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Conserved domains on  [gi|410957808|ref|XP_003985516|]
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toll-like receptor 6 [Felis catus]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 5.93e-39

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 140.92  E-value: 5.93e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808   641 QFHAFISYSEHDsaWVKNELVPYLEK--EDLRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410957808   719 AHHNLFHEGSNNLILILLEPIPQNcIPSKYHKLKALMtQRTYLEWPKEKSKHglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-531 2.78e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 2.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 251 LLNFTLKHVETTWKCLVRVFQFLWPKPVEYLNIYNLIIVESIDEEDFTYSKTALKALKIEHVTNRVFIYSQTVLYTFFSE 330
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 331 MNIMMLTLSDTPFIHMLcpqtsSTFKFLNFTQNVFTDsVFQNCSKLVRLETLILQKNKLKglyNIGLMTKHMTSLEILDV 410
Cdd:COG4886   96 TNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT---DLPEPLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 411 SWNSLEY-DRHDGNCTwggSIVVLNLSSNILTD--SVFRCLPpKVKVLDLYDNRIRSIPKLIMKLEALQELNVASNSLAH 487
Cdd:COG4886  167 SNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTD 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 410957808 488 LPDCGAFSSLSVLIIDHNSISNPSadFFHSCQKIRSIRAGNNPF 531
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-201 1.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  36 VDMSKMKLTHVPKDLS--PKTKVLDISQNYISKLHISdISYLLGLEVLTLSYNRLQCLDFSIFKFNQdLEYLDLSHNQLQ 113
Cdd:COG4886  164 LDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 114 KTSC-HLIRSLKHLDLSFNDFDVLPickEFGNLTQLNFLGLSGTRLRQLDLLPIAHLHLSHILLDLEGYYAKESETESLQ 192
Cdd:COG4886  242 DLPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318


                 ....*....
gi 410957808 193 ILNTKTLHL 201
Cdd:COG4886  319 LLTTLLLLL 327
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 2.97e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 2.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 410957808   529 NPFQCTCELREFIQNIGQvssEVVEGWPDSYKCDNPESYKGtPLKDFHVSQLSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 5.93e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 140.92  E-value: 5.93e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808   641 QFHAFISYSEHDsaWVKNELVPYLEK--EDLRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410957808   719 AHHNLFHEGSNNLILILLEPIPQNcIPSKYHKLKALMtQRTYLEWPKEKSKHglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-778 2.22e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 85.88  E-value: 2.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  642 FHAFISYSEHDS-AWVKNELVPYLEKEDLRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410957808  721 HNLFhEGSNNLILILLEPIPQNC------IPSKYHKLKALMTQRTYLEWPKE----------KSKH--GLFWANIR 778
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDVrkqtgsFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIA 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-531 2.78e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 2.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 251 LLNFTLKHVETTWKCLVRVFQFLWPKPVEYLNIYNLIIVESIDEEDFTYSKTALKALKIEHVTNRVFIYSQTVLYTFFSE 330
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 331 MNIMMLTLSDTPFIHMLcpqtsSTFKFLNFTQNVFTDsVFQNCSKLVRLETLILQKNKLKglyNIGLMTKHMTSLEILDV 410
Cdd:COG4886   96 TNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT---DLPEPLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 411 SWNSLEY-DRHDGNCTwggSIVVLNLSSNILTD--SVFRCLPpKVKVLDLYDNRIRSIPKLIMKLEALQELNVASNSLAH 487
Cdd:COG4886  167 SNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTD 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 410957808 488 LPDCGAFSSLSVLIIDHNSISNPSadFFHSCQKIRSIRAGNNPF 531
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-201 1.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  36 VDMSKMKLTHVPKDLS--PKTKVLDISQNYISKLHISdISYLLGLEVLTLSYNRLQCLDFSIFKFNQdLEYLDLSHNQLQ 113
Cdd:COG4886  164 LDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 114 KTSC-HLIRSLKHLDLSFNDFDVLPickEFGNLTQLNFLGLSGTRLRQLDLLPIAHLHLSHILLDLEGYYAKESETESLQ 192
Cdd:COG4886  242 DLPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318


                 ....*....
gi 410957808 193 ILNTKTLHL 201
Cdd:COG4886  319 LLTTLLLLL 327
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 2.97e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 2.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 410957808   529 NPFQCTCELREFIQNIGQvssEVVEGWPDSYKCDNPESYKGtPLKDFHVSQLSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
77-133 4.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.37e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808   77 GLEVLTLSYNRLQCLDFSIFKFNQDLEYLDLSHNQLQ---KTSCHLIRSLKHLDLSFNDF 133
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtlsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 35-494 6.78e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  35 AVDMSKMKLT-HVPKDLS--PKTKVLDISQNYISKLHISDISYLLGLEVLTLSYNRLQCLDFSIFKFNQDLEYLDLSHNQ 111
Cdd:PLN00113 144 TLDLSNNMLSgEIPNDIGsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 112 LQ---KTSCHLIRSLKHLDLSFNDFdVLPICKEFGNLTQLNFLGLSGTRLRqlDLLPIAHLHLSH-ILLDL-EGYYAKES 186
Cdd:PLN00113 224 LSgeiPYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKlISLDLsDNSLSGEI 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 187 ETESLQILNTKTLHLvFHPNqlFSVQVNISVNSLRCLQLTNIKLNNDNCQIlikflselirgPTLL----NFTLKHVETt 262
Cdd:PLN00113 301 PELVIQLQNLEILHL-FSNN--FTGKIPVALTSLPRLQVLQLWSNKFSGEI-----------PKNLgkhnNLTVLDLST- 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 263 wkclvrvfQFLWPKPVEYL----NIYNLIIVESIDEEDFTYSKTALKALKIEHVTNRVFiySQTVLYTFFSEMNIMMLTL 338
Cdd:PLN00113 366 --------NNLTGEIPEGLcssgNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF--SGELPSEFTKLPLVYFLDI 435

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 339 SDTPFIHMLCPQT--SSTFKFLNFTQNVFTDSVFQNcSKLVRLETLILQKNKLKGLYNIGLMTkhMTSLEILDVSWNSL- 415
Cdd:PLN00113 436 SNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDS-FGSKRLENLDLSRNQFSGAVPRKLGS--LSELMQLKLSENKLs 512

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 416 -EYDRHDGNCTwggSIVVLNLSSNILTDSVFRCLP--PKVKVLDLYDNRIR-SIPKLIMKLEALQELNVASNSL-AHLPD 490
Cdd:PLN00113 513 gEIPDELSSCK---KLVSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPS 589


                 ....
gi 410957808 491 CGAF 494
Cdd:PLN00113 590 TGAF 593
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-137 8.85e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 8.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  42 KLTHVPKDLSPKTKVLDISQNYISKL--HISDisyllGLEVLTLSYNRLQCLDFSIfkfNQDLEYLDLSHNQLQKTSCHL 119
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELpeRLPS-----ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                         90
                 ....*....|....*...
gi 410957808 120 IRSLKHLDLSFNDFDVLP 137
Cdd:PRK15370 303 PSGITHLNVQSNSLTALP 320
LRR_8 pfam13855
Leucine rich repeat;
432-485 1.96e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 410957808  432 VLNLSSNILT---DSVFRCLPpKVKVLDLYDNRIRSI-PKLIMKLEALQELNVASNSL 485
Cdd:pfam13855   5 SLDLSNNRLTsldDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 5.93e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 140.92  E-value: 5.93e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808   641 QFHAFISYSEHDsaWVKNELVPYLEK--EDLRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410957808   719 AHHNLFHEGSNNLILILLEPIPQNcIPSKYHKLKALMtQRTYLEWPKEKSKHglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-778 2.22e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 85.88  E-value: 2.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  642 FHAFISYSEHDS-AWVKNELVPYLEKEDLRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410957808  721 HNLFhEGSNNLILILLEPIPQNC------IPSKYHKLKALMTQRTYLEWPKE----------KSKH--GLFWANIR 778
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDVrkqtgsFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIA 155
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-738 1.71e-18

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 81.98  E-value: 1.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  645 FISYSEHDSAWVKnELVPYLEKEDLRICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 724
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 410957808  725 HEGSNNLILILLEP 738
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-531 2.78e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 2.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 251 LLNFTLKHVETTWKCLVRVFQFLWPKPVEYLNIYNLIIVESIDEEDFTYSKTALKALKIEHVTNRVFIYSQTVLYTFFSE 330
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 331 MNIMMLTLSDTPFIHMLcpqtsSTFKFLNFTQNVFTDsVFQNCSKLVRLETLILQKNKLKglyNIGLMTKHMTSLEILDV 410
Cdd:COG4886   96 TNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT---DLPEPLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 411 SWNSLEY-DRHDGNCTwggSIVVLNLSSNILTD--SVFRCLPpKVKVLDLYDNRIRSIPKLIMKLEALQELNVASNSLAH 487
Cdd:COG4886  167 SNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTD 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 410957808 488 LPDCGAFSSLSVLIIDHNSISNPSadFFHSCQKIRSIRAGNNPF 531
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-201 1.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  36 VDMSKMKLTHVPKDLS--PKTKVLDISQNYISKLHISdISYLLGLEVLTLSYNRLQCLDFSIFKFNQdLEYLDLSHNQLQ 113
Cdd:COG4886  164 LDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 114 KTSC-HLIRSLKHLDLSFNDFDVLPickEFGNLTQLNFLGLSGTRLRQLDLLPIAHLHLSHILLDLEGYYAKESETESLQ 192
Cdd:COG4886  242 DLPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318


                 ....*....
gi 410957808 193 ILNTKTLHL 201
Cdd:COG4886  319 LLTTLLLLL 327
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-546 4.04e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 4.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 356 KFLNFTQNVFTDsVFQNCSKLVRLETLILQKNKLKglyNIGLMTKHMTSLEILDVSWNSLEYDRHD-GNCTwggSIVVLN 434
Cdd:COG4886  139 KELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLSNNQITDLPEPlGNLT---NLEELD 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 435 LSSNILTD---SVFRClpPKVKVLDLYDNRIRSIPKLiMKLEALQELNVASNSLAHLPDCGAFSSLSVLIIDHNSISNPS 511
Cdd:COG4886  212 LSGNQLTDlpePLANL--TNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 410957808 512 ADFFHSCQKIRSIRAGNNPFQCTCELREFIQNIGQ 546
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 2.97e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 2.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 410957808   529 NPFQCTCELREFIQNIGQvssEVVEGWPDSYKCDNPESYKGtPLKDFHVSQLSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
77-133 4.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.37e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808   77 GLEVLTLSYNRLQCLDFSIFKFNQDLEYLDLSHNQLQ---KTSCHLIRSLKHLDLSFNDF 133
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtlsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-162 6.01e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 6.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  47 PKDLSPKTKVLDISQNYISKLHISDISYLLGLEVLTLSYNRlqcldfSIFKFnQDLEYLDLSHNQLQKTSCHL--IRSLK 124
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNL-TNLESLDLSGNQLTDLPEELanLTNLK 139

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 410957808 125 HLDLSFNDFDVLPicKEFGNLTQLNFLGLSGTRLRQLD 162
Cdd:COG4886  140 ELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLP 175
LRR_8 pfam13855
Leucine rich repeat;
52-112 9.60e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 9.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410957808   52 PKTKVLDISQNYISKLHISDISYLLGLEVLTLSYNRLQCLDFSIFKFNQDLEYLDLSHNQL 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 35-494 6.78e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  35 AVDMSKMKLT-HVPKDLS--PKTKVLDISQNYISKLHISDISYLLGLEVLTLSYNRLQCLDFSIFKFNQDLEYLDLSHNQ 111
Cdd:PLN00113 144 TLDLSNNMLSgEIPNDIGsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 112 LQ---KTSCHLIRSLKHLDLSFNDFdVLPICKEFGNLTQLNFLGLSGTRLRqlDLLPIAHLHLSH-ILLDL-EGYYAKES 186
Cdd:PLN00113 224 LSgeiPYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKlISLDLsDNSLSGEI 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 187 ETESLQILNTKTLHLvFHPNqlFSVQVNISVNSLRCLQLTNIKLNNDNCQIlikflselirgPTLL----NFTLKHVETt 262
Cdd:PLN00113 301 PELVIQLQNLEILHL-FSNN--FTGKIPVALTSLPRLQVLQLWSNKFSGEI-----------PKNLgkhnNLTVLDLST- 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 263 wkclvrvfQFLWPKPVEYL----NIYNLIIVESIDEEDFTYSKTALKALKIEHVTNRVFiySQTVLYTFFSEMNIMMLTL 338
Cdd:PLN00113 366 --------NNLTGEIPEGLcssgNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF--SGELPSEFTKLPLVYFLDI 435

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 339 SDTPFIHMLCPQT--SSTFKFLNFTQNVFTDSVFQNcSKLVRLETLILQKNKLKGLYNIGLMTkhMTSLEILDVSWNSL- 415
Cdd:PLN00113 436 SNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDS-FGSKRLENLDLSRNQFSGAVPRKLGS--LSELMQLKLSENKLs 512

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 416 -EYDRHDGNCTwggSIVVLNLSSNILTDSVFRCLP--PKVKVLDLYDNRIR-SIPKLIMKLEALQELNVASNSL-AHLPD 490
Cdd:PLN00113 513 gEIPDELSSCK---KLVSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPS 589


                 ....
gi 410957808 491 CGAF 494
Cdd:PLN00113 590 TGAF 593
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 351-529 8.75e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 8.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 351 TSSTFKFLNFTQNVFTDSVFQncSKLVRLETLILQKNKLKG-LYN-IGLmtkhMTSLEILDVSWNSL--EYDRHDGNCTw 426
Cdd:PLN00113 116 TSSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGeIPNdIGS----FSSLKVLDLGGNVLvgKIPNSLTNLT- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 427 ggSIVVLNLSSNILTDSVFRCLpPKVKVLDL----YDNRIRSIPKLIMKLEALQELNVASNSLAHL--PDCGAFSSLSVL 500
Cdd:PLN00113 189 --SLEFLTLASNQLVGQIPREL-GQMKSLKWiylgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPipSSLGNLKNLQYL 265

                        170       180
                 ....*....|....*....|....*....
gi 410957808 501 IIDHNSISNPSADFFHSCQKIRSIRAGNN 529
Cdd:PLN00113 266 FLYQNKLSGPIPPSIFSLQKLISLDLSDN 294
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-137 8.85e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 8.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  42 KLTHVPKDLSPKTKVLDISQNYISKL--HISDisyllGLEVLTLSYNRLQCLDFSIfkfNQDLEYLDLSHNQLQKTSCHL 119
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELpeRLPS-----ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                         90
                 ....*....|....*...
gi 410957808 120 IRSLKHLDLSFNDFDVLP 137
Cdd:PRK15370 303 PSGITHLNVQSNSLTALP 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 51-508 1.66e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808  51 SPKTKVLDISQNYISKLHISDISYLLGLEVLTLSYNRLQC-LDFSIFKFNQDLEYLDLSHNQLQKT-SCHLIRSLKHLDL 128
Cdd:PLN00113  68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSiPRGSIPNLETLDL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 129 SFNDFDVlPICKEFGNLTQLNFLGLSGTRLrqldllpiahlhLSHILLDLegyyakeSETESLQILNTKTlhlvfhpNQL 208
Cdd:PLN00113 148 SNNMLSG-EIPNDIGSFSSLKVLDLGGNVL------------VGKIPNSL-------TNLTSLEFLTLAS-------NQL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 209 FSvQVNISVNSLRCLQLTNIKLNNDNCQILIKflselIRGPTLLNftlkHVETTWKCLVRvfqflwPKPVEYLNIYNLii 288
Cdd:PLN00113 201 VG-QIPRELGQMKSLKWIYLGYNNLSGEIPYE-----IGGLTSLN----HLDLVYNNLTG------PIPSSLGNLKNL-- 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 289 vesidEEDFTYSKTalkalkiehvtnrvfiYSQTVLYTFFSEMNIMMLTLSDTPF---IHMLCPQTSsTFKFLNFTQNVF 365
Cdd:PLN00113 263 -----QYLFLYQNK----------------LSGPIPPSIFSLQKLISLDLSDNSLsgeIPELVIQLQ-NLEILHLFSNNF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 366 TDSVFQNCSKLVRLETLILQKNKLKGLY--NIGlmtKHmTSLEILDVSWNSLEYDRHDGNCTwGGSIVVLNLSSNILTDS 443
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQLWSNKFSGEIpkNLG---KH-NNLTVLDLSTNNLTGEIPEGLCS-SGNLFKLILFSNSLEGE 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 444 VFRCLP--------------------------PKVKVLDLYDNRIR-SIPKLIMKLEALQELNVASNS-LAHLPDCGAFS 495
Cdd:PLN00113 396 IPKSLGacrslrrvrlqdnsfsgelpseftklPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSK 475

                        490
                 ....*....|...
gi 410957808 496 SLSVLIIDHNSIS 508
Cdd:PLN00113 476 RLENLDLSRNQFS 488
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-565 5.05e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 5.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 353 STFKFLNFTQNVFTDSVFQNCSKLVRLETLILQKNKLKGlyNIGLMTKHMTSLEIldvswnsleydrhdgnctwggsivv 432
Cdd:PLN00113 260 KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG--EIPELVIQLQNLEI------------------------- 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 433 LNLSSNILTDSVFRCLP--PKVKVLDLYDNRIR-SIPKLIMKLEALQELNVASNSLA-HLPD--CGAfSSLSVLIIDHNS 506
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEglCSS-GNLFKLILFSNS 391

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410957808 507 ISNPSADFFHSCQKIRSIRAGNNPFqcTCEL-REFIQ----NIGQVSSEVVEGWPDSYKCDNPE 565
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
432-485 1.96e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 410957808  432 VLNLSSNILT---DSVFRCLPpKVKVLDLYDNRIRSI-PKLIMKLEALQELNVASNSL 485
Cdd:pfam13855   5 SLDLSNNRLTsldDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 373-507 7.61e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 7.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410957808 373 CSKLVRLETLILQKNKLKGlyNIGLMTKHMTSLEILDVSWNSLEYDRHDGNCTWGGSIVVLNLSSNILTDSVFRCLPPKV 452
Cdd:PLN00113  65 CNNSSRVVSIDLSGKNISG--KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNL 142

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410957808 453 KVLDLYDNRIR-SIPKLIMKLEALQELNVASNSL-AHLP-DCGAFSSLSVLIIDHNSI 507
Cdd:PLN00113 143 ETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPnSLTNLTSLEFLTLASNQL 200
LRR_8 pfam13855
Leucine rich repeat;
450-507 8.67e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 8.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410957808  450 PKVKVLDLYDNRIRSI-PKLIMKLEALQELNVASNSLAHLPDcGAFS---SLSVLIIDHNSI 507
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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