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Conserved domains on  [gi|512951106|ref|XP_004837986|]
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protein tilB homolog isoform X6 [Heterocephalus glaber]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-161 2.73e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 89.07  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  23 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 72
Cdd:cd21340   48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  73 LALNNIEKIENLEGCEVLTKLDLTVNFIGELSSVK-SLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEID 151
Cdd:cd21340  127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                        170
                 ....*....|
gi 512951106 152 RSERiQALQN 161
Cdd:cd21340  207 DTER-QFLKR 215
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-161 2.73e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 89.07  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  23 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 72
Cdd:cd21340   48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  73 LALNNIEKIENLEGCEVLTKLDLTVNFIGELSSVK-SLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEID 151
Cdd:cd21340  127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                        170
                 ....*....|
gi 512951106 152 RSERiQALQN 161
Cdd:cd21340  207 DTER-QFLKR 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-146 3.81e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 3.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  22 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEVLTKLDLTVN 98
Cdd:COG4886  114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 512951106  99 FIGELSsvKSLTHNIHLKELFLMGNPCADFDGyrqfVVATLQQLKWLD 146
Cdd:COG4886  193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR_9 pfam14580
Leucine-rich repeat;
1-160 4.19e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 55.93  E-value: 4.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106    1 MGRITEDLIRRNAEHNDCVifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106   81 I-ENL-EGCEVLTKLDLTVNFIGELSSVKSLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIDRSERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158


                  ..
gi 512951106  159 LQ 160
Cdd:pfam14580 159 EK 160
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-161 2.73e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 89.07  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  23 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 72
Cdd:cd21340   48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  73 LALNNIEKIENLEGCEVLTKLDLTVNFIGELSSVK-SLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEID 151
Cdd:cd21340  127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                        170
                 ....*....|
gi 512951106 152 RSERiQALQN 161
Cdd:cd21340  207 DTER-QFLKR 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-146 3.81e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 3.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  22 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEVLTKLDLTVN 98
Cdd:COG4886  114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 512951106  99 FIGELSsvKSLTHNIHLKELFLMGNPCADFDGyrqfVVATLQQLKWLD 146
Cdd:COG4886  193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-169 1.74e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEVLTKLDLTVNFIG 101
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512951106 102 ELsSVKSLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIDRSERIQALQNYSVIEQQI 169
Cdd:COG4886  286 DL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
LRR_9 pfam14580
Leucine-rich repeat;
1-160 4.19e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 55.93  E-value: 4.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106    1 MGRITEDLIRRNAEHNDCVifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106   81 I-ENL-EGCEVLTKLDLTVNFIGELSSVKSLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIDRSERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158


                  ..
gi 512951106  159 LQ 160
Cdd:pfam14580 159 EK 160
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 46-86 7.46e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.70  E-value: 7.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 512951106   46 LKILYLQNNLIGKIENVSKLKKLEYLNLALNN-IEKIENLEG 86
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
46-98 2.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 512951106   46 LKILYLQNNLIGKIENVS--KLKKLEYLNLALNNIEKIEN--LEGCEVLTKLDLTVN 98
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-146 2.42e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  46 LKILYLQNNligkiENVSKLKKLEYLNLALNNIEKI-ENLEGCEVLTKLDLTVNFIGELSSvkSLTHNIHLKELFLMGNP 124
Cdd:COG4886   98 LTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQ 170

                         90       100
                 ....*....|....*....|..
gi 512951106 125 CADFDGyrqfVVATLQQLKWLD 146
Cdd:COG4886  171 LTDLPE----ELGNLTNLKELD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-146 3.89e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 3.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  23 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNiekieNLEGCEVLTKLDLTVNFIGE 102
Cdd:COG4886   53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTD 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 512951106 103 LSsvKSLTHNIHLKELFLMGNPCADFDgyrqFVVATLQQLKWLD 146
Cdd:COG4886  128 LP--EELANLTNLKELDLSNNQLTDLP----EPLGNLTNLKSLD 165
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-108 8.39e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 8.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 512951106   66 KKLEYLNLALNNIEKIENLEGCEVLTKLDLT-VNFIGELSSVKS 108
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
22-78 1.45e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 512951106   22 SLEELSLHQQEIERLEhiDKW---CRDLKILYLQNNLIGKIENVS--KLKKLEYLNLALNNI 78
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAfkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-127 3.72e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  49 LYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEVLTKLDLTVNFIGE---LSSVKSLTHNI 113
Cdd:COG5238  269 LYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaIALAKALQENT 348

                         90
                 ....*....|....
gi 512951106 114 HLKELFLMGNPCAD 127
Cdd:COG5238  349 TLHSLDLSDNQIGD 362
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 22-123 4.43e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512951106  22 SLEELSLHQQEIERLEHIDkwcrdlkilyLQNNLIGK------IENVSKLKKLEYLNLALNNIEK------IENLEGCEV 89
Cdd:COG5238  224 GAEILAEALKGNKSLTTLD----------LSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTT 293

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 512951106  90 LTKLDLTVNFIGELSSV---KSLTHNIHLKELFLMGN 123
Cdd:COG5238  294 LTSLDLSVNRIGDEGAIalaEGLQGNKTLHTLNLAYN 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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