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Conserved domains on  [gi|449452054|ref|XP_004143775|]
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sucrose transport protein SUC3 isoform X1 [Cucumis sativus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPH_sucrose super family cl26211
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 66-591 0e+00

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


The actual alignment was detected with superfamily member TIGR01301:

Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 527.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   66 SSLIILILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAG 145
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  146 SLMIAVAVVLIGFSADIGYILGDTkehcrVYKGTRTRAAIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHN--VANA 223
Cdd:TIGR01301  81 AALVAFAVILIGFAADIGHLFGDN-----LDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRtrIANA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  224 VFCSWMAVGNILGFSAGASGNWHKWFPFLLSNACCEACGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPRLSDS 303
Cdd:TIGR01301 156 YFSFFMAIGNVLGYAAGAYSGLYKIFPFTKTEACGVSCANLKSCFLIDIILLAILTYIALSAVKENPLIGSDDFINSEAA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  304 APLLNGSEqnspdilkpelnglngssvdyghheninlknskaeseenqsegyydgpaTVIVKLLTSLRHLPPAMHSVLLV 383
Cdd:TIGR01301 236 PPSKHGEE-------------------------------------------------AFFGELFGAFKYLPRPVWILLLV 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  384 MALSWLSWFPFFLFDTDWMGREVYHGDPKgsltDERVYDQGVREGAFGLLLNSVVLGISSFFIEPMCQRMGA-RVVWAMS 462
Cdd:TIGR01301 267 TCLNWIAWFPFILFDTDWMGREVYGGSVN----QGAKYDDGVRAGAFGLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIV 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  463 NFIVFACMTGTTIISLISV-SHYSEGIEHIIGGNSTIKNAALAVFALLGFPLAITYSVPFSLTAELTADSGGGQGLAIGV 541
Cdd:TIGR01301 343 NIILAICLAATVLVTYVAKnSRYYDGDGESLPPPTGIKASALIVFAILGIPLAITYSIPFALASIRSSNLGAGQGLSMGV 422

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 449452054  542 LNLAVVIPQMIVSLGAGPWDALFSGGNIPAFALASICALAAGVVAVLRLP 591
Cdd:TIGR01301 423 LNLAIVIPQIIVSLGSGPWDQLFGGGNLPAFVVGAVAAFVSGLLALILLP 472
 
Name Accession Description Interval E-value
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 66-591 0e+00

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 527.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   66 SSLIILILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAG 145
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  146 SLMIAVAVVLIGFSADIGYILGDTkehcrVYKGTRTRAAIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHN--VANA 223
Cdd:TIGR01301  81 AALVAFAVILIGFAADIGHLFGDN-----LDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRtrIANA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  224 VFCSWMAVGNILGFSAGASGNWHKWFPFLLSNACCEACGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPRLSDS 303
Cdd:TIGR01301 156 YFSFFMAIGNVLGYAAGAYSGLYKIFPFTKTEACGVSCANLKSCFLIDIILLAILTYIALSAVKENPLIGSDDFINSEAA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  304 APLLNGSEqnspdilkpelnglngssvdyghheninlknskaeseenqsegyydgpaTVIVKLLTSLRHLPPAMHSVLLV 383
Cdd:TIGR01301 236 PPSKHGEE-------------------------------------------------AFFGELFGAFKYLPRPVWILLLV 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  384 MALSWLSWFPFFLFDTDWMGREVYHGDPKgsltDERVYDQGVREGAFGLLLNSVVLGISSFFIEPMCQRMGA-RVVWAMS 462
Cdd:TIGR01301 267 TCLNWIAWFPFILFDTDWMGREVYGGSVN----QGAKYDDGVRAGAFGLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIV 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  463 NFIVFACMTGTTIISLISV-SHYSEGIEHIIGGNSTIKNAALAVFALLGFPLAITYSVPFSLTAELTADSGGGQGLAIGV 541
Cdd:TIGR01301 343 NIILAICLAATVLVTYVAKnSRYYDGDGESLPPPTGIKASALIVFAILGIPLAITYSIPFALASIRSSNLGAGQGLSMGV 422

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 449452054  542 LNLAVVIPQMIVSLGAGPWDALFSGGNIPAFALASICALAAGVVAVLRLP 591
Cdd:TIGR01301 423 LNLAIVIPQIIVSLGSGPWDQLFGGGNLPAFVVGAVAAFVSGLLALILLP 472
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 71-588 8.96e-143

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 420.49  E-value: 8.96e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  71 LILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIA 150
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 151 VAVVLIGFSADIGYILGDtkehcrvykGTRTRAAIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHNVANAVFCSWMA 230
Cdd:cd17313   81 LGLILIPNAADIGLALGD---------GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 231 VGNILGFSAGASGNWHKWFPFLLsnacceaCGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVdqpprlsdsapllngs 310
Cdd:cd17313  152 LGGVLGYLLGAILWDHNWFGFAL-------GGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPE---------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 311 eqnspdilkpelnglngssvdyghheninlknsKAESEENQSEGyydgpaTVIVKLLTSLRHLPPAMHSVLLVMALSWLS 390
Cdd:cd17313  209 ---------------------------------AGEHSENPSLG------EVLKSLLKLLKIMPRSLLRLLLVIFFWWIA 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 391 WFPFFLFDTDWMGREVYHGDPKGSltdeRVYDQGVREGAFGLLLNSVVLGISSFFIEPMCQRMGARVVWAMSNFIVFACM 470
Cdd:cd17313  250 FFPFELFFTDYMGEEVYHGTSAAS----SHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGM 325

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 471 TGTTIISLISVshysegiehiiggnstiknaALAVFALLGFPLAITYSVPFSLTAELTADSGGGQGLAIGVLNLAVVIPQ 550
Cdd:cd17313  326 ALMALVHNVTV--------------------ALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTGLLNLAISLAQ 385

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 449452054 551 MIVSLGAGPWDALFsgGNIPAFALASICALAAGVVAVL 588
Cdd:cd17313  386 ILVSLLAGPIIDVK--GYGTVFPVAAVASFLSLVGALF 421
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
78-590 2.85e-24

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 106.14  E-value: 2.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  78 AAGVQFGWALQLSLLTP-YIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVAVVLI 156
Cdd:COG2211   19 DLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIPLALSFVLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 157 GFSADIGYILgdtkehcrvykgtrtrAAIIFVIGFWMLDLANNTVQGPARALLADLSG-PDQHNVANAVFCSWMAVGNIL 235
Cdd:COG2211   99 FTAPDLSPTG----------------KLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 236 GFSAGasgnwhkwfPFLLSNACCEACGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPrlsdsapllngseqnsp 315
Cdd:COG2211  163 ASVLP---------PPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS----------------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 316 dilkpelnglngssvdyghheninlknskaeseenqsegyydgpatvIVKLLTSLRHLPPAMHsVLLVMALSWLSW---- 391
Cdd:COG2211  217 -----------------------------------------------LKESLKALLKNRPFLL-LLLAYLLFFLALalva 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 392 --FPFFLfdTDWMGREvyhgdpkgsltdervydqgvrEGAFGLLL--NSVVLGISSFFIEPMCQRMGARVVWAMSNFIVF 467
Cdd:COG2211  249 alLLYYF--KYVLGLS---------------------AALVGLLLalYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 468 ACMTGTTIISLISVShysegiehiiggnstiknAALAVFALLGFPLAITYSVPFSLTAElTADSGGGQ------GLAIGV 541
Cdd:COG2211  306 LGLLLLFFLGPGNLW------------------LLLVLAALAGIGLGAILVLPWAMLAD-VVDYDEWKtgrrreGLYFGI 366

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 449452054 542 LNLAVVIPQMIVSLGAGPWDALF---SGGNIPAFALASICALAAGVVAVLRL 590
Cdd:COG2211  367 FTFAIKLGQALAGALAGLLLALFgyvAGAAQSPSALTGIRLLFFLLPAVLLL 418
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 77-286 2.00e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 50.39  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   77 IAAGVqFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVAVVLI 156
Cdd:pfam13347   7 LAAGI-KYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  157 GFSADIGyilgdtkehcRVYKgtrtraAIIFVIGFWMLDLANNTVQGPARALLADLS-GPDQHNVAnAVFCSWMAVGNIL 235
Cdd:pfam13347  86 FTPPELG----------RAPL------FIWLLATYILLRIAYTFFEIPYWSLGPELTrDYDERTSL-TSYRSFFSVGGGL 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 449452054  236 GFSAGAsgnwhkwFPFLLSNaccEACGNLKAAFLIAVLFLTICTLVTIYFA 286
Cdd:pfam13347 149 LAAALA-------FPLVLIL---GGTGLERKGYRIFALIGAVLMLLGVIIT 189
PRK11462 PRK11462
putative transporter; Provisional
 95-162 7.28e-03

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 39.15  E-value: 7.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449452054  95 YIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVAVVLIGFSADI 162
Cdd:PRK11462  36 YTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFGIVCVLAYSTPDL 103
 
Name Accession Description Interval E-value
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 66-591 0e+00

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 527.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   66 SSLIILILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAG 145
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  146 SLMIAVAVVLIGFSADIGYILGDTkehcrVYKGTRTRAAIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHN--VANA 223
Cdd:TIGR01301  81 AALVAFAVILIGFAADIGHLFGDN-----LDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRtrIANA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  224 VFCSWMAVGNILGFSAGASGNWHKWFPFLLSNACCEACGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPRLSDS 303
Cdd:TIGR01301 156 YFSFFMAIGNVLGYAAGAYSGLYKIFPFTKTEACGVSCANLKSCFLIDIILLAILTYIALSAVKENPLIGSDDFINSEAA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  304 APLLNGSEqnspdilkpelnglngssvdyghheninlknskaeseenqsegyydgpaTVIVKLLTSLRHLPPAMHSVLLV 383
Cdd:TIGR01301 236 PPSKHGEE-------------------------------------------------AFFGELFGAFKYLPRPVWILLLV 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  384 MALSWLSWFPFFLFDTDWMGREVYHGDPKgsltDERVYDQGVREGAFGLLLNSVVLGISSFFIEPMCQRMGA-RVVWAMS 462
Cdd:TIGR01301 267 TCLNWIAWFPFILFDTDWMGREVYGGSVN----QGAKYDDGVRAGAFGLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIV 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  463 NFIVFACMTGTTIISLISV-SHYSEGIEHIIGGNSTIKNAALAVFALLGFPLAITYSVPFSLTAELTADSGGGQGLAIGV 541
Cdd:TIGR01301 343 NIILAICLAATVLVTYVAKnSRYYDGDGESLPPPTGIKASALIVFAILGIPLAITYSIPFALASIRSSNLGAGQGLSMGV 422

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 449452054  542 LNLAVVIPQMIVSLGAGPWDALFSGGNIPAFALASICALAAGVVAVLRLP 591
Cdd:TIGR01301 423 LNLAIVIPQIIVSLGSGPWDQLFGGGNLPAFVVGAVAAFVSGLLALILLP 472
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 71-588 8.96e-143

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 420.49  E-value: 8.96e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  71 LILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIA 150
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 151 VAVVLIGFSADIGYILGDtkehcrvykGTRTRAAIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHNVANAVFCSWMA 230
Cdd:cd17313   81 LGLILIPNAADIGLALGD---------GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 231 VGNILGFSAGASGNWHKWFPFLLsnacceaCGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVdqpprlsdsapllngs 310
Cdd:cd17313  152 LGGVLGYLLGAILWDHNWFGFAL-------GGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPE---------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 311 eqnspdilkpelnglngssvdyghheninlknsKAESEENQSEGyydgpaTVIVKLLTSLRHLPPAMHSVLLVMALSWLS 390
Cdd:cd17313  209 ---------------------------------AGEHSENPSLG------EVLKSLLKLLKIMPRSLLRLLLVIFFWWIA 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 391 WFPFFLFDTDWMGREVYHGDPKGSltdeRVYDQGVREGAFGLLLNSVVLGISSFFIEPMCQRMGARVVWAMSNFIVFACM 470
Cdd:cd17313  250 FFPFELFFTDYMGEEVYHGTSAAS----SHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGM 325

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 471 TGTTIISLISVshysegiehiiggnstiknaALAVFALLGFPLAITYSVPFSLTAELTADSGGGQGLAIGVLNLAVVIPQ 550
Cdd:cd17313  326 ALMALVHNVTV--------------------ALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTGLLNLAISLAQ 385

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 449452054 551 MIVSLGAGPWDALFsgGNIPAFALASICALAAGVVAVL 588
Cdd:cd17313  386 ILVSLLAGPIIDVK--GYGTVFPVAAVASFLSLVGALF 421
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
78-590 2.85e-24

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 106.14  E-value: 2.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  78 AAGVQFGWALQLSLLTP-YIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVAVVLI 156
Cdd:COG2211   19 DLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIPLALSFVLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 157 GFSADIGYILgdtkehcrvykgtrtrAAIIFVIGFWMLDLANNTVQGPARALLADLSG-PDQHNVANAVFCSWMAVGNIL 235
Cdd:COG2211   99 FTAPDLSPTG----------------KLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 236 GFSAGasgnwhkwfPFLLSNACCEACGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPrlsdsapllngseqnsp 315
Cdd:COG2211  163 ASVLP---------PPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS----------------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 316 dilkpelnglngssvdyghheninlknskaeseenqsegyydgpatvIVKLLTSLRHLPPAMHsVLLVMALSWLSW---- 391
Cdd:COG2211  217 -----------------------------------------------LKESLKALLKNRPFLL-LLLAYLLFFLALalva 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 392 --FPFFLfdTDWMGREvyhgdpkgsltdervydqgvrEGAFGLLL--NSVVLGISSFFIEPMCQRMGARVVWAMSNFIVF 467
Cdd:COG2211  249 alLLYYF--KYVLGLS---------------------AALVGLLLalYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 468 ACMTGTTIISLISVShysegiehiiggnstiknAALAVFALLGFPLAITYSVPFSLTAElTADSGGGQ------GLAIGV 541
Cdd:COG2211  306 LGLLLLFFLGPGNLW------------------LLLVLAALAGIGLGAILVLPWAMLAD-VVDYDEWKtgrrreGLYFGI 366

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 449452054 542 LNLAVVIPQMIVSLGAGPWDALF---SGGNIPAFALASICALAAGVVAVLRL 590
Cdd:COG2211  367 FTFAIKLGQALAGALAGLLLALFgyvAGAAQSPSALTGIRLLFFLLPAVLLL 418
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 83-582 1.37e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.97  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  83 FGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCsskygRRRPFILAGSLMIAVAVVLIGFSADI 162
Cdd:cd06174   10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLFALGALLFAFAPSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 163 GYILGdtkehcrvykgtrtrAAIIFVIGFWMLDLANNtvqgparALLADLSGPDQHNVANAVFCSWMAVGNILGFSAGAS 242
Cdd:cd06174   85 WLLLL---------------GRFLLGLGSGLIDPAVL-------ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGI 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 243 GNWHKWFPFllsnacceacgnlKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPRLSdsapllngseqnspdilkpel 322
Cdd:cd06174  143 LASSLGFGW-------------RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEAS--------------------- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 323 nglngssvdyghheninlknskaeseenqsegyydgpATVIVKLLTSLRHLPPAMhSVLLVMALSWLSWFPFFLFDTDWM 402
Cdd:cd06174  189 -------------------------------------SKSVLKLLKRVLKNPGLW-LLLLAIFLVNLAYYSFSTLLPLFL 230

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 403 GREVYhgdpkgsltdervydQGVREGAFGLLLNSVVLGISSFFIEPMCQRMGARVVWAMSNFIVFACMTgttiislisvs 482
Cdd:cd06174  231 LDLGG---------------LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL----------- 284

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 483 hysegiehIIGGNSTIKNAALAVFALLGFPLAITYSVPFSLTAELTadSGGGQGLAIGVLNLAVVIPQMIVSLGAGPWDA 562
Cdd:cd06174  285 --------ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF--PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354

                        490       500
                 ....*....|....*....|
gi 449452054 563 LFSGGNIPAFALASICALAA 582
Cdd:cd06174  355 ATFGLTGAFLVLAVLLLLAA 374
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 71-286 4.22e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.58  E-value: 4.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  71 LILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAF-SSFIWLCGPITGLVVQPCVGIWSDKcsskYGRRRPfILAGSLMI 149
Cdd:cd17325  201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqIGLLFGAQGLASALSQPPAGKLSDR----IGRKPL-ILIGLLLS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 150 AVAVVLIGFSADIGYILgdtkehcrvykgtrtraAIIFVIGfwmldLANNTVQGPARALLADLSGPDQHNVANAVFCSWM 229
Cdd:cd17325  276 AVALLLLPLATSFWLLL-----------------LLLALLG-----LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 449452054 230 AVGNILGFSAGAsgnwhkwfpFLLSNacceacGNLKAAFLIAVLFLTICTLVTIYFA 286
Cdd:cd17325  334 SLGMVLGPLLGG---------FLYDA------FGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
58-307 7.40e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.51  E-value: 7.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  58 SPHIRSKPSSLIILILSCTIAAgvqFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDkcssKYGR 137
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSG---LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD----RFGR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 138 RRPFILaGSLMIAVAVVLIGFSADIGYILgdtkehcrvykgtrtraAIIFVIGFwmldlANNTVQGPARALLADLSGPDQ 217
Cdd:COG2814   75 RRVLLL-GLLLFALGSLLCALAPSLWLLL-----------------AARFLQGL-----GAGALFPAALALIADLVPPER 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 218 HNVANAVFCSWMAVGNILGFSAGAsgnwhkwfpFLLSNAcceacgNLKAAFLIAVLFLTICTLVTIYFadeVPLTAVDQP 297
Cdd:COG2814  132 RGRALGLLGAGLGLGPALGPLLGG---------LLADLF------GWRWVFLVNAVLALLALLLLLRL---LPESRPAAR 193

                        250
                 ....*....|
gi 449452054 298 PRLSDSAPLL 307
Cdd:COG2814  194 ARLRGSLREL 203
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 75-307 9.83e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 9.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  75 CTIAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDkcssKYGRRRPfILAGSLMIAVAVV 154
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGRKRL-LLLGLLLLAVSTL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 155 LIGFSADIGYILgdtkehcrvykgtrtraAIIFVIGFWMldlannTVQGPAR-ALLADLSGPDQHNVANAVFCSWMAVGN 233
Cdd:cd17325   77 LFAFATSYWQLL-----------------LARFLQGLAS------AAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGF 133

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449452054 234 ILGFSAGAsgnwhkwfpfLLSNAcceacGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPRLSDSAPLL 307
Cdd:cd17325  134 LIGPLLGG----------LLADA-----LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGL 192
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 77-286 2.00e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 50.39  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   77 IAAGVqFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVAVVLI 156
Cdd:pfam13347   7 LAAGI-KYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  157 GFSADIGyilgdtkehcRVYKgtrtraAIIFVIGFWMLDLANNTVQGPARALLADLS-GPDQHNVAnAVFCSWMAVGNIL 235
Cdd:pfam13347  86 FTPPELG----------RAPL------FIWLLATYILLRIAYTFFEIPYWSLGPELTrDYDERTSL-TSYRSFFSVGGGL 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 449452054  236 GFSAGAsgnwhkwFPFLLSNaccEACGNLKAAFLIAVLFLTICTLVTIYFA 286
Cdd:pfam13347 149 LAAALA-------FPLVLIL---GGTGLERKGYRIFALIGAVLMLLGVIIT 189
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
71-235 1.86e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  71 LILSCTIAAGVQFGWALQLSLLTPYIQT-LGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSskygrRRPFILAGSLMI 149
Cdd:COG2814  209 LLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-----RRRLLLIGLLLL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 150 AVAVVLIGFSAdigyilgdtkehcrvykgtrtrAAIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHNVANAVFCSWM 229
Cdd:COG2814  284 ALGLLLLALAG----------------------SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341


                 ....*.
gi 449452054 230 AVGNIL 235
Cdd:COG2814  342 FLGGPL 347
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 73-156 2.10e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.13  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  73 LSCTIAAGVQFGWalqlsLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVA 152
Cdd:cd17332    9 FGNNLIFQIVSTY-----LLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLALL 83


                 ....
gi 449452054 153 VVLI 156
Cdd:cd17332   84 FVLL 87
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
68-290 2.42e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  68 LIILILSCTIAAGVQFGWALQLSLLTPYI-QTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSkygRRRPFILAGS 146
Cdd:COG2271  179 LLRFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR---RRKLVLAIGL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 147 LMIAVAVVLIGFSADIGYILgdtkehcrvykgtrtraAIIFVIGFwmldlANNTVQGPARALLADLSGPDQHNVAnavfc 226
Cdd:COG2271  256 LLAALALLLLALLPSPALAI-----------------ALLFLAGF-----GLGGAFGLLWALAAELFPKKARGTA----- 308

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449452054 227 swMAVGNILGFSAGASGNWhkWFPFLLSNAcceacgNLKAAFLIAVLFLTICTLVTIYFADEVP 290
Cdd:COG2271  309 --SGLVNTFGFLGGALGPL--LVGYLLDAT------GYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 97-156 4.28e-04

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 43.02  E-value: 4.28e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 449452054  97 QTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSS--KYGRRRPFILAGSLMIAVAVVLI 156
Cdd:cd17491   28 LVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGcgKYGRRKSWHLIGTICVLLSFPFI 89
MFS_1 pfam07690
Major Facilitator Superfamily;
60-236 5.62e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   60 HIRSKPSSLIILILSCTIAAGVQFgwalqLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKcsskYGRRR 139
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGL-----LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR----LGRRR 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  140 PFILAGSLMIAVAVVLIGFSADIGYILGdtkehcrvykgtrtrAAIIFVIGFwmldlANNTVQGPARALLADLSGPDQHN 219
Cdd:pfam07690 267 RLLLALLLLILAALGLLLLSLTLSSLWL---------------LLALLLLGF-----GFGLVFPALNALVSDLAPKEERG 326

                         170
                  ....*....|....*..
gi 449452054  220 VANAVFCSWMAVGNILG 236
Cdd:pfam07690 327 TASGLYNTAGSLGGALG 343
MFS_1 pfam07690
Major Facilitator Superfamily;
75-318 7.98e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.02  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054   75 CTIAAGVQFGWALQLSLLTPYI-QTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSskygrRRPFILAGSLMIAVAV 153
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG-----RRRVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  154 VLIGFSADIGyilgdtkehcrvykgtrtraaiIFVIGFWMLDLANNTVQGPARALLADLSGPDQHNVANAVFCSWMAVGN 233
Cdd:pfam07690  77 LLLLFASSLW----------------------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGA 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  234 ILGFSAGAsgnwhkwfpFLLSNacceacGNLKAAFLIAVLFLTICTLVTIYFADEVPLTAVDQPPRLSDSAPLLNGSEQN 313
Cdd:pfam07690 135 ALGPLLGG---------LLASL------FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLR 199


                  ....*
gi 449452054  314 SPDIL 318
Cdd:pfam07690 200 DPVLW 204
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 46-285 9.77e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  46 PNGSQPEHSFPSSPHIRSKpssliILILSCTIAAGVQFGWALQLSLLTPYIQTLGIEHAfsSFIWLCGPITGLVVQPCVG 125
Cdd:cd17489  176 VAAEEAEAGTRAFRRLVEK-----KVLPPALILFLASIAYGAISTFLPLYAAERGISNA--GLFFTVYAIALLLSRPFSG 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 126 IWSDKcsskyGRRRPFILAGSLMIAVAVVLIGFSADIGYILGdtkehcrvykgtrtrAAIIFVIGFWMLDLANNtvqgpa 205
Cdd:cd17489  249 KLSDR-----KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL---------------AAVLYGLGFGLLFPALQ------ 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 206 rALLADLSGPDQHNVANAVFCSWMAVGniLGFSAGASGNWHKWFPFllsnacceacgnlKAAFLIAVLFLTICTLVTIYF 285
Cdd:cd17489  303 -ALAVDLVPPHRRGAANGTFFIFFDLG--IGLGGLLLGLVAELFGY-------------RAMFLLAAVVVLLALVLYIFL 366
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 68-258 1.21e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  68 LIILILSCTIAAgvqFGWALQLSLLTPYI-QTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKcsskYGRRrPFILAGS 146
Cdd:cd17329    1 LWVLLIGSFLNR---LGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR----FGRK-PVMLAGL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054 147 LMIAVAVVLIGFSADIgyilgdtkehcrvykgtrtraaIIFVIGFWMLDLANNTVQGPARALLADLSGPDQHNVANAVFc 226
Cdd:cd17329   73 LLRALGFALLGFAHSP----------------------WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL- 129

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 449452054 227 SWM-----AVGNILG-FSAGASGNWhkwfPFLLSNACC 258
Cdd:cd17329  130 YWAinlgvAIGPLLGgLLLLYSFRL----LFLAAAVLF 163
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 92-166 1.37e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.44  E-value: 1.37e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449452054  92 LTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKcsskYGRRRPFILAGSLMIAVAVVLIGFSADIGYIL 166
Cdd:cd17490   19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDR----IGKRKLFIIIGLLFTVLASLIMILFPSPWGLL 89
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 83-236 2.86e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.29  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  83 FGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKcsskYGRRrPFILAGSLMIAVAVVLIGFSADI 162
Cdd:cd17390   10 FGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDV----VGRR-PVLLICLLLTALGYVLLGFSTSL 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449452054 163 gYILGDTKEHCRVYKGTrtraaiifvigfwmldlanntvQGPARALLADLSGPDQHNVANAVFCSWMAVGNILG 236
Cdd:cd17390   85 -ALLFLSRIPLGIFKHT----------------------QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILG 135
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
64-161 5.43e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449452054  64 KPSSLIILILsctIAAGVQFGWALQLSLLTPYIQ-TLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKcsskYGRRRPFI 142
Cdd:COG2211  226 KNRPFLLLLL---AYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR----FGKKKAFI 298

                         90
                 ....*....|....*....
gi 449452054 143 LAGSLMIAVAVVLIGFSAD 161
Cdd:COG2211  299 IGLLLAALGLLLLFFLGPG 317
PRK11462 PRK11462
putative transporter; Provisional
 95-162 7.28e-03

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 39.15  E-value: 7.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449452054  95 YIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCSSKYGRRRPFILAGSLMIAVAVVLIGFSADI 162
Cdd:PRK11462  36 YTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFGIVCVLAYSTPDL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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