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Conserved domains on  [gi|528490878|ref|XP_005167976|]
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uncharacterized protein LOC327557 isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02568 super family cl33517
polyamine oxidase
 8-493 9.73e-86

polyamine oxidase


The actual alignment was detected with superfamily member PLN02568:

Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 274.01  E-value: 9.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   8 AKVLVIGSGFAGLAAASKLIEAG-----FEdVLVLEAKERVGGRVHTTKpFTENIIEVGANWIHGQKGNPLYKIAKEKN- 81
Cdd:PLN02568   6 PRIVIIGAGMAGLTAANKLYTSSaandmFE-LTVVEGGDRIGGRINTSE-FGGERIEMGATWIHGIGGSPVYKIAQEAGs 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  82 LLSEGP-SAMKNmcLPHSVSPrdyfFNEDGKPVPKSVVDQVCARFSKLTDKAFDDELD---------------------- 138
Cdd:PLN02568  84 LESDEPwECMDG--FPDRPKT----VAEGGFEVDPSIVESISTLFRGLMDDAQGKLIEpsevdevdfvklaakaarvces 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 139 ------GKYRKLTLGAYLDD--------AFGGTELSKTEDArqVYEWCKRVECTDEACSSLYEISASQLSNYTELEGGFF 204
Cdd:PLN02568 158 ggggsvGSFLRRGLDAYWDSvsadeqikGYGGWSRKLLEEA--IFTMHENTQRTYTSADDLSTLDLAAESEYRMFPGEEI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 205 NTlgPGGYQAILDVLLRDVPSEAVRCNAPVKTIRWdlvkegqseeEDHPVQVVCENGQTFEADHVIVTVSLGVLK---EH 281
Cdd:PLN02568 236 TI--AKGYLSVIEALASVLPPGTIQLGRKVTRIEW----------QDEPVKLHFADGSTMTADHVIVTVSLGVLKagiGE 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 282 AKTMFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDCAGVQLVWKEGPEDKDVYEDLSEGEDWkqtWFKKITGFDT 361
Cdd:PLN02568 304 DSGLFSPPLPDFKTDAISRLGFGVVNKLFVELSPRPDGSPEDVAKFPFLQMAFHRSDSEARHDKIPW---WMRRTASICP 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 362 VARHPTALCGWITGREALYMESLQDREI----------------------QEVCVRLLRSSTGWPVPEVSKTLISRWGSD 419
Cdd:PLN02568 381 IHKNSSVLLSWFAGKEALELEKLSDEEIirgvqttlssflkrrvaglgsqSHPLCNGGASSNDGSRWKFVKVLKSKWGTD 460

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528490878 420 PQVRGSYTFVPDGVDGvEAHKALASPLP--PKHRSRGRKNLQVLFAGEATHVNFYTTTHGAYLSGQREAERLISYY 493
Cdd:PLN02568 461 PLFLGSYSYVAVGSSG-DDLDRMAEPLPriSDHDQAGGPPLQLLFAGEATHRTHYSTTHGAYFSGLREANRLLQHY 535
 
Name Accession Description Interval E-value
PLN02568 PLN02568
polyamine oxidase
 8-493 9.73e-86

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 274.01  E-value: 9.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   8 AKVLVIGSGFAGLAAASKLIEAG-----FEdVLVLEAKERVGGRVHTTKpFTENIIEVGANWIHGQKGNPLYKIAKEKN- 81
Cdd:PLN02568   6 PRIVIIGAGMAGLTAANKLYTSSaandmFE-LTVVEGGDRIGGRINTSE-FGGERIEMGATWIHGIGGSPVYKIAQEAGs 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  82 LLSEGP-SAMKNmcLPHSVSPrdyfFNEDGKPVPKSVVDQVCARFSKLTDKAFDDELD---------------------- 138
Cdd:PLN02568  84 LESDEPwECMDG--FPDRPKT----VAEGGFEVDPSIVESISTLFRGLMDDAQGKLIEpsevdevdfvklaakaarvces 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 139 ------GKYRKLTLGAYLDD--------AFGGTELSKTEDArqVYEWCKRVECTDEACSSLYEISASQLSNYTELEGGFF 204
Cdd:PLN02568 158 ggggsvGSFLRRGLDAYWDSvsadeqikGYGGWSRKLLEEA--IFTMHENTQRTYTSADDLSTLDLAAESEYRMFPGEEI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 205 NTlgPGGYQAILDVLLRDVPSEAVRCNAPVKTIRWdlvkegqseeEDHPVQVVCENGQTFEADHVIVTVSLGVLK---EH 281
Cdd:PLN02568 236 TI--AKGYLSVIEALASVLPPGTIQLGRKVTRIEW----------QDEPVKLHFADGSTMTADHVIVTVSLGVLKagiGE 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 282 AKTMFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDCAGVQLVWKEGPEDKDVYEDLSEGEDWkqtWFKKITGFDT 361
Cdd:PLN02568 304 DSGLFSPPLPDFKTDAISRLGFGVVNKLFVELSPRPDGSPEDVAKFPFLQMAFHRSDSEARHDKIPW---WMRRTASICP 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 362 VARHPTALCGWITGREALYMESLQDREI----------------------QEVCVRLLRSSTGWPVPEVSKTLISRWGSD 419
Cdd:PLN02568 381 IHKNSSVLLSWFAGKEALELEKLSDEEIirgvqttlssflkrrvaglgsqSHPLCNGGASSNDGSRWKFVKVLKSKWGTD 460

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528490878 420 PQVRGSYTFVPDGVDGvEAHKALASPLP--PKHRSRGRKNLQVLFAGEATHVNFYTTTHGAYLSGQREAERLISYY 493
Cdd:PLN02568 461 PLFLGSYSYVAVGSSG-DDLDRMAEPLPriSDHDQAGGPPLQLLFAGEATHRTHYSTTHGAYFSGLREANRLLQHY 535
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
1-490 2.82e-78

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 251.38  E-value: 2.82e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   1 MSTGPENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGRVHT-TKPFTENIIEVGANWIHGQKGNpLYKIAKE 79
Cdd:COG1231    1 MSRRARGKDVVIVGAGLAGLAAARELRKAGL-DVTVLEARDRVGGRVWTlRFGDDGLYAELGAMRIPPSHTN-LLALARE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  80 KNLLSEgpsamknmclPHSVSPRDYFFNEDGKPVPKSVVDQVCARFSKLTDKA---FDDELDG------KYRKLTLGAYL 150
Cdd:COG1231   79 LGLPLE----------PFPNENGNALLYLGGKRVRAGEIAADLRGVAELLAKLlraLAAALDPwahpaaELDRESLAEWL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 151 DDAfggtelSKTEDARQVYEwckrVECTDEACSSLYEISASQLSNYTELEGGFFNTLGP-GGYQAILDVLLRDVPsEAVR 229
Cdd:COG1231  149 RRN------GASPSARRLLG----LLGAGEYGADPDELSLLDLLRYAASAGGGAQQFRIvGGMDQLPRALAAELG-DRIR 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 230 CNAPVKTIRWDlvkegqseeeDHPVQVVCENGQTFEADHVIVTVSLGVLKehaKTMFDPTLPEKKLSAINDLGFGIVNKI 309
Cdd:COG1231  218 LGAPVTRIRQD----------GDGVTVTTDDGGTVRADAVIVTVPPSVLR---RIEFDPPLPAAKRAAIQRLPYGAAIKV 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 310 FLFFEKSFWPDDcagvqlvwkeGPEDKDVYEDLsegeDWKQTWFkkiTGFDTVARHPTaLCGWITGREALYMESLQDREI 389
Cdd:COG1231  285 FLQFDRPFWEED----------GLYGGISLTDL----PIRQTWY---PSNGPDGGAGV-LLGYVGGDDARALAALSPEER 346

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 390 QEVCVRLLRSSTGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGvEAHKALASPlppkhrsRGRknlqVLFAGEATHV 469
Cdd:COG1231  347 VAAALEQLARIFGVYAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLT-AAGPALAEP-------DGR----IHFAGEHTSD 414

                        490       500
                 ....*....|....*....|.
gi 528490878 470 NFYTTTHGAYLSGQREAERLI 490
Cdd:COG1231  415 EWPGWVEGALESGERAAAEIL 435
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 17-490 8.88e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.09  E-value: 8.88e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   17 FAGLAAASKLIEAGFeDVLVLEAKERVGGRVHTtKPFTENIIEVGANWIHGqKGNPLYKIAKEKNLLSEgPSAMKNMCLP 96
Cdd:pfam01593   1 LAGLAAARELLRAGH-DVTVLEARDRVGGRIRT-VRDDGFLIELGAMWFHG-AQPPLLALLKELGLEDR-LVLPDPAPFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   97 HSVSPRDYFFNEDGKPVPKSVVDQVCARF-----SKLTDKAFDDELDGKYRKLTLGAYLDD---AFGGTELSKTEDARQV 168
Cdd:pfam01593  77 TVLFAGGRRYPGDFRRVPAGWEGLLEFGRllsipEKLRLGLAALASDALDEFDLDDFSLAEsllFLGRRGPGDVEVWDRL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  169 YEWCKRveCTDEACSSLYEISASQLS---------NYTELEGGffNTLGPGGYQAILDVLLRDVPSEAVRCNAPVKTIRW 239
Cdd:pfam01593 157 IDPELF--AALPFASGAFAGDPSELSaglalpllwALLGEGGS--LLLPRGGLGALPDALAAQLLGGDVRLNTRVRSIDR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  240 DlvkegqseeeDHPVQVVCENGQTFEADHVIVTVSLGVLKEHaktMFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWP 319
Cdd:pfam01593 233 E----------GDGVTVTLTDGEVIEADAVIVTVPLGVLKRI---LFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  320 DDCAGVQLVWKegpedkdvYEDLSEGEDWKQTWFKKITGfdtvarHPTALCGWIT-GREALYMESLQDREIQEVCVRLLR 398
Cdd:pfam01593 300 DLGLLGLLSEL--------LTGLGTAFSWLTFPNRAPPG------KGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLR 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  399 SSTGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGVEAHKALASPLPPkhrsrgrknlqVLFAGEATHVNFYTTTHGA 478
Cdd:pfam01593 366 KLFGEEAPEPLRVLVSDWHTDPWPRGSYSLPQYGPGHDDYRPLARTPDPG-----------LFFAGEHTSTGYPGTVEGA 434

                         490
                  ....*....|..
gi 528490878  479 YLSGQREAERLI 490
Cdd:pfam01593 435 IESGRRAARAVL 446
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 8-280 6.26e-07

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 51.76  E-value: 6.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878    8 AKVLVIGSGFAGLAAA---SKLIEAGFEDVLVLEAKERVGGRVHTTKpftEN--IIEVGANWIHG-QKGNP-LYKIAKEK 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAyylEKEIPELPVELTLVEASDRVGGKIQTVK---EDgyLIERGPDSFLErKKSAPdLVKDLGLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   81 NLLSEGPSAMKnmclphsvsprdYFFNEDGK--PVPKSVVDQVcaRFSKLTdkafddeLDGKYRKLTLGAYlddafggtE 158
Cdd:TIGR00562  80 HVLVSDATGQR------------YVLVNRGKlmPVPTKIAPFV--KTGLFS-------LGGKLRAGMDFIR--------P 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  159 LSKTEDaRQVYEWCKR------VECTDEA-CSSLYEISASQLS--------NYTELEGGFF------NTLGPGGYQAIL- 216
Cdd:TIGR00562 131 ASPGKD-ESVEEFVRRrfgdevVENLIEPlLSGIYAGDPSKLSlkstfpkfYQTEQKHGSLilgmkkTRNLPQGSGLQLt 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528490878  217 ------DVL-----LRDVPsEAVRcNAPVKTIRWDLVKEGQSEEEDHPVQVVCENGQTFEADHVIVTV----SLGVLKE 280
Cdd:TIGR00562 210 akkqgqDFQtlatgLETLP-EEIE-KRLKLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAphkaAAGLLSE 286
NAD_bind_Shikimate_DH cd01065
NAD(P) binding domain of Shikimate dehydrogenase; Shikimate dehydrogenase (DH) is an amino ...
 4-37 7.98e-03

NAD(P) binding domain of Shikimate dehydrogenase; Shikimate dehydrogenase (DH) is an amino acid DH family member. Shikimate pathway links metabolism of carbohydrates to de novo biosynthesis of aromatic amino acids, quinones and folate. It is essential in plants, bacteria, and fungi but absent in mammals, thus making enzymes involved in this pathway ideal targets for broad spectrum antibiotics and herbicides. Shikimate DH catalyzes the reduction of 3-hydroshikimate to shikimate using the cofactor NADH. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DHs, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133443 [Multi-domain]  Cd Length: 155  Bit Score: 37.25  E-value: 7.98e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528490878   4 GPENAKVLVIGSGFAGLAAASKLIEAGFEDVLVL 37
Cdd:cd01065   16 ELKGKKVLILGAGGAARAVAYALAELGAAKIVIV 49
 
Name Accession Description Interval E-value
PLN02568 PLN02568
polyamine oxidase
 8-493 9.73e-86

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 274.01  E-value: 9.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   8 AKVLVIGSGFAGLAAASKLIEAG-----FEdVLVLEAKERVGGRVHTTKpFTENIIEVGANWIHGQKGNPLYKIAKEKN- 81
Cdd:PLN02568   6 PRIVIIGAGMAGLTAANKLYTSSaandmFE-LTVVEGGDRIGGRINTSE-FGGERIEMGATWIHGIGGSPVYKIAQEAGs 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  82 LLSEGP-SAMKNmcLPHSVSPrdyfFNEDGKPVPKSVVDQVCARFSKLTDKAFDDELD---------------------- 138
Cdd:PLN02568  84 LESDEPwECMDG--FPDRPKT----VAEGGFEVDPSIVESISTLFRGLMDDAQGKLIEpsevdevdfvklaakaarvces 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 139 ------GKYRKLTLGAYLDD--------AFGGTELSKTEDArqVYEWCKRVECTDEACSSLYEISASQLSNYTELEGGFF 204
Cdd:PLN02568 158 ggggsvGSFLRRGLDAYWDSvsadeqikGYGGWSRKLLEEA--IFTMHENTQRTYTSADDLSTLDLAAESEYRMFPGEEI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 205 NTlgPGGYQAILDVLLRDVPSEAVRCNAPVKTIRWdlvkegqseeEDHPVQVVCENGQTFEADHVIVTVSLGVLK---EH 281
Cdd:PLN02568 236 TI--AKGYLSVIEALASVLPPGTIQLGRKVTRIEW----------QDEPVKLHFADGSTMTADHVIVTVSLGVLKagiGE 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 282 AKTMFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDCAGVQLVWKEGPEDKDVYEDLSEGEDWkqtWFKKITGFDT 361
Cdd:PLN02568 304 DSGLFSPPLPDFKTDAISRLGFGVVNKLFVELSPRPDGSPEDVAKFPFLQMAFHRSDSEARHDKIPW---WMRRTASICP 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 362 VARHPTALCGWITGREALYMESLQDREI----------------------QEVCVRLLRSSTGWPVPEVSKTLISRWGSD 419
Cdd:PLN02568 381 IHKNSSVLLSWFAGKEALELEKLSDEEIirgvqttlssflkrrvaglgsqSHPLCNGGASSNDGSRWKFVKVLKSKWGTD 460

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528490878 420 PQVRGSYTFVPDGVDGvEAHKALASPLP--PKHRSRGRKNLQVLFAGEATHVNFYTTTHGAYLSGQREAERLISYY 493
Cdd:PLN02568 461 PLFLGSYSYVAVGSSG-DDLDRMAEPLPriSDHDQAGGPPLQLLFAGEATHRTHYSTTHGAYFSGLREANRLLQHY 535
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
1-490 2.82e-78

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 251.38  E-value: 2.82e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   1 MSTGPENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGRVHT-TKPFTENIIEVGANWIHGQKGNpLYKIAKE 79
Cdd:COG1231    1 MSRRARGKDVVIVGAGLAGLAAARELRKAGL-DVTVLEARDRVGGRVWTlRFGDDGLYAELGAMRIPPSHTN-LLALARE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  80 KNLLSEgpsamknmclPHSVSPRDYFFNEDGKPVPKSVVDQVCARFSKLTDKA---FDDELDG------KYRKLTLGAYL 150
Cdd:COG1231   79 LGLPLE----------PFPNENGNALLYLGGKRVRAGEIAADLRGVAELLAKLlraLAAALDPwahpaaELDRESLAEWL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 151 DDAfggtelSKTEDARQVYEwckrVECTDEACSSLYEISASQLSNYTELEGGFFNTLGP-GGYQAILDVLLRDVPsEAVR 229
Cdd:COG1231  149 RRN------GASPSARRLLG----LLGAGEYGADPDELSLLDLLRYAASAGGGAQQFRIvGGMDQLPRALAAELG-DRIR 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 230 CNAPVKTIRWDlvkegqseeeDHPVQVVCENGQTFEADHVIVTVSLGVLKehaKTMFDPTLPEKKLSAINDLGFGIVNKI 309
Cdd:COG1231  218 LGAPVTRIRQD----------GDGVTVTTDDGGTVRADAVIVTVPPSVLR---RIEFDPPLPAAKRAAIQRLPYGAAIKV 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 310 FLFFEKSFWPDDcagvqlvwkeGPEDKDVYEDLsegeDWKQTWFkkiTGFDTVARHPTaLCGWITGREALYMESLQDREI 389
Cdd:COG1231  285 FLQFDRPFWEED----------GLYGGISLTDL----PIRQTWY---PSNGPDGGAGV-LLGYVGGDDARALAALSPEER 346

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 390 QEVCVRLLRSSTGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGvEAHKALASPlppkhrsRGRknlqVLFAGEATHV 469
Cdd:COG1231  347 VAAALEQLARIFGVYAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLT-AAGPALAEP-------DGR----IHFAGEHTSD 414

                        490       500
                 ....*....|....*....|.
gi 528490878 470 NFYTTTHGAYLSGQREAERLI 490
Cdd:COG1231  415 EWPGWVEGALESGERAAAEIL 435
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 17-490 8.88e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.09  E-value: 8.88e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   17 FAGLAAASKLIEAGFeDVLVLEAKERVGGRVHTtKPFTENIIEVGANWIHGqKGNPLYKIAKEKNLLSEgPSAMKNMCLP 96
Cdd:pfam01593   1 LAGLAAARELLRAGH-DVTVLEARDRVGGRIRT-VRDDGFLIELGAMWFHG-AQPPLLALLKELGLEDR-LVLPDPAPFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   97 HSVSPRDYFFNEDGKPVPKSVVDQVCARF-----SKLTDKAFDDELDGKYRKLTLGAYLDD---AFGGTELSKTEDARQV 168
Cdd:pfam01593  77 TVLFAGGRRYPGDFRRVPAGWEGLLEFGRllsipEKLRLGLAALASDALDEFDLDDFSLAEsllFLGRRGPGDVEVWDRL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  169 YEWCKRveCTDEACSSLYEISASQLS---------NYTELEGGffNTLGPGGYQAILDVLLRDVPSEAVRCNAPVKTIRW 239
Cdd:pfam01593 157 IDPELF--AALPFASGAFAGDPSELSaglalpllwALLGEGGS--LLLPRGGLGALPDALAAQLLGGDVRLNTRVRSIDR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  240 DlvkegqseeeDHPVQVVCENGQTFEADHVIVTVSLGVLKEHaktMFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWP 319
Cdd:pfam01593 233 E----------GDGVTVTLTDGEVIEADAVIVTVPLGVLKRI---LFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  320 DDCAGVQLVWKegpedkdvYEDLSEGEDWKQTWFKKITGfdtvarHPTALCGWIT-GREALYMESLQDREIQEVCVRLLR 398
Cdd:pfam01593 300 DLGLLGLLSEL--------LTGLGTAFSWLTFPNRAPPG------KGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLR 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  399 SSTGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGVEAHKALASPLPPkhrsrgrknlqVLFAGEATHVNFYTTTHGA 478
Cdd:pfam01593 366 KLFGEEAPEPLRVLVSDWHTDPWPRGSYSLPQYGPGHDDYRPLARTPDPG-----------LFFAGEHTSTGYPGTVEGA 434

                         490
                  ....*....|..
gi 528490878  479 YLSGQREAERLI 490
Cdd:pfam01593 435 IESGRRAARAVL 446
PLN02268 PLN02268
probable polyamine oxidase
 10-487 5.59e-56

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 192.59  E-value: 5.59e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  10 VLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTKPFTENIiEVGANWIHGQ-KGNPLYKIAKEKNLLSEGPS 88
Cdd:PLN02268   3 VIVIGGGIAGIAAARALHDASFK-VTLLESRDRIGGRVHTDYSFGFPV-DMGASWLHGVcNENPLAPLIGRLGLPLYRTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  89 AMKNMCLPHSVspRDY-FFNEDGKPVPKSVVDQVCARFSKL---TDKAFDDELDGkyrkltlgAYLDDAFGgTELSKTED 164
Cdd:PLN02268  81 GDNSVLYDHDL--ESYaLFDMDGNQVPQELVTKVGETFERIleeTEKVRDEHEED--------MSLLQAIS-IVLERHPE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 165 ARQ------VYEWCK-RVECTDEACSSlyEISasqLSNYTE---LEGGffNTLGPGGYQAILDVLLRDVPseaVRCNAPV 234
Cdd:PLN02268 150 LRLeglaheVLQWYLcRMEGWFAADAD--TIS---LKSWDQeelLEGG--HGLMVRGYDPVINTLAKGLD---IRLNHRV 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 235 KTIrwdlvkegqsEEEDHPVQVVCENGQTFEADHVIVTVSLGVLKehAKTM-FDPTLPEKKLSAINDLGFGIVNKIFLFF 313
Cdd:PLN02268 220 TKI----------VRRYNGVKVTVEDGTTFVADAAIIAVPLGVLK--ANIIkFEPELPEWKEEAISDLGVGIENKIALHF 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 314 EKSFWPDdcagVQLVWKEGPEDKDVYEDLSegedwkqtwFKKITGfdtvarHPTALCgWITGREALYMESLQDREIQEVC 393
Cdd:PLN02268 288 DSVFWPN----VEFLGVVAPTSYGCSYFLN---------LHKATG------HPVLVY-MPAGRLARDIEKLSDEAAANFA 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 394 VRLLRSStgWP-VPEVSKTLISRWGSDPQVRGSYTFVPDGVdGVEAHKALASPLppkhrsrgrKNLqvLFAGEATHVNFY 472
Cdd:PLN02268 348 MSQLKKM--LPdATEPVQYLVSRWGSDPNSLGCYSYDLVGK-PHDLYERLRAPV---------DNL--FFAGEATSSDFP 413

                        490
                 ....*....|....*
gi 528490878 473 TTTHGAYLSGQREAE 487
Cdd:PLN02268 414 GSVHGAYSTGVMAAE 428
PLN02529 PLN02529
lysine-specific histone demethylase 1
 10-491 5.04e-50

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 182.40  E-value: 5.04e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  10 VLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTKPFTEN---IIEVGANWIHGQKGNPLYKIAKEknllseg 86
Cdd:PLN02529 163 VIIVGAGLAGLAAARQLLSFGFK-VVVLEGRNRPGGRVYTQKMGRKGqfaAVDLGGSVITGIHANPLGVLARQ------- 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  87 psamknMCLP-HSVSPRDYFFNEDGKPVPKSVVDQVCARFSKLTDKAFD--DELDGKYRKLTLGAYLDDAFGGTELSKTE 163
Cdd:PLN02529 235 ------LSIPlHKVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTElrQIMGGFANDISLGSVLERLRQLYGVARST 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 164 DARQVYEW-CKRVECTDEACssLYEISASQLSNYTELEGGFFNTLGPGGYQAILDVLLRDVPseaVRCNAPVKTIRWDlv 242
Cdd:PLN02529 309 EERQLLDWhLANLEYANAGC--LSDLSAAYWDQDDPYEMGGDHCFLAGGNWRLINALCEGVP---IFYGKTVDTIKYG-- 381

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 243 kegqseeeDHPVQVVCeNGQTFEADHVIVTVSLGVLKEHAkTMFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDC 322
Cdd:PLN02529 382 --------NDGVEVIA-GSQVFQADMVLCTVPLGVLKKRT-IRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL 451

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 323 agvqlvwkegpedkDVYEDLSEGEDwKQTWFKKITGFDTVARHPtALCGWITGREALYMESLQDREIQEVCVRLLR---S 399
Cdd:PLN02529 452 --------------DTFGCLNESSN-KRGEFFLFYGYHTVSGGP-ALVALVAGEAAQRFENTDPSTLLHRVLSVLRgiyN 515

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 400 STGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGVEaHKALASPLppkhrsRGRknlqVLFAGEATHVNFYTTTHGAY 479
Cdd:PLN02529 516 PKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSGSD-YDILAESV------SGR----LFFAGEATTRQYPATMHGAF 584

                        490
                 ....*....|..
gi 528490878 480 LSGQREAERLIS 491
Cdd:PLN02529 585 LSGLREASRILH 596
PLN03000 PLN03000
amine oxidase
 3-492 1.15e-49

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 182.53  E-value: 1.15e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   3 TGPENAKVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTKPFTENI---IEVGANWIHGQKGNPLYKIAKE 79
Cdd:PLN03000 180 AQSSKSSVVIVGAGLSGLAAARQLMRFGFK-VTVLEGRKRPGGRVYTKKMEANRVgaaADLGGSVLTGTLGNPLGIIARQ 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  80 knlLSEGPSAMKNMCLPHSVsprdyffneDGKPVPKSVVDQVCARFSKLTDKAfddeldGKYRKLTLGAYLDDAFGgtel 159
Cdd:PLN03000 259 ---LGSSLYKVRDKCPLYRV---------DGKPVDPDVDLKVEVAFNQLLDKA------SKLRQLMGDVSMDVSLG---- 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 160 SKTEDARQVyewckrveCTDEACSSLYEISASQLSNYTELEGGFFNTLG-------------------PGGYQAILDVLL 220
Cdd:PLN03000 317 AALETFRQV--------SGNDVATEEMGLFNWHLANLEYANAGLVSKLSlafwdqddpydmggdhcflPGGNGRLVQALA 388

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 221 RDVPseaVRCNAPVKTIRWDlvkegqseeeDHPVQVVCENgQTFEADHVIVTVSLGVLKeHAKTMFDPTLPEKKLSAIND 300
Cdd:PLN03000 389 ENVP---ILYEKTVQTIRYG----------SNGVKVIAGN-QVYEGDMVLCTVPLGVLK-NGSIKFVPELPQRKLDCIKR 453

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 301 LGFGIVNKIFLFFEKSFWPDDCagvqlvwkegpedkDVYEDLSEGEDWKQTWFkKITGFDTVARHPTaLCGWITGREALY 380
Cdd:PLN03000 454 LGFGLLNKVAMLFPYVFWSTDL--------------DTFGHLTEDPNYRGEFF-LFYSYAPVAGGPL-LIALVAGEAAHK 517

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 381 MESLQDREIQEVCVRLLR---SSTGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGvEAHKALASPLppkhrSRGRkn 457
Cdd:PLN03000 518 FETMPPTDAVTRVLHILRgiyEPQGINVPDPLQTVCTRWGGDPFSLGSYSNVAVGASG-DDYDILAESV-----GDGR-- 589

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 528490878 458 lqVLFAGEATHVNFYTTTHGAYLSGQREAERLISY 492
Cdd:PLN03000 590 --LFFAGEATTRRYPATMHGAFVTGLREAANMAQS 622
PLN02676 PLN02676
polyamine oxidase
 1-491 1.56e-46

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 168.74  E-value: 1.56e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   1 MSTGPENAKVLVIGSGFAGLAAASKLIEAGFEDVLVLEAKERVGGRVHTTKpFTENIIEVGANWI---HGQKGNPLYKIA 77
Cdd:PLN02676  20 AMDAKPSPSVIIVGAGMSGISAAKTLSEAGIEDILILEATDRIGGRMRKAN-FAGVSVELGANWVegvGGPESNPIWELA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  78 KEKNLlsegpsamkNMCLPHSVSPRDYFFNEDGKPVPKSVVdqvcarfSKLTDKAFDDELDGKYRKLTLGAYLDDAFGGT 157
Cdd:PLN02676  99 NKLKL---------RTFYSDFDNLSSNIYKQDGGLYPKKVV-------QKSMKVADASDEFGENLSISLSAKKAVDISIL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 158 ELSKTEDARQV-------------YEWCKRVECTdeacSSLYEISASQLSNYTELEggFFnTLGPGGYQAILDVLLRDVP 224
Cdd:PLN02676 163 TAQRLFGQVPKtplemvidyynydYEFAEPPRVT----SLKNTEPNPTFVDFGEDE--YF-VADPRGYESLVYYLAEQFL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 225 SEA--------VRCNAPVKTIRWDlvKEGqseeedhpVQVVCENGQTFEADHVIVTVSLGVLKEhAKTMFDPTLPEKKLS 296
Cdd:PLN02676 236 STKsgkitdprLKLNKVVREISYS--KNG--------VTVKTEDGSVYRAKYVIVSVSLGVLQS-DLIKFKPPLPDWKIE 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 297 AINDLGFGIVNKIFLFFEKSFWPddcagvqlvwkEGPEDK-DVYEDLSEG--EDWkQTWFKKITG----FDTVarhptal 369
Cdd:PLN02676 305 AIYQFDMAVYTKIFLKFPYKFWP-----------SGPGTEfFLYAHERRGyyPFW-QHLENEYPGsnvlFVTV------- 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 370 cgwiTGREALYMESLQDREIQEVCVRLLRSSTGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGVEaHKALASPLppk 449
Cdd:PLN02676 366 ----TDEESRRIEQQPDSETKAEIMEVLRKMFGPNIPEATDILVPRWWSNRFFKGSYSNWPIGVSRYE-FDQIRAPV--- 437

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 528490878 450 hrsrGRknlqVLFAGEATHVNFYTTTHGAYLSGQREAERLIS 491
Cdd:PLN02676 438 ----GR----VYFTGEHTSEKYNGYVHGAYLAGIDTANDLLE 471
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 4-490 4.66e-45

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 169.02  E-value: 4.66e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   4 GPENAKVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTKPFTENII---EVGANWIHGQKGNPLYKIAKEk 80
Cdd:PLN02328 235 GVEPANVVVVGAGLAGLVAARQLLSMGFK-VVVLEGRARPGGRVKTMKMKGDGVVaaaDLGGSVLTGINGNPLGVLARQ- 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  81 nllsegpsamknMCLP-HSVspRDY--FFNEDGKPVPKSVVDQVCARFSKLTDK------AFDDELdgKYRKLTLGAYLD 151
Cdd:PLN02328 313 ------------LGLPlHKV--RDIcpLYLPDGKAVDAEIDSKIEASFNKLLDRvcklrqAMIEEV--KSVDVNLGTALE 376

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 152 DAFGGTELSKTEDARQVYEWckrvectdeACSSLYEISASQLSNYT--------ELEGGFFNTLGPGGYQAILDVLLRDV 223
Cdd:PLN02328 377 AFRHVYKVAEDPQERMLLNW---------HLANLEYANASLMSNLSmaywdqddPYEMGGDHCFIPGGNDTFVRELAKDL 447

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 224 PseaVRCNAPVKTIRWDLvkEGQseeedhpvqVVCENGQTFEADHVIVTVSLGVLKEhAKTMFDPTLPEKKLSAINDLGF 303
Cdd:PLN02328 448 P---IFYERTVESIRYGV--DGV---------IVYAGGQEFHGDMVLCTVPLGVLKK-GSIEFYPELPQRKKDAIQRLGY 512

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 304 GIVNKIFLFFEKSFWpddcagvqlvwkegPEDKDVYEDLSEGEDWKQTWFkKITGFDTVARHPTaLCGWITGREALYMES 383
Cdd:PLN02328 513 GLLNKVALLFPYNFW--------------GGEIDTFGHLTEDPSMRGEFF-LFYSYSSVSGGPL-LIALVAGDAAVKFET 576

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 384 LQDREIQEVCVRLLRS---STGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGvEAHKALASPLppkhrSRGRknlqV 460
Cdd:PLN02328 577 LSPVESVKRVLQILRGifhPKGIVVPDPVQAVCTRWGKDCFTYGSYSYVAVGSSG-DDYDILAESV-----GDGR----V 646

                        490       500       510
                 ....*....|....*....|....*....|
gi 528490878 461 LFAGEATHVNFYTTTHGAYLSGQREAERLI 490
Cdd:PLN02328 647 FFAGEATNKQYPATMHGAFLSGMREAANIL 676
PLN02976 PLN02976
amine oxidase
 6-490 2.01e-34

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 138.08  E-value: 2.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878    6 ENAKVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTKPFTENIIEVGANWIHGQKGN-------------- 71
Cdd:PLN02976  692 DRKKIIVVGAGPAGLTAARHLQRQGFS-VTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVEADvaterrpdpsslic 770

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   72 --------------PLYKI---------------AKEKNLLSE--------GPSAMKnMCLPHSVsprDYFFNEDGKPVP 114
Cdd:PLN02976  771 aqlgleltvlnsdcPLYDVvtgekvpadldealeAEYNSLLDDmvllvaqkGEHAMK-MSLEDGL---EYALKRRRMPRP 846

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  115 KSVVDQvcARFSKLTDKAFDDELDGKYrkltlGAYLDDAFGGTELSKTEdaRQVYEWckRVECTDEACS-SLYEISASQL 193
Cdd:PLN02976  847 GVDIDE--TELGNAADDLYDSASTGVD-----GGHCEKESKEDVLSPLE--RRVMNW--HFAHLEYGCAaLLKEVSLPYW 915

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  194 sNYTELEGGFFntlGP-----GGYQAILDVLLRDVPseaVRCNAPVKTIRWDLVKEGQSEEEDHPVQVVCENGQTFEADH 268
Cdd:PLN02976  916 -NQDDVYGGFG---GAhcmikGGYSNVVESLAEGLD---IHLNHVVTDVSYGSKDAGASGSSRKKVKVSTSNGSEFLGDA 988

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  269 VIVTVSLGVLKehAKTM-FDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDCagvqlvwkegpedkDVYEDLSEGED 347
Cdd:PLN02976  989 VLITVPLGCLK--AETIkFSPPLPDWKYSSIQRLGFGVLNKVVLEFPEVFWDDSV--------------DYFGATAEETD 1052

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  348 WKQTWF-----KKITGfdtvarhPTALCGWITGREALYMESLQDREIQEVCVRLLRSSTGWP-VPEVSKTLISRWGSDPQ 421
Cdd:PLN02976 1053 LRGQCFmfwnvKKTVG-------APVLIALVVGKAAIDGQSMSSSDHVNHALMVLRKLFGEAlVPDPVASVVTDWGRDPF 1125

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528490878  422 VRGSYTFVPDGVDGvEAHKALASPLppkhrsrgrKNLqVLFAGEATHVNFYTTTHGAYLSGQREAERLI 490
Cdd:PLN02976 1126 SYGAYSYVAIGASG-EDYDILGRPV---------ENC-LFFAGEATCKEHPDTVGGAMMSGLREAVRII 1183
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 9-338 1.30e-21

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 97.21  E-value: 1.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGRVHTTKpFTENIIEVGANWIHGQKGnPLYKIAKEKNLLSE--- 85
Cdd:COG1232    3 RVAVIGGGIAGLTAAYRLAKAGH-EVTVLEASDRVGGLIRTVE-VDGFRIDRGPHSFLTRDP-EVLELLRELGLGDElvw 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  86 --------------------GPSAMKNMCLPHSVSPR---DYFFNEDGKPVPKSVVDQVCARFSK-LTDKAFDDELDGKY 141
Cdd:COG1232   80 pntrksyiyyggklhplpqgPLALLRSPLLSLAGKLRallELLAPRRPPGEDESLAEFVRRRFGReVYERLVEPLLEGVY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 142 rkltlGAYLDdafggtELSKTEDARQVYEwckrvecTDEACSSLyeISASQLSNYTELEGGFFNTLgPGGYQAILDVLLR 221
Cdd:COG1232  160 -----AGDPD------ELSADWAFPRLKR-------LELEHGSL--IKGALALRKGAKAGEVFGYL-RGGLGTLVEALAE 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 222 DVPSEAVRCNAPVKTIRWDlvkegqseeeDHPVQVVCENGQTFEADHVIVTVSLGVLKEhaktMFDPTLPE--KKLSAIN 299
Cdd:COG1232  219 ALEAGEIRLGTRVTAIERE----------GGGWRVTTSDGETIEADAVVSATPAPALAR----LLAPLPPEvaAALAGIP 284

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 528490878 300 DLGFGIVNkifLFFEKSFWPD-DCAGVqLVwkegPEDKDV 338
Cdd:COG1232  285 YASVAVVA---LGFDRPDLPPpDGFGW-LV----PRDEGV 316
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 9-278 3.67e-13

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 71.42  E-value: 3.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGRVHTtkpFTEN--IIEVGANWI-HGQKGNPLYK---IAKEKNL 82
Cdd:COG1233    5 DVVVIGAGIGGLAAAALLARAGY-RVTVLEKNDTPGGRART---FERPgfRFDVGPSVLtMPGVLERLFRelgLEDYLEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  83 LSEGPSAmknmclphsvsprDYFFnEDGKP--VPKSvVDQVCARFSKLTD------KAFDDELDGKYRKL---------- 144
Cdd:COG1233   81 VPLDPAY-------------RVPF-PDGRAldLPRD-LERTAAELERLFPgdaeayRRFLAELRRLYDALledllyrpll 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 145 --------------------TLGAYLDDAFggtelsKTEDARQVYEWC-KRVECTDEACSSLYEISAsqlsnYTELEGGF 203
Cdd:COG1233  146 slrdllrplalarllrlllrSLRDLLRRYF------KDPRLRALLAGQaLYLGLSPDRTPALYALIA-----YLEYAGGV 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528490878 204 FntLGPGGYQAILDVLLRDVpsEA----VRCNAPVKTIrwdLVKEGQSeeedhpVQVVCENGQTFEADHVIVTVSLGVL 278
Cdd:COG1233  215 W--YPKGGMGALADALARLA--EElggeIRTGAEVERI---LVEGGRA------TGVRLADGEEIRADAVVSNADPAHT 280
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
12-79 4.54e-13

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 64.09  E-value: 4.54e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528490878   12 VIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGRVHtTKPFTENIIEVGANWIHGQKGNPLYKIAKE 79
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF-RVLVLEKRDRLGGNAY-SYRVPGYVFDYGAHIFHGSDEPNVRDLLDE 66
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 9-47 7.87e-10

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 61.02  E-value: 7.87e-10
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGRV 47
Cdd:COG3349    5 RVVVVGGGLAGLAAAVELAEAGF-RVTLLEARPRLGGRA 42
PRK07233 PRK07233
hypothetical protein; Provisional
 9-302 5.64e-09

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 57.97  E-value: 5.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTkpfteniiEVGANWI-----HGQKGN-PLYKIAKEKNL 82
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHE-VTVFEADDQLGGLAASF--------EFGGLPIerfyhHIFKSDeALLELLDELGL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  83 LS-----EGPSAMknmclphsvsprdYFfneDGKPVPKSVVDQVcARFSKLT--DKAfddeldgKYRKLTLGA-YLDDaf 154
Cdd:PRK07233  72 EDklrwrETKTGY-------------YV---DGKLYPLGTPLEL-LRFPHLSliDKF-------RLGLLTLLArRIKD-- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 155 gGTELSKTEdarqVYEWCKRvECTDEACSSLYE-------------ISASQLSNYTELEG-----GFFNTLG--PGGYQA 214
Cdd:PRK07233 126 -WRALDKVP----AEEWLRR-WSGEGVYEVFWEplleskfgdyaddVSAAWLWSRIKRRGnrrysLFGEKLGylEGGFAT 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 215 ILDVLLRDVPSE--AVRCNAPVKTIRwdlvkegqseEEDHPVQVVCENGQTFEADHVIVTVSLGVLkehAKTMfdPTLPE 292
Cdd:PRK07233 200 LIDALAEAIEARggEIRLGTPVTSVV----------IDGGGVTGVEVDGEEEDFDAVISTAPPPIL---ARLV--PDLPA 264

                        330
                 ....*....|...
gi 528490878 293 K---KLSAINDLG 302
Cdd:PRK07233 265 DvlaRLRRIDYQG 277
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 2-45 8.69e-09

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 57.57  E-value: 8.69e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 528490878   2 STGPENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:COG2072    1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGG 43
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 9-285 1.34e-08

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 57.17  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFE-DVLVLEAKERVGGRVHTTKP--FTeniIEVGANWIHGQK-GNPlyKIAKEKNLLS 84
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKKGPDaDITLLEASDRLGGKIQTVRKdgFP---IELGPESFLARKpSAP--ALVKELGLED 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  85 E--GPSAMKN----------------MCLPHSVSPrDYF---FNEDGK------PVPK--------SVVDQVCARFSK-L 128
Cdd:PRK11883  77 ElvANTTGQSyiyvngklhpippgtvMGIPTSIAP-FLFaglVSPIGKlraaadLRPPrwkpgqdqSVGAFFRRRFGDeV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 129 TDKAFDDELDGKY----RKLTLGAylddAFggTELSKTEDARQvyewckrvectdeacsSLYEISASQLSNYTELEGGFF 204
Cdd:PRK11883 156 VENLIEPLLSGIYagdiDTLSLRA----TF--PQLAQAEDKYG----------------SLLRGMRKALPKEKKKTKGVF 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878 205 NTLgPGGYQAILDVLLRDVPSEAVRCNAPVKTIRwdlvKEGQSEEedhpvqVVCENGQTFEADHVIVTVSLGVL------ 278
Cdd:PRK11883 214 GTL-KGGLQSLIEALEEKLPAGTIHKGTPVTKID----KSGDGYE------IVLSNGGEIEADAVIVAVPHPVLpslfva 282

                        330
                 ....*....|
gi 528490878 279 ---KEHAKTM 285
Cdd:PRK11883 283 ppaFALFKTI 292
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 8-280 6.26e-07

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 51.76  E-value: 6.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878    8 AKVLVIGSGFAGLAAA---SKLIEAGFEDVLVLEAKERVGGRVHTTKpftEN--IIEVGANWIHG-QKGNP-LYKIAKEK 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAyylEKEIPELPVELTLVEASDRVGGKIQTVK---EDgyLIERGPDSFLErKKSAPdLVKDLGLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   81 NLLSEGPSAMKnmclphsvsprdYFFNEDGK--PVPKSVVDQVcaRFSKLTdkafddeLDGKYRKLTLGAYlddafggtE 158
Cdd:TIGR00562  80 HVLVSDATGQR------------YVLVNRGKlmPVPTKIAPFV--KTGLFS-------LGGKLRAGMDFIR--------P 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  159 LSKTEDaRQVYEWCKR------VECTDEA-CSSLYEISASQLS--------NYTELEGGFF------NTLGPGGYQAIL- 216
Cdd:TIGR00562 131 ASPGKD-ESVEEFVRRrfgdevVENLIEPlLSGIYAGDPSKLSlkstfpkfYQTEQKHGSLilgmkkTRNLPQGSGLQLt 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528490878  217 ------DVL-----LRDVPsEAVRcNAPVKTIRWDLVKEGQSEEEDHPVQVVCENGQTFEADHVIVTV----SLGVLKE 280
Cdd:TIGR00562 210 akkqgqDFQtlatgLETLP-EEIE-KRLKLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAphkaAAGLLSE 286
PLN02576 PLN02576
protoporphyrinogen oxidase
 10-114 8.72e-07

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 51.17  E-value: 8.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878  10 VLVIGSGFAGLAAASKLIEAGFEDVLVLEAKERVGGRVHTtkpFTEN--IIEVGANWIhgQKGNPLYKIAKEKNLlsegp 87
Cdd:PLN02576  15 VAVVGAGVSGLAAAYALASKHGVNVLVTEARDRVGGNITS---VSEDgfIWEEGPNSF--QPSDPELTSAVDSGL----- 84

                         90       100
                 ....*....|....*....|....*..
gi 528490878  88 saMKNMCLPHSVSPRdyFFNEDGKPVP 114
Cdd:PLN02576  85 --RDDLVFPDPQAPR--YVVWNGKLRP 107
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
9-49 2.11e-06

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 49.49  E-value: 2.11e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHT 49
Cdd:COG3380    5 DIAIIGAGIAGLAAARALQDAGHE-VTVFEKSRGVGGRMAT 44
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
9-57 8.88e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 47.42  E-value: 8.88e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528490878   9 KVLVIGSGFAGLAAAsklIEAGFE--DVLVLEAKErVGGRVHTTKPfTENI 57
Cdd:COG0492    2 DVVIIGAGPAGLTAA---IYAARAglKTLVIEGGE-PGGQLATTKE-IENY 47
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 10-46 1.00e-05

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 48.04  E-value: 1.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528490878   10 VLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGR 46
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGI-PVTVVEQRDKPGGR 36
flavo_cyto_c TIGR01813
flavocytochrome c; This model describes a family of redox proteins related to the succinate ...
 10-45 1.31e-05

flavocytochrome c; This model describes a family of redox proteins related to the succinate dehydrogenases and fumarate reductases of E. coli, mitochondria, and other well-characterized systems. A member of this family from Shewanella frigidimarina NCIMB400 is characterized as a water-soluble periplasmic protein with four heme groups, a non-covalently bound FAD, and essentially unidirectional fumarate reductase activity. At least seven distinct members of this family are found in Shewanella oneidensis, a species able to use a wide variety of pathways for respiraton. [Energy metabolism, Electron transport]


Pssm-ID: 273816 [Multi-domain]  Cd Length: 439  Bit Score: 47.34  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528490878   10 VLVIGSGFAGLAAASKLIEAGFEDVLVLEAKERVGG 45
Cdd:TIGR01813   2 VVVVGSGFAGLSAALSAKKAGAANVVLLEKMPVIGG 37
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 10-49 1.40e-05

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 47.52  E-value: 1.40e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 528490878  10 VLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGrvHT 49
Cdd:COG1053    6 VVVVGSGGAGLRAALEAAEAGL-KVLVLEKVPPRGG--HT 42
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 9-45 2.81e-05

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 46.28  E-value: 2.81e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:COG0493  123 KVAVVGSGPAGLAAAYQLARAGH-EVTVFEALDKPGG 158
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 10-45 5.32e-05

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 45.36  E-value: 5.32e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528490878   10 VLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:pfam00890   2 VLVIGGGLAGLAAALAAAEAGL-KVAVVEKGQPFGG 36
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
5-63 6.21e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 45.62  E-value: 6.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   5 PENAKVLVIGSGFAGLAAASKLIEAGFEDVLVlEAKERVGGRV---HTTKPF--------TENIIEVGAN 63
Cdd:COG1148  138 PVNKRALVIGGGIAGMTAALELAEQGYEVYLV-EKEPELGGRAaqlHKTFPGldcpqcilEPLIAEVEAN 206
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 9-45 7.48e-05

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 45.17  E-value: 7.48e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:PRK11749 142 KVAVIGAGPAGLTAAHRLARKGY-DVTIFEARDKAGG 177
PRK07208 PRK07208
hypothetical protein; Provisional
 5-45 9.17e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 44.88  E-value: 9.17e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 528490878   5 PENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:PRK07208   2 TNKKSVVIIGAGPAGLTAAYELLKRGY-PVTVLEADPVVGG 41
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 9-45 1.22e-04

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 44.38  E-value: 1.22e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:PRK12810 145 KVAVVGSGPAGLAAADQLARAGH-KVTVFERADRIGG 180
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
6-39 2.13e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 43.36  E-value: 2.13e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528490878   6 ENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEA 39
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLER 33
PLN02487 PLN02487
zeta-carotene desaturase
 9-83 2.15e-04

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 43.64  E-value: 2.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTKPFTENIIEVGANWIHGQKGNpLYKIAK----EKNLL 83
Cdd:PLN02487  77 KVAIIGAGLAGMSTAVELLDQGHE-VDIYESRPFIGGKVGSFVDKNGNHIEMGLHVFFGCYNN-LFRLMKkvgaDENLL 153
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
9-49 4.27e-04

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 42.80  E-value: 4.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 528490878   9 KVLVIGSGFAGLAAASKLieAGFEDVLVLEAKERVGGRVHT 49
Cdd:COG2907    5 RIAVIGSGISGLTAAWLL--SRRHDVTLFEANDRLGGHTHT 43
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 9-46 5.33e-04

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 41.92  E-value: 5.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528490878    9 KVLVIGSGFAGLAAASKLIEAGFEDVLVLEAKERVGGR 46
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGTCPYGG 39
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 9-68 7.00e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 41.61  E-value: 7.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528490878    9 KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGGrvHTTkpfteniievGAN--WIHGQ 68
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGL-SVTLLERGDDPGS--GAS----------GRNagLIHPG 49
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
4-45 8.44e-04

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 41.70  E-value: 8.44e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 528490878   4 GPENAKVLVIGSGFAGLAAASKLIEAGFEdVLVL--EAKERVGG 45
Cdd:COG3573    2 AAMDADVIVVGAGLAGLVAAAELADAGRR-VLLLdqEPEANLGG 44
PRK13984 PRK13984
putative oxidoreductase; Provisional
 5-45 1.84e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 40.91  E-value: 1.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 528490878   5 PENAKVLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGG 45
Cdd:PRK13984 281 KKNKKVAIVGSGPAGLSAAYFLATMGYE-VTVYESLSKPGG 320
PRK12843 PRK12843
FAD-dependent oxidoreductase;
5-83 2.83e-03

FAD-dependent oxidoreductase;


Pssm-ID: 237225 [Multi-domain]  Cd Length: 578  Bit Score: 40.10  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490878   5 PENAK--VLVIGSGFAGLAAASKLIEAGFEdVLVLEAKERVGGRVHTTkpfteniieVGANWI----HGQKGNPLYKIAK 78
Cdd:PRK12843  12 RWDAEfdVIVIGAGAAGMSAALFAAIAGLK-VLLVERTEYVGGTTATS---------AGTTWIpgtrHGLAVGPDDSLEA 81


                 ....*
gi 528490878  79 EKNLL 83
Cdd:PRK12843  82 ARTYL 86
PRK12834 PRK12834
putative FAD-binding dehydrogenase; Reviewed
 6-48 3.24e-03

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 183782 [Multi-domain]  Cd Length: 549  Bit Score: 39.88  E-value: 3.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 528490878   6 ENAKVLVIGSGFAGLAAASKLIEAGFEdVLVL--EAKERVGGRVH 48
Cdd:PRK12834   3 MDADVIVVGAGLAGLVAAAELADAGKR-VLLLdqENEANLGGQAF 46
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
11-44 3.92e-03

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 39.65  E-value: 3.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528490878  11 LVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVG 44
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGA-RVLLLEKNPKVG 33
PRK12778 PRK12778
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ...
 2-45 4.02e-03

bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase;


Pssm-ID: 237200 [Multi-domain]  Cd Length: 752  Bit Score: 39.73  E-value: 4.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 528490878   2 STGPENA-KVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:PRK12778 425 EVAEKNGkKVAVIGSGPAGLSFAGDLAKRGY-DVTVFEALHEIGG 468
PRK12831 PRK12831
putative oxidoreductase; Provisional
 4-45 6.94e-03

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 38.85  E-value: 6.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 528490878   4 GPENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEAKERVGG 45
Cdd:PRK12831 137 EKKGKKVAVIGSGPAGLTCAGDLAKMGY-DVTIFEALHEPGG 177
PRK05329 PRK05329
glycerol-3-phosphate dehydrogenase subunit GlpB;
7-36 7.47e-03

glycerol-3-phosphate dehydrogenase subunit GlpB;


Pssm-ID: 235412  Cd Length: 422  Bit Score: 38.68  E-value: 7.47e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 528490878   7 NAKVLVIGSGFAGLAAASKLIEAGFEDVLV 36
Cdd:PRK05329   2 KFDVLVIGGGLAGLTAALAAAEAGKRVALV 31
PRK06847 PRK06847
hypothetical protein; Provisional
 9-45 7.60e-03

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 38.70  E-value: 7.60e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 528490878   9 KVLVIGSGFAGLAAASKLIEAGFE-DVLVLEAKERVGG 45
Cdd:PRK06847   6 KVLIVGGGIGGLSAAIALRRAGIAvDLVEIDPEWRVYG 43
NAD_bind_Shikimate_DH cd01065
NAD(P) binding domain of Shikimate dehydrogenase; Shikimate dehydrogenase (DH) is an amino ...
 4-37 7.98e-03

NAD(P) binding domain of Shikimate dehydrogenase; Shikimate dehydrogenase (DH) is an amino acid DH family member. Shikimate pathway links metabolism of carbohydrates to de novo biosynthesis of aromatic amino acids, quinones and folate. It is essential in plants, bacteria, and fungi but absent in mammals, thus making enzymes involved in this pathway ideal targets for broad spectrum antibiotics and herbicides. Shikimate DH catalyzes the reduction of 3-hydroshikimate to shikimate using the cofactor NADH. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DHs, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133443 [Multi-domain]  Cd Length: 155  Bit Score: 37.25  E-value: 7.98e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528490878   4 GPENAKVLVIGSGFAGLAAASKLIEAGFEDVLVL 37
Cdd:cd01065   16 ELKGKKVLILGAGGAARAVAYALAELGAAKIVIV 49
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 5-49 8.42e-03

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 38.38  E-value: 8.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 528490878   5 PENAKVLVIGSGFAGLAAASKLIEAGFeDVLVLEAK--ERVGGRVHT 49
Cdd:COG0654    1 MMRTDVLIVGGGPAGLALALALARAGI-RVTVVERAppPRPDGRGIA 46
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 5-45 9.08e-03

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 38.55  E-value: 9.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 528490878   5 PENAKVLVIGSGFAGLAAASKLIEAGfeDVLVLeAKERVGG 45
Cdd:COG0029    2 RLKTDVLVIGSGIAGLSAALKLAERG--RVTLL-TKGELGE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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