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Conserved domains on  [gi|499039741|ref|XP_004570504|]
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nucleolar protein 58 isoform X2 [Maylandia zebra]

Protein Classification

NOP5/NOP56 family protein( domain architecture ID 12087092)

NOP5/NOP56 family protein similar to human nucleolar protein 58 (NOP58, also known as NOP5) which is a core component of box C/D small nucleolar ribonucleoparticles

CATH:  1.10.246.90
Gene Ontology:  GO:0005730|GO:0030515|GO:0006364

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
170-398 7.88e-117

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


:

Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 344.44  E-value: 7.88e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  170 LDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIG-DRTNVASSDLSDILPEEIEAEVKLAAEISMGTEVS 248
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGnDREDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  249 EEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAGSLLNLAKHPASTVQILGAEKALFR 328
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLESRMSAIAPNLTALVGPLVAARLISHAGGLTNLAKMPASNIQILGAEKALFR 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  329 ALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGeDTNAEMGAENRAKLEARLRQ 398
Cdd:pfam01798 161 ALKTGFNTPKYGLIYHSPLVQATPPKLRGKAARLLAAKCALAARVDAFS-EPDGSYGEKLREEIEKRLEK 229
NOP5NT pfam08156
NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 ...
2-52 5.35e-16

NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 family.


:

Pssm-ID: 462382  Cd Length: 66  Bit Score: 72.49  E-value: 5.35e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499039741    2 LVLFETAAGYAIFKVLNE----SKLQQVDslyKEFETPEKANKIVKLKHFEKFQD 52
Cdd:pfam08156   1 LVLFETAAGYALFKVKDEeeigKKLKEVQ---ESFQDLEKFSKMVKLKAFSPFKS 52
 
Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
170-398 7.88e-117

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 344.44  E-value: 7.88e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  170 LDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIG-DRTNVASSDLSDILPEEIEAEVKLAAEISMGTEVS 248
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGnDREDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  249 EEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAGSLLNLAKHPASTVQILGAEKALFR 328
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLESRMSAIAPNLTALVGPLVAARLISHAGGLTNLAKMPASNIQILGAEKALFR 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  329 ALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGeDTNAEMGAENRAKLEARLRQ 398
Cdd:pfam01798 161 ALKTGFNTPKYGLIYHSPLVQATPPKLRGKAARLLAAKCALAARVDAFS-EPDGSYGEKLREEIEKRLEK 229
SIK1 COG1498
Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and ...
147-396 4.11e-73

Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441107 [Multi-domain]  Cd Length: 352  Bit Score: 236.39  E-value: 4.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 147 LSRYKLKFSPDKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIGDRTNVASSDLSDI 226
Cdd:COG1498  108 ATRRKVREAAQARDLQIIQAIRALDDIDKTANLLAERLREWYGLHFPELDTGVKDHEEYARIVAELGPRENITKENLAEK 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 227 LPEeieaevklAAEISMGTEVSEEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAGSL 306
Cdd:COG1498  188 IAE--------AAKKSMGADLSDEDLEIIKSLAERILDLYDERKSLEEYIERVMPEVAPNLTALAGPVLGARLISLAGGL 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 307 LNLAKHPASTVQILGAEKALFRALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGedtnAEMGA 386
Cdd:COG1498  260 ERLAKLPASTIQVLGAEKALFRHLRGGAPPPKHGVIFQHPAIHGSPRWQRGKIARALAAKLAIAARIDHYS----GEIGP 335
                        250
                 ....*....|
gi 499039741 387 ENRAKLEARL 396
Cdd:COG1498  336 ELKEELEKRI 345
PRK14552 PRK14552
C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional
146-402 1.82e-70

C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional


Pssm-ID: 237753 [Multi-domain]  Cd Length: 414  Bit Score: 231.40  E-value: 1.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 146 SLSRYKLKFSPDKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIGDRTNVASSDLSD 225
Cdd:PRK14552 124 ELTRRKLRSAAQKRDKLAIQAIRAIDDIDKTINLFSERLREWYSLHFPELDELVKKHEEYVKLVSELGDRENYTREKLKK 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 226 I-LPEEIEAEVKLAAEISMGTEVSEEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAG 304
Cdd:PRK14552 204 LgLPENKARKIAEAAKKSMGADLSEFDLEAIKKLANEILDLYKLREELEDYLETVMKEVAPNLTALVGPSLGARLISLAG 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 305 SLLNLAKHPASTVQILGAEKALFRALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGEDTNAEM 384
Cdd:PRK14552 284 GLEELAKMPASTIQVLGAEKALFRHLRTGAKPPKHGVIFQYPAIHGSPWWQRGKIARALAAKLAIAARVDYFSGRYIGDE 363
                        250
                 ....*....|....*...
gi 499039741 385 GAEnraKLEARLRQLEDK 402
Cdd:PRK14552 364 LKE---ELNKRIEEIKEK 378
NOSIC smart00931
NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.
163-214 1.80e-24

NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.


Pssm-ID: 197999 [Multi-domain]  Cd Length: 52  Bit Score: 96.08  E-value: 1.80e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 499039741   163 IVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIGD 214
Cdd:smart00931   1 IIQAINLLDDIDKEINLFHMRVREWYSWHFPELEKLVPDPLDYAKVVKLLGN 52
NOP5NT pfam08156
NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 ...
2-52 5.35e-16

NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 family.


Pssm-ID: 462382  Cd Length: 66  Bit Score: 72.49  E-value: 5.35e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499039741    2 LVLFETAAGYAIFKVLNE----SKLQQVDslyKEFETPEKANKIVKLKHFEKFQD 52
Cdd:pfam08156   1 LVLFETAAGYALFKVKDEeeigKKLKEVQ---ESFQDLEKFSKMVKLKAFSPFKS 52
 
Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
170-398 7.88e-117

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 344.44  E-value: 7.88e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  170 LDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIG-DRTNVASSDLSDILPEEIEAEVKLAAEISMGTEVS 248
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGnDREDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  249 EEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAGSLLNLAKHPASTVQILGAEKALFR 328
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLESRMSAIAPNLTALVGPLVAARLISHAGGLTNLAKMPASNIQILGAEKALFR 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741  329 ALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGeDTNAEMGAENRAKLEARLRQ 398
Cdd:pfam01798 161 ALKTGFNTPKYGLIYHSPLVQATPPKLRGKAARLLAAKCALAARVDAFS-EPDGSYGEKLREEIEKRLEK 229
SIK1 COG1498
Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and ...
147-396 4.11e-73

Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441107 [Multi-domain]  Cd Length: 352  Bit Score: 236.39  E-value: 4.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 147 LSRYKLKFSPDKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIGDRTNVASSDLSDI 226
Cdd:COG1498  108 ATRRKVREAAQARDLQIIQAIRALDDIDKTANLLAERLREWYGLHFPELDTGVKDHEEYARIVAELGPRENITKENLAEK 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 227 LPEeieaevklAAEISMGTEVSEEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAGSL 306
Cdd:COG1498  188 IAE--------AAKKSMGADLSDEDLEIIKSLAERILDLYDERKSLEEYIERVMPEVAPNLTALAGPVLGARLISLAGGL 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 307 LNLAKHPASTVQILGAEKALFRALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGedtnAEMGA 386
Cdd:COG1498  260 ERLAKLPASTIQVLGAEKALFRHLRGGAPPPKHGVIFQHPAIHGSPRWQRGKIARALAAKLAIAARIDHYS----GEIGP 335
                        250
                 ....*....|
gi 499039741 387 ENRAKLEARL 396
Cdd:COG1498  336 ELKEELEKRI 345
PRK14552 PRK14552
C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional
146-402 1.82e-70

C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional


Pssm-ID: 237753 [Multi-domain]  Cd Length: 414  Bit Score: 231.40  E-value: 1.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 146 SLSRYKLKFSPDKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIGDRTNVASSDLSD 225
Cdd:PRK14552 124 ELTRRKLRSAAQKRDKLAIQAIRAIDDIDKTINLFSERLREWYSLHFPELDELVKKHEEYVKLVSELGDRENYTREKLKK 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 226 I-LPEEIEAEVKLAAEISMGTEVSEEDIGNIRHLCDQVVEISEYRAQLYDYLKNRMMAIAPNLTVMVGELVGARLISHAG 304
Cdd:PRK14552 204 LgLPENKARKIAEAAKKSMGADLSEFDLEAIKKLANEILDLYKLREELEDYLETVMKEVAPNLTALVGPSLGARLISLAG 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499039741 305 SLLNLAKHPASTVQILGAEKALFRALKTRKDTPKYGLIYHASLVGQTTAKNKGKISRMLAAKAALAIRYDALGEDTNAEM 384
Cdd:PRK14552 284 GLEELAKMPASTIQVLGAEKALFRHLRTGAKPPKHGVIFQYPAIHGSPWWQRGKIARALAAKLAIAARVDYFSGRYIGDE 363
                        250
                 ....*....|....*...
gi 499039741 385 GAEnraKLEARLRQLEDK 402
Cdd:PRK14552 364 LKE---ELNKRIEEIKEK 378
NOSIC smart00931
NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.
163-214 1.80e-24

NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.


Pssm-ID: 197999 [Multi-domain]  Cd Length: 52  Bit Score: 96.08  E-value: 1.80e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 499039741   163 IVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKVITDNLAYCKSVRKIGD 214
Cdd:smart00931   1 IIQAINLLDDIDKEINLFHMRVREWYSWHFPELEKLVPDPLDYAKVVKLLGN 52
NOP5NT pfam08156
NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 ...
2-52 5.35e-16

NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 family.


Pssm-ID: 462382  Cd Length: 66  Bit Score: 72.49  E-value: 5.35e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499039741    2 LVLFETAAGYAIFKVLNE----SKLQQVDslyKEFETPEKANKIVKLKHFEKFQD 52
Cdd:pfam08156   1 LVLFETAAGYALFKVKDEeeigKKLKEVQ---ESFQDLEKFSKMVKLKAFSPFKS 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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