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Conserved domains on  [gi|512819256|ref|XP_004911603|]
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GPI mannosyltransferase 2 [Xenopus tropicalis]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 13-473 9.05e-94

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam04188:

Pssm-ID: 473917  Cd Length: 439  Bit Score: 290.66  E-value: 9.05e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256   13 EILRFSLCCRGATLAMQVVFN-LLIPDHIADAFSPPRAPPSGYGDQFTELLLGGLGRWDAEHFLFIAEHGYVFEHNMAFF 91
Cdd:pfam04188   3 ELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256   92 PLFPLTLAGLAHGLLWPLGFMLSLRSRLLLSATLLNTACFVLAAIVLYRLGCVALQSRRSAFLAALLFCMSPASIFMTAA 171
Cdd:pfam04188  83 PLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTSI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  172 YSESLFAMATFAGLWQLEKCRTFRGCSLFLLATAARANGLVNAGFLLYFGAQSVVQGTMSCRRISKI-------LLATAV 244
Cdd:pfam04188 163 YSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFvkaicfpFLSGSL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  245 IMLPFALFQHYSFHHFCLvsaidekvspelmqlaieksYRVRGPPVPaWCAASLPLAYSNIQSDYWGVGLLRYFQLRQLP 324
Cdd:pfam04188 243 MFLPFLYFQYYLYKTFCP--------------------QRSAGNEPP-WCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  325 NFLLALPVILLGTRAIWEYGCANVNLCLTLGLW-----EKRQKSSSGYYGPRIFVYVAHLTALMMFGVFCMHVQVITRFL 399
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQypsynKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512819256  400 fSSSPVLFWFCSLRLQQNEPWMWGSEtgmsASNPAIRLLHSWTslqrptrsllgYFLGYWVLGSALHVNFLPWT 473
Cdd:pfam04188 382 -SFLPLHYWFLADLLVSDKKKMWNPL----GDDKIVKFYIYWL-----------ACSFYILLGTLLFANFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 13-473 9.05e-94

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 290.66  E-value: 9.05e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256   13 EILRFSLCCRGATLAMQVVFN-LLIPDHIADAFSPPRAPPSGYGDQFTELLLGGLGRWDAEHFLFIAEHGYVFEHNMAFF 91
Cdd:pfam04188   3 ELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256   92 PLFPLTLAGLAHGLLWPLGFMLSLRSRLLLSATLLNTACFVLAAIVLYRLGCVALQSRRSAFLAALLFCMSPASIFMTAA 171
Cdd:pfam04188  83 PLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTSI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  172 YSESLFAMATFAGLWQLEKCRTFRGCSLFLLATAARANGLVNAGFLLYFGAQSVVQGTMSCRRISKI-------LLATAV 244
Cdd:pfam04188 163 YSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFvkaicfpFLSGSL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  245 IMLPFALFQHYSFHHFCLvsaidekvspelmqlaieksYRVRGPPVPaWCAASLPLAYSNIQSDYWGVGLLRYFQLRQLP 324
Cdd:pfam04188 243 MFLPFLYFQYYLYKTFCP--------------------QRSAGNEPP-WCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  325 NFLLALPVILLGTRAIWEYGCANVNLCLTLGLW-----EKRQKSSSGYYGPRIFVYVAHLTALMMFGVFCMHVQVITRFL 399
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQypsynKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512819256  400 fSSSPVLFWFCSLRLQQNEPWMWGSEtgmsASNPAIRLLHSWTslqrptrsllgYFLGYWVLGSALHVNFLPWT 473
Cdd:pfam04188 382 -SFLPLHYWFLADLLVSDKKKMWNPL----GDDKIVKFYIYWL-----------ACSFYILLGTLLFANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
69-251 1.02e-10

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 61.12  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  69 WDAEHFLFIAEHGYVF----EHNmAFFPLFPLTLAGLAHGLLWPLGFmlslrsrlllsATLLNTACFVLAAIVLYRLgCV 144
Cdd:COG5542    4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYLGLPFLLA-----------GKLVSILADLVAAYLLYRW-VK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256 145 ALQSRRSAFLAALLFCMSPASIFMTAAY--SESLFAMATFAGLWQLEKCRTFRGCSLFLLATAARANGLVNAGFLLYFga 222
Cdd:COG5542   71 KYYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLIL-- 148

                        170       180
                 ....*....|....*....|....*....
gi 512819256 223 qsVVQGTMSCRRISKILLATAVIMLPFAL 251
Cdd:COG5542  149 --LLKERIRLAYLLLAPVVYALALLPALL 175
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 13-473 9.05e-94

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 290.66  E-value: 9.05e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256   13 EILRFSLCCRGATLAMQVVFN-LLIPDHIADAFSPPRAPPSGYGDQFTELLLGGLGRWDAEHFLFIAEHGYVFEHNMAFF 91
Cdd:pfam04188   3 ELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256   92 PLFPLTLAGLAHGLLWPLGFMLSLRSRLLLSATLLNTACFVLAAIVLYRLGCVALQSRRSAFLAALLFCMSPASIFMTAA 171
Cdd:pfam04188  83 PLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTSI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  172 YSESLFAMATFAGLWQLEKCRTFRGCSLFLLATAARANGLVNAGFLLYFGAQSVVQGTMSCRRISKI-------LLATAV 244
Cdd:pfam04188 163 YSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFvkaicfpFLSGSL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  245 IMLPFALFQHYSFHHFCLvsaidekvspelmqlaieksYRVRGPPVPaWCAASLPLAYSNIQSDYWGVGLLRYFQLRQLP 324
Cdd:pfam04188 243 MFLPFLYFQYYLYKTFCP--------------------QRSAGNEPP-WCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  325 NFLLALPVILLGTRAIWEYGCANVNLCLTLGLW-----EKRQKSSSGYYGPRIFVYVAHLTALMMFGVFCMHVQVITRFL 399
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQypsynKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512819256  400 fSSSPVLFWFCSLRLQQNEPWMWGSEtgmsASNPAIRLLHSWTslqrptrsllgYFLGYWVLGSALHVNFLPWT 473
Cdd:pfam04188 382 -SFLPLHYWFLADLLVSDKKKMWNPL----GDDKIVKFYIYWL-----------ACSFYILLGTLLFANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
69-251 1.02e-10

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 61.12  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256  69 WDAEHFLFIAEHGYVF----EHNmAFFPLFPLTLAGLAHGLLWPLGFmlslrsrlllsATLLNTACFVLAAIVLYRLgCV 144
Cdd:COG5542    4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYLGLPFLLA-----------GKLVSILADLVAAYLLYRW-VK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512819256 145 ALQSRRSAFLAALLFCMSPASIFMTAAY--SESLFAMATFAGLWQLEKCRTFRGCSLFLLATAARANGLVNAGFLLYFga 222
Cdd:COG5542   71 KYYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLIL-- 148

                        170       180
                 ....*....|....*....|....*....
gi 512819256 223 qsVVQGTMSCRRISKILLATAVIMLPFAL 251
Cdd:COG5542  149 --LLKERIRLAYLLLAPVVYALALLPALL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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