|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
84-847 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1433.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 84 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIREATWESVSMMLQLGGTVIGSARCKDF 163
Cdd:cd00764 1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 164 REREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITAEEATKSSYLNIVGLVGSIDNDFCGT 243
Cdd:cd00764 81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 244 DMTIGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 323
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 324 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTP 403
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 404 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMNDRKFDEAMKLRGRSFMNNWEVYKLLAHVRPPVTKaPGSTHTVAVMNVGA 483
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLP-EKTNLNIAIVNVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 484 PAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNI 563
Cdd:cd00764 400 PAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 564 QGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFII 643
Cdd:cd00764 480 DGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIV 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 644 ETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKG 723
Cdd:cd00764 560 ETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKG 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 724 IFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQT 803
Cdd:cd00764 640 VFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....
gi 511892015 804 dFEHRIPKEQWWLKLRPILKILAKYEIDLDTSEHAHLEHISRKR 847
Cdd:cd00764 720 -FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
87-828 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1206.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIREATWESVSMMLQLGGTVIGSARCKDFRER 166
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMT 246
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 326
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 327 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACV 406
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 407 VSLSGNQAVRLPLMECVQVTKDVTKAMNDRKFDEAMKLRGRSFMNNWEVYKLLAHVRPPVTKAPGSTH--TVAVMNVGAP 484
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEASrlRIAIIHVGAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 485 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 564
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 565 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 644
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 645 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 724
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 725 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPV-TELKDQT 803
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVkQLLANET 719
|
730 740
....*....|....*....|....*
gi 511892015 804 DFEHRIPKEQWWLKLRPILKILAKY 828
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
87-454 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 544.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIREATWESVSMMLQLGGTVIGSARCKDFRER 166
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDllsdlqkagkitaeeatKSSYLNIVGLVGSIDNDFCGTDMT 246
Cdd:cd00363 79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 326
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 327 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACV 406
Cdd:cd00363 222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 511892015 407 VSLSGNQAVRLPLMECVQVTKDVtkamndrkfdeAMKLRGRSFMNNWE 454
Cdd:cd00363 302 QNLNENQVVRHPLTEAVNMTKRV-----------GVDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
89-392 |
2.27e-141 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 419.05 E-value: 2.27e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 89 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIREATWESVSMMLQLGGTVIGSARCKDFREREG 168
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 169 RLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllsdlqkagkitaeeatkssyLNIVGLVGSIDNDFCGTDMTIG 248
Cdd:pfam00365 80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 249 TDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 328
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 511892015 329 NIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAV 392
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
87-429 |
1.20e-125 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 381.34 E-value: 1.20e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIREATWESVSMMLQLGGTVIGSARCKDFRER 166
Cdd:COG0205 2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITAEEAtkssyLNIVGLVGSIDNDFCGTDMT 246
Cdd:COG0205 80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 326
Cdd:COG0205 138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 327 RLNIIIVAEGAIDKNGKPI---------------TSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEA 391
Cdd:COG0205 215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294
|
330 340 350
....*....|....*....|....*....|....*...
gi 511892015 392 VMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDV 429
Cdd:COG0205 295 VELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
87-442 |
1.45e-123 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 375.19 E-value: 1.45e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIREATWESVSMMLQLGGTVIGSARCKDFRER 166
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 EGRLRAAHNLVKRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQkagkitaeeatkssyLNIVGLVGSIDNDFCGTDMT 246
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK--------RLTEHG---------------IPVIGLPGTIDNDIAGTDYT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 326
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 327 RLNIIIVAEGAIDKngkpitsEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacV 406
Cdd:PRK03202 214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283
|
330 340 350
....*....|....*....|....*....|....*.
gi 511892015 407 VSLSGNQAVRLPLMECVQVTKdvtkamndRKFDEAM 442
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVENMK--------HPFDKDL 311
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
476-758 |
2.19e-104 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 323.14 E-value: 2.19e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 476 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 552
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEgre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 553 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 632
Cdd:pfam00365 82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 633 AAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLvQKMKTTVkrgLVLRNEKCNenyTTDF 712
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFS---IIVVAEGAS---DGEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 511892015 713 IFNLYsEEGKGIfDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 758
Cdd:pfam00365 228 LAKLI-EEGTGI-ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
89-421 |
1.79e-103 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 321.99 E-value: 1.79e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 89 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIREATWESVSMMLQLGGTVIGSARCKDFREREG 168
Cdd:TIGR02482 2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 169 RLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGKItaeeatkssylNIVGLVGSIDNDFCGTDMTIG 248
Cdd:TIGR02482 80 REKAVENLKKLGIEGLVVIGGDGSYTGA-----------QKLYEEGGI-----------PVIGLPGTIDNDIPGTDYTIG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 249 TDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDweeHLCRRLSETRTRGSRL 328
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 329 NIIIVAEGAIDKNGKpitseDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacVVS 408
Cdd:TIGR02482 215 SIIIVAEGNIVGSAK-----EVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MIG 286
|
330
....*....|...
gi 511892015 409 LSGNQAVRLPLME 421
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
87-435 |
1.47e-98 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 309.73 E-value: 1.47e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIREATWESVSMMLQLGGTVIGSARCKDFRER 166
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 EGRLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllsdlqkagKITAEEAtkssyLNIVGLVGSIDNDFCGTDMT 246
Cdd:cd00763 79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGA------------------MRLTEHG-----FPCVGLPGTIDNDIPGTDYT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 326
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 327 RLNIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGtpdTPACV 406
Cdd:cd00763 213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLA 282
|
330 340
....*....|....*....|....*....
gi 511892015 407 VSLSGNQAVRLPLMECVQVTKDVTKAMND 435
Cdd:cd00763 283 VGIQNEQLVHHDIIDAIENMKPFKKDWLA 311
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
89-423 |
2.41e-81 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 264.55 E-value: 2.41e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 89 IAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGgDHIREATWESVSMMLQLGGTVIGSARCKDFR-ER 166
Cdd:TIGR02483 2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 EGRLRAAHNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGkitaeeatkssyLNIVGLVGSIDNDFCGTDMT 246
Cdd:TIGR02483 81 DGDDKIVANLKELGLDALIAIGGDGTLGIA-----------RRLADKG------------LPVVGVPKTIDNDLEATDYT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPddDWEEhLCRRLSETRTRGS 326
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 327 RLNIIIVAEGAIDKNGKPITSEDIKN----------------LVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVE 390
Cdd:TIGR02483 215 RFAIVVVAEGAKPKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294
|
330 340 350
....*....|....*....|....*....|...
gi 511892015 391 AVMALLEGTPDTpacVVSLSGNQAVRLPLMECV 423
Cdd:TIGR02483 295 AVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
83-429 |
1.17e-60 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 209.93 E-value: 1.17e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 83 LGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGGDHIREATWESVSMMLQLGGTVIGSARCK 161
Cdd:PRK14071 1 MGEKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 162 D---FREREGRLR--------AAHNLvkrGITNLCVIGGDGSLTgadtfrsewsdLLSDLQKAGKItaeeatkssylNIV 230
Cdd:PRK14071 81 DpfaFPMPDGSLRdrsqeiidGYHSL---GLDALIGIGGDGSLA-----------ILRRLAQQGGI-----------NLV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 231 GLVGSIDNDFCGTDMTIGTDSALHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddw 310
Cdd:PRK14071 136 GIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 311 EEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSED-------------IKNLVVKRLGYDTRVTVLGHVQRGGTPS 377
Cdd:PRK14071 213 LENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 511892015 378 AFDRILGSRMGVEAVMALLEGTPDTpacVVSLSGNQAVRLPLMECVQVTKDV 429
Cdd:PRK14071 293 PRDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAV 341
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
86-413 |
6.71e-55 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 202.95 E-value: 6.71e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 86 GKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIREATWESVSMMLQLGGTVIGSARckDFRE 165
Cdd:TIGR02478 389 RLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGTNR--SLPG 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 166 REGRLRAAHnLVKRGITNLCVIGGDGSLTGadtfrsewsdlLSDLQKagkitAEEATKSSYLNIVGLVGSIDNDFCGTDM 245
Cdd:TIGR02478 465 DDLGTIAYY-FQQHKIDGLIIIGGFEAFEA-----------LYQLDA-----AREKYPAFRIPMVVIPATISNNVPGTEY 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 246 TIGTDSALHRIIEIVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-DDWEE---HLCRRLSE 320
Cdd:TIGR02478 528 SLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISlKDLQEdieHLKETFAE 607
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 321 TRTRGsrlnIIIVAEGAIdkngKPITSEDIKNLVVK--RLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLE- 397
Cdd:TIGR02478 608 GRAGK----LILRNEKAS----KVYTTDFIARIISEegKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEk 679
|
330 340
....*....|....*....|....*.
gi 511892015 398 ----------GTPDTPACVVSLSGNQ 413
Cdd:TIGR02478 680 ikankhadklSADDTSAVVIGIRGSN 705
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
476-756 |
2.70e-52 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 185.96 E-value: 2.70e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 476 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQIS 555
Cdd:cd00363 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 556 A---NITKFNIQGLVIIGGFEAYTGGLELmegRKQFDELCIPFVVI--PATVSNNVPGSDFSVGADTALNTICTTCDRIK 630
Cdd:cd00363 83 KaaeNLKKHGIDALVVIGGDGSYTGADLL---TEEWPSKYQGFNVIglPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 631 QSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDlqanVEHLVQKMKTTVKRG----LVLRNEKcne 706
Cdd:cd00363 160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 511892015 707 nyTTDFIFNLYSEEG-------KGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 756
Cdd:cd00363 232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEA 286
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
475-824 |
3.50e-52 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 185.66 E-value: 3.50e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 475 TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKS---F 551
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTeegR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 552 EQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 631
Cdd:COG0205 83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 632 SAAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLqanVEHLVQKMKTTVKRGLV-----LRNEKCNE 706
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIvvaegAGDEDGEA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 707 NYTTD-FIFNLYSEEGKGI-----------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNW-MSGKikesyrngri 773
Cdd:COG0205 233 VLEADtDAFGHVRLGGIGEylakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELlLEGK---------- 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 511892015 774 fantpdSGCVLGMRKRALVFQPVTELKDQtdfEHRIPKEQWWLKLRPILKI 824
Cdd:COG0205 303 ------TGVMVGIRRGEIVLVPLEEVANK---EKPVDPDSPLIQLARELGI 344
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
476-756 |
7.75e-51 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 181.05 E-value: 7.75e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 476 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 552
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgra 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 553 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRkqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 632
Cdd:PRK03202 84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 633 AAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEK-CNENYTTD 711
Cdd:PRK03202 157 AS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAK 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 511892015 712 FIfnlyseEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 756
Cdd:PRK03202 233 EI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
476-756 |
1.98e-49 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 177.22 E-value: 1.98e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 476 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRtLPKKSFEQIS 555
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 556 A----NITKFNIQGLVIIGGFEAYTGGLELMEgrkqfdeLCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 631
Cdd:cd00763 82 AkaieQLKKHGIDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 632 SAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEKCnenYTTD 711
Cdd:cd00763 155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 511892015 712 FIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 756
Cdd:cd00763 228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
89-349 |
9.36e-23 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 102.43 E-value: 9.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 89 IAVLTSGGDAQGMNAAVRAVVRVGIFTGA--RVFFVHEGYQGLVDGgDHIrEATWESVSMMLQLGGTVIGSARCKDFRER 166
Cdd:PTZ00286 90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKE-DWI-KLDPKDVKTIHRLGGTILGSSRGGFDPKV 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 egrlrAAHNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITAEEATKSSYLNIVGLVGSIDNDFCGTDMT 246
Cdd:PTZ00286 168 -----MVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 247 IGTDSALHRIIEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPEcppdDDWEEHLCRRLSETRTR 324
Cdd:PTZ00286 226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPE----FDIPLEGVLEYIEQRLQ 301
|
250 260
....*....|....*....|....*..
gi 511892015 325 GSRLNIIIVAEGAID--KNGKPITSED 349
Cdd:PTZ00286 302 KKGHCVIVVAEGAGQslKDADLDLGTD 328
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
90-419 |
7.24e-22 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 99.56 E-value: 7.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 90 AVLTSGGDAQGMNAAVRAVVRV-----GIftgARVFFVHEGYQGLVDGGDH-IREATWESVSMMLQLGGTVIGSARckdf 163
Cdd:PRK06830 84 AIVTCGGLCPGLNDVIRAIVLElhhhyGV---RRILGIRYGYQGLIPRYGHdPVELTPEVVADIHEFGGTILGSSR---- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 164 rereGRLRAAH---NLVKRGITNLCVIGGDGSLTGadtfrsewsdllsdlqkAGKITAEEATKSSYLNIVGLVGSIDNDF 240
Cdd:PRK06830 157 ----GPQDPEEivdTLERMNINILFVIGGDGTLRG-----------------ASAIAEEIERRGLKISVIGIPKTIDNDI 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 241 CGTDMTIGTDSALHRIIEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWE----EHL 314
Cdd:PRK06830 216 NFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPngllAAL 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 315 CRRLSEtrtRGSRlnIIIVAEGA----IDKNGKpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTP-------------- 376
Cdd:PRK06830 296 EKRLAE---RGHA--VIVVAEGAgqelFDDTGE---TDASGNPKLGDIGLFLKDRIKEYFKARGIPinlkyidpsyiirs 367
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 511892015 377 ---SAFDRILGSRMGVEAVMALLEGTPDtpaCVVSLSGNQAVRLPL 419
Cdd:PRK06830 368 vpaNANDSVYCGFLGQNAVHAAMAGKTG---MVVGRWNNRFVHLPI 410
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
471-758 |
6.48e-18 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 86.28 E-value: 6.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 471 GSTHTVAVMNVGAPAAGMNAAVRSTVRIGLIQ-GNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKR--- 544
Cdd:PRK14071 2 GEKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgd 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 545 ---------TLPKKSfEQISANITKFNIQGLVIIGGfeayTGGLELMegRKQFDELCIPFVVIPATVSNNVPGSDFSVGA 615
Cdd:PRK14071 82 pfafpmpdgSLRDRS-QEIIDGYHSLGLDALIGIGG----DGSLAIL--RRLAQQGGINLVGIPKTIDNDVGATEVSIGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 616 DTALNTICTTCDRIKQSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIrdlqanvEHLVQKMKTTVKR 695
Cdd:PRK14071 155 DTAVNIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 696 G----LVLRNEKC----NENYTTDFIF--NLYSEEGKGIFD---------SRKNVLGHMQQGGSPTPFDRNFATKMGAKA 756
Cdd:PRK14071 227 GknfcLVVVSEAVrteeGEQVTKTQALgeDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAA 306
|
..
gi 511892015 757 MN 758
Cdd:PRK14071 307 VD 308
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
187-398 |
7.60e-16 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 80.67 E-value: 7.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 187 IGGDGSltgADTfrsewsdllsdlqkAGKItAEEATKSSY-LNIVGLVGSIDNDFCGTDMTIGTDSALHRI----IEI-- 259
Cdd:PRK14072 110 NGGNDS---MDT--------------ALKV-SQLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIatsvLEAal 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 260 -VDAITTTaqshQRTFVLEVMGRHCGYLALVTSLSC-----GADWVFIPECPPDDDweehlcRRLSETRTRGSRLN--II 331
Cdd:PRK14072 172 dVAAMANT----SKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFDEE------KFLADVRAIVKRYGycVV 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 332 IVAEGAIDKNGKPI----TSED-------------IKNLVVKRLGYDTRVTVLGHVQR--GGTPSAFDRILGSRMGVEAV 392
Cdd:PRK14072 242 VVSEGIRDADGKFIaeagLAEDafghaqlggvapvLANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAV 321
|
....*.
gi 511892015 393 MALLEG 398
Cdd:PRK14072 322 EYALAG 327
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
90-429 |
1.52e-14 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 76.77 E-value: 1.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 90 AVLTSGGDAQGMNAAVRAVV-RVGIFTGARVFFVHEGYQGLVDGGDHIREATWESVSMMLQLGGTVIGSARckdfrereG 168
Cdd:PLN02884 57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------G 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 169 RLRAAH---NLVKRGITNLCVIGGDGSLTGADTfrsewsdllsdlqkagkITAEEATKSSYLNIVGLVGSIDNDFCGTDM 245
Cdd:PLN02884 129 GAKTSDivdSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 246 TIGTDSALHRIIEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWEEHLCRRLSE-TR 322
Cdd:PLN02884 192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHlIE 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 323 TRGSRlnIIIVAEGAIDKNGKPITSEDIK-NLVVKRLGYDTRVTVLGHVQRGGTPS-----------------AFDRILG 384
Cdd:PLN02884 272 TKGSA--VVCVAEGAGQDLLQKTNATDASgNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILC 349
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 511892015 385 SRMGVEAVMALLEGtpdTPACVVSLSGNQAVRLPLMECVQVTKDV 429
Cdd:PLN02884 350 TVLGQNAVHGAFAG---FSGITVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
87-337 |
5.22e-14 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 75.04 E-value: 5.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVR--VGIFTGARVFFVHEGYQGLVdGGDHIR--EATWESVSMMLQLGGTVIGSARCK- 161
Cdd:PRK06555 4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLL-LGDSIEitPAVRANAGLLHRYGGSPIGNSRVKl 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 162 ----D------FREREGRLR-AAHNLVKRGITNLCVIGGDGSLTGAdtfrsewSDLLSDLQKAGkitaeeatkssY-LNI 229
Cdd:PRK06555 83 tnvaDcvkrglVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG-----------YdLTV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 230 VGLVGSIDNDFCGTDMTIGTDSALHRIIEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTS----------------- 291
Cdd:PRK06555 145 VGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayrewldrqeyvpgfg 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 511892015 292 LSCGA---DWVFIPECPPDDDWEehlCRRLSETRTRGSRLNiIIVAEGA 337
Cdd:PRK06555 225 LSAERwdiHAVYLPEMAFDLEAE---AERLKAVMDEVGNVN-IFLSEGA 269
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
90-337 |
9.16e-12 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 68.24 E-value: 9.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 90 AVLTSGGDAQGMNAAVRAVVrVGIFTG---ARVFFVHEGYQGLVdgGDHIREATWESVSMMLQLGGTVIGSARckdfrer 166
Cdd:PLN02564 91 CIVTCGGLCPGLNTVIREIV-CGLSYMygvTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSR------- 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 167 egrlrAAHNLVK-------RGITNLCVIGGDGSLTGADTFRSEwsdllsdLQKAGKITAeeatkssylnIVGLVGSIDND 239
Cdd:PLN02564 161 -----GGHDTSKivdsiqdRGINQVYIIGGDGTQKGASVIYEE-------IRRRGLKVA----------VAGIPKTIDND 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 240 FCGTDMTIGTDSALHRIIEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSL-SCGADWVFIPECPPDDDWE----EH 313
Cdd:PLN02564 219 IPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFYLEGKgglfEF 298
|
250 260
....*....|....*....|....
gi 511892015 314 LCRRLSEtrtrgSRLNIIIVAEGA 337
Cdd:PLN02564 299 IEKRLKE-----NGHMVIVVAEGA 317
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
461-654 |
5.00e-08 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 56.20 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 461 HVRPPVTKApgsthtvAVMNVGAPAAGMNAAVRSTVRIGLI--QGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGS 538
Cdd:PTZ00286 82 YFNPKEVKA-------GIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGT 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 539 KLGTKRTlpKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELM-EGRKQfdELCIPFVVIPATVSNNVPGSDFSVGADT 617
Cdd:PTZ00286 155 ILGSSRG--GFDPKVMVDTLIRHGINILFTLGGDGTHRGALAIYkELRRR--KLNISVVGIPKTIDNDIPIIDESFGFQT 230
|
170 180 190
....*....|....*....|....*....|....*..
gi 511892015 618 ALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLA 654
Cdd:PTZ00286 231 AVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIA 267
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
48-339 |
3.95e-07 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 54.27 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 48 LKSLHAMddpgtmegiPVLKNEWIMTHEEHHAAKTLGIGkaiaVLTSGGDAQGMNAAVRavvrvGIFTGARVFFVHEGYQ 127
Cdd:PTZ00287 152 LKNLHNL---------PILNVKETNNHESFKGGNVLKIG----IILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVI 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 128 GLVDGGDHIREATWESV--SMM---LQLGG-TVIGSARCKdFREREGrLRAAHNLV-KRGITNLCVIGGDGSLTGAdtfr 200
Cdd:PTZ00287 214 GFLGGIDGLYSKNYVTItdSLMnrfRNLGGfNMLWSGRGK-VRNKDD-LIAIENIVaKLKLNGLVIIGGDGSNSNA---- 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 201 sewsDLLSDLQKAGKITaeeatkssyLNIVGLVGSIDNDFC--GTDMTIGTDSALHRIIEIVDAITTTAQS-HQRTFVLE 277
Cdd:PTZ00287 288 ----ALISEYFAERQIP---------ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVR 354
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 511892015 278 VMGRHCGYLALVTSLSCGADWVFIPECPPDD-----DWEEHLCRRLSETRTRGSRLNIIIVAEGAID 339
Cdd:PTZ00287 355 VMGRSASHVVLECALQTRPNIVLIGEEVEKEnlslkDIVSNIVNTILKRRSLNKNYGVILIPEGLIE 421
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
87-339 |
2.51e-04 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 44.97 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 87 KAIAVLTSGGDAQGMNAAVRAVVR-VGIFTGARVFFvheGYQGLVDG--GDHIREATWESVSMMLQLGG-TVIGSARCKd 162
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVIAGLMSyIKLCNQSSQLF---GFLGGPEGvySERYRELTEDDINGILNQGGfNIICSGRHK- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 163 fREREGRLRAAHNLV-KRGITNLCVIGGDGSLTGAdtfrsewsdllsdlqkagKITAEEATK-SSYLNIVGLVGSIDNDF 240
Cdd:PTZ00468 179 -IETEEQMRASLEICeKLKLHGLVVIGGDDSNTNA------------------AVLAEYFKRnSSSTVVVGCPKTIDGDL 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511892015 241 CG--TDMTIGTDSALHRIIEIVDAITTTAQSHQ-RTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD---------D 308
Cdd:PTZ00468 240 KNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEenrslmsivD 319
|
250 260 270
....*....|....*....|....*....|.
gi 511892015 309 DWEEHLCRRLSetrtRGSRLNIIIVAEGAID 339
Cdd:PTZ00468 320 EIVEMILKRDS----LGKKHGIVLLPEGLIE 346
|
|
| |
