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Conserved domains on  [gi|530364572|ref|XP_005245150|]
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kelch-like protein 20 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 1.31e-92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 280.88  E-value: 1.31e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18249   81 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
PHA03098 super family cl33709
kelch-like protein; Provisional
 63-586 1.74e-83

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 271.26  E-value: 1.74e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  63 KHRELCD--VVLVVGAKKIYAHRVILSACSPYFRAMFTGELAEsrqtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:PHA03098   5 ELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE----NEINLNIDYDSFNEVIKYIYTGKINITSNNVKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISS 220
Cdd:PHA03098  81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 221 DELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL-----VGTVGSDPLIKSDEECRDLVDEAKNYLl 295
Cdd:PHA03098 161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIkklkrWKLRIKKKKIVFNKRCIKIIYSKKYNL- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 296 lpQERPLMQGPRTRPrkpircgeVLFAVGGWcsGDAISSVERYDPqTNEWRMVASMSKRRCgVGVSVLDDLLYAVGGHDG 375
Cdd:PHA03098 240 --NKILPRSSTFGSI--------IYIHITMS--IFTYNYITNYSP-LSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNK 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 376 SSY-LNSVERYDPKTNQWSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVA 454
Cdd:PHA03098 306 NNLsVNSVVSYDTKTKSWN-KVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 455 VAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR---DDTTELSSAERYNPR 530
Cdd:PHA03098 385 VVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPV 464

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572 531 TNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Cdd:PHA03098 465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
 
Name Accession Description Interval E-value
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 1.31e-92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 280.88  E-value: 1.31e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18249   81 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
PHA03098 PHA03098
kelch-like protein; Provisional
 63-586 1.74e-83

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 271.26  E-value: 1.74e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  63 KHRELCD--VVLVVGAKKIYAHRVILSACSPYFRAMFTGELAEsrqtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:PHA03098   5 ELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE----NEINLNIDYDSFNEVIKYIYTGKINITSNNVKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISS 220
Cdd:PHA03098  81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 221 DELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL-----VGTVGSDPLIKSDEECRDLVDEAKNYLl 295
Cdd:PHA03098 161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIkklkrWKLRIKKKKIVFNKRCIKIIYSKKYNL- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 296 lpQERPLMQGPRTRPrkpircgeVLFAVGGWcsGDAISSVERYDPqTNEWRMVASMSKRRCgVGVSVLDDLLYAVGGHDG 375
Cdd:PHA03098 240 --NKILPRSSTFGSI--------IYIHITMS--IFTYNYITNYSP-LSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNK 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 376 SSY-LNSVERYDPKTNQWSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVA 454
Cdd:PHA03098 306 NNLsVNSVVSYDTKTKSWN-KVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 455 VAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR---DDTTELSSAERYNPR 530
Cdd:PHA03098 385 VVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPV 464

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572 531 TNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Cdd:PHA03098 465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 164-263 3.42e-72

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 226.93  E-value: 3.42e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90       100
                 ....*....|....*....|
gi 530364572 244 QERRPQLPQVLQHVRLPLLS 263
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLLS 100
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
344-600 2.97e-61

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 204.62  E-value: 2.97e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 344 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTS-VGVAVLGGFLYAVGG-- 420
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSE-LAPLPGPPRHhAAAVAQDGKLYVFGGft 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 421 --QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 498
Cdd:COG3055   81 gaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 499 HLGCAV-YQDMIYAVGGRDDTTElssaerynprTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGttYLKTIEVFDPD 577
Cdd:COG3055  161 HLAAAVlPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                        250       260
                 ....*....|....*....|...
gi 530364572 578 ANTWRLYGGMNYRRLGGGVGVIK 600
Cdd:COG3055  229 TNTWTALGELPTPRHGHAAVLTD 251
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 170-271 3.01e-47

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 160.79  E-value: 3.01e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQ 249
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 530364572  250 LPQVLQHVRLPLLSPKFLVGTV 271
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 170-268 1.81e-41

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 145.18  E-value: 1.81e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572   170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQ 249
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 530364572   250 LPQVLQHVRLPLLSPKFLV 268
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 59-165 1.65e-37

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 134.69  E-value: 1.65e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572   59 NLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQItVEEGNV 138
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90       100
                  ....*....|....*....|....*..
gi 530364572  139 QTLLPAACLLQLAEIQEACCEFLKRQL 165
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 69-165 1.96e-30

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 114.71  E-value: 1.96e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572    69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 148
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 530364572   149 QLAEIQEACCEFLKRQL 165
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
 
Name Accession Description Interval E-value
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 1.31e-92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 280.88  E-value: 1.31e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18249   81 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
PHA03098 PHA03098
kelch-like protein; Provisional
 63-586 1.74e-83

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 271.26  E-value: 1.74e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  63 KHRELCD--VVLVVGAKKIYAHRVILSACSPYFRAMFTGELAEsrqtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:PHA03098   5 ELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE----NEINLNIDYDSFNEVIKYIYTGKINITSNNVKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISS 220
Cdd:PHA03098  81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 221 DELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL-----VGTVGSDPLIKSDEECRDLVDEAKNYLl 295
Cdd:PHA03098 161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIkklkrWKLRIKKKKIVFNKRCIKIIYSKKYNL- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 296 lpQERPLMQGPRTRPrkpircgeVLFAVGGWcsGDAISSVERYDPqTNEWRMVASMSKRRCgVGVSVLDDLLYAVGGHDG 375
Cdd:PHA03098 240 --NKILPRSSTFGSI--------IYIHITMS--IFTYNYITNYSP-LSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNK 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 376 SSY-LNSVERYDPKTNQWSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVA 454
Cdd:PHA03098 306 NNLsVNSVVSYDTKTKSWN-KVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 455 VAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR---DDTTELSSAERYNPR 530
Cdd:PHA03098 385 VVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPV 464

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572 531 TNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Cdd:PHA03098 465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 164-263 3.42e-72

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 226.93  E-value: 3.42e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90       100
                 ....*....|....*....|
gi 530364572 244 QERRPQLPQVLQHVRLPLLS 263
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLLS 100
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
344-600 2.97e-61

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 204.62  E-value: 2.97e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 344 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTS-VGVAVLGGFLYAVGG-- 420
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSE-LAPLPGPPRHhAAAVAQDGKLYVFGGft 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 421 --QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 498
Cdd:COG3055   81 gaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 499 HLGCAV-YQDMIYAVGGRDDTTElssaerynprTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGttYLKTIEVFDPD 577
Cdd:COG3055  161 HLAAAVlPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                        250       260
                 ....*....|....*....|...
gi 530364572 578 ANTWRLYGGMNYRRLGGGVGVIK 600
Cdd:COG3055  229 TNTWTALGELPTPRHGHAAVLTD 251
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 165-278 1.49e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 193.99  E-value: 1.49e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIK 278
Cdd:cd18445   81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-172 1.68e-59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 194.05  E-value: 1.68e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVE 134
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18238   83 VDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 165-300 2.33e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 194.54  E-value: 2.33e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQER 300
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
317-575 5.90e-59

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 198.46  E-value: 5.90e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS-KRRCGVGVSVLDDLLYAVGG----HDGSSYLNSVERYDPKTNQ 391
Cdd:COG3055   22 DGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGftgaNPSSTPLNDVYVYDPATNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 392 WSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVL-GGFLYAVGGSDG 470
Cdd:COG3055  102 WT-KLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 471 TSPLNTverynpqenrWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTteLSSAERYNPRTNQWSPVVAMTSRRSGVGLA 550
Cdd:COG3055  181 SGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                        250       260
                 ....*....|....*....|....*....
gi 530364572 551 VVNGQLMAVGGFD----GTTYLKTIEVFD 575
Cdd:COG3055  249 LTDGKVYVIGGETkpgvRTPLVTSAEVYD 277
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-167 2.08e-55

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 183.40  E-value: 2.08e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18235    4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18235   84 EIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-170 1.83e-50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 170.31  E-value: 1.83e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFA 126
Cdd:cd18242    1 TNSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530364572 127 YTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18242   81 YTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-167 5.91e-48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 163.48  E-value: 5.91e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 170-271 3.01e-47

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 160.79  E-value: 3.01e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQ 249
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 530364572  250 LPQVLQHVRLPLLSPKFLVGTV 271
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-172 1.12e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 160.26  E-value: 1.12e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  48 DKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAY 127
Cdd:cd18256    1 DKHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18256   81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-172 1.23e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 160.35  E-value: 1.23e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18237    3 KLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18237   83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-171 3.05e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 158.30  E-value: 3.05e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAAC 146
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                         90       100
                 ....*....|....*....|....*
gi 530364572 147 LLQLAEIQEACCEFLKRQLDPSNCL 171
Cdd:cd18234   81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-166 5.59e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 158.31  E-value: 5.59e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  48 DKHPRQTLEVINLLRKHRELCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLI 123
Cdd:cd18248    2 EDHTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530364572 124 DFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLD 166
Cdd:cd18248   82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-164 6.61e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 157.83  E-value: 6.61e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  51 PRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQ 130
Cdd:cd18247    3 PSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGR 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530364572 131 ITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164
Cdd:cd18247   83 IAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 164-267 1.32e-45

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 156.72  E-value: 1.32e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....
gi 530364572 244 QERRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFL 104
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 165-267 2.81e-45

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 155.93  E-value: 2.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|...
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFL 103
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 165-293 9.07e-44

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 152.53  E-value: 9.07e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNY 293
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKY 129
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-167 4.02e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 151.34  E-value: 4.02e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFA 126
Cdd:cd18246   19 SKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYA 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530364572 127 YTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18246   99 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-167 1.37e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 149.07  E-value: 1.37e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18338    3 RHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYT 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18338   83 AEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-167 5.99e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 147.56  E-value: 5.99e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18339   84 EIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 170-268 1.81e-41

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 145.18  E-value: 1.81e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572   170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQ 249
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 530364572   250 LPQVLQHVRLPLLSPKFLV 268
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-170 1.03e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 141.44  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18250   84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 165-293 2.35e-39

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 140.55  E-value: 2.35e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNY 293
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKY 129
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-174 2.49e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 140.57  E-value: 2.49e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 174
Cdd:cd18336   82 VLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 59-165 1.65e-37

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 134.69  E-value: 1.65e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572   59 NLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQItVEEGNV 138
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90       100
                  ....*....|....*....|....*..
gi 530364572  139 QTLLPAACLLQLAEIQEACCEFLKRQL 165
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 164-267 2.31e-37

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 134.42  E-value: 2.31e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 530364572 244 QERRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-170 6.78e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 133.22  E-value: 6.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  53 QTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQIT 132
Cdd:cd18240    3 MACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVP 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 133 VEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18240   83 ITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 164-267 1.22e-36

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 132.35  E-value: 1.22e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 530364572 244 QERRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-173 1.49e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 133.41  E-value: 1.49e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVV--------GAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMEL 121
Cdd:cd18273    9 HARALLAQLKSFYDARLLTDVTIEVngpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMAL 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530364572 122 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18273   89 IIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-172 2.71e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 132.26  E-value: 2.71e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18259   15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18259   95 KLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-170 5.59e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 131.11  E-value: 5.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-174 6.21e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 131.34  E-value: 6.21e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18337    6 HAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 174
Cdd:cd18337   86 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 165-267 6.88e-36

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 130.14  E-value: 6.88e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-174 1.73e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 129.78  E-value: 1.73e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 174
Cdd:cd18335   82 CLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 164-260 2.27e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 128.19  E-value: 2.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 530364572 244 QERRPQLPQVLQHVRLP 260
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-173 3.31e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 128.92  E-value: 3.31e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18306   81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-172 8.32e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 127.82  E-value: 8.32e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD-IDERAMELLIDFAYT 128
Cdd:cd18254    5 HPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLDFAYS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18254   85 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-170 9.05e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 127.51  E-value: 9.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18255   81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-172 9.63e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 127.58  E-value: 9.63e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18265    6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18265   86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 164-254 1.36e-34

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 125.87  E-value: 1.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18458    1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|.
gi 530364572 244 QERRPQLPQVL 254
Cdd:cd18458   81 ENRRQYLEALL 91
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 165-266 2.69e-34

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 125.50  E-value: 2.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|..
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKF 266
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 165-271 9.98e-34

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 124.12  E-value: 9.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*..
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFLVGTV 271
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETV 107
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-173 1.27e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 125.49  E-value: 1.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD-IDERAMELLIDFAYT 128
Cdd:cd18267   23 YADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLLDYAYS 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18267  103 SRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-148 3.92e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 121.51  E-value: 3.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAAC 146
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 530364572 147 LL 148
Cdd:cd18186   81 KL 82
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 165-263 1.25e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 118.13  E-value: 1.25e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*....
gi 530364572 245 ERRPQLPQVLQHVRLPLLS 263
Cdd:cd18467   81 ERQKYLAQLLHCVRLPLLS 99
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-173 3.90e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 117.78  E-value: 3.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYA-HRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18274    5 HACSILQQLKAMYDEGQLTDIVVEVDHGKTFScHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18274   85 SRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 69-165 1.96e-30

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 114.71  E-value: 1.96e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572    69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 148
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 530364572   149 QLAEIQEACCEFLKRQL 165
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-173 3.79e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 114.88  E-value: 3.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  53 QTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQIT 132
Cdd:cd18268    9 ELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEIL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530364572 133 VEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18268   89 ITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-173 7.31e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 114.13  E-value: 7.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  48 DKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAY 127
Cdd:cd18276    2 QKHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18276   82 SSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-172 1.10e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 113.79  E-value: 1.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:cd18236   18 LRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQR 97

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18236   98 VLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-169 2.48e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 112.60  E-value: 2.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18251    1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18251   81 FIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 166-241 9.06e-29

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 109.04  E-value: 9.06e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 241
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKH 76
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-173 1.28e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 110.96  E-value: 1.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:cd18269   21 LLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQD 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18269  101 IFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 166-267 2.68e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 108.65  E-value: 2.68e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQE 245
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 530364572 246 RRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-162 2.76e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 108.97  E-value: 2.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ--TEVVIRDIDERAMELLIDFAYTSQIT 132
Cdd:cd18245    2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGstYKIELEGISVEVMEEILDYIYTGQIK 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 530364572 133 VEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18245   82 LSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-172 3.47e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 109.53  E-value: 3.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIY-AHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18252    4 HPADFLDAFRTFYLDGLFTDITLQCASGQIFhCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYT 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18252   84 SQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-173 2.67e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 107.23  E-value: 2.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  64 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLP 143
Cdd:cd18340   24 HNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFA 103

                         90       100       110
                 ....*....|....*....|....*....|
gi 530364572 144 AACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18340  104 AANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 165-262 5.26e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 104.93  E-value: 5.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*...
gi 530364572 245 ERRPQLPQVLQHVRLPLL 262
Cdd:cd18514   81 KRKDYLPELLRNVRLALL 98
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 165-267 6.33e-26

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 102.17  E-value: 6.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18466    1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                         90       100
                 ....*....|....*....|...
gi 530364572 245 ERRPQLPQVLQHVRLPLLSPKFL 267
Cdd:cd18466   81 KRKKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 164-241 1.63e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 100.16  E-value: 1.63e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 241
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-171 3.75e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 100.85  E-value: 3.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDF 125
Cdd:cd18270    5 INTEYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITY 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530364572 126 AYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 171
Cdd:cd18270   85 AYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 165-241 7.97e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 98.07  E-value: 7.97e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEV-MESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 241
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDH 78
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-171 1.69e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 99.27  E-value: 1.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFA 126
Cdd:cd18261    8 SKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 127 YTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 171
Cdd:cd18261   88 YTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-161 4.90e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 97.31  E-value: 4.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  58 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQIT---VE 134
Cdd:cd18287   13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTltdLK 92

                         90       100
                 ....*....|....*....|....*..
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18287   93 EDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 163-263 6.00e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 96.36  E-value: 6.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 163 RQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 242
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|.
gi 530364572 243 IQERRPQLPQVLQHVRLPLLS 263
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLT 101
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-173 7.11e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 97.22  E-value: 7.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:cd18341   21 LLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQD 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18341  101 IFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-177 9.20e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 97.27  E-value: 9.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18266    3 YRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVID 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 177
Cdd:cd18266   83 FLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 165-246 9.99e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 95.08  E-value: 9.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 530364572 245 ER 246
Cdd:cd18480   81 AR 82
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 167-254 1.17e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 95.46  E-value: 1.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 167 PSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQER 246
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                 ....*...
gi 530364572 247 RPQLPQVL 254
Cdd:cd18455   82 KVHLKDLM 89
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 167-262 1.59e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 95.26  E-value: 1.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 167 PSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQER 246
Cdd:cd18464    2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                         90
                 ....*....|....*.
gi 530364572 247 RPQLPQVLQHVRLPLL 262
Cdd:cd18464   82 HEVLPELLRSVRLALL 97
PHA02713 PHA02713
hypothetical protein; Provisional
 43-545 2.44e-23

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 104.32  E-value: 2.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  43 MPYISDKHPRQTLEVINLLRKHRELCDVVLVVG-AKKIYAHRVILSACSPYFRAMFTGEL-AESRQTEVVIRDIDERAME 120
Cdd:PHA02713   1 MDIDDIKHNRRVVSNISNLLDDDILCDVIITIGdGEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 121 LLIDFAYTSQITveEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI--RAFADTHScrELLRIADKFTQHNFQ 198
Cdd:PHA02713  81 NIVQYLYNRHIS--SMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMyhRLYEMSHI--PIVKYIKRMLMSNIP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 199 EVMESEEFMLLPANQLIDIISS-DELNVRSEEQVFNAVMAWVKYS-IQERrpQLPQVLQHVRLPLLSPKFLVgTVGSDPL 276
Cdd:PHA02713 157 TLITTDAFKKTVFEILFDIISTnDNVYLYREGYKVTILLKWLEYNyITEE--QLLCILSCIDIQNLDKKSRL-LLYSNKT 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 277 IKSDEEC-RDLVDEAKNYLLLPQERPLMqgprtrprkpirCGEVLFAVGGWCsgdaissVERYDPQTNEWRMVASMSKRR 355
Cdd:PHA02713 234 INMYPSCiQFLLDNKQNRNIIPRQLCLV------------CHDTKYNVCNPC-------ILVYNINTMEYSVISTIPNHI 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 356 CGVGVSVLDDLLYAVGGHD-GSSYLNSVERYDPKtNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYD 434
Cdd:PHA02713 295 INYASAIVDNEIIIAGGYNfNNPSLNKVYKINIE-NKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYT 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 435 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGS------------------DGTSPLNTVERYNPQENRWHTIAPMGTR 496
Cdd:PHA02713 374 MGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRtehidytsvhhmnsidmeEDTHSSNKVIRYDTVNNIWETLPNFWTG 453

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530364572 497 RKHLGCAVYQDMIYAVGG-RDDTTELSSAERYNPRT-NQWSPVVAMTSRRS 545
Cdd:PHA02713 454 TIRPGVVSHKDDIYVVCDiKDEKNVKTCIFRYNTNTyNGWELITTTESRLS 504
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 66-157 8.24e-23

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 93.18  E-value: 8.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  66 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAA 145
Cdd:cd18314    5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84

                         90
                 ....*....|..
gi 530364572 146 CLLQLAEIQEAC 157
Cdd:cd18314   85 SKYQVPDLEKLC 96
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 164-261 2.13e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 92.04  E-value: 2.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*...
gi 530364572 244 QERRPQLPQVLQHVRLPL 261
Cdd:cd18447   81 PNRQPYMVDILAKVRFPL 98
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-173 7.37e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 91.43  E-value: 7.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDF 125
Cdd:cd18271    3 VAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDY 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530364572 126 AYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18271   83 AYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-170 9.88e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 91.02  E-value: 9.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVG--AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELL 122
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGdgDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530364572 123 IDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 167-262 2.07e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 89.26  E-value: 2.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 167 PSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQER 246
Cdd:cd18515    2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                         90
                 ....*....|....*.
gi 530364572 247 RPQLPQVLQHVRLPLL 262
Cdd:cd18515   82 HCYLSELLQTVRLALL 97
PHA02790 PHA02790
Kelch-like protein; Provisional
 79-586 2.54e-21

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 97.42  E-value: 2.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  79 IYAHRVILSACSPYFRAMFTGELAESRQ-TEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEAC 157
Cdd:PHA02790  33 IIVNSTILKKLSPYFRTHLRQKYTKNKDpVTRVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTC 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 158 CEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMES--EEFMLLPANQlidIISSDELNVRSEEQVFNAV 235
Cdd:PHA02790 113 INFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDiiDNFDYLSMKL---ILESDELNVPDEDYVVDFV 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 236 MAWVkysiQERRPQLPQVL----QHVRLPLLSPKFLVGT---VGSDPLIKSDEECRdlvdeaKNYlllpqERPLMQGPRT 308
Cdd:PHA02790 190 IKWY----MKRRNRLGNLLllikNVIRSNYLSPRGINNVkwiLDCTKIFHCDKQPR------KSY-----KYPFIEYPMN 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 309 RPR--------KPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRcgvgvsvlddlLYAVGGhdgssyln 380
Cdd:PHA02790 255 MDQiidifhmcTSTHVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPR-----------LYASGV-------- 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 381 sverydPKTNQwssdvaptstcrtsvgvavlggfLYAVGGQDGVSClniVERYDPKENKWTRVASMSTRRLGVAVAVLGG 460
Cdd:PHA02790 316 ------PANNK-----------------------LYVVGGLPNPTS---VERWFHGDAAWVNMPSLLKPRCNPAVASINN 363

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 461 FLYAVGGSDGTSplNTVERYNPQENRWHtIAPMGTRRKHLGCA-VYQDMIYAVGgrddttelSSAERYNPRTNQWSPVVA 539
Cdd:PHA02790 364 VIYVIGGHSETD--TTTEYLLPNHDQWQ-FGPSTYYPHYKSCAlVFGRRLFLVG--------RNAEFYCESSNTWTLIDD 432

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 530364572 540 MTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Cdd:PHA02790 433 PIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNIWDG 479
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 165-264 2.73e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 89.02  E-value: 2.73e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90       100
                 ....*....|....*....|
gi 530364572 245 ERRPQLPQVLQHVRLPLLSP 264
Cdd:cd18485   81 SRVQHLVELLKQVRLELVSP 100
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 165-259 9.76e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 87.03  E-value: 9.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 530364572 245 ERRPQLPQVLQHVRL 259
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-172 1.05e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 88.11  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  51 PRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR---QTEVVIRDIDERAMELLIDFAY 127
Cdd:cd18258    1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGggeKLELTMSNINADVLELLLEFVY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172
Cdd:cd18258   81 TGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 55-171 1.48e-20

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 87.56  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVE 134
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 171
Cdd:cd18263   81 WENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-169 5.65e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 85.79  E-value: 5.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  66 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT---SQITVEEGNVQTLL 142
Cdd:cd18297   11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTggvESLDVAQDDALELL 90

                         90       100
                 ....*....|....*....|....*..
gi 530364572 143 PAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18297   91 RAASFFQLDGLKRHCEILLSQQIDLDN 117
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 165-262 6.13e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 84.85  E-value: 6.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*...
gi 530364572 245 ERRPQLPQVLQHVRLPLL 262
Cdd:cd18460   81 HRQHFWPELLQHVRLPFV 98
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 165-264 7.26e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 84.79  E-value: 7.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELnVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 530364572 245 ERRPQLPQVLQHVRLPLLSP 264
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-161 7.30e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 85.37  E-value: 7.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  36 GVPQParmpyisdKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDID 115
Cdd:cd18326    2 GIPFP--------DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVS 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530364572 116 ERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18326   74 AEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 67-149 9.50e-20

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 83.75  E-value: 9.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAAC 146
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                 ...
gi 530364572 147 LLQ 149
Cdd:cd18315   80 LLQ 82
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-170 9.85e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 85.62  E-value: 9.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  43 MPY---ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAM 119
Cdd:cd18264    1 MSYflaYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530364572 120 ELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18264   81 QRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 165-260 8.09e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 81.83  E-value: 8.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 530364572 245 ERRPQLPQVLQH-VRLP 260
Cdd:cd18483   81 KREMHLPEIFAKcIRMP 97
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 165-245 1.01e-18

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 81.51  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQlIDII--SSDELNVRSEEQVFNAVMAWVKYS 242
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQ-IEVIleSNQELESINERKLCQLVLEWVQRS 79


                 ...
gi 530364572 243 IQE 245
Cdd:cd18502   80 IEE 82
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 165-262 2.08e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 80.66  E-value: 2.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*...
gi 530364572 245 ERRPQLPQVLQHVRLPLL 262
Cdd:cd18477   81 NRQKALPTVFESIRFRLL 98
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-165 3.01e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 81.06  E-value: 3.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT----EVVIRDIDE---RAMELL 122
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvspaGKCVLDLHHvtvTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530364572 123 IDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-170 5.18e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 80.67  E-value: 5.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  59 NLLRKHRELCDVVLVVG---AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD------IDERAMELLIDFAYTS 129
Cdd:cd18241   15 NEQRKQGLFCDITLAFGgagGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18241   95 RIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-162 5.76e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 79.91  E-value: 5.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  36 GVPQParmpyisdKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDID 115
Cdd:cd18198    2 GIPFP--------DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVS 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530364572 116 ERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18198   74 PEALTALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-173 9.53e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 79.94  E-value: 9.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  52 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQI 131
Cdd:cd18272   17 RVAQSIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTV 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530364572 132 TVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18272   97 KLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 166-220 9.83e-18

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 77.32  E-value: 9.83e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530364572 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISS 220
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-168 2.18e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 78.56  E-value: 2.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFMYS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPS 168
Cdd:cd18230   84 AHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-167 3.26e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 78.17  E-value: 3.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDE----RAMELLIDF 125
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT--VAEGDQTMNMIQLDSEvvtaEAFAALIDM 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530364572 126 AYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18196   82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-171 3.40e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 77.93  E-value: 3.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRqteVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQR---VELNDISPLGLATVITYAYTG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 171
Cdd:cd18260   78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-160 4.52e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 77.28  E-value: 4.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelaesRQTEVVIRDIDERA-MELLIDFAY 127
Cdd:cd18206    4 QHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV------DQKDVVHLDISNAAgLGQVLEFMY 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEACCEF 160
Cdd:cd18206   78 TAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-161 4.87e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 77.23  E-value: 4.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  36 GVPQParmpyisdKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDID 115
Cdd:cd18328    2 GIPFP--------NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVT 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530364572 116 ERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18328   74 PEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 168-262 9.52e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 75.95  E-value: 9.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 168 SNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERR 247
Cdd:cd18516    4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                         90
                 ....*....|....*
gi 530364572 248 PQLPQVLQHVRLPLL 262
Cdd:cd18516   84 KALPVLLESIRFRLM 98
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 70-145 2.45e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 73.85  E-value: 2.45e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572  70 VVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAA 145
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 165-262 3.61e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 74.04  E-value: 3.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*...
gi 530364572 245 ERRPQLPQVLQHVRLPLL 262
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLM 98
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-161 3.65e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 74.59  E-value: 3.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  66 ELCDVVLVVG--AKKIYAHRVILSACSPYFRAMF-TGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 142
Cdd:cd18294   13 EFSDVKFLVGpeRQEIFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92

                         90
                 ....*....|....*....
gi 530364572 143 PAACLLQLAEIQEACCEFL 161
Cdd:cd18294   93 AAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-162 9.16e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 73.74  E-value: 9.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18332    1 RHSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-169 1.02e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 74.01  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAeSRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 142
Cdd:cd18281   22 LSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTL 100

                         90       100
                 ....*....|....*....|....*..
gi 530364572 143 PAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18281  101 YTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-161 1.05e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 73.56  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18277    5 YESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQ-ADAELNITLPEEVTVKGFEPLIQ 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18277   84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-163 1.30e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 73.46  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHR-ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGEL---AESRQTEvvIRDIDERAME 120
Cdd:cd18207    4 YQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEgdgGTPRELE--MHTISSKVFG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530364572 121 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 163
Cdd:cd18207   82 DILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
Kelch smart00612
Kelch domain;
415-460 2.24e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 70.28  E-value: 2.24e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530364572   415 LYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGG 460
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-161 6.18e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 71.52  E-value: 6.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18278    9 YESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQ-TENDLVVSLPEEVTARGFGPLLQ 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18278   88 FAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-161 6.93e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 70.58  E-value: 6.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAEsrqtEVVIRDIDE---RAMELLIDFAYTSQITVEEGNVQTLLP 143
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDG----DLVITLPEEvtvKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                         90
                 ....*....|....*...
gi 530364572 144 AACLLQLAEIQEACCEFL 161
Cdd:cd18955   77 CAEFLGVHNIEKACFDFL 94
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 165-239 7.17e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 69.72  E-value: 7.17e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 239
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
Kelch smart00612
Kelch domain;
319-365 8.11e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.74  E-value: 8.11e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 530364572   319 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDD 365
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
366-413 8.19e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.74  E-value: 8.19e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530364572   366 LLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTSVGVAVLGG 413
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTP-LPSMPTPRSGHGVAVING 47
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-165 8.45e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 71.02  E-value: 8.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  59 NLLRKHReLCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNV 138
Cdd:cd18279   11 NLWENSR-FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMA 89

                         90       100
                 ....*....|....*....|....*..
gi 530364572 139 QTLLPAACLLQLAEIQEACCEFLKRQL 165
Cdd:cd18279   90 DDLLAAADKYALERLKVMCEDALCSNL 116
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-160 1.18e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 70.29  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18215    1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEF 160
Cdd:cd18215   81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-162 2.43e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 69.87  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  36 GVPQParmpyisdKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR------QTEV 109
Cdd:cd18327    2 GIPFP--------EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgaggGQDV 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530364572 110 VIRD-IDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18327   74 CELDfVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-160 4.09e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 68.29  E-value: 4.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  68 CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERA---MELLIDFAYTSQITVEEGNVQTLLPA 144
Cdd:cd18307    2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSpetVEQLLDYFYTGKIVISEKNVEDLLKG 81

                         90
                 ....*....|....*.
gi 530364572 145 ACLLQLAEIQEACCEF 160
Cdd:cd18307   82 AKYFNIPRLKDHCVDF 97
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 165-261 5.06e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 68.22  E-value: 5.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90
                 ....*....|....*..
gi 530364572 245 ERRPQLPQVLQHVRLPL 261
Cdd:cd18462   81 KRIECAYDLLSSIKLDL 97
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-159 6.51e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 68.66  E-value: 6.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  60 LLRKHRE-----LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGEL-AESRQTEVVIRDIDERAMELLIDFAYTSQITV 133
Cdd:cd18293    3 FLQLHRQqnsgvFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPpPAGQKVVLELQGLKAHTLLKLVDFLYTSELEV 82

                         90       100
                 ....*....|....*....|....*.
gi 530364572 134 EEGNVQTLLPAACLLQLAEIQEACCE 159
Cdd:cd18293   83 SSEEAQDVLAAARRLQISELESLCLE 108
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 354-393 7.42e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 65.71  E-value: 7.42e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 530364572  354 RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS 393
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-170 8.33e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 68.83  E-value: 8.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Cdd:cd18244    8 YNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQ 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18244   88 FMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-164 1.11e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 67.64  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  66 ELCDVVLVVGAKK--IYAHRVILSACSPYFRAMFTgELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLP 143
Cdd:cd18231   13 DLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFT-QNKQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLN 91

                         90       100
                 ....*....|....*....|.
gi 530364572 144 AACLLQLAEIQEACCEFLKRQ 164
Cdd:cd18231   92 AAAVLQMNDIAASCQELIDSR 112
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 165-239 1.26e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 66.38  E-value: 1.26e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530364572 165 LDPSNCLGIRAFADTHSCREL-LRIADKFTQHnFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 239
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLqEHCIRVLLRD-FAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWV 75
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 165-258 1.29e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 66.76  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQE-VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 243
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 530364572 244 QERRPQLPQVLQHVR 258
Cdd:cd18482   81 KERAASAAEVLKCVR 95
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-157 1.49e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 67.57  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVV-IRDIDERAMELLIDFAY 127
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVdLSGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEAC 157
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-160 1.56e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 67.31  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  52 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFT-GELAESRQTEVVIRDIDE--RAMELLIDFAYT 128
Cdd:cd18292    2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELVEDPEcaAVFEKFLRYLYT 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 129 SQITVeegNVQTLLPaacLLQLAE------IQEACCEF 160
Cdd:cd18292   82 GQISV---NLETALP---LLMLADkynvtdLKQLCVDF 113
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-161 1.68e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 67.19  E-value: 1.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18331    6 RHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYT 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18331   86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
Kelch smart00612
Kelch domain;
509-554 1.77e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.89  E-value: 1.77e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530364572   509 IYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNG 554
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-160 4.86e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 65.55  E-value: 4.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESrqteVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFYTG 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEF 160
Cdd:cd18232   77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 449-494 5.99e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.40  E-value: 5.99e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530364572  449 RRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMG 494
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
462-507 6.43e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.35  E-value: 6.43e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530364572   462 LYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQD 507
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 403-447 6.48e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.01  E-value: 6.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 530364572  403 RTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMS 447
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-157 1.10e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 65.23  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRaMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18194    6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKRDLVRLNSDIvTAPAFGLLLDFMYE 84

                         90       100
                 ....*....|....*....|....*....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEAC 157
Cdd:cd18194   85 GRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-169 2.05e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 64.10  E-value: 2.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 148
Cdd:cd18345   20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAADKY 99

                         90       100
                 ....*....|....*....|.
gi 530364572 149 QLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18345  100 ALERLKVMCEEALCSNLSVEN 120
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 170-262 2.06e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 63.39  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRPQ 249
Cdd:cd18465    6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRAS 84

                         90
                 ....*....|...
gi 530364572 250 LPQVLQHVRLPLL 262
Cdd:cd18465   85 ASHVLCHIRFPLM 97
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-165 2.15e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 63.57  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 144
Cdd:cd18282    9 DVHFIVGppggTQRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYA 87

                         90       100
                 ....*....|....*....|.
gi 530364572 145 ACLLQLAEIQEACCEFLKRQL 165
Cdd:cd18282   88 AKKYLVPHLARACVQFLETSL 108
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 66-165 2.15e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 63.80  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  66 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITV-EEGNVQTLLPA 144
Cdd:cd18300    8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPIlEDGDCVGLIVL 87

                         90       100
                 ....*....|....*....|.
gi 530364572 145 ACLLQLAEIQEACCEFLKRQL 165
Cdd:cd18300   88 ANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-165 2.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 64.46  E-value: 2.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRaMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18323    6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDLVCINNEIvTAPAFSLLLEFMYE 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACceflKRQL 165
Cdd:cd18323   85 GRLSFNDTPVEDVLAAASYLHMNDIVKVC----KKRL 117
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-162 2.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 63.91  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR-AMFTGELaeSRQTEVVIRdiDERAMELLIDFAYTSQITV 133
Cdd:cd18222   13 LSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRdHMSLNEM--STVSISVIK--NPTVFEQLLSFCYTGRICL 88

                         90       100
                 ....*....|....*....|....*....
gi 530364572 134 EEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18222   89 QLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-161 3.06e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 63.74  E-value: 3.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDERAMELLIDfAYTSQITVE 134
Cdd:cd18197   13 LQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQSAEVGRKLLLS-CYTGALEVK 89

                         90       100
                 ....*....|....*....|....*..
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18197   90 KKELLKYLTAASYLQMVHIVEKCTEAL 116
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 165-241 4.54e-12

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 61.98  E-value: 4.54e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 241
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-167 4.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 63.31  E-value: 4.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  48 DKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDERAMELLIDfAY 127
Cdd:cd18214    6 ENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVGRQLLLS-CY 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18214   83 TGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-169 5.89e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 63.10  E-value: 5.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:cd18343   15 LWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADN 94

                         90       100
                 ....*....|....*....|....*....
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18343   95 LLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-166 6.68e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 62.67  E-value: 6.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  53 QTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR-QTEVVIRDIDE-RAMELLIDFAYTSQ 130
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCdQTTVTHLDVVAvQGFSVILDFMYSGN 86

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530364572 131 ITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLD 166
Cdd:cd18201   87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-128 7.60e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 62.73  E-value: 7.60e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  59 NLLRKhRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Cdd:cd18280    7 ALLES-EEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-141 7.72e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 62.20  E-value: 7.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESrQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYSS 79

                         90
                 ....*....|..
gi 530364572 130 QITVEEGNVQTL 141
Cdd:cd18209   80 SLFVEKSSLAAV 91
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 165-246 1.13e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 61.13  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ..
gi 530364572 245 ER 246
Cdd:cd18451   81 ER 82
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-169 1.32e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 62.37  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelaesrQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18243   15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEYLYTA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18243   88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 137-263 1.38e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 61.09  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 137 NVQTLLPAACLLQLAEIQEACCEFLKRqldpsnclgirafadthscrellriadkftqhNFQEVMESEEFMLLPANQLID 216
Cdd:cd14822    5 NVCLIYDVASLYSLDDLCQTCCQFMDR--------------------------------NAQEVLSSEGFLTLSKSALKE 52

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530364572 217 IISSDELNVrSEEQVFNAVMAWVKYSiQERRPQLPQVLQHVRLPLLS 263
Cdd:cd14822   53 LLSRDSFCA-PEVDIFNAVRRWCEHN-PDSKEDAKEILEAVRLPLMS 97
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-162 2.20e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 61.06  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGelAESRQTEVVIRDI-DERAMELLIDFAYTSQITVEEGNVQTLLPAA 145
Cdd:cd18233   18 LCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQN--SSSQKNDVFHLDIkNVGGIGQILDFMYTSHLDLNQDNVQVMLDIA 95

                         90
                 ....*....|....*..
gi 530364572 146 CLLQLAEIQEACCEFLK 162
Cdd:cd18233   96 QCLQVQNVLNMCYTFLK 112
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 67-145 2.24e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 60.95  E-value: 2.24e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAA 145
Cdd:cd18352   13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 543-588 2.60e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.78  E-value: 2.60e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530364572  543 RRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMN 588
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-173 2.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 60.58  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFtgelaeSRQTeVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 148
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARL------SRDI-LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                         90       100
                 ....*....|....*....|....*
gi 530364572 149 QLAEIQEACCEFLKRQLDPSNCLGI 173
Cdd:cd18275   79 QMPCAAQCAVDAVRAQLCLGNCYEV 103
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-157 2.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 60.54  E-value: 2.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgelaESRQTEVVIRD---IDERAMELLIDFA 126
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFLDqsqVSADGFQKLLEFI 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530364572 127 YTSQITVEEGNVQTLLPAACLLQLAEIQEAC 157
Cdd:cd18217   76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 496-541 3.74e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.39  E-value: 3.74e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530364572  496 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMT 541
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
555-599 4.01e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.95  E-value: 4.01e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 530364572   555 QLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-163 4.98e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 60.24  E-value: 4.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTS 129
Cdd:cd18216    3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLDQDMV----SPTVFQQILDFIYTG 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530364572 130 QI---TVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 163
Cdd:cd18216   79 KLldsLFEEPNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-165 5.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 60.25  E-value: 5.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  47 SDKHPRQTLEVINLLRKHRELCDVVLVV---GAKKIY-AHRVILSACSPYFRAMFTGE-LAESRQTEVVIRDIDERAMEL 121
Cdd:cd18211    5 SKSAPSNLLNEMHKLRLLGHLCDVTVQVehqGSKEEFsAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFAS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530364572 122 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEfLKRQL 165
Cdd:cd18211   85 FLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ-LKKQM 127
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-162 6.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 60.05  E-value: 6.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELaESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18325    6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQL-DKRDIVHLNSDIvTAPAFSLLLEFMYE 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18325   85 GKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLK 118
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-162 8.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 59.57  E-value: 8.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQteVVIRDI-DERAMELLIDFAYTSQITV 133
Cdd:cd18227   13 LQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVL--LKNSRR--IVLPDVmNPRVFENILLSCYTGRLVL 88

                         90       100
                 ....*....|....*....|....*....
gi 530364572 134 EEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18227   89 PAPEIVSYLTAASFLQMWHVVDKCTELLE 117
PLN02153 PLN02153
epithiospecifier protein
 355-561 8.41e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 63.85  E-value: 8.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 355 RCGVGVSVLDDLLYAVGGH-------DGSSYLnsverYDPKTNQWS----SDVAPTSTCRTSVGVAVlGGFLYAVGGQDG 423
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkpnehiDKDLYV-----FDFNTHTWSiapaNGDVPRISCLGVRMVAV-GTKLYIFGGRDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 424 VSCLNIVERYDPKENKWTRVASMSTR-----RLGVAVAVLGGFLYAVGG-SDG---TSP--LNTVERYNPQENRWHTIAP 492
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvSKGglmKTPerFRTIEAYNIADGKWVQLPD 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 493 MG---TRRKHLGCAVYQDMIYAV---------GGRDDtTELSSAERYNPRTNQWSPVV---AMTSRRSGVGLAVVNGQLM 557
Cdd:PLN02153 177 PGenfEKRGGAGFAVVQGKIWVVygfatsilpGGKSD-YESNAVQFFDPASGKWTEVEttgAKPSARSVFAHAVVGKYII 255


                 ....
gi 530364572 558 AVGG 561
Cdd:PLN02153 256 IFGG 259
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-165 9.79e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 59.23  E-value: 9.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  60 LLRKHRELCDVVLVVGA----KKIYAHRVILSACSPYFRAMFTGELAESRqTEVVIRDIDERAMELLIDFAYTSQITVEE 135
Cdd:cd18349    1 LMFNNELMADVHFIVGPpgasQRVPAHKYVLAVGSSVFYAMFYGDLAEVK-SEIHIPDVEPAAFLILLKYMYSDEIDLEA 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 530364572 136 GNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
Cdd:cd18349   80 DTVLATLYAAKKYIVPALAKACVNFLETSL 109
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-156 1.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 59.42  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTEVVIRDIDERAMELLIDFA 126
Cdd:cd18212    3 SKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEFI 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 530364572 127 YTSQITVEEGNVQTLLPAACLLQLAEIQEA 156
Cdd:cd18212   82 YTGCLQVGEKSLEQILATAQFLKVNDLVKA 111
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-169 1.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 59.58  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  44 PYISDkhPRQTLEV-INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELL 122
Cdd:cd18344    1 PAIKD--PRHMLTDdLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530364572 123 IDFAYTSQI-TVEEGNVQT-LLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18344   79 MGFIYTGKApHLHSHSMACdVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-167 1.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 59.12  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDERAMELLIDfAYTS 129
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRVVADLLLS-CYTG 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18203   85 ALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-169 1.31e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 59.32  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESrQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 142
Cdd:cd18347   22 LSDVHFLVGkglgSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                         90       100
                 ....*....|....*....|....*..
gi 530364572 143 PAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18347  101 YTAKKYAVPALEAHCVEFLKKNLRADN 127
PLN02193 PLN02193
nitrile-specifier protein
 403-581 1.43e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.82  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 403 RTSVGVAVLGGFLYAVGGQdgvsclniverYDPKE--NKWTRVASMSTRR---------------LGVAVAVLGGFLYAV 465
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGE-----------FTPNQpiDKHLYVFDLETRTwsispatgdvphlscLGVRMVSIGSTLYVF 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 466 GGSDGTSPLNTVERYNPQENRWHTIAPMG---TRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQW----SPVV 538
Cdd:PLN02193 235 GGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcsTPGD 314

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530364572 539 AMTSrRSGVGLAVVNGQLMAVGGFDGTTyLKTIEVFDPDANTW 581
Cdd:PLN02193 315 SFSI-RGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKW 355
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-162 1.44e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 58.83  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACsPYFRAMFTGELAESRQTEVVIRDIDER--AMELLIDFA--YTSQITVEEGNVQTLLPA 144
Cdd:cd18305   17 DITICALGREWKLHKIYLCQS-GYFASMFSGSWKESKETVINLEIPDDNitVEALNVVFGslYRDEIEIKPSRVVSILAA 95

                         90
                 ....*....|....*...
gi 530364572 145 ACLLQLAEIQEACCEFLK 162
Cdd:cd18305   96 ATLLQLDGLIQQCSEVMK 113
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-163 1.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 58.83  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTS 129
Cdd:cd18334    4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMV----NPTVFRQILDFIYTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 130 QITVE----EGNVQTLLPAACLLQLAEIQEACCEFLKR 163
Cdd:cd18334   80 KLLTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-160 1.85e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 58.89  E-value: 1.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRdidERAMELLIDFAYTSQITVE 134
Cdd:cd18290   15 LECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQ---PQSFQQILSFCYTGRLSMN 91

                         90       100
                 ....*....|....*....|....*.
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEF 160
Cdd:cd18290   92 VGDQFLLMYTAGFLQIQEIMEKGTEF 117
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-165 2.17e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 58.12  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTeVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYTA 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEflKRQL 165
Cdd:cd18204   80 KISVKKEDVNLMMSSGQILGIRFLDKLCSQ--KRDV 113
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-168 2.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 58.29  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  61 LRKHRE---LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYTSQITVEEG 136
Cdd:cd18956   14 LRQQRElgfLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVRLNGDIvTAPAFGRLLDFMYEGRLDLRSL 93

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530364572 137 NVQTLLPAACLLQLAEIQEACCEFLkRQLDPS 168
Cdd:cd18956   94 PVEDVLAAASYLHMYDIVKVCKGRL-REKDPA 124
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-164 2.92e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 58.90  E-value: 2.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELaESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18324    6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQL-DKRDIVHLNSDIvTAPAFALLLEFMYE 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164
Cdd:cd18324   85 GKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-163 5.01e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 57.27  E-value: 5.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYtSQITVEEGNVQ--TLLPAAC 146
Cdd:cd18286   19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIY-GGVLDLPDDVNlgELLSLAD 97

                         90
                 ....*....|....*..
gi 530364572 147 LLQLAEIQEACCEFLKR 163
Cdd:cd18286   98 MYGLDGLKDVVAYTLRR 114
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 59-162 6.88e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 56.45  E-value: 6.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  59 NLLrkHRELC-DVVLVVGAK-KIYAHRVILSACSPYFRAMFtgelaeSRQTEVVI-RDIDERAMELLIDFAYTSQITVEE 135
Cdd:cd18299    5 NLL--HSPSCaDVVFILQGGvRIFAHRIVLAAASSVFADLF------LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENE 76

                         90       100
                 ....*....|....*....|....*..
gi 530364572 136 GNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18299   77 DDLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-161 8.15e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 8.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVYS 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18329   84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 169-263 8.66e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 56.04  E-value: 8.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRP 248
Cdd:cd18470    5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                         90
                 ....*....|....*
gi 530364572 249 QLPQVLQHVRLPLLS 263
Cdd:cd18470   84 YAADLLSNIRFGTIS 98
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-161 1.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 56.28  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 128
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFSIILDFVYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18199   81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-157 1.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 55.70  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  58 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYTSQITVEEG 136
Cdd:cd18330    9 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIvTSEAFSIILDFLYSGKLDLCSE 88

                         90       100
                 ....*....|....*....|.
gi 530364572 137 NVQTLLPAACLLQLAEIQEAC 157
Cdd:cd18330   89 NVIEVMSAASYLQMTDVVNFC 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 316-352 1.87e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.38  E-value: 1.87e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530364572  316 CGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS 352
Cdd:pfam01344  10 VGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-145 2.29e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 54.91  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRamftGELAESRQTEVVIR-DIDERAMELLIDFAYT 128
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFR----ERLLGSNGPLPPLSlEVTPVGWEAVLTFAYT 76

                         90
                 ....*....|....*..
gi 530364572 129 SQITVEEGNVQTLLPAA 145
Cdd:cd18262   77 GVLGRNPATVGDILVAA 93
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-157 3.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 55.22  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  42 RMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVViRDIDERAMEL 121
Cdd:cd18224    1 RIKLHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVV-DFITPANFEK 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530364572 122 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEAC 157
Cdd:cd18224   80 VLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-152 3.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 54.81  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  47 SDKHPRQTLEVINLLR-KHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelaESRQTEVVIRD-IDERAMELLID 124
Cdd:cd18226    1 SLQYNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS----KNPNTDAVTLDhVSYSVFQHLLE 76

                         90       100
                 ....*....|....*....|....*...
gi 530364572 125 FAYTSQITVEEGNVQTLLPAACLLQLAE 152
Cdd:cd18226   77 FLYTSEFFVYENEIPLVLEAAKFLDIID 104
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-169 3.74e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 55.11  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 140
Cdd:cd18342   16 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADD 95

                         90       100
                 ....*....|....*....|....*....
gi 530364572 141 LLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18342   96 LLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-136 3.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 54.90  E-value: 3.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDID---ERAMEL----- 121
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATqspERVLELpgvka 80

                         90       100
                 ....*....|....*....|
gi 530364572 122 -----LIDFAYTSQITVEEG 136
Cdd:cd18195   81 gvfsdVLNFIYSSRVALPGS 100
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-129 4.14e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 54.22  E-value: 4.14e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT----EVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYTD 84
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-161 4.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 54.27  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgelaeSRQTEVVIRD-IDERAMELLIDFAYT 128
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF------HRNSQHYTLDfLSPKTFQQILEYAYT 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 129 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18205   75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-169 4.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 55.06  E-value: 4.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVG----------AKKIYAHRVILSACSPYFRAMFTGELAESrQTEVVIRDIDERAMELLIDFAYTSQITVEEG 136
Cdd:cd18346   22 LSDVRFVVGkgrprgpgpgAQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPE 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 137 NVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18346  101 TVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-171 8.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 54.21  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  44 PYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAeSRQTEVVIRDIDERAMELLI 123
Cdd:cd18351    1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPS-AENTCIEISYVKYHIFQLVM 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530364572 124 DFAY---TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 171
Cdd:cd18351   80 QYLYcggTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-163 9.27e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 53.75  E-value: 9.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIderaMELLIDFAYTS 129
Cdd:cd18333    4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGI----FRLILDYIYTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 130 QIT-VEEGNVQTL---LPAACLLQLAEIQEACCEFLKR 163
Cdd:cd18333   80 RLSeGDPGSEQNLgavLAAASYLQIPDLVALCKKKLKR 117
PRK14131 PRK14131
N-acetylneuraminate epimerase;
436-561 1.00e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 57.72  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 436 KENKWTRVASM-STRRLGVAVAVLGGFLYAVGGS----DGTSP--LNTVERYNPQENRWH---TIAPMGTrRKHLGCAVY 505
Cdd:PRK14131  60 PSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnSEGSPqvFDDVYKYDPKTNSWQkldTRSPVGL-AGHVAVSLH 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 506 QDMIYAVGGRD---------DTTEL---SSAER----------------------YNPRTNQWSPVVAMT-SRRSGVGLA 550
Cdd:PRK14131 139 NGKAYITGGVNknifdgyfeDLAAAgkdKTPKDkindayfdkkpedyffnkevlsYDPSTNQWKNAGESPfLGTAGSAVV 218

                        170
                 ....*....|.
gi 530364572 551 VVNGQLMAVGG 561
Cdd:PRK14131 219 IKGNKLWLING 229
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-162 1.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 53.49  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdIDERAMELLIDFAYTSQITVE 134
Cdd:cd18220   13 LSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVI---KNPNVFEQLLSFCYTGRMSLQ 89

                         90       100
                 ....*....|....*....|....*...
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18220   90 LKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 55-149 1.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 53.36  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVL-VVGAKKIYAHRVILSACSPYFrAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITV 133
Cdd:cd18311    2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYF-NVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEF 80

                         90
                 ....*....|....*.
gi 530364572 134 EEGNVQTLLPAACLLQ 149
Cdd:cd18311   81 EEKSYGKLLRTAKELN 96
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-159 1.18e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 53.29  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  51 PRQTLEVINLLRKHRE---LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAY 127
Cdd:cd18192    2 PSHSSYVLQQLNNQREwgfLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMY 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530364572 128 TSQITVEEGNVQTLLPAACLLQLAEIQEaCCE 159
Cdd:cd18192   82 LGKIMTAPSDFEQLKVAMNYLQLYYIPE-CLE 112
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 56-166 1.95e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 52.68  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  56 EVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT-----EVVIRDIDERAMELLIDFAYT-- 128
Cdd:cd18296    6 ELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTdd 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530364572 129 SQITVEegNVQTLLPAACLLQLAEIQEACCEFLKRQLD 166
Cdd:cd18296   86 TDLPPE--NAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-161 2.09e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 52.54  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRamftGELAESRQTEVVIRDI-DERAMELLIDFAYTSQITV 133
Cdd:cd18210    9 LESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLASAYTGKLTM 84

                         90       100
                 ....*....|....*....|....*...
gi 530364572 134 EEGNVQTLLPAACLLQLAEIQEACCEFL 161
Cdd:cd18210   85 LADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-162 3.02e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 51.86  E-value: 3.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLT---NPNPGQWCLGEGISPSTFKQLLDFVYGE 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530364572 130 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18218   78 SVEVQPGELRPLLEAARALEVESLEEACWRALG 110
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-156 3.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 51.93  E-value: 3.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRqteVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPL---VEIEGVSNMAFRHLIEFTYTA 77

                         90       100
                 ....*....|....*....|....*...
gi 530364572 130 QITVE-EGNVQTLLPAACLLQLAEIQEA 156
Cdd:cd18221   78 KLMVQgEEEANDVWKAAEYLQMQEAIKA 105
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-157 4.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 52.16  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  64 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTE--VVIRDIDERAMELLIDFAY---TSQITVEEGNV 138
Cdd:cd18350   21 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSktIEISDIKYHIFQMLMQYLYyggTESMEIPIADV 100

                         90
                 ....*....|....*....
gi 530364572 139 QTLLPAACLLQLAEIQEAC 157
Cdd:cd18350  101 LELLSAASLFQLDALQRHC 119
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-161 6.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 50.97  E-value: 6.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVV-GAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAY--TSQITVEEGNVQTLLPAA 145
Cdd:cd18191    3 DLRFLLdGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHgcRGCDANEDDEKSDQSPEG 82

                         90
                 ....*....|....*...
gi 530364572 146 CLLQ--LAEIQEACCEFL 161
Cdd:cd18191   83 DLMKssLGQTLEVAGRFL 100
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-163 1.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 50.45  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTSQITVE 134
Cdd:cd18208   13 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVV----SVQSVQKLIDFMYSGVLRVS 88

                         90       100
                 ....*....|....*....|....*....
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFLKR 163
Cdd:cd18208   89 QSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-167 1.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 50.80  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  57 VINLLRKHREL---CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGelaESRQTEVVIRDIDERAMELLIDFAYTSQITV 133
Cdd:cd18289   16 VLGCLNEQRLMglyCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG---NSKSAFELPATVPPACFQQILSFCYTGKLTM 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530364572 134 EEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 167
Cdd:cd18289   93 AASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126
Kelch_6 pfam13964
Kelch motif;
450-497 1.38e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 48.10  E-value: 1.38e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530364572  450 RLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRR 497
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-163 1.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 49.95  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 148
Cdd:cd18298   14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93

                         90
                 ....*....|....*
gi 530364572 149 QLAEIQEACCEFLKR 163
Cdd:cd18298   94 CEERLKKLCEDIIKQ 108
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-162 1.55e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 49.85  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgeLAESRQTEVVIRDIDERAMELLIDFAYTSQITVE 134
Cdd:cd18200    6 LETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSGRLTLC 82

                         90       100
                 ....*....|....*....|....*...
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFLK 162
Cdd:cd18200   83 MDALPSHLLVASGLQMWQVVDRCSELLK 110
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-163 1.63e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 49.86  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  52 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTSQI 131
Cdd:cd18229    3 KSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVV----PAQTVRQLVEFMYSGSL 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530364572 132 TVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 163
Cdd:cd18229   79 VVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-145 2.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 49.79  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSS 80

                         90
                 ....*....|....*.
gi 530364572 130 QITVEEGNVQTLLPAA 145
Cdd:cd18223   81 KVVVKRQETVTDLVAA 96
PLN02193 PLN02193
nitrile-specifier protein
 338-514 2.42e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.42  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 338 YDPQTNEWRM---VASMSKRRC-GVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS--SDVAPTSTCRTSVGVAVL 411
Cdd:PLN02193 198 FDLETRTWSIspaTGDVPHLSClGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKllTPVEEGPTPRSFHSMAAD 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 412 GGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMS---TRRLGVAVAVLGGFLYAVGGSDGTSpLNTVERYNPQENRWH 488
Cdd:PLN02193 278 EENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGdsfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWT 356

                        170       180
                 ....*....|....*....|....*....
gi 530364572 489 TIAPMGTR---RKHLGCAVYQDMIYAVGG 514
Cdd:PLN02193 357 QVETFGVRpseRSVFASAAVGKHIVIFGG 385
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 142-239 2.58e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 48.34  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 142 LPAACLLQLAEIQEACCEFLKRqldpsnclgirafadthscrellriadkftqhNFQEVMESEEFMLLPANQLIDIISSD 221
Cdd:cd18493    9 LQYAKMCGHKELAEACLEFIAW--------------------------------NFEKVLKSPDWLNLDLDLLVSLLQSS 56

                         90
                 ....*....|....*...
gi 530364572 222 ELNVRSEEQVFNAVMAWV 239
Cdd:cd18493   57 DLVVEDEYTLFQAVEKWL 74
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-158 2.65e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 49.56  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRqtEVVIRD--IDERAMELLIDFAYTSQITVEEGNVQTLLPAA- 145
Cdd:cd18295   21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKR--EINLKHplVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAk 98

                         90
                 ....*....|....*
gi 530364572 146 -C-LLQLAEIQEACC 158
Cdd:cd18295   99 qCrLEELIEELEAKC 113
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 169-260 3.02e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 48.57  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRP 248
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                         90
                 ....*....|..
gi 530364572 249 QLPQVLQHVRLP 260
Cdd:cd18449   84 FAAKLMENIRFP 95
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 169-246 4.01e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 47.96  E-value: 4.01e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530364572 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSdelNVRSEEQVFNAVMAWVKYSIQER 246
Cdd:cd18481    5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEER 79
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-157 4.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 4.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  52 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDiderAMELLIDFAYTSQI 131
Cdd:cd18225    8 RQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPE----EFALLLEMVYTGKL 83

                         90       100
                 ....*....|....*....|....*.
gi 530364572 132 TVEEGNVQTLLPAACLLQLAEIQEAC 157
Cdd:cd18225   84 PPGKHNFTKIISVADSLQMFDVAVSC 109
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-169 6.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 48.86  E-value: 6.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 142
Cdd:cd18348   21 MADIHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATL 99

                         90       100
                 ....*....|....*....|....*..
gi 530364572 143 PAACLLQLAEIQEACCEFLKRQLDPSN 169
Cdd:cd18348  100 YAAKKYIVPHLARACVNFLETSLSAKN 126
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 69-146 1.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 46.74  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD--IDERAMELLIDFAYTSQ-ITVEEGNVQTLLPAA 145
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEEngISIEAMRAVIDFSVTGRlDLFSVENVHEVLELA 80


                 .
gi 530364572 146 C 146
Cdd:cd18190   81 S 81
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 65-169 1.23e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 47.77  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  65 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI--DERAMELLIDFAYTSQITVEEGNVQTLL 142
Cdd:cd18309   18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIYYGDVTMPPEDSLYLF 97

                         90       100
                 ....*....|....*....|....*....
gi 530364572 143 PAACLLQLA--EIQEACCEFLKRQLDPSN 169
Cdd:cd18309   98 SAPYFYGFTnnRLQAYCKQNLEMNVSFEN 126
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 165-262 1.76e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 46.68  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Cdd:cd18461    1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYHYTPEQ 80

                         90       100
                 ....*....|....*....|...
gi 530364572 245 ERRPQL-----PQVLQHVRLPLL 262
Cdd:cd18461   81 VEKDQVslqepPKLLEAVRFPLM 103
Kelch_6 pfam13964
Kelch motif;
402-450 1.83e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.83e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530364572  402 CRTSVGVAVLGGFLYAVGGQ-DGVSCLNIVERYDPKENKWTRVASMSTRR 450
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 63-142 1.92e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 46.97  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  63 KHRELCDVVLV-VGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQI-TVEEGNVQT 140
Cdd:cd18302    1 KHSDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEAsAVKESQNVE 80


                 ..
gi 530364572 141 LL 142
Cdd:cd18302   81 FL 82
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-131 1.92e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 46.75  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFT--GELAEsrqtevvIRDIDERAMELLIDFA 126
Cdd:cd18219    3 QYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSvaGQVVE-------LNFIRADIFAEILNYI 75


                 ....*
gi 530364572 127 YTSQI 131
Cdd:cd18219   76 YSSKI 80
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 187-250 6.62e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 44.99  E-value: 6.62e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530364572 187 RIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVrSEEQVFNAVMAWVKYS----IQERRPQL 250
Cdd:cd18489   24 RQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEHQlikrMEEREPNL 90
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-166 7.49e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 45.72  E-value: 7.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQIT-VEEGNVQTLLPAA-- 145
Cdd:cd18358   22 DVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSpTADLDPLELIALAnr 101

                         90       100
                 ....*....|....*....|....
gi 530364572 146 -CLLQLAEI--QEACCEFLKRQLD 166
Cdd:cd18358  102 fCLPHLVALteQHAVQELTKASKS 125
PRK14131 PRK14131
N-acetylneuraminate epimerase;
456-579 1.12e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 48.09  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 456 AVLGGFLYaVG-GSDGTS--PLNTveryNPQENRWHTIAPM-GTRRKHLGCAVYQDMIYAVGGRDDTTE------LSSAE 525
Cdd:PRK14131  35 AIDNNTVY-VGlGSAGTSwyKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVY 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530364572 526 RYNPRTNQWSPVvaMTsrRSGVGLAVV------NGQLMAVGG-----FDGttYLKTIEVFDPDAN 579
Cdd:PRK14131 110 KYDPKTNSWQKL--DT--RSPVGLAGHvavslhNGKAYITGGvnkniFDG--YFEDLAAAGKDKT 168
Kelch_6 pfam13964
Kelch motif;
497-544 1.46e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530364572  497 RKHLGCAVYQDMIYAVGGRDDTTELSSA-ERYNPRTNQWSPVVAMTSRR 544
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKlEVYNPLTKSWEELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 403-581 1.69e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 47.29  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 403 RTSVGVAVLGGFLYAVGGQ--DGVSCLNIVERYDPKENKWT------RVASMSTrrLGVAVAVLGGFLYAVGGSDGTSPL 474
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkPNEHIDKDLYVFDFNTHTWSiapangDVPRISC--LGVRMVAVGTKLYIFGGRDEKREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 475 NTVERYNPQENRWHTIAPMGTR-----RKHLGCAVYQDMIYAVGG------RDDTTELSSAERYNPRTNQWSPVV---AM 540
Cdd:PLN02153 101 SDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYNIADGKWVQLPdpgEN 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530364572 541 TSRRSGVGLAVVNGQLMAVGGFdGTTYL---------KTIEVFDPDANTW 581
Cdd:PLN02153 181 FEKRGGAGFAVVQGKIWVVYGF-ATSILpggksdyesNAVQFFDPASGKW 229
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-132 2.12e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 44.22  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  50 HPRQTLEVINLLRKHrELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 129
Cdd:cd18359    4 HVRRTNRVKECLAKG-TFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTG 82


                 ...
gi 530364572 130 QIT 132
Cdd:cd18359   83 QFS 85
Kelch_6 pfam13964
Kelch motif;
544-591 4.29e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 4.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530364572  544 RSGVGLAVVNGQLMAVGGF-DGTTYLKTIEVFDPDANTWRLYGGMNYRR 591
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
COG5276 COG5276
Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...
 357-578 9.51e-05

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];


Pssm-ID: 444087 [Multi-domain]  Cd Length: 320  Bit Score: 44.93  E-value: 9.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 357 GVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNqwSSDVAPTSTCRtsvGVAVLGGFLYAVG-GQDGVSCLNIVERYDP 435
Cdd:COG5276   22 ANDVWVSGEYAYVAGGSNGLAIVDVSDPANPVLV--GSLPTPGGTWR---DVKVSGDYLYVASeGSEGLQIFDISDPANP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 436 KEnkwtrVASMSTRRLGV-AVAVLGGFLYAVGGSDG-------TSPLNTVErynpqENRWHTIapmGTRRKHlGCAVYQD 507
Cdd:COG5276   97 KL-----VGRYDTGGSGAhNIAVDGNYAYVAGGSDNglvivdiSDPTNPVL-----VGRYSLP---GQAYLH-DVQVVGD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 508 MIYAVGGRD-----DTTELS-----SAERYNPRTNQWSPVVamtsrrsgvglaVVNGQLMAVGG-FDGTTYLKTIEVFDP 576
Cdd:COG5276  163 YAYVADWEDglvivDVSDPSnpkliGSYDYSPPGYTHTAVP------------VEDGNYAYVGDeLGGPNGLRILDVSDP 230


                 ..
gi 530364572 577 DA 578
Cdd:COG5276  231 AN 232
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
250-485 1.07e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 250 LPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVggwCSG 329
Cdd:COG3391   12 LLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVA---NSG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 330 DaiSSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVgghdgSSYLNSVERYDPKTNQwssDVAPTSTCRTSVGVA 409
Cdd:COG3391   89 S--GRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVA-----DSGNGRVSVIDTATGK---VVATIPVGAGPHGIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 410 V--LGGFLYAV-GGQDGVSClnIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS--PLNTVERYNPQE 484
Cdd:COG3391  159 VdpDGKRLYVAnSGSNTVSV--IVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTSngGSNTVSVIDLAT 236


                 .
gi 530364572 485 N 485
Cdd:COG3391  237 L 237
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 354-393 1.08e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 40.01  E-value: 1.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530364572  354 RRCGVGVSVLDDLLYAVGGHD--GSSYLNSVERYDPKTNQWS 393
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWT 42
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-170 1.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 41.93  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  57 VINLLRKHReLCDVVLVVGAKKIYAHRVILSACSPYFRAmftGELAESRQTEvvIRDIDERAMELLIDFAYTSQI--TVE 134
Cdd:cd18303    9 VASLFDKEL-YSDITIKLADKSIPAHKFVLAARSEKWSN---ENLASTNELD--LSDISYEVVLALLRWLYTDELdlTLD 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530364572 135 EGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Cdd:cd18303   83 DEFLLELMKAAKRFQLTDLVERCERALMSSVNVDNC 118
Kelch_4 pfam13418
Galactose oxidase, central domain;
354-393 1.44e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.52  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530364572  354 RRCGVGVSVLDDLLYAVGGHDGS-SYLNSVERYDPKTNQWS 393
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWT 42
PRK14131 PRK14131
N-acetylneuraminate epimerase;
409-468 1.52e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530364572 409 AVLGGFLYAVGG-----QDG-VSCLNIVERYDPKENKWTRVASMSTRRL--GVAVAVLGGFLYAVGGS 468
Cdd:PRK14131  81 AFIDGKLYVFGGigktnSEGsPQVFDDVYKYDPKTNSWQKLDTRSPVGLagHVAVSLHNGKAYITGGV 148
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 165-262 1.64e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 41.04  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMES--EEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 242
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90       100
                 ....*....|....*....|
gi 530364572 243 IqeRRPQLPQVLQHVRLPLL 262
Cdd:cd18471   81 C--RYQYMDELLQYVRFGLM 98
Kelch_6 pfam13964
Kelch motif;
355-403 1.82e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 1.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530364572  355 RCGVGVSVLDDLLYAVGG-HDGSSYLNSVERYDPKTNQWSSdVAPTSTCR 403
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEE-LPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
412-458 2.30e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 2.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530364572  412 GGFLYAVGG--QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVL 458
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
449-495 2.76e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 2.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 530364572  449 RRLGVAVAVLGGFLYAVGGSDG-TSPLNTVERYNPQENRWHTIAPMGT 495
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSLPS 49
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 66-152 3.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 40.39  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  66 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgELAESRQTEVVIRDI--DERAMELLIDFAYTSQITVEEGNVQTLLP 143
Cdd:cd18312    8 EPSDITVRVGNTTFHLHKFPLCSKSGYFKRLAS-SSSESDPSEIELNDFpgGAEAFELVAKFCYGMPINLTATNVVGLRC 86


                 ....*....
gi 530364572 144 AACLLQLAE 152
Cdd:cd18312   87 AAEYLEMTE 95
Kelch_3 pfam13415
Galactose oxidase, central domain;
317-363 4.58e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 4.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530364572  317 GEVLFAVGGWC--SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVL 363
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 449-493 5.15e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.09  E-value: 5.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530364572  449 RRLGVAVAVLGGFLYAVGGSDGTSPL--NTVERYNPQENRWHTIAPM 493
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLssSDVLVYDPETNVWTEVPRL 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
496-537 6.49e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 6.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 530364572  496 RRKHLGCAVYQDMIYAVGGR-DDTTELSSAERYNPRTNQWSPV 537
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEgEDGTLLSDLWVFDLSTNEWTRL 44
PLN02153 PLN02153
epithiospecifier protein
 317-467 6.83e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 42.28  E-value: 6.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS-----KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVER------Y 385
Cdd:PLN02153  85 GTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDeeggpEARTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaY 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 386 DPKTNQWSS--DVAPTSTCRTSVGVAVLGGFLYAV---------GGQDGVSClNIVERYDPKENKWTRVASMSTR---RL 451
Cdd:PLN02153 165 NIADGKWVQlpDPGENFEKRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKpsaRS 243

                        170
                 ....*....|....*.
gi 530364572 452 GVAVAVLGGFLYAVGG 467
Cdd:PLN02153 244 VFAHAVVGKYIIIFGG 259
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 169-264 7.20e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 39.49  E-value: 7.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 169 NCLGIRAFADTHSC-----RELLriaDKFTQHNFQEVMESEEFM-LLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 242
Cdd:cd18454    5 NCAEIMRLLDDFSVniegvREKL---DSFLLENFVPLMSRPDFLsYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHD 81

                         90       100
                 ....*....|....*....|..
gi 530364572 243 iQERRPQLPQVLQHVRLPLLSP 264
Cdd:cd18454   82 -RRRWRHTDTIIQNIRFCLMTP 102
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-152 8.04e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.85  E-value: 8.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIR--DIDERAMELLIDFAYTSQITVEEGNVQTLlpaAC 146
Cdd:cd18283    4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPtaGIDVPMFSALLRYLYTGEFGSEDSRSQNL---DV 80


                 ....*.
gi 530364572 147 LLQLAE 152
Cdd:cd18283   81 LIQLSE 86
PRK14131 PRK14131
N-acetylneuraminate epimerase;
341-467 8.18e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.92  E-value: 8.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 341 QTNEWRMVASM-SKRRCGVGVSVLDDLLYAVGG-----HDGS-SYLNSVERYDPKTNQWSSdvAPTSTCRT---SVGVAV 410
Cdd:PRK14131  60 PSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSpQVFDDVYKYDPKTNSWQK--LDTRSPVGlagHVAVSL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 411 LGGFLYAVGG----------QDGVSC------------------------LNIVERYDPKENKWtRVASMST--RRLGVA 454
Cdd:PRK14131 138 HNGKAYITGGvnknifdgyfEDLAAAgkdktpkdkindayfdkkpedyffNKEVLSYDPSTNQW-KNAGESPflGTAGSA 216

                        170
                 ....*....|...
gi 530364572 455 VAVLGGFLYAVGG 467
Cdd:PRK14131 217 VVIKGNKLWLING 229
Kelch_3 pfam13415
Galactose oxidase, central domain;
459-504 1.11e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530364572  459 GGFLYAVGGSD--GTSPLNTVERYNPQENRWHTIAPMGT-RRKHLGCAV 504
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPpRSGHSATYI 49
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 67-165 2.43e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 37.91  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT-SQITVEEGNVQTLLPAA 145
Cdd:cd18360   10 LADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdSCCPASILQAMALLICA 89

                         90       100
                 ....*....|....*....|
gi 530364572 146 CLLQLAEIQEACCEFLKRQL 165
Cdd:cd18360   90 EMYQVSRLQHICELYIITQL 109
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
305-551 4.35e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 39.23  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 305 GPRTRPRKPircgevlfAVGG----WCSGDAISSVERYDPQTNEWRMVASMSkrrcGVGVSVLddllyAVgGHDGS---- 376
Cdd:COG4257   14 APGSGPRDV--------AVDPdgavWFTDQGGGRIGRLDPATGEFTEYPLGG----GSGPHGI-----AV-DPDGNlwft 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 377 -SYLNSVERYDPKTNQWSSdVAPTSTCRTSVGVAVLG-GFLYaVGGQDGvsclNIVERYDPKENKWTRVASMSTrrlgva 454
Cdd:COG4257   76 dNGNNRIGRIDPKTGEITT-FALPGGGSNPHGIAFDPdGNLW-FTDQGG----NRIGRLDPATGEVTEFPLPTG------ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572 455 vavlGGFLYAVG-GSDGT-----SPLNTVERYNPQENRWHTIAPM----GTRRkhlGCAVYQDMIYAVggrdDTTElSSA 524
Cdd:COG4257  144 ----GAGPYGIAvDPDGNlwvtdFGANAIGRIDPDTGTLTEYALPtpgaGPRG---LAVDPDGNLWVA----DTGS-GRI 211

                        250       260
                 ....*....|....*....|....*..
gi 530364572 525 ERYNPRTNQWSPVVAMTSRRSGVGLAV 551
Cdd:COG4257  212 GRFDPKTGTVTEYPLPGGGARPYGVAV 238
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 381-561 4.54e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 38.92  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  381 SVERYDPKTNQ--WSSDVAPTSTCrtsvGVAVLGGFLYAVGGQDGVSCLNIveryDPKENKWTRVASmstRRLGVAVAVL 458
Cdd:pfam13360   4 VVTALDAATGAelWRVDLETGLGG----GVAVDGGRLFVATGGGQLVALDA----ATGKLLWRQTLS---GEVLGAPLVA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364572  459 GGFLYAVGGSdgtsplNTVERYNPQENR--WH--TIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELssaeryNPRTNQ- 533
Cdd:pfam13360  73 GGRVFVVAGD------GSLIALDAADGRrlWSyqRSGEPLALRSSGSPAVVGDTVVAGFSSGKLVAL------DPATGKv 140

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 530364572  534 -WSPVVAMTSRRSGV--------GLAVVNGQLMAVGG 561
Cdd:pfam13360 141 rWEAPLAAPRGTNELerlvditgTPVVAGGRVFASAY 177
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 183-240 4.83e-03

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 36.33  E-value: 4.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530364572 183 RELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVrSEEQVFNAVMAWVK 240
Cdd:cd18507   22 KTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGA-DEMTKFQAALAWSR 78
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-128 5.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 37.57  E-value: 5.36e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530364572  50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirDIDERAMELLIDFAYT 128
Cdd:cd18213    4 HSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPT--DIQPDIFSYLLHIMYT 80
Kelch_6 pfam13964
Kelch motif;
320-355 7.54e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 7.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530364572  320 LFAVGGWC-SGDAISSVERYDPQTNEWRMVASMSKRR 355
Cdd:pfam13964  14 IYVFGGYTnASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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