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Conserved domains on  [gi|528944722|ref|XP_005204757|]
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R-spondin-1 isoform X1 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 3.00e-50

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


:

Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 160.29  E-value: 3.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944722   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQESLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 528944722  122 KGRCYPACPEGSAPADGTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 8.73e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 42.27  E-value: 8.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528944722  148 CEMSEWSLWGPCSKKkklCGfrRGLEERTRRVLHAPGGDHAVCSDTKETRKCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 3.00e-50

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 160.29  E-value: 3.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944722   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQESLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 528944722  122 KGRCYPACPEGSAPADGTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 8.73e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.27  E-value: 8.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528944722  148 CEMSEWSLWGPCSKKkklCGfrRGLEERTRRVLHAPGGDHAVCSDTKETRKCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 100-142 1.59e-03

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 35.57  E-value: 1.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 528944722 100 EHCEACFSH--NFCTKCQESLYLHKGRCYPACPEGSAPADGTMEC 142
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 3.00e-50

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 160.29  E-value: 3.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528944722   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQESLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 528944722  122 KGRCYPACPEGSAPADGTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 8.73e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.27  E-value: 8.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528944722  148 CEMSEWSLWGPCSKKkklCGfrRGLEERTRRVLHAPGGDHAVCSDTKETRKCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 100-142 1.59e-03

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 35.57  E-value: 1.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 528944722 100 EHCEACFSH--NFCTKCQESLYLHKGRCYPACPEGSAPADGTMEC 142
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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