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Conserved domains on  [gi|426381771|ref|XP_004057507|]
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X2 [Gorilla gorilla gorilla]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein catalyzes the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

CATH:  1.20.120.1760
EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0016020|GO:0000287
PubMed:  24923293|24573438|21259003|24942835
SCOP:  3002413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 7-103 1.68e-12

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 62.95  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   7 FLFVPNLIGYARIVFA--IISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLA 84
Cdd:COG0558    8 LLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLV 87

                         90
                 ....*....|....*....
gi 426381771  85 LLYPGATLFFQISMSLDVA 103
Cdd:COG0558   88 LLGLLPAWLALLILLRELL 106
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 7-103 1.68e-12

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 62.95  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   7 FLFVPNLIGYARIVFA--IISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLA 84
Cdd:COG0558    8 LLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLV 87

                         90
                 ....*....|....*....
gi 426381771  85 LLYPGATLFFQISMSLDVA 103
Cdd:COG0558   88 LLGLLPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 10-94 7.97e-12

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 60.65  E-value: 7.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   10 VPNLIGYARI--VFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLY 87
Cdd:pfam01066   3 LPNLLTLLRIllVPVFVVLLLGPGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALSILG 82


                  ....*..
gi 426381771   88 PGATLFF 94
Cdd:pfam01066  83 LLPWWFV 89
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
10-92 4.90e-05

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 42.53  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771  10 VPNLIGYARIV---FAIISFYF-MPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLAL 85
Cdd:PRK10832   5 IPTLLTLFRVIlipFFVLVFYLpFTWAPFVCALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVLVTE 84

                         90
                 ....*....|....
gi 426381771  86 LY-------PGATL 92
Cdd:PRK10832  85 HYhswwvtlPAATM 98
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 10-86 2.05e-04

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 40.41  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   10 VPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLL-------DAFDGHAARALNQGTRFGAMLDMLTDRcstmcLLVN 82
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVSPFIGALLfifaavtDWLDGYLARKWNQVSNFGKFLDPLADK-----VLVL 77


                  ....
gi 426381771   83 LALL 86
Cdd:TIGR00560  78 AVLI 81
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 7-103 1.68e-12

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 62.95  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   7 FLFVPNLIGYARIVFA--IISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLA 84
Cdd:COG0558    8 LLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLV 87

                         90
                 ....*....|....*....
gi 426381771  85 LLYPGATLFFQISMSLDVA 103
Cdd:COG0558   88 LLGLLPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 10-94 7.97e-12

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 60.65  E-value: 7.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   10 VPNLIGYARI--VFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLY 87
Cdd:pfam01066   3 LPNLLTLLRIllVPVFVVLLLGPGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALSILG 82


                  ....*..
gi 426381771   88 PGATLFF 94
Cdd:pfam01066  83 LLPWWFV 89
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
10-92 4.90e-05

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 42.53  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771  10 VPNLIGYARIV---FAIISFYF-MPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLAL 85
Cdd:PRK10832   5 IPTLLTLFRVIlipFFVLVFYLpFTWAPFVCALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVLVTE 84

                         90
                 ....*....|....
gi 426381771  86 LY-------PGATL 92
Cdd:PRK10832  85 HYhswwvtlPAATM 98
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 10-86 2.05e-04

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 40.41  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   10 VPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLL-------DAFDGHAARALNQGTRFGAMLDMLTDRcstmcLLVN 82
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVSPFIGALLfifaavtDWLDGYLARKWNQVSNFGKFLDPLADK-----VLVL 77


                  ....
gi 426381771   83 LALL 86
Cdd:TIGR00560  78 AVLI 81
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
6-72 5.69e-04

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 39.80  E-value: 5.69e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 426381771   6 IFLFVPNLI-------GYARIVFAIISFYFMpccpltASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTD 72
Cdd:COG1183    8 AIYLLPNLFtllnlfcGFLAIVAAIEGDFEL------AALLILLAAVFDGLDGRVARLLNVQSEFGAELDSLAD 75
PLN02794 PLN02794
cardiolipin synthase
 7-89 1.76e-03

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 38.67  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   7 FLFVPNLIGYARIVFAIIsFYFMPCCPLTASSFYLL--SGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCL---LV 81
Cdd:PLN02794 141 FVNLPNLISISRLVSGPV-IGWMIVNEMYLSAFVGLaiSGASDWLDGYVARKMGINSVVGSYLDPLADKVLIGCValaMV 219


                 ....*...
gi 426381771  82 NLALLYPG 89
Cdd:PLN02794 220 EKDLLHPG 227
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 7-86 7.95e-03

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 36.16  E-value: 7.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426381771   7 FLFVPNLIGYARIV---FAIISFYFMPCCPLTAS-SFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRcstmcLLVN 82
Cdd:PLN02558   8 VLTLPTVLTLGRVAavpLLVATFYVDSWWGRTATtSIFIAAAITDWLDGYLARKMKLGTAFGAFLDPVADK-----LMVA 82


                 ....
gi 426381771  83 LALL 86
Cdd:PLN02558  83 AALI 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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