRTVVVLGGGISGLAASYHLSRAPCPpKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGALgartLLLVSELGL- 80
Cdd:PLN02576  12 SKDVAVVGAGVSGLAAAYALASKHGV-NVLVTEARDRVGGNITSVSE-DGFIWEEGPNSFQPSDPE----LTSAVDSGLr 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  81 DSEVLPVrgdhPAAqNRFLYVGGALHALPTGLRGLlrpspPFSKPLFWAG-LRELTKP----RGKEPD--ETVHSFAQRR 153
Cdd:PLN02576  86 DDLVFPD----PQA-PRYVVWNGKLRPLPSNPIDL-----PTFDLLSAPGkIRAGLGAfgwkRPPPPGreESVGEFVRRH 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 154 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSI-----LLGLLLGAGRTPQP-DSALIRQalaERWSQW 227
Cdd:PLN02576 156 LGDEVFERLIDPFVSGVYAGDPSSLSMKAAFPKLWNLEKRGGSIiggaiKAIQEAKKNPKPEPrDPRLPKP---KGQTVG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 228 SLRGGLEMLPQALETHLTSRGVSVlrGQPVCGLSLQAEGRWKVSLRD----SSLEADHVISAIPASVLSELLPAEAAPLA 303
Cdd:PLN02576 233 SFRGGLQTLPDALAKRLGKDKVKL--NWKVLSLSKNDDGGYSLTYDTpegkVNVTAKAVVMTAPLYVVSEMLRPKSPAAA 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767909636 304 RALSAITAVSVAVVNLQY--------QGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPeqDGSPPGLRV-TVMLGGS 372
Cdd:PLN02576 311 DALPEFYYPPVAAVTTSYpkeavkreRLIDGPLEGFGQLHPRKQGVKTLGTIYSSSLFP--DRAPEGRVLlLNYIGGS 386
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-402 4.50e-41

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 153.42  E-value: 4.50e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   12 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGAlgaRTLLLVSELGLDSEVlpvRGDH 91
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQP---PLLALLKELGLEDRL---VLPD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   92 PAAQNRFLYVGG-----ALHALPTGLRGLLRPSPPFS---------KPLFWAGLRELtKPRGKEPDETVHSFAQRRLGP- 156
Cdd:pfam01593  72 PAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSipeklrlglAALASDALDEF-DLDDFSLAESLLFLGRRGPGDv 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  157 -------EVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglllgagrtpqpdsalirqalaerwsqWSL 229
Cdd:pfam01593 151 evwdrliDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL-----------------------------LLP 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  230 RGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARAL 306
Cdd:pfam01593 202 RGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPEKARAI 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  307 SAITAVSVAVVNLQYQGAHLPVQgfGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAsgcvLS 385
Cdd:pfam01593 279 RNLGYGPVNKVHLEFDRKFWPDL--GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG----LS 352

                         410
                  ....*....|....*..
gi 767909636  386 QELFQQRAQEAAATQLG 402
Cdd:pfam01593 353 DEELLQAVLRDLRKLFG 369
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-321 9.83e-25

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 106.54  E-value: 9.83e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   2 GRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGP-NGAIFELGPRGIRPAgalGARTLLLVSELGL 80
Cdd:COG1231    7 GKDVVIVGAGLAGLAAARELRKAGL--DVTVLEARDRVGGRVWTLRFGdDGLYAELGAMRIPPS---HTNLLALARELGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  81 DSEVLPvrgdhPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK---PLFwAGLRELTKPRGKEPDETVHSFAQRRLGPE 157
Cdd:COG1231   82 PLEPFP-----NENGNALLYLGGKRVRAGEIAADLRGVAELLAKllrALA-AALDPWAHPAAELDRESLAEWLRRNGASP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 158 VASLAMDSLCRGVFAGNSRELSIrscfpslfqaeqthrsillglllgagrtpqpdSALIRQALAERWS--QWSLRGGLEM 235
Cdd:COG1231  156 SARRLLGLLGAGEYGADPDELSL--------------------------------LDLLRYAASAGGGaqQFRIVGGMDQ 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 236 LPQALETHLTSRgvsVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARALSAITAV 312
Cdd:COG1231  204 LPRALAAELGDR---IRLGAPVTRIR-QDGDGVTVTTDDgGTVRADAVIVTVPPSVLRriEFDPPLPAAKRAAIQRLPYG 279


                 ....*....
gi 767909636 313 SVAVVNLQY 321
Cdd:COG1231  280 AAIKVFLQF 288
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 3-340 8.44e-17

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 82.95  E-value: 8.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAP----CPPKVVLVESSERLGGWIRSVRGpNGAIFELGprgirpAGALGAR---TLLLV 75
Cdd:PRK12416   2 KTVVVIGGGITGLSTMFYLEKLKkdynIDLNLILVEKEEYLGGKIHSVEE-KDFIMESG------ADSIVARnehVMPLV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  76 SELGLDSEVLpvrgdHPAAQNRFLYVGGALH--------ALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVH 147
Cdd:PRK12416  75 KDLNLEEEMV-----YNETGISYIYSDNTLHpipsdtifGIPMSVESLFSSTLVSTKGKIVALKDFITKNKEFTKDTSLA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 148 SFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILlglllgagrtpqpdsalirQALAERWSQW 227
Cdd:PRK12416 150 LFLESFLGKELVERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSII-------------------KGFEENKKQF 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 228 ---------SLRGGLEMLPQALETHLTSrgVSVLRGQPVCGLSLQAEgRWKVSLRD-SSLEADHVISAIPASVLSELLpa 297
Cdd:PRK12416 211 qsagnkkfvSFKGGLSTIIDRLEEVLTE--TVVKKGAVTTAVSKQGD-RYEISFANhESIQADYVVLAAPHDIAETLL-- 285

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767909636 298 EAAPLARALSAITAVSVAVVNLQYQ--GAHLPVQGFGHLVPSSED 340
Cdd:PRK12416 286 QSNELNEQFHTFKNSSLISIYLGFDilDEQLPADGTGFIVTENSD 330
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-331 1.18e-16

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 82.21  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   1 MGRTVVVLGGGISGLAASYHLSRAPCPpkVVLVESSERLGGWIRSVRGPN-GAIFELGPRGIrpagaLGA--RTLLLVSE 77
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFR--VTLLEARPRLGGRARSFPDPDtGLPIDNGQHVL-----LGCyrNTLDLLRR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  78 LGLDsevlpvrgDHPAAQNRFLYvggalhALPTGLRGLLRPSPPfskPLFWAGLRELTKPRGKEPDEtvhsfaqrRLGpe 157
Cdd:COG3349   75 IGAA--------DNLVGPEPLQF------PLPGGRRWTLRAPRL---PAPLHLLRALLRAPGLSLAD--------RLA-- 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 158 VASLAMDSLCRGVFAGnsRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPqPDSA-------LIRQALA---ERWSQW 227
Cdd:COG3349  128 LLRLLTACRERRWREL--DDISVADWLRRHGQSPRLIRRLWEPLLLAALNTP-PEQAsarlaltVLRETLLagpAASDLL 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 228 SLRGGL-EMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPA-EAAPLAR 304
Cdd:COG3349  205 VPRGPLsELFVDPALAYLEARGGEVRLGTRVRALEFDGGRVTGLVLADgETVPADAVVLAVPPEVAARLLPElARLPELG 284

                        330       340       350
                 ....*....|....*....|....*....|.
gi 767909636 305 ALSAITAVSVAVVNLQYQG----AHLPVQGF 331
Cdd:COG3349  285 LLAPLEYSPIVNVHLWLDRpvtlGPPPFAGL 315
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-319 1.35e-12

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 69.88  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   1 MGRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALGArtllLVSELGL 80
Cdd:COG1233    2 MMYDVVVIGAGIGGLAAAALLARAGY--RVTVLEKNDTPGGRARTFERP-GFRFDVGPSVLTMPGVLER----LFRELGL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  81 DSEV----LPVRGDHPAAQNRFLYV------------------GGALHAL--------PTGLRGLL-RPSPPFSKPLFWA 129
Cdd:COG1233   75 EDYLelvpLDPAYRVPFPDGRALDLprdlertaaelerlfpgdAEAYRRFlaelrrlyDALLEDLLyRPLLSLRDLLRPL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 130 GLRELtkprGKEPDETVHSFAQRRLGPEVAslamdslcRGVFAgnsrelsirscFPSLFqaeqthrsillglllgAGRTP 209
Cdd:COG1233  155 ALARL----LRLLLRSLRDLLRRYFKDPRL--------RALLA-----------GQALY----------------LGLSP 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 210 QPDSAL--IRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEADHVISAI 286
Cdd:COG1233  196 DRTPALyaLIAYLEYAGGVWYPKGGMGALADALARLAEELGGEIRTGAEVERILVEGGRATGVRLADgEEIRADAVVSNA 275

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 767909636 287 -PASVLSELLPAEAAP--LARALSAIT-AVSVAVVNL 319
Cdd:COG1233  276 dPAHTYLRLLGEEALParYRRRLERFRySPSAFKLYL 312
PRK07233 PRK07233
hypothetical protein; Provisional
 4-317 1.81e-11

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 66.06  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   4 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWirsvrgpnGAIFELGprgirpaG----------ALGARTLL 73
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGH--EVTVFEADDQLGGL--------AASFEFG-------GlpierfyhhiFKSDEALL 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  74 -LVSELGLDSEVLPVRGdhpaaQNRFlYVGGALHALPTGLRgLLRpSPPFS--------KPLFWAGLRELTKPRGKEPDE 144
Cdd:PRK07233  64 eLLDELGLEDKLRWRET-----KTGY-YVDGKLYPLGTPLE-LLR-FPHLSlidkfrlgLLTLLARRIKDWRALDKVPAE 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 145 TvhsFAQRRLGPEVASLAMDSLCRGVFAGNSRELS---------IRScfpslfqaeqthRSillglllgagrtpqpDSAL 215
Cdd:PRK07233 136 E---WLRRWSGEGVYEVFWEPLLESKFGDYADDVSaawlwsrikRRG------------NR---------------RYSL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 216 IRQALAerwsqwSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELL 295
Cdd:PRK07233 186 FGEKLG------YLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILARLV 259

                        330       340
                 ....*....|....*....|..
gi 767909636 296 PAEAAPLARALSAITAVSVAVV 317
Cdd:PRK07233 260 PDLPADVLARLRRIDYQGVVCM 281
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-73 2.44e-09

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 53.69  E-value: 2.44e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909636    7 VLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGALGARTLL 73
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF--RVLVLEKRDRLGGNAYSYR-VPGYVFDYGAHIFHGSDEPNVRDLL 64
PLN02268 PLN02268
probable polyamine oxidase
 4-43 1.02e-05

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 47.76  E-value: 1.02e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767909636   4 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWI 43
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASF--KVTLLESRDRIGGRV 39
PRK07208 PRK07208
hypothetical protein; Provisional
 1-308 1.42e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 47.58  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   1 MGRTVVVLGGGISGLAASYHLSRAPCPpkVVLVESSERLGGWIRSVRGpNGAIFELGprgirpagalGARTLLLVSE-LG 79
Cdd:PRK07208   3 NKKSVVIIGAGPAGLTAAYELLKRGYP--VTVLEADPVVGGISRTVTY-KGNRFDIG----------GHRFFSKSPEvMD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  80 LDSEVLPVRgdhpaaqnRFL--------YVGGALHALPTGLRGLLRPSPP-------FSkpLFWAGLReltkPRgkEPDE 144
Cdd:PRK07208  70 LWNEILPDD--------DFLlrprlsriYYRGKFFDYPLKAFDALKNLGLwrtakcgAS--YLKARLR----PR--KEED 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 145 TVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELS-------IRSCfpSLFQAEqthRSILLGLLLGAGRTPQPDSALIR 217
Cdd:PRK07208 134 SFEDWVINRFGRRLYSTFFKGYTEKVWGVPCDEISadwaaqrIKGL--SLGKAI---RNALRRSLGLKRRNKEVETSLIE 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636 218 QALAERWsqwslrgGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGR-WKVSLRDS-----SLEADHVISAIPASVL 291
Cdd:PRK07208 209 EFRYPKL-------GPGQLWETAAEKLEALGGKVVLNAKVVGLHHDGDGRiAVVVVNDTdgteeTVTADQVISSMPLREL 281

                        330
                 ....*....|....*..
gi 767909636 292 SELLPAEAAPLARALSA 308
Cdd:PRK07208 282 VAALDPPPPPEVRAAAA 298
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-41 4.89e-05

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 45.88  E-value: 4.89e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767909636   1 MGRTVVVLGGGISGLAASYHLSRApcpPKVVLVESSERLGG 41
Cdd:COG2907    2 ARMRIAVIGSGISGLTAAWLLSRR---HDVTLFEANDRLGG 39
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
3-44 1.19e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.85  E-value: 1.19e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767909636   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIR 44
Cdd:COG1148  141 KRALVIGGGIAGMTAALELAEQGY--EVYLVEKEPELGGRAA 180
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-42 1.19e-04

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 44.47  E-value: 1.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767909636   5 VVVLGGGISGLAASYHLSRApCPPkVVLVESSERLGG-W 42
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRA-GID-FVVLEKADDVGGtW 45
HpnE TIGR03467
squalene-associated FAD-dependent desaturase; The sequences in this family are members of the ...
 244-324 1.61e-04

squalene-associated FAD-dependent desaturase; The sequences in this family are members of the pfam01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, pfam01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.


Pssm-ID: 274593 [Multi-domain]  Cd Length: 419  Bit Score: 44.28  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636  244 LTSRGVSVLRGQPVCGLSLQAEG-RWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPlaRALSAITAVSVAVVNLQYQ 322
Cdd:TIGR03467 207 LDSRGGEVRLGTRVRSIEANAGGiRALVRSGGETLPADAVVLAVPPRHAASLLPGEDLG--ALLTALGYSPITTVHLRLD 284


                  ..
gi 767909636  323 GA 324
Cdd:TIGR03467 285 RA 286
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
5-81 8.40e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 41.81  E-value: 8.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909636   5 VVVLGGGISGLAASYHLSRAPCppKVVLVE-------SSERLGGWIRSvrgpngAIFELGPRGIRPAGALGARTLL-LVS 76
Cdd:COG0665    5 VVVIGGGIAGLSTAYHLARRGL--DVTVLErgrpgsgASGRNAGQLRP------GLAALADRALVRLAREALDLWReLAA 76


                 ....*
gi 767909636  77 ELGLD 81
Cdd:COG0665   77 ELGID 81
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 5-41 9.77e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 41.61  E-value: 9.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767909636    5 VVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGG 41
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARR--GLSVTLLERGDDPGS 36
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-40 4.63e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 39.55  E-value: 4.63e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767909636   3 RTVVVLGGGISGLAASYHLSR-APCPPKVVLVESSERLG 40
Cdd:COG4529    6 KRIAIIGGGASGTALAIHLLRrAPEPLRITLFEPRPELG 44
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
235-286 7.32e-03

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 38.74  E-value: 7.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909636 235 MLP----QALETHLTSRGVSVLRGQPVCGLSLQAEGrWKVSLRDS-SLEADHVISAI 286
Cdd:PRK04965 180 LMPpevsSRLQHRLTEMGVHLLLKSQLQGLEKTDSG-IRATLDSGrSIEVDAVIAAA 235
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 2-44 8.39e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 38.70  E-value: 8.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767909636   2 GRTVVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGGWIR 44
Cdd:PRK12771 137 GKRVAVIGGGPAGLSAAYHLRRM--GHAVTIFEAGPKLGGMMR 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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