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Conserved domains on  [gi|525025196|ref|XP_005060059|]
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PREDICTED: muellerian-inhibiting factor [Ficedula albicollis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 125-543 2.71e-122

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


:

Pssm-ID: 461402  Cd Length: 389  Bit Score: 368.38  E-value: 2.71e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  125 SHYESSFIKLLRRRRSWDGTFPGTFGLCPARGAGAAPHPLQRIHEHVLEPGLQRFLVLHLEEVQWEAQVKLRFQLVFQAE 204
Cdd:pfam04709   1 SDYEAAFLEALGRDGEWGPQDLATFGICSPSDSSSALPLLQRLVAWLGEPGGQGLLVLHLEEVTWEPTITLTFQLPLLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  205 VGRalgeLQAAVMLFYLGRRESSGPPrELLLTGPGLARDQRLCLSRDTQFLALAAAAASVTRSAERLRFSASLAIHGGAR 284
Cdd:pfam04709  81 ASP----PELALLLLYPGPGTGGSLP-EVTVTGAGLPNTQSLCISEDTRYLLLAVDRPTGAWSEGQLRWGISLELRPRGN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  285 GAPLPRTEVQQLLFGSDDKCFTRMTPVLLLLAKTRQQeeeeeeEEALAPSSYLSAEGVVDTAPYPQLSPaqagseelptP 364
Cdd:pfam04709 156 GSPLSTAELQALLFGGDSGCFTRMTPVLLLLSGEEGT------DTRLSGPSPLPAHGQLDTVPFPQPRP----------S 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  365 TAPSHANTSSPAPGGSaqFLAVLTQFIRQLLNSSSEPPPQPSAHHWLDFEVMETLPHQLLNLSEEAALERLVQSEEPSVL 444
Cdd:pfam04709 220 PEPEEGSSSAPPQTDP--FLCELTRFLRALLGPPARAPQQKSPRLALDLDALASLPPLLLNLSDPAALERLINSEEPTLL 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  445 LLPQDsGAVLEQHLGDWQPEGTVLQLLTGKLQLLIQELRDIPAFQANAA-LFQHLLGFCYFPaepgqagPAERGRDPRKL 523
Cdd:pfam04709 298 LFTGW-PAGLQGHSGEWALSPALLRRLAQRLQAAAAELRDLPGLPPAATpLLARLLALCAGQ-------PDEPGADPSPL 369

                         410       420
                  ....*....|....*....|
gi 525025196  524 RTLLLLKALQSVRARWQEHR 543
Cdd:pfam04709 370 RALLLLKALQTVRAEWRGRR 389
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 557-656 4.55e-49

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


:

Pssm-ID: 381635  Cd Length: 99  Bit Score: 166.39  E-value: 4.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRDRHFIVMPTAYVANNCEGPCRLPLSSRiSSYFSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIISLS 636
Cdd:cd13757    1 YCRLRELSVSLRSEKFILSPKRYNINNCQGPCRFPLSDR-PRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELS 79

                         90       100
                 ....*....|....*....|
gi 525025196 637 SDGLEIRKFPNMVAEECGCR 656
Cdd:cd13757   80 DEGTEISLKPNMVATECGCR 99
 
Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 125-543 2.71e-122

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


Pssm-ID: 461402  Cd Length: 389  Bit Score: 368.38  E-value: 2.71e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  125 SHYESSFIKLLRRRRSWDGTFPGTFGLCPARGAGAAPHPLQRIHEHVLEPGLQRFLVLHLEEVQWEAQVKLRFQLVFQAE 204
Cdd:pfam04709   1 SDYEAAFLEALGRDGEWGPQDLATFGICSPSDSSSALPLLQRLVAWLGEPGGQGLLVLHLEEVTWEPTITLTFQLPLLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  205 VGRalgeLQAAVMLFYLGRRESSGPPrELLLTGPGLARDQRLCLSRDTQFLALAAAAASVTRSAERLRFSASLAIHGGAR 284
Cdd:pfam04709  81 ASP----PELALLLLYPGPGTGGSLP-EVTVTGAGLPNTQSLCISEDTRYLLLAVDRPTGAWSEGQLRWGISLELRPRGN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  285 GAPLPRTEVQQLLFGSDDKCFTRMTPVLLLLAKTRQQeeeeeeEEALAPSSYLSAEGVVDTAPYPQLSPaqagseelptP 364
Cdd:pfam04709 156 GSPLSTAELQALLFGGDSGCFTRMTPVLLLLSGEEGT------DTRLSGPSPLPAHGQLDTVPFPQPRP----------S 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  365 TAPSHANTSSPAPGGSaqFLAVLTQFIRQLLNSSSEPPPQPSAHHWLDFEVMETLPHQLLNLSEEAALERLVQSEEPSVL 444
Cdd:pfam04709 220 PEPEEGSSSAPPQTDP--FLCELTRFLRALLGPPARAPQQKSPRLALDLDALASLPPLLLNLSDPAALERLINSEEPTLL 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  445 LLPQDsGAVLEQHLGDWQPEGTVLQLLTGKLQLLIQELRDIPAFQANAA-LFQHLLGFCYFPaepgqagPAERGRDPRKL 523
Cdd:pfam04709 298 LFTGW-PAGLQGHSGEWALSPALLRRLAQRLQAAAAELRDLPGLPPAATpLLARLLALCAGQ-------PDEPGADPSPL 369

                         410       420
                  ....*....|....*....|
gi 525025196  524 RTLLLLKALQSVRARWQEHR 543
Cdd:pfam04709 370 RALLLLKALQTVRAEWRGRR 389
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 557-656 4.55e-49

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 166.39  E-value: 4.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRDRHFIVMPTAYVANNCEGPCRLPLSSRiSSYFSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIISLS 636
Cdd:cd13757    1 YCRLRELSVSLRSEKFILSPKRYNINNCQGPCRFPLSDR-PRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELS 79

                         90       100
                 ....*....|....*....|
gi 525025196 637 SDGLEIRKFPNMVAEECGCR 656
Cdd:cd13757   80 DEGTEISLKPNMVATECGCR 99
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 558-656 7.75e-30

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 113.14  E-value: 7.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196   558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFsHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:smart00204   1 CRRRQLYVDFKDlgwDDWIIAPKGYNAYYCEGECPFPLSTSLNATN-HAIVQTLVHLLGPNPVPKPCCVPTKLSPLSMLY 79

                           90       100
                   ....*....|....*....|...
gi 525025196   635 LSSDG-LEIRKFPNMVAEECGCR 656
Cdd:smart00204  80 YDDDGnVVLRNYPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
557-655 5.26e-24

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 96.63  E-value: 5.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSD-QLI 632
Cdd:pfam00019   1 ECRRHSLYVDFEDlgwDDWIIAPKGYNAYYCSGSCPSHLNPQLSAT-NHAILQSLLHSLKPANVPKPCCVPTKLSPlSVL 79

                          90       100
                  ....*....|....*....|...
gi 525025196  633 ISLSSDGLEIRKFPNMVAEECGC 655
Cdd:pfam00019  80 YYDDEGNVVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 125-543 2.71e-122

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


Pssm-ID: 461402  Cd Length: 389  Bit Score: 368.38  E-value: 2.71e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  125 SHYESSFIKLLRRRRSWDGTFPGTFGLCPARGAGAAPHPLQRIHEHVLEPGLQRFLVLHLEEVQWEAQVKLRFQLVFQAE 204
Cdd:pfam04709   1 SDYEAAFLEALGRDGEWGPQDLATFGICSPSDSSSALPLLQRLVAWLGEPGGQGLLVLHLEEVTWEPTITLTFQLPLLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  205 VGRalgeLQAAVMLFYLGRRESSGPPrELLLTGPGLARDQRLCLSRDTQFLALAAAAASVTRSAERLRFSASLAIHGGAR 284
Cdd:pfam04709  81 ASP----PELALLLLYPGPGTGGSLP-EVTVTGAGLPNTQSLCISEDTRYLLLAVDRPTGAWSEGQLRWGISLELRPRGN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  285 GAPLPRTEVQQLLFGSDDKCFTRMTPVLLLLAKTRQQeeeeeeEEALAPSSYLSAEGVVDTAPYPQLSPaqagseelptP 364
Cdd:pfam04709 156 GSPLSTAELQALLFGGDSGCFTRMTPVLLLLSGEEGT------DTRLSGPSPLPAHGQLDTVPFPQPRP----------S 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  365 TAPSHANTSSPAPGGSaqFLAVLTQFIRQLLNSSSEPPPQPSAHHWLDFEVMETLPHQLLNLSEEAALERLVQSEEPSVL 444
Cdd:pfam04709 220 PEPEEGSSSAPPQTDP--FLCELTRFLRALLGPPARAPQQKSPRLALDLDALASLPPLLLNLSDPAALERLINSEEPTLL 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  445 LLPQDsGAVLEQHLGDWQPEGTVLQLLTGKLQLLIQELRDIPAFQANAA-LFQHLLGFCYFPaepgqagPAERGRDPRKL 523
Cdd:pfam04709 298 LFTGW-PAGLQGHSGEWALSPALLRRLAQRLQAAAAELRDLPGLPPAATpLLARLLALCAGQ-------PDEPGADPSPL 369

                         410       420
                  ....*....|....*....|
gi 525025196  524 RTLLLLKALQSVRARWQEHR 543
Cdd:pfam04709 370 RALLLLKALQTVRAEWRGRR 389
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 557-656 4.55e-49

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 166.39  E-value: 4.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRDRHFIVMPTAYVANNCEGPCRLPLSSRiSSYFSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIISLS 636
Cdd:cd13757    1 YCRLRELSVSLRSEKFILSPKRYNINNCQGPCRFPLSDR-PRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELS 79

                         90       100
                 ....*....|....*....|
gi 525025196 637 SDGLEIRKFPNMVAEECGCR 656
Cdd:cd13757   80 DEGTEISLKPNMVATECGCR 99
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 558-656 7.75e-30

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 113.14  E-value: 7.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196   558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFsHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:smart00204   1 CRRRQLYVDFKDlgwDDWIIAPKGYNAYYCEGECPFPLSTSLNATN-HAIVQTLVHLLGPNPVPKPCCVPTKLSPLSMLY 79

                           90       100
                   ....*....|....*....|...
gi 525025196   635 LSSDG-LEIRKFPNMVAEECGCR 656
Cdd:smart00204  80 YDDDGnVVLRNYPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
557-655 5.26e-24

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 96.63  E-value: 5.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196  557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSD-QLI 632
Cdd:pfam00019   1 ECRRHSLYVDFEDlgwDDWIIAPKGYNAYYCSGSCPSHLNPQLSAT-NHAILQSLLHSLKPANVPKPCCVPTKLSPlSVL 79

                          90       100
                  ....*....|....*....|...
gi 525025196  633 ISLSSDGLEIRKFPNMVAEECGC 655
Cdd:pfam00019  80 YYDDEGNVVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 558-655 3.46e-23

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 94.31  E-value: 3.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISsYFSHTVLLLDVQERGSPLR-RAPCCVPVRYSDQ-LI 632
Cdd:cd13756    1 CRRRPLYVDFSDlgwDDWIIAPKGYNANYCAGSCPFPLSSHAN-ATNHAILQALLHSLNPKKSvPKPCCVPTKYSPLsVL 79

                         90       100
                 ....*....|....*....|...
gi 525025196 633 ISLSSDGLEIRKFPNMVAEECGC 655
Cdd:cd13756   80 YYDEDGNVVLKTYPDMVVEECGC 102
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 558-655 1.16e-16

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 75.77  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCrlPLSSRISSYFSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd13752    1 CCRESFYVSFTDigwDDWIIAPSGYYANYCKGSC--SGSSSPFRSHHTTILQKYLSKNKAKSELTPCCTPTKMSPLSLLY 78

                         90       100
                 ....*....|....*....|...
gi 525025196 635 LSSDGLeIRK--FPNMVAEECGC 655
Cdd:cd13752   79 YDSDGN-IVKkdLPNMIVESCGC 100
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 558-656 3.44e-16

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 74.54  E-value: 3.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd13761    2 CRRHNLYVDFRDlgwQDWIIAPDGYNAYYCSGECSFPLNSHMNAT-NHAIVQTLVHLMNPNRVPKPCCAPTKLSPISVLY 80

                         90       100
                 ....*....|....*....|...
gi 525025196 635 LS-SDGLEIRKFPNMVAEECGCR 656
Cdd:cd13761   81 YDdNSNVVLKKYKNMVVESCGCH 103
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 558-655 9.18e-16

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 73.28  E-value: 9.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRDR---HFIVMPTAYVANNCEGPCRlplsSRISSYFSHTVLLLDVQERGSPLRRA--PCCVPVRYSDQLI 632
Cdd:cd08698    1 CCKQPLYVNFKDLgglNWIIAPSGFTANYCRGSCN----SESSATTNHTKLLQWSRTRRHTPREElkPCCVPTSYEPLSI 76

                         90       100
                 ....*....|....*....|....
gi 525025196 633 ISLSSDGLEIRKF-PNMVAEECGC 655
Cdd:cd08698   77 LYYDNNGTVVETLlPNLIVTECGC 100
TGF_beta_GDF1_3_like cd13764
transforming growth factor beta (TGF-beta) like domain found in embryonic growth ...
 558-656 3.61e-15

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.


Pssm-ID: 381642  Cd Length: 102  Bit Score: 71.73  E-value: 3.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVL---LLDVQERGSPLrraPCCVPVRYSDql 631
Cdd:cd13764    1 CKKRRLYISFRDvgwQNWIIAPQGYMANYCHGECPFPLTESLNGT-NHAILqtlVHSVDPEGTPQ---PCCVPTRLSP-- 74

                         90       100
                 ....*....|....*....|....*....
gi 525025196 632 iISL----SSDGLEIRKFPNMVAEECGCR 656
Cdd:cd13764   75 -ISMlyydNNDNVVLRHYEDMVVDECGCR 102
TGF_beta_GDP9_9B_like cd13762
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 557-656 3.57e-13

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381640  Cd Length: 104  Bit Score: 65.94  E-value: 3.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLII 633
Cdd:cd13762    2 ICRRHRLRVRFRDlkwNGWIIAPTRYTANYCKGTCPRVLGQDLNPT-NHAIVQNILHHLLDKSVPRPSCVPTELHPLSVL 80

                         90       100
                 ....*....|....*....|....
gi 525025196 634 SLSSDGLEI-RKFPNMVAEECGCR 656
Cdd:cd13762   81 YYEEDGSIIyKEYPDMVASSCGCR 104
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 558-655 4.35e-13

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 65.41  E-value: 4.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRDR---HFIVMPTAYVANNCEGPCrLPLSSRISSYFSHTVLLLDVQERGSPlrrAPCCVPVRYSDQLIIS 634
Cdd:cd13753    1 CCLRPLYINFRRDlgwKWIHEPKGFNANYCAGAC-PYLWSADTQHSTVLQLYNRLNPVASA---APCCSPRELEPLTILY 76

                         90       100
                 ....*....|....*....|.
gi 525025196 635 LSSDGLEIRKFPNMVAEECGC 655
Cdd:cd13753   77 YDGRNPKIETLSNMIVTSCKC 97
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 558-656 7.30e-13

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 65.00  E-value: 7.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRApCCVPVRYSDQLIIS 634
Cdd:cd19390    3 CKRHPLYVDFSDvgwNDWIVAPPGYHAFYCHGECPFPLADHLNST-NHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLY 80

                         90       100
                 ....*....|....*....|...
gi 525025196 635 LSSDGLEIRK-FPNMVAEECGCR 656
Cdd:cd19390   81 LDENEKVVLKnYQDMVVEGCGCR 103
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 558-655 4.04e-12

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 62.67  E-value: 4.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQeLTIDLRDR--HFIVMPTAYVANNCEGPCRLplsSRISSYfSHTVLlldVQERGSPLRRAPCCVPVRYSD-QLIIS 634
Cdd:cd13751    4 CRYP-LTVDFEEFgwDWIIAPKTYDANYCSGECPF---VYLQSY-PHTHL---VQQANPRGSAGPCCTPTKMSPlSMLYF 75

                         90       100
                 ....*....|....*....|.
gi 525025196 635 LSSDGLEIRKFPNMVAEECGC 655
Cdd:cd13751   76 DEDGNIIYGTLPDMVVERCGC 96
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 558-656 7.16e-11

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 59.43  E-value: 7.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19387    3 CQRHSLYVDFKDvgwSDWIIAPRGYQAYRCAGECPFPLNEHLNGT-NHAIIQTLVNSIDPSNVPKACCAPTKLSSISMLY 81

                         90       100
                 ....*....|....*....|...
gi 525025196 635 L-SSDGLEIRKFPNMVAEECGCR 656
Cdd:cd19387   82 FdNNDNVVLRQYEDMVVEACGCR 104
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 550-656 7.31e-11

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 59.25  E-value: 7.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 550 RSARHQAHCRLQELTIDlrdrHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTV---LLLDVQERGSPlrrAPCCVPVR 626
Cdd:cd19399    1 RCSRKALHVNFKDMGWD----DWIIAPLEYEAFHCEGLCEFPLRSHLEPT-NHAViqtLMNSMDPESTP---PTCCVPTR 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 525025196 627 YSDQLIISL-SSDGLEIRKFPNMVAEECGCR 656
Cdd:cd19399   73 LSPISILFIdSANNVVYKQYEDMVVESCGCR 103
TGF_beta_BMP3_like cd13763
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 558-656 9.42e-11

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381641  Cd Length: 103  Bit Score: 58.91  E-value: 9.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRIS----SYFSHTVLLLDVQErGSPlrrAPCCVPVRYSDQ 630
Cdd:cd13763    1 CSRRPLTVDFADigwSDWIISPKSFDAYYCAGSCPFPLTKELRpsnhATIQSIVHAVGIQP-GVP---APCCVPDKMSSL 76

                         90       100
                 ....*....|....*....|....*..
gi 525025196 631 LIISLSSDG-LEIRKFPNMVAEECGCR 656
Cdd:cd13763   77 TLLYFDENRnVVLKNYPNMTVESCACR 103
TGF_beta_NODAL cd13759
transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; ...
 557-656 1.88e-10

transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development.


Pssm-ID: 381637  Cd Length: 103  Bit Score: 58.09  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVL--LLDVQERGS-PLrraPCCVPVRYSDQ 630
Cdd:cd13759    2 LCRRVDFYVDFDRigwGSWIVYPKKYNAYRCEGECPSPVDEDFKPT-NHAYMqsLLKLYQPDRvPL---PCCVPTKLSPL 77

                         90       100
                 ....*....|....*....|....*.
gi 525025196 631 LIISLSSDGLEIRKFPNMVAEECGCR 656
Cdd:cd13759   78 SMLYYEHGEVVVRHHEDMIVEECGCR 103
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 558-655 4.74e-10

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 56.96  E-value: 4.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRDR--HFIVMPTAYVANNCEGPCRLPLSSRISSyfsHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIISL 635
Cdd:cd19378    3 CCLYDLTIDFEEIgwNFIIAPKKYNANMCRGDCKSNHHHRPNS---ASILLNPITRSESKQEHGSCCHPTEYDPITVVYF 79

                         90       100
                 ....*....|....*....|.
gi 525025196 636 SSDG-LEIRKFPNMVAEECGC 655
Cdd:cd19378   80 NEDGqLKIKTINGMIAKKCSC 100
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 558-655 6.32e-10

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 56.59  E-value: 6.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19396    2 CRKHELYVSFQDlgwQDWIIAPKGYAANYCDGECSFPLNAHMNAT-NHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 80

                         90       100
                 ....*....|....*....|..
gi 525025196 635 LSSDG-LEIRKFPNMVAEECGC 655
Cdd:cd19396   81 FDDNSnVILKKYRNMVVRACGC 102
TGF_beta_INHBB cd19405
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ...
 558-655 8.99e-10

transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381675  Cd Length: 107  Bit Score: 56.48  E-value: 8.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRlQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFS-HTVLLLDVQERG-SPLRRAPCCVPVRYSDQLI 632
Cdd:cd19405    4 CR-QQFYIDFRLigwNDWIIAPVGYYGNYCEGSCPAYMAGVPGSASSfHTAVVNQYRMRGmNPGTVNSCCIPTKLSTMSM 82

                         90       100
                 ....*....|....*....|....
gi 525025196 633 ISLSSD-GLEIRKFPNMVAEECGC 655
Cdd:cd19405   83 LYFDDEyNIVKRDVPNMIVEECGC 106
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 553-656 1.24e-09

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 56.00  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 553 RHQAHCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSD 629
Cdd:cd19392    3 GHQNLCRRHPLYVDFSDvgwDDWIVAPLGYDAYYCNGECPFPLADYLNAT-NHAVVQTLVNSVDPQAVPKACCVPTELSS 81

                         90       100
                 ....*....|....*....|....*...
gi 525025196 630 QLIISLSS-DGLEIRKFPNMVAEECGCR 656
Cdd:cd19392   82 IAMLYVDEhDKVVLKNYQDMVVEGCGCR 109
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 555-655 1.35e-09

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 55.82  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 555 QAHCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQL 631
Cdd:cd19397    3 RQACKKHELYVSFRDlgwQDWIIAPEGYAAYYCEGECAFPLNSYMNAT-NHAIVQTLVHFINPETVPKPCCAPTQLNAIS 81

                         90       100
                 ....*....|....*....|....*
gi 525025196 632 IISLS-SDGLEIRKFPNMVAEECGC 655
Cdd:cd19397   82 VLYFDdSSNVILKKYRNMVVRACGC 106
TGF_beta_GDF5_6_7 cd13766
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 558-656 1.51e-09

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.


Pssm-ID: 381644  Cd Length: 102  Bit Score: 55.52  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFSHTV--LLLDVQERGSPlrrAPCCVPVRYSDQLI 632
Cdd:cd13766    1 CSRKPLHVNFKDlgwDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIqtLMNSMDPESTP---PSCCVPTKLSPISI 77

                         90       100
                 ....*....|....*....|....*
gi 525025196 633 ISL-SSDGLEIRKFPNMVAEECGCR 656
Cdd:cd13766   78 LYIdSANNVVYKQYEDMVVESCGCR 102
TGF_beta_BMP8 cd19398
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ...
 558-655 1.91e-09

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.


Pssm-ID: 381668  Cd Length: 105  Bit Score: 55.31  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19398    4 CKRHELYVSFQDlgwLDWVIAPQGYSAYYCEGECSFPLDSCMNAT-NHAILQSLVHLMKPEAVPKACCAPTKLSATSVLY 82

                         90       100
                 ....*....|....*....|..
gi 525025196 635 L-SSDGLEIRKFPNMVAEECGC 655
Cdd:cd19398   83 YdSNNNVILKKHRNMVVKSCGC 104
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 549-655 3.32e-09

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 55.09  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 549 NRSARHQAhCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPV 625
Cdd:cd19395    4 NTSEQKQA-CKKHELYVSFRDlgwQDWIIAPEGYAAFYCDGECSFPLNAHMNAT-NHAIVQTLVHLMFPDNVPKPCCAPT 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 525025196 626 RYSDQLIISLS-SDGLEIRKFPNMVAEECGC 655
Cdd:cd19395   82 KLNAISVLYFDdSSNVILKKYRNMVVRSCGC 112
TGF_beta_LEFTY1_2 cd13758
transforming growth factor beta (TGF-beta) like domain found in left-right determination ...
 558-655 4.51e-09

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.


Pssm-ID: 381636  Cd Length: 90  Bit Score: 53.91  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRlQELTIDLRD----RHFIVMPTAYVANNCEGPCRLPLSSRISSYFSHtvllldvqergsplrraPCCVPVRYSDQLII 633
Cdd:cd13758    3 CR-QEYYIDFREltwtDYWIIEPPGYQAYECVGGCPQPPPPLAWPSLGH-----------------RQCGVSESASLPMM 64

                         90       100
                 ....*....|....*....|....*.
gi 525025196 634 SLSSDG----LEIRKFPNMVAEECGC 655
Cdd:cd13758   65 YLVKKGdyteVEVAEFPNMIVEKCGC 90
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 557-656 6.15e-09

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 53.90  E-value: 6.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFSHTVLLLDVQERGSPLRRAPCCVPVR-YSDQLI 632
Cdd:cd13765    2 SCQRHELYVDFEEigwSGWIISPKGYNAYHCKGSCPFPLGQNQKPTNHATVQSIVHALKLAKGVEMPCCVPDKlYSISLL 81

                         90       100
                 ....*....|....*....|....
gi 525025196 633 ISLSSDGLEIRKFPNMVAEECGCR 656
Cdd:cd13765   82 YFDDDENVVLKQYDDMVAASCGCH 105
TGF_beta_GDF15 cd19376
transforming growth factor beta (TGF-beta) like domain found in mammalian growth ...
 558-656 7.92e-09

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.


Pssm-ID: 381646  Cd Length: 101  Bit Score: 53.47  E-value: 7.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQeLTIDLRD---RHFIVMPTAYVANNCEGPCrlPLSSRISSyfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19376    4 CRFS-LRVSFKEigwADWVLAPESYNAYYCDGSC--PHNYKPAN--MHAQIKSRLHRLNPGAVPAPCCVPSSYEPLTLLH 78

                         90       100
                 ....*....|....*....|...
gi 525025196 635 LSSDG-LEIRKFPNMVAEECGCR 656
Cdd:cd19376   79 YDSDGkLTLTEFDDMIVKDCHCA 101
TGF_beta_BMP3 cd19393
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 557-656 4.27e-08

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.


Pssm-ID: 381663  Cd Length: 110  Bit Score: 51.57  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGS-PLRRAPCCVPVRYSDQLI 632
Cdd:cd19393    7 NCARRYLKVDFADigwSEWIISPKSFDAYYCSGACQFPMPKSLKPS-NHATIQSIVRAVGVvPGIPEPCCVPEKMSSLSI 85

                         90       100
                 ....*....|....*....|....*
gi 525025196 633 ISL-SSDGLEIRKFPNMVAEECGCR 656
Cdd:cd19393   86 LFFdENKNVVLKVYPNMTVESCACR 110
TGF_beta_GDF8 cd19388
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 555-655 6.61e-08

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.


Pssm-ID: 381658  Cd Length: 108  Bit Score: 51.19  E-value: 6.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 555 QAHCRLQELTIDLRD--RHFIVMPTAYVANNCEGPCRLPLSSRissyFSHTVLLLDVQERGSPlrrAPCCVPVRYSDqlI 632
Cdd:cd19388   11 ESRCCRYPLTVDFEAfgWDWIIAPKRYKANYCSGECEFVFLQK----YPHTHLVHQANPRGSA---GPCCTPTKMSP--I 81

                         90       100
                 ....*....|....*....|....*.
gi 525025196 633 ISLSSDGLE---IRKFPNMVAEECGC 655
Cdd:cd19388   82 NMLYFNGKEqiiYGKIPAMVVDRCGC 107
TGF_beta_INHA_B_like cd19377
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ...
 558-655 7.40e-08

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381647  Cd Length: 101  Bit Score: 50.55  E-value: 7.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQeLTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFShTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19377    2 CRVA-LFVSFEElgwNRWIIAPPGFNFHFCHGGCALHIVPDLSLPVP-SAPPTPARPYSVLPGAQPCCAPTKVTPLSVLY 79

                         90       100
                 ....*....|....*....|..
gi 525025196 635 LSSDGLEIRK-FPNMVAEECGC 655
Cdd:cd19377   80 TSDGGTIKYEtIPDLIVQECGC 101
TGF_beta_BMP9 cd19400
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 ...
 557-656 4.83e-07

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).


Pssm-ID: 381670  Cd Length: 105  Bit Score: 48.34  E-value: 4.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 557 HCRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLII 633
Cdd:cd19400    2 HCRKTSLRVNFKDigwDSWIIAPKEYDAYECKGGCYFPLTDDVTPT-KHAIIQTLVHLKNPKKAGKACCVPTKLDPISVL 80

                         90       100
                 ....*....|....*....|....*
gi 525025196 634 SLSSDGLE--IRKFPNMVAEECGCR 656
Cdd:cd19400   81 YKDDMGVPtlKYHYEGMKVAECGCR 105
TGF_beta_INHBA cd19404
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ...
 558-655 5.94e-07

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381674  Cd Length: 108  Bit Score: 48.38  E-value: 5.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYFS-HTVLLLDVQERG-SPLRR-APCCVPVRYSDQL 631
Cdd:cd19404    3 CCKKQFYVSFKDigwSDWIIAPSGYHANYCEGECPSHIAGTSGSSLSfHSTVINHYRMRGySPFANlKSCCVPTKLRAMS 82

                         90       100
                 ....*....|....*....|....*
gi 525025196 632 IISLSSDGLEIRK-FPNMVAEECGC 655
Cdd:cd19404   83 MLYYDDGQNIIKKdIQNMIVEECGC 107
TGF_beta_maverick cd13755
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 558-655 9.88e-07

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.


Pssm-ID: 381633  Cd Length: 102  Bit Score: 47.69  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRlQELTIDLRDR---HFIVMPTAYVANNCEGPC---RLPLS--SRISSYFSHtvllldvqeRGSPLRRaPCCVPVRYSD 629
Cdd:cd13755    5 CR-HSLKVDFKKLpgfEWIIQPKEFDAGYCKGRCpprYNYANnhALIQSLLRR---------MKKKVPR-PCCAPSKLES 73

                         90       100
                 ....*....|....*....|....*....
gi 525025196 630 QLIISLS---SDGLEIRKFPNMVAEECGC 655
Cdd:cd13755   74 LEVLHYDesdSSKLKVTKWKGMIVSECAC 102
TGF_beta_GDF10 cd19394
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 558-656 4.62e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins; GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381664  Cd Length: 112  Bit Score: 46.06  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSsRISSYFSHTVLLLDVQERG-SPLRRAPCCVPVRYSDQLII 633
Cdd:cd19394   10 CSRRYLKVDFADigwSEWIISPKSFDAYYCAGACEFPMP-KVVRPSNHATIQSIVKAVGiIPGVPEPCCVPDKMNSLSVL 88

                         90       100
                 ....*....|....*....|....
gi 525025196 634 SL-SSDGLEIRKFPNMVAEECGCR 656
Cdd:cd19394   89 FLdENRNVVLKVYPNMSVETCACR 112
TGF_beta_GDF9 cd19403
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 554-656 4.99e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381673  Cd Length: 106  Bit Score: 45.62  E-value: 4.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 554 HQAHCRLQELTI---DLRDRHFIVMPTAYVANNCEGPCRLPLSSRISSYFsHTVLLLDVQERG-SPLRRaPCCVPVRYSD 629
Cdd:cd19403    1 PQNECELHDFRLsfsQLKWDHWIIAPHRYNPRYCKGSCPRAVGHRYGSPV-HTMVQNIIYEKLdSSIPR-PSCVPSEYNP 78

                         90       100
                 ....*....|....*....|....*...
gi 525025196 630 QLIISLSSDG-LEIRKFPNMVAEECGCR 656
Cdd:cd19403   79 LSVLTIEPDGsIAYKEYEDMIATKCTCR 106
TGF_beta_GDF9B cd19402
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 558-656 5.26e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9B (GDF-9B) and similar proteins; GDF-9B, also termed bone morphogenetic protein 15 (BMP15), acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.


Pssm-ID: 381672  Cd Length: 104  Bit Score: 45.58  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSRISSYfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19402    3 CSLHSFWVSFHQlgwDHWIIAPHRYNPGYCKGDCPRILHYGYNSP-NHAIVQNFINQLVDANVPRPSCVPYKYGPISVLM 81

                         90       100
                 ....*....|....*....|...
gi 525025196 635 LSSDG-LEIRKFPNMVAEECGCR 656
Cdd:cd19402   82 IEPNGnILYKEYEDMIAESCTCR 104
TGF_beta_INHBC_E cd19406
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ...
 558-655 1.96e-05

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381676  Cd Length: 104  Bit Score: 43.99  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRD---RHFIVMPTAYVANNCEGPCRLPLSSR--ISSYFsHTVLLLDVQERGSPLRRAPCCVPVRYSDQLI 632
Cdd:cd19406    1 CCRRDFYVDFKDigwNDWIIKPEGYQMNYCMGQCPLHIAGSpgIAASF-HTAVLNLVKANNIATAVHSCCVPTARRPLSL 79

                         90       100
                 ....*....|....*....|....
gi 525025196 633 ISLSSDGLEIRK-FPNMVAEECGC 655
Cdd:cd19406   80 LYFDRNSNIVKTdIPDMIVEACGC 103
TGF_beta_TGFB1 cd19384
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 558-656 4.32e-05

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins; TGF-beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.


Pssm-ID: 381654  Cd Length: 99  Bit Score: 42.93  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 558 CRLQELTIDLRDR---HFIVMPTAYVANNCEGPCRLPLSSRIssyfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQLIIS 634
Cdd:cd19384    2 CCVRQLYIDFRKDlgwKWIHEPKGYHANFCLGPCPYIWSLDT----QYSKVLALYNQHNPGASAAPCCVPQALEPLPIVY 77

                         90       100
                 ....*....|....*....|..
gi 525025196 635 LSSDGLEIRKFPNMVAEECGCR 656
Cdd:cd19384   78 YVGRKPKVEQLSNMIVRSCKCS 99
TGF_beta_TGFB3 cd19386
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 555-655 7.11e-05

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381656  Cd Length: 101  Bit Score: 42.31  E-value: 7.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525025196 555 QAHCRLQELTIDLRDR---HFIVMPTAYVANNCEGPCRLPLSSRIssyfSHTVLLLDVQERGSPLRRAPCCVPVRYSDQL 631
Cdd:cd19386    1 EENCCVRPLYIDFRQDlgwKWVHEPKGYFANFCSGPCPYLRSADT----THSTVLGLYNTLNPEASASPCCVPQDLEPLT 76

                         90       100
                 ....*....|....*....|....
gi 525025196 632 IISLSSDGLEIRKFPNMVAEECGC 655
Cdd:cd19386   77 ILYYVGRTPKVEQLSNMVVKSCKC 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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