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Conserved domains on  [gi|528476825|ref|XP_005164862|]
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transcription factor GATA-3 isoform X1 [Danio rerio]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 309-360 2.82e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 2.82e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528476825 309 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNRK 360
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 255-305 1.91e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.57  E-value: 1.91e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528476825 255 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 309-360 2.82e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 2.82e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528476825 309 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNRK 360
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 255-305 1.91e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.57  E-value: 1.91e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528476825 255 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
305-354 1.55e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.92  E-value: 1.55e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 528476825   305 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 354
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
251-299 3.66e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 69.37  E-value: 3.66e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528476825   251 SEGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 299
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 310-341 3.25e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 3.25e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528476825  310 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 341
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 256-290 3.62e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 3.62e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528476825  256 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 290
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
309-360 1.24e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.72  E-value: 1.24e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528476825 309 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNINR-PLTMKKEGIQTRNRK 360
Cdd:COG5641  160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSR 217
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
249-334 8.97e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 51.03  E-value: 8.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476825 249 SSSEGRECVNCGATSTPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWR 322
Cdd:COG5641  154 NSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTE 233

                         90
                 ....*....|..
gi 528476825 323 RNANGDPVCNAC 334
Cdd:COG5641  234 SIGNSSASKLTK 245
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 309-360 2.82e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 2.82e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528476825 309 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNRK 360
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 255-305 1.91e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.57  E-value: 1.91e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528476825 255 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
305-354 1.55e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.92  E-value: 1.55e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 528476825   305 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 354
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
251-299 3.66e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 69.37  E-value: 3.66e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528476825   251 SEGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 299
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 310-341 3.25e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 3.25e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528476825  310 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 341
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 256-290 3.62e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 3.62e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528476825  256 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 290
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
309-360 1.24e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.72  E-value: 1.24e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528476825 309 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNINR-PLTMKKEGIQTRNRK 360
Cdd:COG5641  160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSR 217
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
242-359 4.18e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.18  E-value: 4.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476825 242 KTRPKTRSSSEGREcVNCGATSTPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTSCANCQTTTTTL 320
Cdd:COG5641  288 STPKLVLPSDKKRS-TLTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNK 364

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528476825 321 WRRNANGdpvCNACGLYYKLHNINRPLTMKKEGIQTRNR 359
Cdd:COG5641  365 ILSPPTT---SNSPGAQVKLPNQTRSTGATKKKITRRRM 400
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
249-334 8.97e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 51.03  E-value: 8.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476825 249 SSSEGRECVNCGATSTPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWR 322
Cdd:COG5641  154 NSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTE 233

                         90
                 ....*....|..
gi 528476825 323 RNANGDPVCNAC 334
Cdd:COG5641  234 SIGNSSASKLTK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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