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Conserved domains on  [gi|528968698|ref|XP_005212804|]
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beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 222-485 0e+00

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23986:

Pssm-ID: 480271  Cd Length: 270  Bit Score: 551.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 222 ELLCALRGRVQVRTLDGTEPPFSALGWRALVPPVPLSRLLPRRLRTCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTR 301
Cdd:cd23986    6 ELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 302 GYEKDVGNKTTVRIINSQILTNPSYHFMDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYVQHRQRNPNQPFYIL 381
Cdd:cd23986   86 GYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPFYIL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 382 HPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAACTLGAYHPLLYEK 461
Cdd:cd23986  166 HPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLLYEK 245

                        250       260
                 ....*....|....*....|....
gi 528968698 462 LLVQRLNVGTHGDLHRKGKVVLPG 485
Cdd:cd23986  246 LLIQRMNKGTEDDLYRKGKVILPG 269
PHA03378 super family cl33729
EBNA-3B; Provisional
 35-152 2.33e-03

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  35 PAKPAPSSFSFLETRRLLPAQGRQRAIMGASEGLPEGADLRRGSPRGLPsGPLRTWAGdgfereqeflsvQTGRTSLSSF 114
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAAT-GRARPPAA------------APGRARPPAA 739

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528968698 115 APEDSAP--GTSGRLFPGDPGPEGARPPRAAPGRRAKRGP 152
Cdd:PHA03378 740 APGRARPpaAAPGRARPPAAAPGRARPPAAAPGAPTPQPP 779
 
Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 222-485 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 551.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 222 ELLCALRGRVQVRTLDGTEPPFSALGWRALVPPVPLSRLLPRRLRTCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTR 301
Cdd:cd23986    6 ELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 302 GYEKDVGNKTTVRIINSQILTNPSYHFMDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYVQHRQRNPNQPFYIL 381
Cdd:cd23986   86 GYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPFYIL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 382 HPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAACTLGAYHPLLYEK 461
Cdd:cd23986  166 HPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLLYEK 245

                        250       260
                 ....*....|....*....|....
gi 528968698 462 LLVQRLNVGTHGDLHRKGKVVLPG 485
Cdd:cd23986  246 LLIQRMNKGTEDDLYRKGKVILPG 269
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 267-480 1.29e-34

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 130.42  E-value: 1.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN--SQILTNPSYHFMDSALYKDVILVA--- 341
Cdd:pfam00777  45 RCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFSHPRDPFVEFVLvpf 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  342 ------WDPAP-YSANLNLWYKKpdynLFTpYVQHRQRNPNQPFYILHPKFIWQLWDIIQEntKEKIQPNPPSSGFIGIL 414
Cdd:pfam00777 125 kgrdllWLPAFlTKGNVSRSLRV----LYT-LKEVKIPVDPDKVLFLHPDFLRYVANFWLR--SHGLKGRRPSTGLLMLS 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968698  415 LMMNLCGEVHVYEYVP---SVRQTDlcHYHEPYHDAACTLGAYHPLLYEKLLVQRlnvgthgdLHRKGK 480
Cdd:pfam00777 198 LALHLCDEVSLYGFGPfldSRGNSH--HYYDNVLMKKGGFYGVHDMPFEFKLLQK--------LHKEGV 256
PHA03378 PHA03378
EBNA-3B; Provisional
 35-152 2.33e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  35 PAKPAPSSFSFLETRRLLPAQGRQRAIMGASEGLPEGADLRRGSPRGLPsGPLRTWAGdgfereqeflsvQTGRTSLSSF 114
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAAT-GRARPPAA------------APGRARPPAA 739

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528968698 115 APEDSAP--GTSGRLFPGDPGPEGARPPRAAPGRRAKRGP 152
Cdd:PHA03378 740 APGRARPpaAAPGRARPPAAAPGRARPPAAAPGAPTPQPP 779
 
Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 222-485 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 551.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 222 ELLCALRGRVQVRTLDGTEPPFSALGWRALVPPVPLSRLLPRRLRTCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTR 301
Cdd:cd23986    6 ELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 302 GYEKDVGNKTTVRIINSQILTNPSYHFMDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYVQHRQRNPNQPFYIL 381
Cdd:cd23986   86 GYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPFYIL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 382 HPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAACTLGAYHPLLYEK 461
Cdd:cd23986  166 HPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLLYEK 245

                        250       260
                 ....*....|....*....|....
gi 528968698 462 LLVQRLNVGTHGDLHRKGKVVLPG 485
Cdd:cd23986  246 LLIQRMNKGTEDDLYRKGKVILPG 269
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 222-486 2.52e-153

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 437.22  E-value: 2.52e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 222 ELLCALRGRVQVRTLDGTEPPFSALGWRALVPPvPLSRLLPRRLRTCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTR 301
Cdd:cd23985    3 ELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPK-KSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 302 GYEKDVGNKTTVRIINSQILTNPSYHFMDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYVQHRQRNPNQPFYIL 381
Cdd:cd23985   82 GFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYIL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 382 HPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAACTLGAYHPLLYEK 461
Cdd:cd23985  162 HPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYEK 241

                        250       260
                 ....*....|....*....|....*
gi 528968698 462 LLVQRLNVGTHGDLHRKGKVVLPGL 486
Cdd:cd23985  242 NLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 222-486 1.39e-145

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 417.44  E-value: 1.39e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 222 ELLCALRGRVQVRTLDGTEPPFSALGWRALVPPvPLSRLLPRRLRTCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTR 301
Cdd:cd23968    3 DLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFP-ESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 302 GYEKDVGNKTTVRIINSQILTNPSYHFMDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYVQHRQRNPNQPFYIL 381
Cdd:cd23968   82 GFEKDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 382 HPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAACTLGAYHPLLYEK 461
Cdd:cd23968  162 DPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEK 241

                        250       260
                 ....*....|....*....|....*
gi 528968698 462 LLVQRLNVGTHGDLHRKGKVVLPGL 486
Cdd:cd23968  242 LLVRHLNVGSDDDIFRKGRATLPGF 266
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 268-467 1.93e-47

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 162.53  E-value: 1.93e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILT----NPSYHFMDSALYKDVILVAWD 343
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGfylrGPRCGCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 344 PAPYSANLNLWYKKpdynlftpyvqhrqRNPNQPFYILH--PKFIWQLWDIIQ-ENTKEKIQPNPPSSGFIGILLMMNLC 420
Cdd:cd19952   81 AAAADFKRLKRRKK--------------RHDNAVLLLTDpaPDLLSYVRKRLEkLGLKSFFGGNAPSSGLLAVLLALQLC 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 528968698 421 GEVHVY--EYVPSVRQTDLCHYHEPYHDAACTlgAYHPLLYEKLLVQRL 467
Cdd:cd19952  147 DSVDLYgfGVDSGHAPKVPYHYYDLVEAEEGT--AVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 267-480 1.29e-34

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 130.42  E-value: 1.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN--SQILTNPSYHFMDSALYKDVILVA--- 341
Cdd:pfam00777  45 RCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFSHPRDPFVEFVLvpf 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  342 ------WDPAP-YSANLNLWYKKpdynLFTpYVQHRQRNPNQPFYILHPKFIWQLWDIIQEntKEKIQPNPPSSGFIGIL 414
Cdd:pfam00777 125 kgrdllWLPAFlTKGNVSRSLRV----LYT-LKEVKIPVDPDKVLFLHPDFLRYVANFWLR--SHGLKGRRPSTGLLMLS 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968698  415 LMMNLCGEVHVYEYVP---SVRQTDlcHYHEPYHDAACTLGAYHPLLYEKLLVQRlnvgthgdLHRKGK 480
Cdd:pfam00777 198 LALHLCDEVSLYGFGPfldSRGNSH--HYYDNVLMKKGGFYGVHDMPFEFKLLQK--------LHKEGV 256
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 267-466 3.38e-31

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 120.04  E-value: 3.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN----SQILTNPsyHFMDSALYKDVILVAW 342
Cdd:cd23965    3 TCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVShsslPRLLRNA--ILLLAGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 343 DPapySANLNLWyKKPDYNLFTPYVqhrQRNPNQPFYILHPKFIWQLWDIIQENT-KEKIQPNP-PSSGFIGILLMMNLC 420
Cdd:cd23965   81 GP---ETKMNKD-GAGKYNLLRSLS---KKYPDVEFYSLTPEKMDYADELFEKETgKSRIKSGTwLSTGWFTMLLALDVC 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528968698 421 GEVHVYEYVPSvrqtDLC----------HYHEP----------YHDAACTLGayHPLLYEKLLVQR 466
Cdd:cd23965  154 DEIKVYGMVPE----NYCrehpnskvpyHYYEPgglkectyynYHENALKGG--HRFITEKAVFAR 213
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 268-467 1.52e-28

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 112.00  E-value: 1.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRiinsqiLTNPSYHFMDSALYK---DVILVAWDP 344
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFR------MFYPESAFRDPEEYDsdwLLVLVPFKS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 345 APYS-----------ANLNLWYKKPDYNLftPYvqhrqrNPNQpFYILHPKFIWQL-WDIIQENTKEKIQPNPPSSGFIG 412
Cdd:cd23967   79 MDLLwlqavikgkkpNGKGGFWKKIATSV--PK------PPKK-IRILNPYILQEAaFDLIGLPMNGKQGKNVPTTGIIA 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528968698 413 ILLMMNLCGEVHV--YEYVPSVRQTDLcHYHEPYHDAACTLGAYHPLLYEKLLVQRL 467
Cdd:cd23967  150 IVMALHYCDEVDIagFGYDPSDPNAPL-HYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 267-479 2.56e-27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 110.81  E-value: 2.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILT----NPSYHFMDSALYKDVilvaw 342
Cdd:cd23963   65 TCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKrrynSLKKNRDRDKFLNRL----- 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 343 dpapysANLN---LWYKKPDYN-----LFTPYVQHRQRNPNQPFYILHPKF---IWQLWdiiqentKEKIQPNPPSSGFI 411
Cdd:cd23963  140 ------KEYNgsiLWYPKFSFKsstnlLLKAARALKKNGLNLTVVYSNPEHflaVQKFW-------KRRGLEKRPSTGLY 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968698 412 GILLMMNLCGEVHVYEYVPSvrQTDL------CHYHEpyHDAACTLGAYHPLLYE-KLLVQrlnvgthgdLHRKG 479
Cdd:cd23963  207 LVSLALTFCDEIHLYGFWPF--PTDPngrpvpYHYYD--DLSPSTKNKVHNMPEEfKLLRE---------LHKKG 268
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 267-467 8.59e-26

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 104.36  E-value: 8.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRII-------NSQILTNPSYHFmdsalykdvIL 339
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesaqfDPGIENDPDTLL---------VL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 340 VAWDPAPYSANLNLWY--KKPDYNLFTPYVQHRQRNPNQpFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILLMM 417
Cdd:cd23982   75 VPFKPLDFYWLYEILSneKRVRKGFWKQPPRIWDANPKQ-IRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITLAL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528968698 418 NLCGEVHV--YEYVPSVRQTDLCHYHEPYhdaacTL----GAYHPLLYEKLLVQRL 467
Cdd:cd23982  154 HLCDEVHIagFGYPDNGNSNQPIHYYNQI-----TLksmaNSGHNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 267-467 2.40e-22

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 94.81  E-value: 2.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQ-ILTNPSYHFMDSAlykdVILVAWDPA 345
Cdd:cd23984    4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPEsIFSDPSHYDPNTT----VVLIPFKPH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 346 PY----------SANLNLWYKKPDYNLftpyvqhrQRNPNQpFYILHPKFI----WQLWDIIQENTKEKIqPNPPSSGFI 411
Cdd:cd23984   80 DLrwlldllmgkKVSAKGFWKKPALNL--------IYKPNQ-IRILNPFILriaaYELLHFPKRFPKEKK-PKHPTTGII 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968698 412 GILLMMNLCGEVHV--YEYVPSVRQTDLcHYHEPYHDAACTLGAYHPLLYEKLLVQRL 467
Cdd:cd23984  150 AITLALHICNEVHIagFKYDFSNLNSTL-HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 268-455 2.52e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 95.31  E-value: 2.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQ----ILTNPSYHFMDSAlykDVILVAWD 343
Cdd:cd23977    4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQQSR---DTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 344 PapySANLNLWYKKPDYNLFtpyVQHRQRNPNQPFYILHPKFIWQLWDIIQENT-KEKIQPNP-PSSGFIGILLMMNLCG 421
Cdd:cd23977   81 P---ERNMDRDGGGKTYRAL---LTLAKMYPHLQVYTLTEEKMAYCDGVFQNETgKNRMKSGSfLSTGWFTMILALELCE 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 528968698 422 EVHVYEYV----------PSVRQtdlcHYHEPYHDAACTLGAYH 455
Cdd:cd23977  155 EILVYGMVsdsycrnknhSSVPY----HYYEKGRLDECRMYLVH 194
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 268-466 3.47e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 92.23  E-value: 3.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN----SQILTNPSYhFMDsaLYKDVILVAWD 343
Cdd:cd23978    4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQE-FLN--RTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 344 PApysanlNLWYKKPDYNLFTPYVQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPP--SSGFIGILLMMNLCG 421
Cdd:cd23978   81 PP------NKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAVELCD 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528968698 422 EVHVYEYVP----SVRQTDL---CHYHEPYHDAACTL---------GAYHPLLYEKLLVQR 466
Cdd:cd23978  155 NVHVYGMVPpnycSKRPTPKkmpYHYYEPKGPDECVTyiqnehgrrGNHHRFITEKRVFAR 215
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 233-442 3.64e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 87.70  E-value: 3.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 233 VRTLDGTEPPFSALGWRALVPPVplsrllprrlrTCAVVTSAGaILNSS-LGEEIDSHDAVLRFNSAPTRGYEKDVGNKT 311
Cdd:cd23964   61 LRNLNLTSSRYMFVLRGGRPRCI-----------RCAVVGNGG-ILNGSgKGKEIDAHDYVFRVNHALTKGFEKDVGTKT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 312 T------VRIINSQILTNPS---------------YHFMDSALykdvilvAWDPAPYSANLNLWYKKpdynLFTPYVQhr 370
Cdd:cd23964  129 SfytffpESLHNSLLKHVPQdkdtkylfipfkirdYDYLDAVL-------SGKPVPDGCDKGKRPPP----LFGPKLN-- 195

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528968698 371 qrnpNQPFYILHPKFI------WQlwdiiqeNTKeKIqpNPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDlcHYHE 442
Cdd:cd23964  196 ----ATNVRLLHPDFIrylfnrWL-------NSS-TS--YRPTTGALMLLTALHTCDQVSVYGFGYDPRFSL--HYYD 257
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 268-446 9.88e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 84.98  E-value: 9.88e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQ----ILTNPSYHFMDSalyKDVILVAWD 343
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKET---NETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 344 PApysANLNLWYKKPDYNLFTPYVQHRqrnPNQPFYILHPKFIWQLWDIIQENT-KEKIQPNP-PSSGFIGILLMMNLCG 421
Cdd:cd23975   81 PF---RNMRKDGKGIVYNMLKKAVESY---PQAKIYVTTEKRMSYCDTVFKKETgKDRVQSGSyLSTGWFTLILAMDACY 154

                        170       180       190
                 ....*....|....*....|....*....|..
gi 528968698 422 EVHVYEYVPSV-------RQTDLcHYHEPYHD 446
Cdd:cd23975  155 GIHVYGMINDTycktegyRKVPY-HYYEPGRD 185
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 267-461 1.56e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 84.92  E-value: 1.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN----SQILTNpSYHFMDSAlyKDVILVAW 342
Cdd:cd23976   17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAhssiQRILRN-RNELLNVS--QGTVFIFW 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 343 DPAPYsanlnlwYKKPDYNLFTPYVQ-HRQRNPNQPFYILHPKFIWQLWDIIQENTKE--KIQPNPPSSGFIGILLMMNL 419
Cdd:cd23976   94 GPSNY-------MRRDGKGLVYNNLQlMNQILPKLKVYTITRHKMLQFDELFKRETGKdrKISNTWLSTGWFTMIIALEL 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528968698 420 CGEVHVYEYVPSvrqtDLC----------HYHEPYHDAACTL---------GAYHPLLYEK 461
Cdd:cd23976  167 CDRINVYGMVPP----DFCrdpnhpsvpyHYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 267-445 1.40e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 82.69  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTrGYEKDVGNKTTVRIINSQILT----NPSY---HFMDS-ALYKDVI 338
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNLVTANPSILRekfhNLKKrrrPFVERmKVYGNAL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 339 LvaWDPA-PYSANlnlwyKKPDYNLFtpYVQHRQRNPNQPFYiLHPKFIWQL---WdiiqentKEK-IQPNPPSSGFIGI 413
Cdd:cd23971  145 L--LLPAfSYTSN-----TEPSLRAL--YTLEDFGSPQKVLF-FNPEYLRNLsryW-------KSKgLKARRLSTGLMLV 207

                        170       180       190
                 ....*....|....*....|....*....|..
gi 528968698 414 LLMMNLCGEVHVYEYVPSvrQTDLCHYHEPYH 445
Cdd:cd23971  208 SAALELCENVHLYGFWPF--STDLDGNPISHH 237
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 267-428 2.21e-17

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 82.33  E-value: 2.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILTN--PSYHF-------MD-----SA 332
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDldPGVHLvlvpfkvLDlqwliSA 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 333 LYKDVILVAWDPAPysANLNLWYKKpdynlftpyVQhrqrnpnqpfyILHPKFIWQlwdiIQENTKEKiQPNPPSSGFIG 412
Cdd:cd23966  159 LTTGEITRTYTPVK--RFIKADKDK---------VL-----------VINPAFIKY----VHDNWTEH-HGRYPSTGFLA 211

                        170
                 ....*....|....*.
gi 528968698 413 ILLMMNLCGEVHVYEY 428
Cdd:cd23966  212 LIFALHICDEVSVFGF 227
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 267-483 5.80e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 80.92  E-value: 5.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILTNPSYHFMDSALYK----------D 336
Cdd:cd23969   66 TCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEkfverlrqlgD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 337 VILvaWDPAPYSANLNlwykkpdynlftPYVQHRQR---NPNQPFYILHP-----KFIWQLWdiiqenTKEKIQPNPPSS 408
Cdd:cd23969  146 SIL--WIPAFVSKGGE------------EHVQWTNEiilKHKLNVKTAYPplrlnHAIRGYW------LTTKFRIKRPST 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 409 GFIGILLMMNLCGEVHVYEYVP---SVRQTDLcHYHepYHD--AACTLGAYH--PLLYEKLLVqrlnvgthgdLHRKGKV 481
Cdd:cd23969  206 GLLMYTLATRFCDEIHLYGFYPfseDGNGRAV-KYH--YYDnrKYLTTARPHkmPEEFRALRS----------LHQRGAL 272


                 ..
gi 528968698 482 VL 483
Cdd:cd23969  273 RL 274
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 267-483 6.81e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 80.90  E-value: 6.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQIL----------TNPSYHFMDSALYKD 336
Cdd:cd23970   70 TCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILekyynnlltiQDRNNFFLSLKKLDG 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 337 VILvaWDPA---PYSAnlnlwykKPDYNLFTPYVQHRqRNPNQ----PFYILhpKFIWQLWdiiqenTKEKIQPNPPSSG 409
Cdd:cd23970  150 AIL--WIPAfffHTSA-------TVTRTLVDFFVEHR-GQLKVqlawPGNIM--QHVNRYW------KTKHLSPKRLSTG 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 410 figiLLMMNL----CGEVHVYEYVPSvrQTDLCHYHEPYH-----DAACTLG--AYHPLLYEKLLVQRlnvgthgdLHRK 478
Cdd:cd23970  212 ----ILMYTLasaiCEEIHLYGFWPF--GFDPTGTPLPYHyydkkGTKFTTKwqESHQLPAEFVLLYK--------MHGA 277


                 ....*
gi 528968698 479 GKVVL 483
Cdd:cd23970  278 GVLKL 282
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 268-467 3.35e-16

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 77.47  E-value: 3.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRII------NSQILTNPSYHFMdSALYKDVILvA 341
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegapKSEQEYDPTSLFV-AVLFKSVDF-A 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 342 W-------DPAPYSANLNLWYKKPDYNLFTPYvQHRQRNP----NQPFYILH---PKFIWQLWDiiqentkekiqPNPPS 407
Cdd:cd23983   83 WlkamvkkEPLSFWSRLFFWKEVADSIPLKPS-QFRILNPliikETALDILQypePQSRLWGWD-----------KNVPT 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528968698 408 SGFIGILLMMNLCGEVHVYEYVPSVRQTDL-CHYHEPYHDAACTLGAYHPLLYEKLLVQRL 467
Cdd:cd23983  151 LGVTAVVLATHLCDEVSLAGFGYDLSQPHApLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 268-467 6.15e-15

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 73.42  E-value: 6.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILTNPSYHFMDSALYkdvILVAWDPAPY 347
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLF---VLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 348 SANLNLWYKKPDYNLFTPYVQHRQRNPNQP--FYILHPKFIWQ-LWDIIQENTKEKI--QPNPPSSGFIGILLMMNLCGE 422
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPheIRILNPYFIQEaAFSFIGLPFNNGLmgRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 528968698 423 VHV--YEYVPSVRQTDLcHYHEPYHDAACTLGAYHPLLYEKLLVQRL 467
Cdd:cd23981  162 VAVagFGYDMNTPNAPL-HYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 268-467 6.39e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 72.48  E-value: 6.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINsqilTNPSYHFMDSalYKDvilVAWDPAPY 347
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFS----TNTLMNSLRA--YAG---VGFNGPPQ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 348 SAN---LNLWYKKPDYNLF------TPYVQHRQRNPNQPFY-----------ILHPKFIWQ-----LWDIIQENTKEKIQ 402
Cdd:cd23974  158 SKEtryIFLPDHDRDYLLVkaalthTPIDRGRDKSKRPSKYfgkdvtaekfkIYHPDFIRYlrnrfLWSPILNTKQRDIY 237

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968698 403 pnPPSSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAAcTLGAYHPLLYEKLLVQRL 467
Cdd:cd23974  238 --RPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSDHYYDKTYHKV-VFYANHDLRLEMQLWQKL 299
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 267-429 1.29e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 71.71  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILTNP-----SYHFMDSALYKDV--IL 339
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSlmilqKRGFKNIPQDKDIkyIL 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 340 VAWDPAPYS--ANLNLWYKKPDYNLFTPYVQHR---QRNPNQpFYILHPKFIWQLWD-IIQENTKEKI--QPNPPSSGFI 411
Cdd:cd23973  165 FPEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYfsgDFTEDK-YLVLHPDFLRYVKNrFLRSKTLKGKywAIYRPTTGAF 243

                        170
                 ....*....|....*...
gi 528968698 412 GILLMMNLCGEVHVYEYV 429
Cdd:cd23973  244 LLLTALHLCDTVSAYGFI 261
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 268-442 2.31e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 70.17  E-value: 2.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRG-YEKDVGNKTTVRIINSQILT----------NPSYHfmDSALYKD 336
Cdd:cd23991   67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISikyaklnerrKPFLE--TVSVYGD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 337 VILVAwdPA-PYSANLNLWYKkpdynlfTPYVQHRQRNPNQPFYiLHPKF---IWQLWdiiqentKEK-IQPNPPSSGFI 411
Cdd:cd23991  145 AFLLL--PAfSYRSNTALSFK-------VYYTLEDFKAKQKVIF-FHPIYlkhLAQFW-------RSKgVQVYRLSTGLM 207

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 528968698 412 GILLMMNLCGEVHVYEYVPSVRQTD----LCHYHE 442
Cdd:cd23991  208 ITSAALELCEEVKLYGFWPFSKNTEgkpiSHHYYD 242
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 267-428 6.76e-13

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 69.14  E-value: 6.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTvriinsqiltnpsYHFMDSALYKDV------ILV 340
Cdd:cd23980   83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-------------HHFVYPESFRELaqnvsmILV 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 341 AWD--------PAPYSANLNLWYkkpdynlfTPyVQHRQRNPNQPFYILHPKFIWQLWDIIQENtkekiQPNPPSSGFIG 412
Cdd:cd23980  150 PFKtldlewviSATTTGTISHTY--------VP-VPRKIKVKKEKILIYHPAFIKYVFDRWLQG-----HGRYPSTGILS 215

                        170
                 ....*....|....*.
gi 528968698 413 ILLMMNLCGEVHVYEY 428
Cdd:cd23980  216 VIFSLHVCDEVDLYGF 231
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 267-447 5.60e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.12  E-value: 5.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILTNpSYHFMDSALYKDVIL------- 339
Cdd:cd23987   66 TCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQR-AFEDLVNETWKEKFLqrlqsln 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 340 --VAWDPAPYSAN-------LNLWYKKPDYNLFTPYVQHRqrnpnqpfyILHPkfIWQLWdiiqenTKEKIQPNPPSSGF 410
Cdd:cd23987  145 gsILWIPAFMAKGgeervewVNDLILKHHINVRTAYPSLR---------LLHA--VRGYW------LTNKVHIKRPTTGL 207

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 528968698 411 IGILLMMNLCGEVHVYEYVPSVRQTDL--CHYHepYHDA 447
Cdd:cd23987  208 LMYTLATRFCNRIHLYGFWPFPRDQNQnpVKYH--YYDS 244
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 268-426 8.53e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 62.55  E-value: 8.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAP-TRGYEKDVGNKTTVRIINSQILTN----------PSYHFMDSALYKD 336
Cdd:cd23990   67 CAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITErfhklekwrrPFYEVLQVYENAS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 337 VILvawdPAPYSAnlnlwyKKPDYNLFTPYVQHRQRNPnQPFYILHPKFiwqLWDIIQENTKEKIQPNPPSSGFIGILLM 416
Cdd:cd23990  147 VVL----PAFYNT------RNTDVSIRVKYVLDDFESQ-QAVYYFHPQY---LLNVSRFWLRQGVRAKRISSGLMLVTAA 212

                        170
                 ....*....|
gi 528968698 417 MNLCGEVHVY 426
Cdd:cd23990  213 LELCEEVHLY 222
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 267-430 1.04e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 59.20  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILTNPSYHFMDSALYKDVI-------- 338
Cdd:cd23988   66 TCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVhrlsmlnd 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 339 LVAWDPA-------PYSANLNLWYKKPDYNLFTPYVQHRQRNPNQPFYILHpkfiwqlwdiiqentkeKIQPNPPSSGFI 411
Cdd:cd23988  146 SVLWIPAfmvkggeKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTN-----------------KVNIKRPSTGLL 208

                        170
                 ....*....|....*....
gi 528968698 412 GILLMMNLCGEVHVYEYVP 430
Cdd:cd23988  209 MYTLATRFCDEIHLYGFWP 227
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 268-468 1.10e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 59.45  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKT-----TVRIINSQILTNPSYHFMDSALYKDV--ILV 340
Cdd:cd23972   85 CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNSLISYWNLGFTRTPQGQDLqyIFI 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 341 AWDPAPY----SANLNL----WYKKPDYnlftpyvQHRQRNPN---QPFYILHPKFIWQLWDIIQENTKEKIQPNP---P 406
Cdd:cd23972  165 PSDIRDYvmlrSAILGVpvpeGLDKGDR-------PHKYFGPEasaKKFKLLHPDFISYLTDRFLKSKLLNTHYGHlymP 237

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968698 407 SSGFIGILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPyHDAACTLGAYHPLLYEKLLVQRLN 468
Cdd:cd23972  238 STGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYER-KKKPLVFYANHDMLLEAALWRRLH 298
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 268-329 4.78e-09

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 57.57  E-value: 4.78e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968698 268 CAVVTSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTvriinsqiltnpsYHFM 329
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT-------------HHFM 131
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 267-462 1.02e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 47.13  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 267 TCAVVTSAGAILNSSLGEEIDSHDAVLRFNSAP-TRGYEKDVGNKTtvriinsQILT-NPsyhfmdSALYKDVILVAWDP 344
Cdd:cd23989   65 KCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT-------QLVTaNP------SIIDKRFQNLLWSR 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698 345 APYSANLNLWYKK----PDYNL-------FTPYVQHRQRNPNQPFYILHPKFIWQlwdiIQENTKEK-IQPNPPSSGFIG 412
Cdd:cd23989  132 KSFVESMKVYGRSyiymPAFSMktgtdpsLRVYYTLADVGANQTVLFANPNFLRN----VGKFWKSKgVHAKRLSTGLFL 207

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968698 413 ILLMMNLCGEVHVYEYVPSVRQTDLCHYHEPYHDAACTLGAYHPLLYEKL 462
Cdd:cd23989  208 VSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHAMPEEFL 257
PHA03378 PHA03378
EBNA-3B; Provisional
 35-152 2.33e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968698  35 PAKPAPSSFSFLETRRLLPAQGRQRAIMGASEGLPEGADLRRGSPRGLPsGPLRTWAGdgfereqeflsvQTGRTSLSSF 114
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAAT-GRARPPAA------------APGRARPPAA 739

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528968698 115 APEDSAP--GTSGRLFPGDPGPEGARPPRAAPGRRAKRGP 152
Cdd:PHA03378 740 APGRARPpaAAPGRARPPAAAPGRARPPAAAPGAPTPQPP 779
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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